Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease
Identifieur interne : 001720 ( Istex/Corpus ); précédent : 001719; suivant : 001721Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease
Auteurs : Frédéric Courbon ; Christine Brefel-Courbon ; Claire Thalamas ; Marie Jeanne Alibelli ; Isabelle Berry ; Jean-Louis Montastruc ; Olivier Rascol ; Jean-Michel SenardSource :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
English descriptors
Abstract
[123I]Metaiodobenzylguanidine ([123I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [123I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (P < 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10461
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease</title><author><name sortKey="Courbon, Frederic" sort="Courbon, Frederic" uniqKey="Courbon F" first="Frédéric" last="Courbon">Frédéric Courbon</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Service de Médecine Nucléaire, 1 avenue Jean Poulhès, CHU Rangueil, 31403 Toulouse Cedex 4, France</mods:affiliation></affiliation></author><author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Alibelli, Marie Jeanne" sort="Alibelli, Marie Jeanne" uniqKey="Alibelli M" first="Marie Jeanne" last="Alibelli">Marie Jeanne Alibelli</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Berry, Isabelle" sort="Berry, Isabelle" uniqKey="Berry I" first="Isabelle" last="Berry">Isabelle Berry</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Montastruc, Jean Ouis" sort="Montastruc, Jean Ouis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Senard, Jean Ichel" sort="Senard, Jean Ichel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F0F8E3F36BB538F3323C070CEE5B4E26857F27FD</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10461</idno><idno type="url">https://api.istex.fr/document/F0F8E3F36BB538F3323C070CEE5B4E26857F27FD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001720</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001720</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease</title><author><name sortKey="Courbon, Frederic" sort="Courbon, Frederic" uniqKey="Courbon F" first="Frédéric" last="Courbon">Frédéric Courbon</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Service de Médecine Nucléaire, 1 avenue Jean Poulhès, CHU Rangueil, 31403 Toulouse Cedex 4, France</mods:affiliation></affiliation></author><author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Alibelli, Marie Jeanne" sort="Alibelli, Marie Jeanne" uniqKey="Alibelli M" first="Marie Jeanne" last="Alibelli">Marie Jeanne Alibelli</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Berry, Isabelle" sort="Berry, Isabelle" uniqKey="Berry I" first="Isabelle" last="Berry">Isabelle Berry</name><affiliation><mods:affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Montastruc, Jean Ouis" sort="Montastruc, Jean Ouis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Senard, Jean Ichel" sort="Senard, Jean Ichel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name><affiliation><mods:affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-08">2003-08</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="890">890</biblScope><biblScope unit="page" to="897">897</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F0F8E3F36BB538F3323C070CEE5B4E26857F27FD</idno><idno type="DOI">10.1002/mds.10461</idno><idno type="ArticleID">MDS10461</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic failure</term><term>cardiac MIBG scintigraphy</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">[123I]Metaiodobenzylguanidine ([123I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [123I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (P < 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Frédéric Courbon MD</name><affiliations><json:string>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</json:string><json:string>Service de Médecine Nucléaire, 1 avenue Jean Poulhès, CHU Rangueil, 31403 Toulouse Cedex 4, France</json:string></affiliations></json:item><json:item><name>Christine Brefel‐Courbon MD</name><affiliations><json:string>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</json:string></affiliations></json:item><json:item><name>Claire Thalamas MD</name><affiliations><json:string>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</json:string></affiliations></json:item><json:item><name>Marie Jeanne Alibelli MD</name><affiliations><json:string>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</json:string></affiliations></json:item><json:item><name>Isabelle Berry MD, PhD</name><affiliations><json:string>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</json:string></affiliations></json:item><json:item><name>Jean‐Louis Montastruc MD, PhD</name><affiliations><json:string>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</json:string></affiliations></json:item><json:item><name>Olivier Rascol MD, PhD</name><affiliations><json:string>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</json:string><json:string>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</json:string></affiliations></json:item><json:item><name>Jean‐Michel Senard MD, PhD</name><affiliations><json:string>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cardiac MIBG scintigraphy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic failure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item></subject><articleId><json:string>MDS10461</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>[123I]Metaiodobenzylguanidine ([123I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [123I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (P > 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society</abstract><qualityIndicators><score>7.227</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1670</abstractCharCount><pdfWordCount>4227</pdfWordCount><pdfCharCount>27240</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>254</abstractWordCount></qualityIndicators><title>Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease</title><refBibs><json:item><author><json:item><name>S Gilman</name></json:item><json:item><name>P Low</name></json:item><json:item><name>N Quinn</name></json:item><json:item><name> 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MIBG</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>897</last><first>890</first></pages><issn><json:string>0885-3185</json:string></issn><issue>8</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & 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type="first">Christine</forename><surname>Brefel‐Courbon</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Claire</forename><surname>Thalamas</surname></persName><roleName type="degree">MD</roleName><affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Marie Jeanne</forename><surname>Alibelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Isabelle</forename><surname>Berry</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Jean‐Louis</forename><surname>Montastruc</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Olivier</forename><surname>Rascol</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Jean‐Michel</forename><surname>Senard</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-08"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="890">890</biblScope><biblScope unit="page" to="897">897</biblScope></imprint></monogr><idno type="istex">F0F8E3F36BB538F3323C070CEE5B4E26857F27FD</idno><idno type="DOI">10.1002/mds.10461</idno><idno type="ArticleID">MDS10461</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>[123I]Metaiodobenzylguanidine ([123I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [123I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (P < 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Parkinson's disease</term></item><item><term>cardiac MIBG scintigraphy</term></item><item><term>autonomic failure</term></item><item><term>multiple system atrophy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-06-19">Received</change><change when="2003-01-15">Registration</change><change when="2003-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F0F8E3F36BB538F3323C070CEE5B4E26857F27FD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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affiliationRef="#af2"><personName><givenNames>Christine</givenNames><familyName>Brefel‐Courbon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Claire</givenNames><familyName>Thalamas</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marie Jeanne</givenNames><familyName>Alibelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Isabelle</givenNames><familyName>Berry</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2 #af4"><personName><givenNames>Jean‐Louis</givenNames><familyName>Montastruc</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Olivier</givenNames><familyName>Rascol</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2 #af4"><personName><givenNames>Jean‐Michel</givenNames><familyName>Senard</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">cardiac MIBG scintigraphy</keyword><keyword xml:id="kwd3">autonomic failure</keyword><keyword xml:id="kwd4">multiple system atrophy</keyword></keywordGroup><fundingInfo><fundingAgency>France Parkinson Association</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>[<sup>123</sup>I]Metaiodobenzylguanidine ([<sup>123</sup>I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [<sup>123</sup>I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (<i>P</i> < 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cardiac MIBG Scintigraphy in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Frédéric</namePart><namePart type="family">Courbon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</affiliation><affiliation>Service de Médecine Nucléaire, 1 avenue Jean Poulhès, CHU Rangueil, 31403 Toulouse Cedex 4, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Brefel‐Courbon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">Thalamas</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie Jeanne</namePart><namePart type="family">Alibelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isabelle</namePart><namePart type="family">Berry</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Médecine Nucléaire, University Rangueil Hospital, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Louis</namePart><namePart type="family">Montastruc</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olivier</namePart><namePart type="family">Rascol</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Michel</namePart><namePart type="family">Senard</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale U317, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-08</dateIssued><dateCaptured encoding="w3cdtf">2002-06-19</dateCaptured><dateValid encoding="w3cdtf">2003-01-15</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">6</extent><extent unit="tables">1</extent><extent unit="references">29</extent><extent unit="words">4916</extent></physicalDescription><abstract lang="en">[123I]Metaiodobenzylguanidine ([123I]MIBG) cardiac scintigraphy could be helpful to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), demonstrating that, in PD with autonomic failure but not in MSA, there is a myocardial postganglionic sympathetic dysfunction. To investigate whether this method is more sensitive than standard autonomic testing to detect early involvement of sympathetic cardiac efferent, we analyse MIBG myocardial uptake in 8 PD patients with normal autonomic testing (nondysautonomia PD group, NDPD) in comparison with 10 PD patients with abnormal autonomic testing (dysautonomia PD group, DPD) and 10 MSA patients. Global MIBG uptake was assessed using the ratio of [123I]MIBG uptake in the heart to the upper mediastinum (H/M) on planar scintigraphic data. Regional MIBG uptake was determined on two single photon emission tomography scans in regions of the left ventricle. The mean H/M ratios were significantly different among the three groups (P < 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M = 1.83 ± 0.50 and 1.24 ± 0.40, respectively) were significantly lower than in MSA patients (H/M = 2.52 ± 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall. Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD. © 2003 Movement Disorder Society</abstract><note type="funding">France Parkinson Association</note><subject lang="en"><genre>keywords</genre><topic>Parkinson's disease</topic><topic>cardiac MIBG scintigraphy</topic><topic>autonomic failure</topic><topic>multiple system atrophy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>890</start><end>897</end><total>8</total></extent></part></relatedItem><identifier type="istex">F0F8E3F36BB538F3323C070CEE5B4E26857F27FD</identifier><identifier type="DOI">10.1002/mds.10461</identifier><identifier type="ArticleID">MDS10461</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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