Risk factors of multiple system atrophy: A case‐control study in French patients
Identifieur interne : 001826 ( Istex/Corpus ); précédent : 001825; suivant : 001827Risk factors of multiple system atrophy: A case‐control study in French patients
Auteurs : Jean-Sébastien Vidal ; Marie Vidailhet ; Alexis Elbaz ; Pascal Derkinderen ; Christophe Tzourio ; Annick AlpérovitchSource :
- Movement Disorders [ 0885-3185 ] ; 2008-04-30.
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Abstract
Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (P = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (P = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (P = 0.004). This case‐control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.21857
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sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><mods:affiliation>INSERM U708, Neuroepidemiology, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>U708, Université Paris 6, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation><mods:affiliation>INSERM U708, Neuroepidemiology, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>U708, Université Paris 6, Paris, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1B70D7EE8D46D33E3294BD13CA164FE92A56515F</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21857</idno><idno 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Salpêtrière, 75651 Paris cedex 13, France</mods:affiliation></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation><mods:affiliation>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U679, Neurology and Experimental Therapeutics, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>INSERM U708, Neuroepidemiology, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>U708, Université Paris 6, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><affiliation><mods:affiliation>Department of Neurology, Center of Clinical Investigations, Hôpital Laënnec, Nantes, France</mods:affiliation></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><mods:affiliation>INSERM U708, Neuroepidemiology, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>U708, Université Paris 6, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation><mods:affiliation>INSERM U708, Neuroepidemiology, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>U708, Université Paris 6, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-30">2008-04-30</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="797">797</biblScope><biblScope unit="page" to="803">803</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1B70D7EE8D46D33E3294BD13CA164FE92A56515F</idno><idno type="DOI">10.1002/mds.21857</idno><idno type="ArticleID">MDS21857</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>anti‐inflammatory agents, nonsteroidal</term><term>environmental exposure</term><term>epidemiology</term><term>food habits</term><term>multiple system atrophy</term><term>occupation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (P = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (P = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (P = 0.004). This case‐control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jean‐Sébastien Vidal MD</name><affiliations><json:string>INSERM U708, Neuroepidemiology, Paris, France</json:string><json:string>U708, Université Paris 6, Paris, France</json:string><json:string>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</json:string><json:string>INSERM Unit 708, Hôpital de La Salpêtrière, 75651 Paris cedex 13, France</json:string></affiliations></json:item><json:item><name>Marie Vidailhet MD</name><affiliations><json:string>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</json:string><json:string>INSERM U679, Neurology and Experimental Therapeutics, Paris, France</json:string></affiliations></json:item><json:item><name>Alexis Elbaz MD, PhD</name><affiliations><json:string>INSERM U708, Neuroepidemiology, Paris, France</json:string><json:string>U708, Université Paris 6, Paris, France</json:string></affiliations></json:item><json:item><name>Pascal Derkinderen MD, PhD</name><affiliations><json:string>Department of Neurology, Center of Clinical Investigations, Hôpital Laënnec, Nantes, France</json:string></affiliations></json:item><json:item><name>Christophe Tzourio MD, PhD</name><affiliations><json:string>INSERM U708, Neuroepidemiology, Paris, France</json:string><json:string>U708, Université Paris 6, Paris, France</json:string></affiliations></json:item><json:item><name>Annick Alpérovitch MD</name><affiliations><json:string>INSERM U708, Neuroepidemiology, Paris, France</json:string><json:string>U708, Université Paris 6, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>environmental exposure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>anti‐inflammatory agents, nonsteroidal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>food habits</value></json:item></subject><articleId><json:string>MDS21857</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (P = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (P = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (P = 0.004). This case‐control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>7.381</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1681</abstractCharCount><pdfWordCount>4381</pdfWordCount><pdfCharCount>28787</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>259</abstractWordCount></qualityIndicators><title>Risk factors of multiple system atrophy: A case‐control study in French patients</title><refBibs><json:item><author><json:item><name>A Schrag</name></json:item><json:item><name>Y Ben‐Shlomo</name></json:item><json:item><name>NP Quinn</name></json:item></author><host><volume>354</volume><pages><last>1775</last><first>1771</first></pages><author></author><title>Lancet</title></host><title>Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross‐sectional 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neurosurgery</json:string></scienceMetrix></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.21857</json:string></doi><id>1B70D7EE8D46D33E3294BD13CA164FE92A56515F</id><score>0.23344558</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/1B70D7EE8D46D33E3294BD13CA164FE92A56515F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/1B70D7EE8D46D33E3294BD13CA164FE92A56515F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1B70D7EE8D46D33E3294BD13CA164FE92A56515F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Risk factors of multiple system atrophy: A case‐control study in French 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xml:id="author-2"><persName><forename type="first">Marie</forename><surname>Vidailhet</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</affiliation><affiliation>INSERM U679, Neurology and Experimental Therapeutics, Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Pascal</forename><surname>Derkinderen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Center of Clinical Investigations, Hôpital Laënnec, Nantes, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Christophe</forename><surname>Tzourio</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Annick</forename><surname>Alpérovitch</surname></persName><roleName type="degree">MD</roleName><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-30"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="797">797</biblScope><biblScope unit="page" to="803">803</biblScope></imprint></monogr><idno type="istex">1B70D7EE8D46D33E3294BD13CA164FE92A56515F</idno><idno type="DOI">10.1002/mds.21857</idno><idno type="ArticleID">MDS21857</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (P = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (P = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (P = 0.004). This case‐control study provided new findings about risk factors of MSA. 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#af4"><personName><givenNames>Marie</givenNames><familyName>Vidailhet</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Alexis</givenNames><familyName>Elbaz</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Pascal</givenNames><familyName>Derkinderen</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Christophe</givenNames><familyName>Tzourio</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Annick</givenNames><familyName>Alpérovitch</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" 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xml:id="kwd2">epidemiology</keyword><keyword xml:id="kwd3">environmental exposure</keyword><keyword xml:id="kwd4">anti‐inflammatory agents, nonsteroidal</keyword><keyword xml:id="kwd5">occupation</keyword><keyword xml:id="kwd6">food habits</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (<i>P</i> = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (<i>P</i> = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (<i>P</i> = 0.004). This case‐control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Risk factors of multiple system atrophy: A case‐control study in French patients</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Risk Factors of Multiple System Atrophy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Risk factors of multiple system atrophy: A case‐control study in French patients</title></titleInfo><name type="personal"><namePart type="given">Jean‐Sébastien</namePart><namePart type="family">Vidal</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation><affiliation>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</affiliation><affiliation>INSERM Unit 708, Hôpital de La Salpêtrière, 75651 Paris cedex 13, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie</namePart><namePart type="family">Vidailhet</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hôpital Saint‐Antoine, Paris, France</affiliation><affiliation>INSERM U679, Neurology and Experimental Therapeutics, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Elbaz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">Derkinderen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Center of Clinical Investigations, Hôpital Laënnec, Nantes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christophe</namePart><namePart type="family">Tzourio</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annick</namePart><namePart type="family">Alpérovitch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM U708, Neuroepidemiology, Paris, France</affiliation><affiliation>U708, Université Paris 6, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-04-30</dateIssued><dateCaptured encoding="w3cdtf">2007-06-19</dateCaptured><dateValid encoding="w3cdtf">2007-10-22</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">40</extent><extent unit="words">5178</extent></physicalDescription><abstract lang="en">Multiple system atrophy (MSA) is a rare sporadic progressive neurodegenerative disorder. MSA risk factors are poorly known. The objectives of this case‐control study were to study environmental risk factors associated with MSA. Cases were recruited through five French referral centers. Controls matched for age, gender, and living area were recruited from healthy relatives of inpatients free of any parkinsonian syndrome of the same centers. Subjects were interviewed about exposure to environmental factors (pesticides, solvents, etc.), occupation and food habits, and use of anti‐inflammatory drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using conditional logistic regression. Seventy‐one cases and 71 matched controls were included. Low education level was more frequent in cases than in controls. Controls drank more alcohol than did cases (OR = 0.5 [0.2–1.1]) and the risk of MSA decreased with increasing alcohol consumption (P = 0.04). Controls ate fish and sea food more often and drank more tea than cases. Aspirin intake was more frequent among controls than did cases (OR = 0.5 [0.2–1.0]) and the risk of MSA decreased with the frequency of intake (P = 0.0002). MSA was not associated to exposure to pesticides, solvents, and other toxics neither to occupations, except plant and machine operators and assemblers (OR = 10.0 [2.1–47.5]) where the risk of MSA increased with number of years in this occupation (P = 0.004). This case‐control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>keywords</genre><topic>multiple system atrophy</topic><topic>epidemiology</topic><topic>environmental exposure</topic><topic>anti‐inflammatory agents, nonsteroidal</topic><topic>occupation</topic><topic>food habits</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>797</start><end>803</end><total>7</total></extent></part></relatedItem><identifier type="istex">1B70D7EE8D46D33E3294BD13CA164FE92A56515F</identifier><identifier type="DOI">10.1002/mds.21857</identifier><identifier type="ArticleID">MDS21857</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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