Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase
Identifieur interne : 001168 ( Istex/Corpus ); précédent : 001167; suivant : 001169Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase
Auteurs : Frederick C. Wedler ; Michael C. Vichnin ; Brenda W. Ley ; Georges Tholey ; Marc Ledig ; Jean-Christoph CopinSource :
- Neurochemical Research [ 0364-3190 ] ; 1994-02-01.
Abstract
Abstract: Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the Kd for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.
Url:
DOI: 10.1007/BF00966809
Links to Exploration step
ISTEX:16DF9811B4BA2AB179E0B396A12842B6D028470ELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title><author><name sortKey="Wedler, Frederick C" sort="Wedler, Frederick C" uniqKey="Wedler F" first="Frederick C." last="Wedler">Frederick C. Wedler</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Vichnin, Michael C" sort="Vichnin, Michael C" uniqKey="Vichnin M" first="Michael C." last="Vichnin">Michael C. Vichnin</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Ley, Brenda W" sort="Ley, Brenda W" uniqKey="Ley B" first="Brenda W." last="Ley">Brenda W. Ley</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Tholey, Georges" sort="Tholey, Georges" uniqKey="Tholey G" first="Georges" last="Tholey">Georges Tholey</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Ledig, Marc" sort="Ledig, Marc" uniqKey="Ledig M" first="Marc" last="Ledig">Marc Ledig</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Copin, Jean Christoph" sort="Copin, Jean Christoph" uniqKey="Copin J" first="Jean-Christoph" last="Copin">Jean-Christoph Copin</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:16DF9811B4BA2AB179E0B396A12842B6D028470E</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1007/BF00966809</idno><idno type="url">https://api.istex.fr/document/16DF9811B4BA2AB179E0B396A12842B6D028470E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001168</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001168</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title><author><name sortKey="Wedler, Frederick C" sort="Wedler, Frederick C" uniqKey="Wedler F" first="Frederick C." last="Wedler">Frederick C. Wedler</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Vichnin, Michael C" sort="Vichnin, Michael C" uniqKey="Vichnin M" first="Michael C." last="Vichnin">Michael C. Vichnin</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Ley, Brenda W" sort="Ley, Brenda W" uniqKey="Ley B" first="Brenda W." last="Ley">Brenda W. Ley</name><affiliation><mods:affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Tholey, Georges" sort="Tholey, Georges" uniqKey="Tholey G" first="Georges" last="Tholey">Georges Tholey</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Ledig, Marc" sort="Ledig, Marc" uniqKey="Ledig M" first="Marc" last="Ledig">Marc Ledig</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Copin, Jean Christoph" sort="Copin, Jean Christoph" uniqKey="Copin J" first="Jean-Christoph" last="Copin">Jean-Christoph Copin</name><affiliation><mods:affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurochemical Research</title><title level="j" type="abbrev">Neurochem Res</title><idno type="ISSN">0364-3190</idno><idno type="eISSN">1573-6903</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1994-02-01">1994-02-01</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="151">151</biblScope></imprint><idno type="ISSN">0364-3190</idno></series><idno type="istex">16DF9811B4BA2AB179E0B396A12842B6D028470E</idno><idno type="DOI">10.1007/BF00966809</idno><idno type="ArticleID">BF00966809</idno><idno type="ArticleID">Art7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-3190</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the Kd for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Frederick C. Wedler</name><affiliations><json:string>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</json:string></affiliations></json:item><json:item><name>Michael C. Vichnin</name><affiliations><json:string>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</json:string></affiliations></json:item><json:item><name>Brenda W. Ley</name><affiliations><json:string>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</json:string></affiliations></json:item><json:item><name>Georges Tholey</name><affiliations><json:string>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</json:string></affiliations></json:item><json:item><name>Marc Ledig</name><affiliations><json:string>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</json:string></affiliations></json:item><json:item><name>Jean-Christoph Copin</name><affiliations><json:string>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</json:string></affiliations></json:item></author><articleId><json:string>BF00966809</json:string><json:string>Art7</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the Kd for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.</abstract><qualityIndicators><score>6.55</score><pdfVersion>1.3</pdfVersion><pdfPageSize>605 x 777.28 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1327</abstractCharCount><pdfWordCount>4306</pdfWordCount><pdfCharCount>26520</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>187</abstractWordCount></qualityIndicators><title>Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title><refBibs><json:item><host><pages><last>34</last><first>3</first></pages><author><json:item><name> Neurology</name></json:item><json:item><name> Psychiatry</name></json:item><json:item><name>S Gabay</name></json:item><json:item><name>J Harris</name></json:item><json:item><name>B,T Ho</name></json:item></author><publicationDate>1985</publicationDate></host></json:item><json:item><host><pages><last>195</last><first>171</first></pages><author><json:item><name>E,J Underwood</name></json:item></author><title>Trace Elements in Human and Animal Nutrition</title><publicationDate>1977</publicationDate></host></json:item><json:item><host><author><json:item><name>Enzyme Manganese In Metabolism</name></json:item><json:item><name> Function</name></json:item><json:item><name>V,L Schramm</name></json:item><json:item><name>F,C Wedler</name></json:item></author><publicationDate>1986</publicationDate></host></json:item><json:item><author><json:item><name>G Gianutsos</name></json:item><json:item><name>M,D Seltzer</name></json:item><json:item><name>R Saymeh</name></json:item><json:item><name>M Wu</name></json:item><json:item><name>W Michel</name></json:item><json:item><name>R,G </name></json:item></author><host><volume>5</volume><pages><last>275</last><first>272</first></pages><author></author><title>Arch. Toxicol</title><publicationDate>1985</publicationDate></host><title>Brain manganese accumulation fol~wing systemic administration of different forms</title><publicationDate>1985</publicationDate></json:item><json:item><author><json:item><name>F,C Wedler</name></json:item><json:item><name>B,W Ley</name></json:item><json:item><name>A,A Grippo</name></json:item></author><host><volume>14</volume><pages><last>1135</last><first>1129</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1989</publicationDate></host><title>Manganese(II ) dynamics and distribution in glial cells cultured from chick cerebral cortex</title><publicationDate>1989</publicationDate></json:item><json:item><author><json:item><name>M Aschner</name></json:item><json:item><name>M Gannon</name></json:item><json:item><name>H,K Kimelberg</name></json:item></author><host><volume>58</volume><pages><last>735</last><first>730</first></pages><author></author><title>J. Neurochem</title><publicationDate>1992</publicationDate></host><title>Manganese uptake and efflux in cultured rat astrocytes</title><publicationDate>1992</publicationDate></json:item><json:item><author><json:item><name>G Tholey</name></json:item><json:item><name>M Ledig</name></json:item><json:item><name>P Kopp</name></json:item><json:item><name>L Sargentini-Maier</name></json:item><json:item><name>M Leroy</name></json:item><json:item><name>A,A Grippo</name></json:item><json:item><name>F,C Wedler</name></json:item></author><host><volume>13</volume><pages><last>1167</last><first>1163</first></pages><author></author><title>Neurochem . Res</title><publicationDate>1988</publicationDate></host><title>Levels and subcellular distribution of physiologically important metal ions in neuronal cells cultured from chick embryo cerebral cortex</title><publicationDate>1988</publicationDate></json:item><json:item><author><json:item><name>G Tholey</name></json:item><json:item><name>M Ledig</name></json:item><json:item><name>P Mandel</name></json:item><json:item><name>L Sargentini</name></json:item><json:item><name>A,H Frivold</name></json:item><json:item><name>M Leroy</name></json:item><json:item><name>A,A Grippo</name></json:item><json:item><name>F,C Wedler</name></json:item></author><host><volume>13</volume><pages><last>50</last><first>45</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1988</publicationDate></host><title>Concentrations of physiologically important metal ions in glial ceils cultured from chick cerebral cortex</title><publicationDate>1988</publicationDate></json:item><json:item><host><pages><last>132</last><first>109</first></pages><author><json:item><name>V,L Schramm</name></json:item></author><title>Evaluation of Mn(II) in metabolic regulation: analysis of proposed sites for regulation, in ref</title><publicationDate>1986</publicationDate></host></json:item><json:item><host><pages><last>163</last><first>147</first></pages><author><json:item><name>M,C Scrutton</name></json:item></author><title>Manganese and pyruvate carboxylase, in ref</title><publicationDate>1986</publicationDate></host></json:item><json:item><host><pages><last>191</last><first>165</first></pages><author><json:item><name>T Nowak</name></json:item></author><title>Manganese and phosphoenolpyruvate carboxykinase</title><publicationDate>1986</publicationDate></host></json:item><json:item><host><pages><last>219</last><first>193</first></pages><author><json:item><name>W,F Beyer</name></json:item><json:item><name> Jr</name></json:item><json:item><name>I Fridovich</name></json:item></author><title>Manganese-catalase and manganese superoxide dismutase: spectroscopic similarity with functional diversity, in ref</title><publicationDate>1986</publicationDate></host></json:item><json:item><host><pages><last>238</last><first>221</first></pages><author><json:item><name>F,C Wedler</name></json:item><json:item><name>R Toms</name></json:item></author><title>Interactions of Mn(II) with mammalian glutamine synthetase, in ref</title><publicationDate>1986</publicationDate></host></json:item><json:item><author><json:item><name>M,R Maurizi</name></json:item><json:item><name>H,B Pinkofsky</name></json:item><json:item><name>A Ginsberg</name></json:item></author><host><volume>26</volume><pages><last>5031</last><first>5023</first></pages><author></author><title>Biochemistry</title><publicationDate>1987</publicationDate></host><title>ADP, chloride ion, and metal ion binding to bovine brain glutamine synthetase</title><publicationDate>1987</publicationDate></json:item><json:item><author><json:item><name>F,C Wedler</name></json:item><json:item><name>B,W Ley</name></json:item></author><host><volume>19</volume><pages><last>144</last><first>139</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1994</publicationDate></host><title>Kinetic, ESR, and trapping evidence for in vivo binding of Mn(II) to glutamine synthetase in brain cells</title><publicationDate>1994</publicationDate></json:item><json:item><author><json:item><name>A Meister</name></json:item></author><host><pages><last>40</last><first>1</first></pages><author></author><title>Glutamine: Metabolism, Enzymology, and Regulation</title><publicationDate>1980</publicationDate></host><title>Catalytic mechanisms of glutamine synthetase: overview of glutamine metabolism</title><publicationDate>1980</publicationDate></json:item><json:item><author><json:item><name>M Sensenbrenner~</name></json:item></author><host><pages><last>213</last><first>191</first></pages><author></author><title>Cell, Tissue, and Organ Culture in Neurobiology</title><publicationDate>1977</publicationDate></host><title>Dissociated brain cells in primary culture</title><publicationDate>1977</publicationDate></json:item><json:item><author><json:item><name>J,E Bottenstein</name></json:item><json:item><name>G,H Sato</name></json:item></author><host><pages><last>517</last><first>514</first></pages><author></author><title>Proc. Nat. Acad. Sci</title><publicationDate>1979</publicationDate></host><title>Growth of a neuroblastoma cell line in serum-free supplemented medium</title><publicationDate>1979</publicationDate></json:item><json:item><author><json:item><name>M,V Frangakis</name></json:item><json:item><name>H,K Kimelberg</name></json:item></author><host><volume>9</volume><pages><last>1698</last><first>1689</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1984</publicationDate></host><title>Dissociation of neonatal rat brain by Dispase for preparation of primary astrocyte cultures</title><publicationDate>1984</publicationDate></json:item><json:item><author><json:item><name>R,C Goldschmidt</name></json:item><json:item><name>H,K Kimelberg</name></json:item></author><host><volume>176</volume><pages><last>45</last><first>41</first></pages><author></author><title>Anal. Biochem</title><publicationDate>1989</publicationDate></host><title>Protein analysis of mammalian cells in monolayer culture using the bicinchononie assay</title><publicationDate>1989</publicationDate></json:item><json:item><author><json:item><name>G Tholey</name></json:item><json:item><name>L Megias-Megias</name></json:item><json:item><name>F,C Wedler</name></json:item><json:item><name>M Ledig</name></json:item></author><host><volume>7</volume><pages><last>754</last><first>751</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1990</publicationDate></host><title>Modulation of Mn 2 § accumulation in cultured rat neuronal and astroglial ceils</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>G,V Blankenfeld</name></json:item><json:item><name>H Kettenmann</name></json:item></author><host><volume>5</volume><pages><last>43</last><first>31</first></pages><author></author><title>Molee. Neurobiol</title><publicationDate>1992</publicationDate></host><title>Glutamate and GABA receptors in vertebrate glial cells</title><publicationDate>1992</publicationDate></json:item><json:item><author><json:item><name>Z Ahmed</name></json:item><json:item><name>C,A Lewis</name></json:item><json:item><name>D,S Faber</name></json:item></author><host><volume>516</volume><pages><last>169</last><first>165</first></pages><author></author><title>Brain Res</title><publicationDate>1990</publicationDate></host><title>Glutamate stimulates release of Ca z § from internal stores in astroglia</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>V Konji</name></json:item><json:item><name>A Montag</name></json:item><json:item><name>G Sandri</name></json:item><json:item><name>K Nordenbrand</name></json:item><json:item><name>L Ernster</name></json:item></author><host><volume>67</volume><pages><last>1250</last><first>1241</first></pages><author></author><title>Biochimie</title><publicationDate>1985</publicationDate></host><title>Transport of Ca 2 § and Mn 2 § by mitochondria from rat liver, heart, and brain</title><publicationDate>1985</publicationDate></json:item><json:item><author><json:item><name>C,E Gavin</name></json:item><json:item><name>K,K Gunter</name></json:item><json:item><name>T,E Gunter</name></json:item></author><host><volume>266</volume><pages><last>334</last><first>329</first></pages><author></author><title>Biochem. J</title><publicationDate>1990</publicationDate></host><title>Manganese and calcium efflux kinetics in brain mitochondria: relevance to manganese toxicity</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>A Allshire</name></json:item><json:item><name>P Bernardi</name></json:item><json:item><name>N-E,L Saris</name></json:item></author><host><volume>807</volume><pages><last>209</last><first>202</first></pages><author></author><title>Biochim. Biophys. Acta</title><publicationDate>1985</publicationDate></host><title>Manganese stimulates calcium fl~ through the mitochondrial uniporter</title><publicationDate>1985</publicationDate></json:item><json:item><host><pages><last>64</last><first>51</first></pages><author><json:item><name>A,E Shamoo</name></json:item></author><title>Mn(II) and Ca(lI) transport in mitochondria, in ref</title><publicationDate>1986</publicationDate></host></json:item><json:item><author><json:item><name>X Li</name></json:item><json:item><name>L Song</name></json:item><json:item><name>R Jope</name></json:item></author><host><volume>15</volume><pages><last>738</last><first>725</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1990</publicationDate></host><title>Modulation of phosphoinositide metabolism in rat brain slices by excitory amino acids, arachidonic acid, and GABA</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>R,S Goldman</name></json:item><json:item><name>L,E Chavez-Noriega</name></json:item><json:item><name>C,F Stevens</name></json:item></author><host><pages><last>7169</last><first>7165</first></pages><author></author><title>Proc. Nat. Acad. Sci</title><publicationDate>1990</publicationDate></host><title>Failure to reverse long-term potentiation by coupling sustained presynaptic activity and N-methyl-D-aspartate receptor blockade</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>P,A Rosenberg</name></json:item></author><host><volume>4</volume><pages><last>100</last><first>91</first></pages><author></author><title>Glia</title><publicationDate>1991</publicationDate></host><title>Accumulation of extraeellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine</title><publicationDate>1991</publicationDate></json:item><json:item><author><json:item><name>J,E Walker</name></json:item></author><host><volume>8</volume><pages><last>548</last><first>521</first></pages><author></author><title>Neurochem. Res</title><publicationDate>1983</publicationDate></host><title>Glutamate, GABA, and CNS disease: a review</title><publicationDate>1983</publicationDate></json:item><json:item><host><pages><last>404</last><first>381</first></pages><author><json:item><name>R,P Shank</name></json:item><json:item><name>G Campbell</name></json:item><json:item><name> Lem</name></json:item></author><title>Glutamate</title><publicationDate>1983</publicationDate></host></json:item><json:item><author><json:item><name>J,T Greenmayre</name></json:item></author><host><volume>43</volume><pages><last>1063</last><first>1058</first></pages><author></author><title>Neurol. Rev</title><publicationDate>1986</publicationDate></host><title>The role of glutamate in neurotransmission and in neurologic disease</title><publicationDate>1986</publicationDate></json:item><json:item><author><json:item><name>S Sahai</name></json:item></author><host><volume>240</volume><pages><last>133</last><first>121</first></pages><author></author><title>Eur. Arch. Psych. Clin. Neurosei</title><publicationDate>1990</publicationDate></host><title>Glutamate in the mammalian CNS</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>M Baudry</name></json:item><json:item><name>G Lynch</name></json:item></author><host><volume>282</volume><pages><last>750</last><first>748</first></pages><author></author><title>Nature</title><publicationDate>1979</publicationDate></host><title>Regulation of glutamate receptors by cations</title><publicationDate>1979</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>19</volume><pages><last>151</last><first>145</first></pages><issn><json:string>0364-3190</json:string></issn><issue>2</issue><subject><json:item><value>Neurosciences</value></json:item><json:item><value>Neurology</value></json:item><json:item><value>Biochemistry, general</value></json:item></subject><journalId><json:string>11064</json:string></journalId><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1573-6903</json:string></eissn><title>Neurochemical Research</title><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1007/BF00966809</json:string></doi><id>16DF9811B4BA2AB179E0B396A12842B6D028470E</id><score>0.112853356</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/16DF9811B4BA2AB179E0B396A12842B6D028470E/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/16DF9811B4BA2AB179E0B396A12842B6D028470E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/16DF9811B4BA2AB179E0B396A12842B6D028470E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><availability><p>Plenum Publishing Corporation, 1994</p></availability><date>1994</date></publicationStmt><notesStmt><note>Original Articles</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title><author xml:id="author-1" corresp="yes"><persName><forename type="first">Frederick</forename><surname>Wedler</surname></persName><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation></author><author xml:id="author-2"><persName><forename type="first">Michael</forename><surname>Vichnin</surname></persName><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation></author><author xml:id="author-3"><persName><forename type="first">Brenda</forename><surname>Ley</surname></persName><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation></author><author xml:id="author-4"><persName><forename type="first">Georges</forename><surname>Tholey</surname></persName><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Marc</forename><surname>Ledig</surname></persName><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Jean-Christoph</forename><surname>Copin</surname></persName><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation></author></analytic><monogr><title level="j">Neurochemical Research</title><title level="j" type="abbrev">Neurochem Res</title><idno type="journal-ID">11064</idno><idno type="pISSN">0364-3190</idno><idno type="eISSN">1573-6903</idno><idno type="issue-article-count">18</idno><idno type="volume-issue-count">12</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1994-02-01"></date><biblScope unit="volume">19</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="151">151</biblScope></imprint></monogr><idno type="istex">16DF9811B4BA2AB179E0B396A12842B6D028470E</idno><idno type="DOI">10.1007/BF00966809</idno><idno type="ArticleID">BF00966809</idno><idno type="ArticleID">Art7</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the Kd for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Neurosciences</term></item><item><term>Neurology</term></item><item><term>Biochemistry, general</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-02-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-23">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-21">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/16DF9811B4BA2AB179E0B396A12842B6D028470E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Kluwer Academic Publishers-Plenum Publishers</PublisherName><PublisherLocation>New York</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>11064</JournalID><JournalPrintISSN>0364-3190</JournalPrintISSN><JournalElectronicISSN>1573-6903</JournalElectronicISSN><JournalTitle>Neurochemical Research</JournalTitle><JournalAbbreviatedTitle>Neurochem Res</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Neurosciences</JournalSubject><JournalSubject Type="Secondary">Neurology</JournalSubject><JournalSubject Type="Secondary">Biochemistry, general</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>19</VolumeIDStart><VolumeIDEnd>19</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>2</IssueIDStart><IssueIDEnd>2</IssueIDEnd><IssueArticleCount>18</IssueArticleCount><IssueHistory><CoverDate><Year>1994</Year><Month>2</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Plenum Publishing Corporation</CopyrightHolderName><CopyrightYear>1994</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art7"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00966809</ArticleID><ArticleDOI>10.1007/BF00966809</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</ArticleTitle><ArticleCategory>Original Articles</ArticleCategory><ArticleFirstPage>145</ArticleFirstPage><ArticleLastPage>151</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>12</Month><Day>27</Day></RegistrationDate><Accepted><Year>1993</Year><Month>5</Month><Day>24</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Plenum Publishing Corporation</CopyrightHolderName><CopyrightYear>1994</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>11064</JournalID><VolumeIDStart>19</VolumeIDStart><VolumeIDEnd>19</VolumeIDEnd><IssueIDStart>2</IssueIDStart><IssueIDEnd>2</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Frederick</GivenName><GivenName>C.</GivenName><FamilyName>Wedler</FamilyName></AuthorName><Contact><Phone>(814) 865-1230</Phone><Fax>(814) 863-7024</Fax></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Michael</GivenName><GivenName>C.</GivenName><FamilyName>Vichnin</FamilyName></AuthorName><Contact><Phone>(814) 865-1230</Phone><Fax>(814) 863-7024</Fax></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Brenda</GivenName><GivenName>W.</GivenName><FamilyName>Ley</FamilyName></AuthorName><Contact><Fax>(814) 865-1230</Fax></Contact></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Georges</GivenName><FamilyName>Tholey</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Marc</GivenName><FamilyName>Ledig</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Jean-Christoph</GivenName><FamilyName>Copin</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory</OrgDivision><OrgName>The Pennsylvania State University</OrgName><OrgAddress><Postcode>16802</Postcode><City>University Park</City><State>Pennsylvania</State></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>LNO-CNRS, Centre de Neurochimie</OrgDivision><OrgName>Universite L. Pasteur</OrgName><OrgAddress><Street>5 rue Bl. Pascal</Street><Postcode>F-67000</Postcode><City>Strasbourg</City><Country>France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the K<Subscript>d</Subscript> for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.</Para></Abstract><KeywordGroup Language="En"><Heading>Key Words</Heading><Keyword>Manganese (II) ions</Keyword><Keyword>Ca(II) ions, effects of</Keyword><Keyword>glutamine synthetase</Keyword><Keyword>trace metals</Keyword><Keyword>L-glutamate metabolism, regulation of</Keyword><Keyword>glia</Keyword><Keyword>astrocytes</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Frederick</namePart><namePart type="given">C.</namePart><namePart type="family">Wedler</namePart><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="given">C.</namePart><namePart type="family">Vichnin</namePart><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brenda</namePart><namePart type="given">W.</namePart><namePart type="family">Ley</namePart><affiliation>Biochemistry Program, Dept. of Molecular & Cell Biology, Althouse Laboratory, The Pennsylvania State University, 16802, University Park, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georges</namePart><namePart type="family">Tholey</namePart><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Ledig</namePart><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Christoph</namePart><namePart type="family">Copin</namePart><affiliation>LNO-CNRS, Centre de Neurochimie, Universite L. Pasteur, 5 rue Bl. Pascal, F-67000, Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1994-02-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Previous studies have demonstrated that in glia and astrocytes Mn(II) is distributed with ca. 30–40% in the cytoplasm, 60–70% in mitochondria. Ca(II) ions were observed to alter both the flux rates and distribution of Mn(II) ions in primary cultues of chick glia and rat astrocytes. External (influxing) Ca(II) ions had the greatest effect on Mn(II) uptake and efflux, compared to internal (effluxing) or internal-external equilibrated Ca(II) ions. External (influxing) Ca(II) ions inhibited the net rate and extent of Mn(II) uptake but enhanced Mn(II) efflux from mitochondria. These observations differ from Ca(II)−Mn(II) effects previously reported with “brain” (neuronal) mitochondria. Overall, increased cytoplasmic Ca(II) acts to block Mn(II) uptake and enhance Mn(II) release by mitochondria, which serve to increase the cytoplasmic concentration of free Mn(II). A hypothesis is presented involving external L-glutamate acting through membrane receptors to mobilize cell Ca(II), which in turn causes mitochondrial Mn(II) to be released. Because the concentration of free cytoplasmic Mn(II) is poised near the Kd for Mn(II) with glutamine synthetase, a slight increase in cytoplasmic Mn(II) will directly enhance the activity of glutamine synthetase, which catalyzes removal of neurotoxic glutamate and ammonia.</abstract><note>Original Articles</note><relatedItem type="host"><titleInfo><title>Neurochemical Research</title></titleInfo><titleInfo type="abbreviated"><title>Neurochem Res</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1994-02-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Neurosciences</topic><topic>Neurology</topic><topic>Biochemistry, general</topic></subject><identifier type="ISSN">0364-3190</identifier><identifier type="eISSN">1573-6903</identifier><identifier type="JournalID">11064</identifier><identifier type="IssueArticleCount">18</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>1994</date><detail type="volume"><number>19</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="pages"><start>145</start><end>151</end></extent></part><recordInfo><recordOrigin>Plenum Publishing Corporation, 1994</recordOrigin></recordInfo></relatedItem><identifier type="istex">16DF9811B4BA2AB179E0B396A12842B6D028470E</identifier><identifier type="DOI">10.1007/BF00966809</identifier><identifier type="ArticleID">BF00966809</identifier><identifier type="ArticleID">Art7</identifier><accessCondition type="use and reproduction" contentType="copyright">Plenum Publishing Corporation, 1994</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Plenum Publishing Corporation, 1994</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001168 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001168 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:16DF9811B4BA2AB179E0B396A12842B6D028470E
|texte= Effects of Ca(II) ions on Mn(II) dynamics in chick glia and rat astrocytes: Potential regulation of glutamine synthetase
}}
| This area was generated with Dilib version V0.6.29. |  |