Microsubthalamotomy effect at day 3: Screening for determinants
Identifieur interne : 001491 ( Istex/Corpus ); précédent : 001490; suivant : 001492Microsubthalamotomy effect at day 3: Screening for determinants
Auteurs : David Maltête ; Nathalie Chastan ; Stéphane Derrey ; Bertrand Debono ; Emmanuel Gérardin ; Romain Lefaucheur ; Bruno Mihout ; Didier HannequinSource :
- Movement Disorders [ 0885-3185 ] ; 2009-01-30.
English descriptors
Abstract
A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22380
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ISTEX:2F4C3DCC74FB1DD94CEADF4F602E05642098C2DELe document en format XML
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France</mods:affiliation></affiliation></author><author><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name><affiliation><mods:affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name><affiliation><mods:affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name><affiliation><mods:affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name><affiliation><mods:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Lefaucheur, Romain" sort="Lefaucheur, Romain" uniqKey="Lefaucheur R" first="Romain" last="Lefaucheur">Romain Lefaucheur</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-30">2009-01-30</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="286">286</biblScope><biblScope unit="page" to="289">289</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE</idno><idno type="DOI">10.1002/mds.22380</idno><idno type="ArticleID">MDS22380</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>microsubthalamotomy</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>David Maltête MD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string><json:string>INSERM U614, Rouen Faculty of Medicine, Rouen, France</json:string><json:string>Department of Neurology, Rouen University Hospital, Charles Nicolle, 76031 Rouen Cedex, France</json:string></affiliations></json:item><json:item><name>Nathalie Chastan MD</name><affiliations><json:string>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Stéphane Derrey MD</name><affiliations><json:string>Department of Neurosurgery, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Bertrand Debono MD</name><affiliations><json:string>Department of Neurosurgery, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Emmanuel Gérardin MD, PhD</name><affiliations><json:string>Department of Radiology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Romain Lefaucheur MD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Bruno Mihout MD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Didier Hannequin MD, PhD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string><json:string>INSERM U614, Rouen Faculty of Medicine, Rouen, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>microsubthalamotomy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>MDS22380</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>6.968</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1176</abstractCharCount><pdfWordCount>16728</pdfWordCount><pdfCharCount>110879</pdfCharCount><pdfPageCount>27</pdfPageCount><abstractWordCount>164</abstractWordCount></qualityIndicators><title>Microsubthalamotomy effect at day 3: Screening for determinants</title><refBibs><json:item><author><json:item><name>G Deuschl</name></json:item><json:item><name>J Herzog</name></json:item><json:item><name>G Kleiner‐Fisman</name></json:item></author><host><volume>21</volume><pages><last>237</last><first>219</first></pages><issue>Suppl.14</issue><author></author><title>Mov Disord</title></host><title>Deep brain stimulation: 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sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22380</json:string></doi><id>2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE</id><score>0.24257824</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Microsubthalamotomy effect at day 3: Screening for determinants</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2008 Movement Disorder Society</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Microsubthalamotomy effect at day 3: Screening for determinants</title><author xml:id="author-1"><persName><forename type="first">David</forename><surname>Maltête</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</affiliation><affiliation>Department of Neurology, Rouen University Hospital, Charles Nicolle, 76031 Rouen Cedex, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Nathalie</forename><surname>Chastan</surname></persName><roleName type="degree">MD</roleName><affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Stéphane</forename><surname>Derrey</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Bertrand</forename><surname>Debono</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Emmanuel</forename><surname>Gérardin</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Romain</forename><surname>Lefaucheur</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Bruno</forename><surname>Mihout</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Didier</forename><surname>Hannequin</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-30"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="286">286</biblScope><biblScope unit="page" to="289">289</biblScope></imprint></monogr><idno type="istex">2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE</idno><idno type="DOI">10.1002/mds.22380</idno><idno type="ArticleID">MDS22380</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>microsubthalamotomy</term></item><item><term>subthalamic nucleus</term></item><item><term>deep brain stimulation</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05-23">Received</change><change when="2008-10-09">Registration</change><change when="2009-01-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/2F4C3DCC74FB1DD94CEADF4F602E05642098C2DE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/mds.v24:2</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2009-01-30">30 January 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="200" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22380</doi><idGroup><id type="unit" value="MDS22380"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-05-23"></event><event type="manuscriptRevised" date="2008-10-07"></event><event type="manuscriptAccepted" date="2008-10-09"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-11-17"></event><event type="firstOnline" date="2008-11-17"></event><event type="publishedOnlineFinalForm" date="2009-01-23"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-04-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">286</numbering><numbering type="pageLast">289</numbering></numberingGroup><correspondenceTo>Department of Neurology, Rouen University Hospital, Charles Nicolle, 76031 Rouen Cedex, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22380.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="19"></count><count type="wordTotal" number="2518"></count></countGroup><titleGroup><title type="main" xml:lang="en">Microsubthalamotomy effect at day 3: Screening for determinants<link href="#fn1"></link></title><title type="short" xml:lang="en">Microsubthalamotomy Effect at Day 3</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>David</givenNames><familyName>Maltête</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="david.maltete@chu-rouen.fr">david.maltete@chu‐rouen.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Nathalie</givenNames><familyName>Chastan</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Stéphane</givenNames><familyName>Derrey</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Bertrand</givenNames><familyName>Debono</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Emmanuel</givenNames><familyName>Gérardin</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Romain</givenNames><familyName>Lefaucheur</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Bruno</givenNames><familyName>Mihout</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Didier</givenNames><familyName>Hannequin</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Department of Radiology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">microsubthalamotomy</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">deep brain stimulation</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, <i>P</i> = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Microsubthalamotomy effect at day 3: Screening for determinants</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Microsubthalamotomy Effect at Day 3</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Microsubthalamotomy effect at day 3: Screening for determinants</title></titleInfo><name type="personal"><namePart type="given">David</namePart><namePart type="family">Maltête</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</affiliation><affiliation>Department of Neurology, Rouen University Hospital, Charles Nicolle, 76031 Rouen Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nathalie</namePart><namePart type="family">Chastan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stéphane</namePart><namePart type="family">Derrey</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bertrand</namePart><namePart type="family">Debono</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emmanuel</namePart><namePart type="family">Gérardin</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Romain</namePart><namePart type="family">Lefaucheur</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Mihout</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Didier</namePart><namePart type="family">Hannequin</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-01-30</dateIssued><dateCaptured encoding="w3cdtf">2008-05-23</dateCaptured><dateValid encoding="w3cdtf">2008-10-09</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">19</extent><extent unit="words">2518</extent></physicalDescription><abstract lang="en">A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post‐traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>keywords</genre><topic>microsubthalamotomy</topic><topic>subthalamic nucleus</topic><topic>deep brain stimulation</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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