Myoclonus of peripheral origin: Two case reports
Identifieur interne : 001333 ( Istex/Corpus ); précédent : 001332; suivant : 001334Myoclonus of peripheral origin: Two case reports
Auteurs : Louise Tyvaert ; Pierre Krystkowiak ; Francois Cassim ; Elise Houdayer ; Alexandre Kreisler ; Alain Destée ; Luc DefebvreSource :
- Movement Disorders [ 0885-3185 ] ; 2009-01-30.
English descriptors
Abstract
The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.21998
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ISTEX:5080EA9C3532425C8D36639145DEADC853AA1DE2Le document en format XML
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3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Hôpital Nord, CHU d'Amiens, 80054 Amiens Cedex 1, France</mods:affiliation></affiliation></author><author><name sortKey="Cassim, Francois" sort="Cassim, Francois" uniqKey="Cassim F" first="Francois" last="Cassim">Francois Cassim</name><affiliation><mods:affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Houdayer, Elise" sort="Houdayer, Elise" uniqKey="Houdayer E" first="Elise" last="Houdayer">Elise Houdayer</name><affiliation><mods:affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><affiliation><mods:affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><mods:affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-30">2009-01-30</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="274">274</biblScope><biblScope unit="page" to="277">277</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5080EA9C3532425C8D36639145DEADC853AA1DE2</idno><idno type="DOI">10.1002/mds.21998</idno><idno type="ArticleID">MDS21998</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>nerve injury</term><term>peripheral myoclonus</term><term>phantom‐limb pain</term><term>spinal myoclonus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Louise Tyvaert MD</name><affiliations><json:string>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item><json:item><name>Pierre Krystkowiak MD, PhD</name><affiliations><json:string>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</json:string><json:string>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</json:string><json:string>Department of Neurology, Hôpital Nord, CHU d'Amiens, 80054 Amiens Cedex 1, France</json:string></affiliations></json:item><json:item><name>Francois Cassim MD, PhD</name><affiliations><json:string>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item><json:item><name>Elise Houdayer PhD</name><affiliations><json:string>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item><json:item><name>Alexandre Kreisler MD</name><affiliations><json:string>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item><json:item><name>Alain Destée MD, PhD</name><affiliations><json:string>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item><json:item><name>Luc Defebvre MD, PhD</name><affiliations><json:string>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>peripheral myoclonus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>spinal myoclonus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>phantom‐limb pain</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nerve injury</value></json:item></subject><articleId><json:string>MDS21998</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>6.764</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1046</abstractCharCount><pdfWordCount>16728</pdfWordCount><pdfCharCount>110879</pdfCharCount><pdfPageCount>27</pdfPageCount><abstractWordCount>147</abstractWordCount></qualityIndicators><title>Myoclonus of peripheral origin: Two case reports</title><refBibs><json:item><author><json:item><name>J Jankovic</name></json:item></author><host><volume>16</volume><pages><last>12</last><first>7</first></pages><author></author><title>Yes! Mov Disord</title></host><title>Can peripheral trauma induce dystonia and other movement disorders?</title></json:item><json:item><author><json:item><name>G Said</name></json:item><json:item><name>N Bathien</name></json:item></author><host><volume>133</volume><pages><last>198</last><first>191</first></pages><author></author><title>Rev Neurol</title></host><title>Myoclonies rythmées du quadriceps en relation avec un envahissement sarcomateux du nerf crural</title></json:item><json:item><author><json:item><name>CD Marsden</name></json:item><json:item><name>JA Obeso</name></json:item><json:item><name>MM Traub</name></json:item></author><host><volume>288</volume><pages><last>176</last><first>173</first></pages><author></author><title>BMJ</title></host><title>Muscle spasms associated with Sudeck's atrophy after injury</title></json:item><json:item><author><json:item><name>G Banks</name></json:item><json:item><name>V Nielsen</name></json:item><json:item><name>M Short</name></json:item><json:item><name>C Kowal</name></json:item></author><host><volume>48</volume><pages><last>584</last><first>582</first></pages><author></author><title>J Neurol Neurosurg Psychiatry</title></host><title>Brachial plexus myoclonus</title></json:item><json:item><author><json:item><name>FX Glocker</name></json:item><json:item><name>G Deuschl</name></json:item><json:item><name>B Volk</name></json:item><json:item><name>J Hasse</name></json:item><json:item><name>CH Lücking</name></json:item></author><host><volume>11</volume><pages><last>575</last><first>571</first></pages><author></author><title>Mov Disord</title></host><title>Bilateral myoclonus of the trapezius muscles after distal lesion of an accessory nerve</title></json:item><json:item><author><json:item><name>G Seidel</name></json:item><json:item><name>P Vieregge</name></json:item><json:item><name>K Wessel</name></json:item><json:item><name>D Kömpf</name></json:item></author><host><volume>20</volume><pages><last>1603</last><first>1602</first></pages><author></author><title>Muscle Nerve</title></host><title>Peripheral myoclonus due to spinal root lesion</title></json:item><json:item><author><json:item><name>F Assal</name></json:item><json:item><name>M Magistris</name></json:item><json:item><name>F Vingerhoets</name></json:item></author><host><volume>64</volume><pages><last>675</last><first>673</first></pages><author></author><title>J Neurol Neurosurg Psychiatry</title></host><title>Post‐traumatic suppressible myoclonus of peripheral origin</title></json:item><json:item><author><json:item><name>MS Martinez</name></json:item><json:item><name>M Fontoira</name></json:item><json:item><name>G Celester</name></json:item><json:item><name>M Castro del Rio</name></json:item><json:item><name>J Permuy</name></json:item><json:item><name>A Iglesias</name></json:item></author><host><volume>16</volume><pages><last>974</last><first>970</first></pages><author></author><title>Mov disord</title></host><title>Myoclonus of peripheral origin: case secondary to a digital nerve lesion</title></json:item><json:item><author><json:item><name>F Camerota</name></json:item><json:item><name>C Celletti</name></json:item><json:item><name>M Paoloni</name></json:item></author><host><volume>21</volume><pages><last>73</last><first>71</first></pages><author></author><title>Mov Disord</title></host><title>Myoclonus of the scapula after acute long thoracic nerve lesion: a case report</title></json:item><json:item><author><json:item><name>CD Marsden</name></json:item><json:item><name>M Hallett</name></json:item><json:item><name>S Fahn</name></json:item></author><host><pages><last>248</last><first>196</first></pages><author></author><title>Movement disorders</title></host><title>The nosology and pathophysiology of myoclonus</title></json:item><json:item><author><json:item><name>H Shibasaki</name></json:item><json:item><name>M Hallett</name></json:item></author><host><volume>31</volume><pages><last>174</last><first>157</first></pages><author></author><title>Muscle Nerve</title></host><title>Electrophysiological studies of myoclonus</title></json:item><json:item><author><json:item><name>JN Caviness</name></json:item><json:item><name>P Brown</name></json:item></author><host><volume>3</volume><pages><last>607</last><first>598</first></pages><author></author><title>Lancet Neurol</title></host><title>Myoclonus: current concepts and recent advances</title></json:item><json:item><author><json:item><name>H Flor</name></json:item></author><host><volume>1</volume><pages><last>189</last><first>182</first></pages><author></author><title>Lancet Neurol</title></host><title>Phantom‐limb pain: characteristics, causes, and treatment</title></json:item><json:item><author><json:item><name>JC Steiner</name></json:item><json:item><name>PV DeJesus</name></json:item><json:item><name>EL Mancall</name></json:item></author><host><volume>99</volume><pages><last>255</last><first>253</first></pages><author></author><title>Trans Am Neurol Assoc</title></host><title>Painful jumping amputation stumps: pathophysiology of a “sore circuit”</title></json:item><json:item><author><json:item><name>JL Henry</name></json:item></author><host><volume>114</volume><pages><last>451</last><first>439</first></pages><author></author><title>Brain Res</title></host><title>Effects of substance P on functionally identified units in cat spinal cord</title></json:item><json:item><author><json:item><name>C Grassi</name></json:item><json:item><name>M Possatore</name></json:item></author><host><volume>9</volume><pages><last>28</last><first>23</first></pages><author></author><title>Ital J Neurol Sci</title></host><title>Action of sympathetic system on skeletal muscle</title></json:item><json:item><author><json:item><name>G Deuschl</name></json:item><json:item><name>H Blumberg</name></json:item><json:item><name>CH Lucking</name></json:item></author><host><volume>48</volume><pages><last>1252</last><first>1247</first></pages><author></author><title>Arch Neurol</title></host><title>Tremor in reflex sympathetic dystrophy</title></json:item><json:item><author><json:item><name>A Curra</name></json:item><json:item><name>C Trompetto</name></json:item><json:item><name>G Abbruzzese</name></json:item><json:item><name>A Berardelli</name></json:item></author><host><volume>19</volume><pages><last>64</last><first>60</first></pages><issue>Suppl 8</issue><author></author><title>Mov Disord</title></host><title>Central effects of botulinum toxin type A: evidence and supposition</title></json:item><json:item><host><author></author><title>Botulinum toxin changes intrafusal feedback in dystonia: a study with the tonic vibration reflex</title></host></json:item><json:item><author><json:item><name>M Cui</name></json:item><json:item><name>S Khanijou</name></json:item><json:item><name>J Rubino</name></json:item><json:item><name>KR Aoki</name></json:item></author><host><volume>107</volume><pages><last>133</last><first>125</first></pages><author></author><title>Pain</title></host><title>Subcutaneous administration of botulinum toxin A reduces formalin‐induced pain</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>4</total><last>277</last><first>274</first></pages><issn><json:string>0885-3185</json:string></issn><issue>2</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement 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Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2008 Movement Disorder Society</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Myoclonus of peripheral origin: Two case reports</title><author xml:id="author-1"><persName><forename type="first">Louise</forename><surname>Tyvaert</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Pierre</forename><surname>Krystkowiak</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation><affiliation>Department of Neurology, Hôpital Nord, CHU d'Amiens, 80054 Amiens Cedex 1, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Francois</forename><surname>Cassim</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Elise</forename><surname>Houdayer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Alexandre</forename><surname>Kreisler</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Alain</forename><surname>Destée</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Luc</forename><surname>Defebvre</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-30"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="274">274</biblScope><biblScope unit="page" to="277">277</biblScope></imprint></monogr><idno type="istex">5080EA9C3532425C8D36639145DEADC853AA1DE2</idno><idno type="DOI">10.1002/mds.21998</idno><idno type="ArticleID">MDS21998</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>peripheral myoclonus</term></item><item><term>spinal myoclonus</term></item><item><term>phantom‐limb pain</term></item><item><term>nerve injury</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-05-16">Received</change><change when="2008-02-02">Registration</change><change when="2009-01-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/5080EA9C3532425C8D36639145DEADC853AA1DE2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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<sup>3</sup>Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">peripheral myoclonus</keyword><keyword xml:id="kwd2">spinal myoclonus</keyword><keyword xml:id="kwd3">phantom‐limb pain</keyword><keyword xml:id="kwd4">nerve injury</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Myoclonus of peripheral origin: Two case reports</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Myoclonus of Peripheral Origin</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Myoclonus of peripheral origin: Two case reports</title></titleInfo><name type="personal"><namePart type="given">Louise</namePart><namePart type="family">Tyvaert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Krystkowiak</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation><affiliation>Department of Neurology, Hôpital Nord, CHU d'Amiens, 80054 Amiens Cedex 1, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francois</namePart><namePart type="family">Cassim</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elise</namePart><namePart type="family">Houdayer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, North Hospital Amiens University, Amiens Cedex, France; 3Department of Clinical Neurophysiology, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandre</namePart><namePart type="family">Kreisler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Destée</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luc</namePart><namePart type="family">Defebvre</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-01-30</dateIssued><dateCaptured encoding="w3cdtf">2007-05-16</dateCaptured><dateValid encoding="w3cdtf">2008-02-02</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">20</extent><extent unit="words">2548</extent></physicalDescription><abstract lang="en">The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause‐and‐effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom‐limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back‐averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>keywords</genre><topic>peripheral myoclonus</topic><topic>spinal myoclonus</topic><topic>phantom‐limb pain</topic><topic>nerve injury</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.</note><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>274</start><end>277</end><total>4</total></extent></part></relatedItem><identifier type="istex">5080EA9C3532425C8D36639145DEADC853AA1DE2</identifier><identifier type="DOI">10.1002/mds.21998</identifier><identifier type="ArticleID">MDS21998</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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