Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats
Identifieur interne : 001804 ( Istex/Corpus ); précédent : 001803; suivant : 001805Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats
Auteurs : François Windels ; Nicolas Bruet ; Annie Poupard ; Claude Feuerstein ; Anne Bertrand ; Marc SavastaSource :
- Journal of Neuroscience Research [ 0360-4012 ] ; 2003-04-15.
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Abstract
High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.
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DOI: 10.1002/jnr.10577
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ISTEX:A521E892B25F314F3E605944102E3E2CA4B8D973Le document en format XML
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Windels</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224</mods:affiliation></affiliation></author><author><name sortKey="Bruet, Nicolas" sort="Bruet, Nicolas" uniqKey="Bruet N" first="Nicolas" last="Bruet">Nicolas Bruet</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroscience Research</title><title level="j" type="abbrev">J. Neurosci. Res.</title><idno type="ISSN">0360-4012</idno><idno type="eISSN">1097-4547</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-04-15">2003-04-15</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="259">259</biblScope><biblScope unit="page" to="267">267</biblScope></imprint><idno type="ISSN">0360-4012</idno></series><idno type="istex">A521E892B25F314F3E605944102E3E2CA4B8D973</idno><idno type="DOI">10.1002/jnr.10577</idno><idno type="ArticleID">JNR10577</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-4012</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amino acids</term><term>deep brain stimulation</term><term>globus pallidus</term><term>high‐performance liquid chromatography</term><term>intracerebral microdialysis</term><term>substantia nigra pars reticulata</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>François Windels</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string><json:string>Current Address: NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224</json:string></affiliations></json:item><json:item><name>Nicolas Bruet</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Annie Poupard</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Claude Feuerstein</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Anne Bertrand</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Marc Savasta</name><affiliations><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</json:string><json:string>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, 38043 Grenoble Cedex 09, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>globus pallidus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>substantia nigra pars reticulata</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>intracerebral microdialysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>amino acids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>high‐performance liquid chromatography</value></json:item></subject><articleId><json:string>JNR10577</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>7.352</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1287</abstractCharCount><pdfWordCount>6094</pdfWordCount><pdfCharCount>36882</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>196</abstractWordCount></qualityIndicators><title>Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title><refBibs><json:item><author><json:item><name>GE Alexander</name></json:item><json:item><name>DM Crutcher</name></json:item></author><host><volume>13</volume><pages><last>271</last><first>266</first></pages><author></author><title>Trends Neurosci</title></host><title>Functionnal architecture of basal 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neurosurgery</json:string></scienceMetrix></categories><publicationDate>2003</publicationDate><copyrightDate>2003</copyrightDate><doi><json:string>10.1002/jnr.10577</json:string></doi><id>A521E892B25F314F3E605944102E3E2CA4B8D973</id><score>0.1680442</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/A521E892B25F314F3E605944102E3E2CA4B8D973/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/A521E892B25F314F3E605944102E3E2CA4B8D973/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A521E892B25F314F3E605944102E3E2CA4B8D973/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><p>Copyright © 2003 Wiley‐Liss, Inc.</p></availability><date>2003</date></publicationStmt><notesStmt><note>Institut National de la Santé et de la Recherche Médicale (INSERM)</note><note>European Community - No. QLK 6 CT 1999 02173, 5th PCRDT;</note><note>French Parkinson's Disease Foundation</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title><author xml:id="author-1"><persName><forename type="first">François</forename><surname>Windels</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><affiliation>Current Address: NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224</affiliation></author><author xml:id="author-2"><persName><forename type="first">Nicolas</forename><surname>Bruet</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Annie</forename><surname>Poupard</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Claude</forename><surname>Feuerstein</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Anne</forename><surname>Bertrand</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Marc</forename><surname>Savasta</surname></persName><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, 38043 Grenoble Cedex 09, France</affiliation></author></analytic><monogr><title level="j">Journal of Neuroscience Research</title><title level="j" type="abbrev">J. Neurosci. Res.</title><idno type="pISSN">0360-4012</idno><idno type="eISSN">1097-4547</idno><idno type="DOI">10.1002/(ISSN)1097-4547</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-04-15"></date><biblScope unit="volume">72</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="259">259</biblScope><biblScope unit="page" to="267">267</biblScope></imprint></monogr><idno type="istex">A521E892B25F314F3E605944102E3E2CA4B8D973</idno><idno type="DOI">10.1002/jnr.10577</idno><idno type="ArticleID">JNR10577</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>deep brain stimulation</term></item><item><term>subthalamic nucleus</term></item><item><term>globus pallidus</term></item><item><term>substantia nigra pars reticulata</term></item><item><term>intracerebral microdialysis</term></item><item><term>amino acids</term></item><item><term>high‐performance liquid chromatography</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-09-02">Received</change><change when="2002-12-17">Registration</change><change when="2003-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A521E892B25F314F3E605944102E3E2CA4B8D973/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1097-4547</doi><issn type="print">0360-4012</issn><issn type="electronic">1097-4547</issn><idGroup><id type="product" value="JNR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF NEUROSCIENCE RESEARCH">Journal of Neuroscience Research</title><title type="short">J. Neurosci. Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/jnr.v72:2</doi><numberingGroup><numbering type="journalVolume" number="72">72</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2003-04-15">15 April 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="140" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jnr.10577</doi><idGroup><id type="unit" value="JNR10577"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2003 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2002-09-02"></event><event type="manuscriptRevised" date="2002-12-02"></event><event type="manuscriptAccepted" date="2002-12-17"></event><event type="publishedOnlineEarlyUnpaginated" date="2003-02-20"></event><event type="firstOnline" date="2003-02-20"></event><event type="publishedOnlineFinalForm" date="2003-03-27"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">259</numbering><numbering type="pageLast">267</numbering></numberingGroup><correspondenceTo>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, 38043 Grenoble Cedex 09, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JNR.JNR10577.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="60"></count><count type="wordTotal" number="6883"></count></countGroup><titleGroup><title type="main" xml:lang="en">Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title><title type="short" xml:lang="en">STN DBS and Impact of Frequency on Neurochemical Changes in GP and SNr</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" currentRef="#curr1"><personName><givenNames>François</givenNames><familyName>Windels</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nicolas</givenNames><familyName>Bruet</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Annie</givenNames><familyName>Poupard</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claude</givenNames><familyName>Feuerstein</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Anne</givenNames><familyName>Bertrand</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Marc</givenNames><familyName>Savasta</familyName></personName><contactDetails><email normalForm="marc.savasta@ujf-grenoble.fr">marc.savasta@ujf‐grenoble.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="curr1"><unparsedAffiliation>NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">deep brain stimulation</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">globus pallidus</keyword><keyword xml:id="kwd4">substantia nigra pars reticulata</keyword><keyword xml:id="kwd5">intracerebral microdialysis</keyword><keyword xml:id="kwd6">amino acids</keyword><keyword xml:id="kwd7">high‐performance liquid chromatography</keyword></keywordGroup><fundingInfo><fundingAgency>Institut National de la Santé et de la Recherche Médicale (INSERM)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>European Community</fundingAgency><fundingNumber>QLK 6 CT 1999 02173, 5th PCRDT</fundingNumber></fundingInfo><fundingInfo><fundingAgency>French Parkinson's Disease Foundation</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STN DBS and Impact of Frequency on Neurochemical Changes in GP and SNr</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats</title></titleInfo><name type="personal"><namePart type="given">François</namePart><namePart type="family">Windels</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><affiliation>Current Address: NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicolas</namePart><namePart type="family">Bruet</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annie</namePart><namePart type="family">Poupard</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claude</namePart><namePart type="family">Feuerstein</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne</namePart><namePart type="family">Bertrand</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Savasta</namePart><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, Grenoble, France</affiliation><affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318—Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, 38043 Grenoble Cedex 09, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2003-04-15</dateIssued><dateCaptured encoding="w3cdtf">2002-09-02</dateCaptured><dateValid encoding="w3cdtf">2002-12-17</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">60</extent><extent unit="words">6883</extent></physicalDescription><abstract lang="en">High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ‐aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency‐dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep‐brain‐stimulation mechanisms. © 2003 Wiley‐Liss, Inc.</abstract><note type="funding">Institut National de la Santé et de la Recherche Médicale (INSERM)</note><note type="funding">European Community - No. QLK 6 CT 1999 02173, 5th PCRDT; </note><note type="funding">French Parkinson's Disease Foundation</note><subject lang="en"><genre>keywords</genre><topic>deep brain stimulation</topic><topic>subthalamic nucleus</topic><topic>globus pallidus</topic><topic>substantia nigra pars reticulata</topic><topic>intracerebral microdialysis</topic><topic>amino acids</topic><topic>high‐performance liquid chromatography</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroscience Research</title></titleInfo><titleInfo type="abbreviated"><title>J. Neurosci. Res.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0360-4012</identifier><identifier type="eISSN">1097-4547</identifier><identifier type="DOI">10.1002/(ISSN)1097-4547</identifier><identifier type="PublisherID">JNR</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>259</start><end>267</end><total>9</total></extent></part></relatedItem><identifier type="istex">A521E892B25F314F3E605944102E3E2CA4B8D973</identifier><identifier type="DOI">10.1002/jnr.10577</identifier><identifier type="ArticleID">JNR10577</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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