Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats
Identifieur interne : 001529 ( Istex/Corpus ); précédent : 001528; suivant : 001530Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats
Auteurs : Zhong-Ge Ni ; Rabia Bouali-Benazzouz ; Dong-Ming Gao ; Alim-Louis Benabid ; Abdelhamid BenazzouzSource :
- Brain Research [ 0006-8993 ] ; 2001.
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- KwdEn :
Abstract
The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.
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DOI: 10.1016/S0006-8993(01)02219-3
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title><author><name sortKey="Ni, Zhong Ge" sort="Ni, Zhong Ge" uniqKey="Ni Z" first="Zhong-Ge" last="Ni">Zhong-Ge Ni</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Bouali Benazzouz, Rabia" sort="Bouali Benazzouz, Rabia" uniqKey="Bouali Benazzouz R" first="Rabia" last="Bouali-Benazzouz">Rabia Bouali-Benazzouz</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Gao, Dong Ming" sort="Gao, Dong Ming" uniqKey="Gao D" first="Dong-Ming" last="Gao">Dong-Ming Gao</name><affiliation><mods:affiliation>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: abdelhamid.benazzouz@ujf-grenoble.fr</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F20B8F902CFAA92C3D35B9364852730C95664D93</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0006-8993(01)02219-3</idno><idno type="url">https://api.istex.fr/document/F20B8F902CFAA92C3D35B9364852730C95664D93/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001529</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title><author><name sortKey="Ni, Zhong Ge" sort="Ni, Zhong Ge" uniqKey="Ni Z" first="Zhong-Ge" last="Ni">Zhong-Ge Ni</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Bouali Benazzouz, Rabia" sort="Bouali Benazzouz, Rabia" uniqKey="Bouali Benazzouz R" first="Rabia" last="Bouali-Benazzouz">Rabia Bouali-Benazzouz</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Gao, Dong Ming" sort="Gao, Dong Ming" uniqKey="Gao D" first="Dong-Ming" last="Gao">Dong-Ming Gao</name><affiliation><mods:affiliation>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation><mods:affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: abdelhamid.benazzouz@ujf-grenoble.fr</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">899</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="142">142</biblScope><biblScope unit="page" to="147">147</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">F20B8F902CFAA92C3D35B9364852730C95664D93</idno><idno type="DOI">10.1016/S0006-8993(01)02219-3</idno><idno type="PII">S0006-8993(01)02219-3</idno><idno type="ArticleID">28993</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6-Hydroxydopamine</term><term>Motor systems and sensorimotor integration</term><term>Parkinson’s disease</term><term>Rat</term><term>Subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Zhong-Ge Ni</name><affiliations><json:string>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</json:string></affiliations></json:item><json:item><name>Rabia Bouali-Benazzouz</name><affiliations><json:string>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</json:string></affiliations></json:item><json:item><name>Dong-Ming Gao</name><affiliations><json:string>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</json:string></affiliations></json:item><json:item><name>Alim-Louis Benabid</name><affiliations><json:string>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</json:string></affiliations></json:item><json:item><name>Abdelhamid Benazzouz</name><affiliations><json:string>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</json:string><json:string>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</json:string><json:string>E-mail: abdelhamid.benazzouz@ujf-grenoble.fr</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Motor systems and sensorimotor integration : Basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>6-Hydroxydopamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rat</value></json:item></subject><articleId><json:string>28993</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.</abstract><qualityIndicators><score>7.012</score><pdfVersion>1.2</pdfVersion><pdfPageSize>598 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1611</abstractCharCount><pdfWordCount>4036</pdfWordCount><pdfCharCount>24360</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title><pii><json:string>S0006-8993(01)02219-3</json:string></pii><refBibs><json:item><author><json:item><name>R.L Albin</name></json:item><json:item><name>A.B Young</name></json:item><json:item><name>J.B Penney</name></json:item></author><host><volume>12</volume><pages><last>375</last><first>366</first></pages><author></author><title>Trends Neurosci.</title></host><title>The functional anatomy of basal ganglia disorders</title></json:item><json:item><author><json:item><name>C Baunez</name></json:item><json:item><name>A Nieoullon</name></json:item><json:item><name>M Amalric</name></json:item></author><host><volume>15</volume><pages><last>6541</last><first>6531</first></pages><author></author><title>J. 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(B) Tyrosine hydroxylase (TH) immunoreactivity showing the SNc dopaminergic neurons on the normal side (left) and 6-OHDA injected side (right) (×4). Note the complete degeneration of TH cells in the 6-OHDA-lesioned side. (C) Schematic representations of the pontamine sky blue dots (stars) and the recorded cells (circles) on reconstructed tacks, from anterior–posterior, laterality and depth measurements, showing that recorded cells, from different groups of rats, lie within the STN.</note><note type="content">Fig. 2: (A) Frequency distribution of the firing rate of STN neurons recorded in normal rats and in four groups of rats with 6-OHDA lesions; (B) Histograms showing the evolution of the firing rate; (C) Histograms showing the evolution of changes in the firing pattern. Note the progressive decrease in the percentage of STN cells exhibiting a random firing pattern. However, the percentage of neurons exhibiting burst and mixed firing patterns increased with time post-lesion.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title><author xml:id="author-1"><persName><forename type="first">Zhong-Ge</forename><surname>Ni</surname></persName><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Rabia</forename><surname>Bouali-Benazzouz</surname></persName><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Dong-Ming</forename><surname>Gao</surname></persName><affiliation>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</affiliation></author><author xml:id="author-4"><persName><forename type="first">Alim-Louis</forename><surname>Benabid</surname></persName><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Abdelhamid</forename><surname>Benazzouz</surname></persName><email>abdelhamid.benazzouz@ujf-grenoble.fr</email><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation><affiliation>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X0317-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">899</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="142">142</biblScope><biblScope unit="page" to="147">147</biblScope></imprint></monogr><idno type="istex">F20B8F902CFAA92C3D35B9364852730C95664D93</idno><idno type="DOI">10.1016/S0006-8993(01)02219-3</idno><idno type="PII">S0006-8993(01)02219-3</idno><idno type="ArticleID">28993</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><item><term>Motor systems and sensorimotor integration</term><term>Basal ganglia</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Subthalamic nucleus</term></item><item><term>Parkinson’s disease</term></item><item><term>6-Hydroxydopamine</term></item><item><term>Rat</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F20B8F902CFAA92C3D35B9364852730C95664D93/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="GR1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="GR2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>BRES</jid><aid>28993</aid><ce:pii>S0006-8993(01)02219-3</ce:pii><ce:doi>10.1016/S0006-8993(01)02219-3</ce:doi><ce:copyright type="full-transfer" year="2001">Elsevier Science B.V.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Research report</ce:textfn></ce:dochead><ce:title>Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</ce:title><ce:author-group><ce:author><ce:given-name>Zhong-Ge</ce:given-name><ce:surname>Ni</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Rabia</ce:given-name><ce:surname>Bouali-Benazzouz</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Dong-Ming</ce:given-name><ce:surname>Gao</ce:surname><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Alim-Louis</ce:given-name><ce:surname>Benabid</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Abdelhamid</ce:given-name><ce:surname>Benazzouz</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address type="email">abdelhamid.benazzouz@ujf-grenoble.fr</ce:e-address></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="30" month="1" year="2001"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0020">The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="neurosci"><ce:keyword><ce:text>Motor systems and sensorimotor integration</ce:text><ce:keyword><ce:text>Basal ganglia</ce:text></ce:keyword></ce:keyword></ce:keywords><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Subthalamic nucleus</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson’s disease</ce:text></ce:keyword><ce:keyword><ce:text>6-Hydroxydopamine</ce:text></ce:keyword><ce:keyword><ce:text>Rat</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats</title></titleInfo><name type="personal"><namePart type="given">Zhong-Ge</namePart><namePart type="family">Ni</namePart><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rabia</namePart><namePart type="family">Bouali-Benazzouz</namePart><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dong-Ming</namePart><namePart type="family">Gao</namePart><affiliation>Department of Physiology, Jinzhou Medical College, 121001 Jinzhou, Liaoning, PR China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim-Louis</namePart><namePart type="family">Benabid</namePart><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Abdelhamid</namePart><namePart type="family">Benazzouz</namePart><affiliation>Laboratoire de Neuroscience Préclinique, INSERM U. 318, CHU — Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France</affiliation><affiliation>Corresponding author. Tel.: +33-4-7676-5634; fax: +33-4-7676-5619</affiliation><affiliation>E-mail: abdelhamid.benazzouz@ujf-grenoble.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2001</dateIssued><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The subthalamic nucleus (STN) plays a key role in motor control. Disorganization of its neuronal activity is implicated in the manifestation of parkinsonian motor symptoms. The aim of the present work was to study the time-course of changes in the firing activity of STN neurons in a rat model of parkinsonism. Electrophysiological recordings were done in normal rats and four groups of rats at different time points after 6-hydroxydopamine (6-OHDA) microinjection into the pars compacta of substantia nigra (SNc). Results showed a significant decrease in firing rate during the first and second weeks post lesion (5.53±0.56 and 7.66±0.73 spikes/s, respectively) compared to normal rats (11.13±0.59 spikes/s). From the 3rd week after 6-OHDA injection the firing rates returned toward baseline, with an average of 9.71±0.51 spikes/s during the 3rd week and 11.13±0.71 spikes/s during the 4th week. With regard to firing pattern, the majority of STN cells (90%) discharged regularly or slightly irregularly in normal animals. Only 4% exhibited burst activity and 6% had mixed firing patterns. After SNc-lesion, the percentage of cells exhibiting burst and mixed patterns increased progressively from 35% during the first week to 56% at week 4 post-lesion. In sum, these experiments revealed that the firing rate of STN neurons was altered only transiently following nigral lesions, whereas a progressive and stable change in the firing pattern was observed up to 4 weeks post lesion, suggesting that the persistence of bursts firing more closely relates to the motor pathologies of this rat model of parkinsonism.</abstract><note type="content">Section title: Research report</note><note type="content">Fig. 1: (A) Cresyl violet staining showing the pontamine sky blue injected after recording a neuron at the end of a track in the STN (×4). (B) Tyrosine hydroxylase (TH) immunoreactivity showing the SNc dopaminergic neurons on the normal side (left) and 6-OHDA injected side (right) (×4). Note the complete degeneration of TH cells in the 6-OHDA-lesioned side. (C) Schematic representations of the pontamine sky blue dots (stars) and the recorded cells (circles) on reconstructed tacks, from anterior–posterior, laterality and depth measurements, showing that recorded cells, from different groups of rats, lie within the STN.</note><note type="content">Fig. 2: (A) Frequency distribution of the firing rate of STN neurons recorded in normal rats and in four groups of rats with 6-OHDA lesions; (B) Histograms showing the evolution of the firing rate; (C) Histograms showing the evolution of changes in the firing pattern. Note the progressive decrease in the percentage of STN cells exhibiting a random firing pattern. However, the percentage of neurons exhibiting burst and mixed firing patterns increased with time post-lesion.</note><subject lang="en"><topic>Motor systems and sensorimotor integration : Basal ganglia</topic></subject><subject lang="en"><genre>Keywords</genre><topic>Subthalamic nucleus</topic><topic>Parkinson’s disease</topic><topic>6-Hydroxydopamine</topic><topic>Rat</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20010427</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X0317-4</identifier><part><date>20010427</date><detail type="volume"><number>899</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>274</end></extent><extent unit="pages"><start>142</start><end>147</end></extent></part></relatedItem><identifier type="istex">F20B8F902CFAA92C3D35B9364852730C95664D93</identifier><identifier type="DOI">10.1016/S0006-8993(01)02219-3</identifier><identifier type="PII">S0006-8993(01)02219-3</identifier><identifier type="ArticleID">28993</identifier><accessCondition type="use and reproduction" contentType="copyright">©2001 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©2001</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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