Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat
Identifieur interne : 001206 ( Istex/Corpus ); précédent : 001205; suivant : 001207Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat
Auteurs : V. Ben ; B. BruguerolleSource :
- Life Sciences [ 0024-3205 ] ; 2000.
Abstract
The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.
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DOI: 10.1016/S0024-3205(00)00751-7
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Ben</name><affiliation><mods:affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</mods:affiliation></affiliation></author><author><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B." last="Bruguerolle">B. Bruguerolle</name><affiliation><mods:affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: bernard.bruguerolle@medecine.univ-mrs.fr</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1549">1549</biblScope><biblScope unit="page" to="1558">1558</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">AB8F7D8B3267253813F1B7834234B6C786D6545F</idno><idno type="DOI">10.1016/S0024-3205(00)00751-7</idno><idno type="PII">S0024-3205(00)00751-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>V. Ben</name><affiliations><json:string>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</json:string></affiliations></json:item><json:item><name>B. Bruguerolle</name><affiliations><json:string>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</json:string><json:string>E-mail: bernard.bruguerolle@medecine.univ-mrs.fr</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Circadian rhythms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chronopharmacology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Heart rate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Body temperature</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Locomotor activity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>6-Hydroxydopamine (6-OHDA)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Telemetry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rats</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</abstract><qualityIndicators><score>6.6</score><pdfVersion>1.2</pdfVersion><pdfPageSize>486 x 720 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>1694</abstractCharCount><pdfWordCount>3600</pdfWordCount><pdfCharCount>21595</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>263</abstractWordCount></qualityIndicators><title>Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><pii><json:string>S0024-3205(00)00751-7</json:string></pii><refBibs><json:item><author><json:item><name>Mm Hoehn</name></json:item><json:item><name>Md Yahr</name></json:item></author><host><volume>50</volume><pages><last>34</last><first>318</first></pages><issue>2</issue><author></author><title>Neurology</title><publicationDate>1998</publicationDate></host><title>Parkinsonism: onset, progression and mortality</title><publicationDate>1998</publicationDate></json:item><json:item><author><json:item><name>Mm Hoehn</name></json:item></author><host><volume>45</volume><pages><last>61</last><first>457</first></pages><author></author><title>Advance Neurology</title><publicationDate>1987</publicationDate></host><title>Parkinson disease: progression and mortality</title><publicationDate>1987</publicationDate></json:item><json:item><host><pages><last>415</last><first>390</first></pages><author><json:item><name>O Hornykiewicz</name></json:item></author><title>Dopamine and extrapyramidal motor function and dysfunction. 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rats</title><publicationDate>1996</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>67</volume><pii><json:string>S0024-3205(00)X0280-9</json:string></pii><pages><last>1558</last><first>1549</first></pages><issn><json:string>0024-3205</json:string></issn><issue>13</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Life Sciences</title><publicationDate>2000</publicationDate></host><categories><wos><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>medicine, research & experimental</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>pharmacology & 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study</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©2000 Elsevier Science Inc.</p></availability><date>2000</date></publicationStmt><notesStmt><note type="content">Section title: Pharmacology letters</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><title level="a" type="sub">A radiotelemetric study</title><author xml:id="author-1"><persName><forename type="first">V.</forename><surname>Ben</surname></persName><affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">B.</forename><surname>Bruguerolle</surname></persName><email>bernard.bruguerolle@medecine.univ-mrs.fr</email><note type="correspondence"><p>Corresponding author. Tel.: 33-4-91-32-44-56; fax: 33-4-91-25-65-26.(B. Bruguerolle)</p></note><affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</affiliation></author></analytic><monogr><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="pISSN">0024-3205</idno><idno type="PII">S0024-3205(00)X0280-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">67</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1549">1549</biblScope><biblScope unit="page" to="1558">1558</biblScope></imprint></monogr><idno type="istex">AB8F7D8B3267253813F1B7834234B6C786D6545F</idno><idno type="DOI">10.1016/S0024-3205(00)00751-7</idno><idno type="PII">S0024-3205(00)00751-7</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson</term></item><item><term>Circadian rhythms</term></item><item><term>Chronopharmacology</term></item><item><term>Heart rate</term></item><item><term>Body temperature</term></item><item><term>Locomotor activity</term></item><item><term>6-Hydroxydopamine (6-OHDA)</term></item><item><term>Telemetry</term></item><item><term>Rats</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-21">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-13">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-16">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/AB8F7D8B3267253813F1B7834234B6C786D6545F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier converted-article found"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LFS</jid><aid>7751</aid><ce:pii>S0024-3205(00)00751-7</ce:pii><ce:doi>10.1016/S0024-3205(00)00751-7</ce:doi><ce:copyright type="full-transfer" year="2000">Elsevier Science Inc.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Pharmacology letters</ce:textfn></ce:dochead><ce:title>Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</ce:title><ce:subtitle>A radiotelemetric study</ce:subtitle><ce:author-group><ce:author><ce:given-name>V.</ce:given-name><ce:surname>Ben</ce:surname></ce:author><ce:author><ce:given-name>B.</ce:given-name><ce:surname>Bruguerolle</ce:surname><ce:cross-ref refid="COR1">*</ce:cross-ref><ce:e-address>bernard.bruguerolle@medecine.univ-mrs.fr</ce:e-address></ce:author><ce:affiliation><ce:textfn>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: 33-4-91-32-44-56; fax: 33-4-91-25-65-26.(B. Bruguerolle)</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parkinson</ce:text></ce:keyword><ce:keyword><ce:text>Circadian rhythms</ce:text></ce:keyword><ce:keyword><ce:text>Chronopharmacology</ce:text></ce:keyword><ce:keyword><ce:text>Heart rate</ce:text></ce:keyword><ce:keyword><ce:text>Body temperature</ce:text></ce:keyword><ce:keyword><ce:text>Locomotor activity</ce:text></ce:keyword><ce:keyword><ce:text>6-Hydroxydopamine (6-OHDA)</ce:text></ce:keyword><ce:keyword><ce:text>Telemetry</ce:text></ce:keyword><ce:keyword><ce:text>Rats</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><subTitle>A radiotelemetric study</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><subTitle>A radiotelemetric study</subTitle></titleInfo><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Ben</namePart><affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Bruguerolle</namePart><affiliation>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France</affiliation><affiliation>E-mail: bernard.bruguerolle@medecine.univ-mrs.fr</affiliation><description>Corresponding author. Tel.: 33-4-91-32-44-56; fax: 33-4-91-25-65-26.(B. Bruguerolle)</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</abstract><note type="content">Section title: Pharmacology letters</note><subject><genre>Keywords</genre><topic>Parkinson</topic><topic>Circadian rhythms</topic><topic>Chronopharmacology</topic><topic>Heart rate</topic><topic>Body temperature</topic><topic>Locomotor activity</topic><topic>6-Hydroxydopamine (6-OHDA)</topic><topic>Telemetry</topic><topic>Rats</topic></subject><relatedItem type="host"><titleInfo><title>Life Sciences</title></titleInfo><titleInfo type="abbreviated"><title>LFS</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20000818</dateIssued></originInfo><identifier type="ISSN">0024-3205</identifier><identifier type="PII">S0024-3205(00)X0280-9</identifier><part><date>20000818</date><detail type="volume"><number>67</number><caption>vol.</caption></detail><detail type="issue"><number>13</number><caption>no.</caption></detail><extent unit="issue pages"><start>1525</start><end>1666</end></extent><extent unit="pages"><start>1549</start><end>1558</end></extent></part></relatedItem><identifier type="istex">AB8F7D8B3267253813F1B7834234B6C786D6545F</identifier><identifier type="DOI">10.1016/S0024-3205(00)00751-7</identifier><identifier type="PII">S0024-3205(00)00751-7</identifier><accessCondition type="use and reproduction" contentType="copyright">©2000 Elsevier Science Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Inc., ©2000</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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