Subthalamic stimulation influences postmovement cortical somatosensory processing in Parkinson's disease
Identifieur interne : 001146 ( Istex/Corpus ); précédent : 001145; suivant : 001147Subthalamic stimulation influences postmovement cortical somatosensory processing in Parkinson's disease
Auteurs : D. Devos ; E. Labyt ; F. Cassim ; J. L. Bourriez ; N. Reyns ; G. Touzet ; S. Blond ; J. D. Guieu ; P. Derambure ; A. Destée ; L. DefebvreSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2003-10.
English descriptors
- KwdEn :
Abstract
In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement‐related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l‐dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self‐paced wrist flexion in four conditions according to the presence or not of stimulation and l‐dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l‐dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l‐dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement‐related somatosensory processing at the end of the movement through the basal ganglia into the cortex.
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DOI: 10.1046/j.1460-9568.2003.02925.x
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<front><div type="abstract" xml:lang="en">In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement‐related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l‐dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self‐paced wrist flexion in four conditions according to the presence or not of stimulation and l‐dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l‐dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l‐dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement‐related somatosensory processing at the end of the movement through the basal ganglia into the cortex.</div>
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<abstract>In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement‐related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l‐dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self‐paced wrist flexion in four conditions according to the presence or not of stimulation and l‐dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l‐dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l‐dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement‐related somatosensory processing at the end of the movement through the basal ganglia into the cortex.</abstract>
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<refBibs><json:item><author><json:item><name>P. Ashby</name>
</json:item>
<json:item><name>Y.J. Kim</name>
</json:item>
<json:item><name>R. Kumar</name>
</json:item>
<json:item><name>A.E. Lang</name>
</json:item>
<json:item><name>A.M. Lozano</name>
</json:item>
</author>
<host><volume>122</volume>
<pages><last>1931</last>
<first>1919</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Neurophysiological effects of stimulation through electrodes in the human subthalamic nucleus</title>
</json:item>
<json:item><author><json:item><name>C. Beurrier</name>
</json:item>
<json:item><name>B. Bioulac</name>
</json:item>
<json:item><name>J. Audin</name>
</json:item>
<json:item><name>C. Hammond</name>
</json:item>
</author>
<host><volume>85</volume>
<pages><last>1356</last>
<first>1351</first>
</pages>
<author></author>
<title>J. Neurophysiol.</title>
</host>
<title>High‐frequency stimulation produces a transient blockade of voltage‐gated currents in subthalamic neurons</title>
</json:item>
<json:item><author><json:item><name>P. Brown</name>
</json:item>
<json:item><name>C.D. Marsden</name>
</json:item>
</author>
<host><volume>351</volume>
<pages><last>1804</last>
<first>1801</first>
</pages>
<author></author>
<title>Lancet</title>
</host>
<title>What do the basal ganglia do? [Review]</title>
</json:item>
<json:item><author><json:item><name>M. Cassidy</name>
</json:item>
<json:item><name>P. Mazzone</name>
</json:item>
<json:item><name>A. Oliviero</name>
</json:item>
<json:item><name>A. Insola</name>
</json:item>
<json:item><name>P. Tonali</name>
</json:item>
<json:item><name>V. Di Lazzaro</name>
</json:item>
<json:item><name>P. Brown</name>
</json:item>
</author>
<host><volume>125</volume>
<pages><last>1246</last>
<first>1235</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Movement‐related changes in synchronization in the human basal ganglia</title>
</json:item>
<json:item><author><json:item><name>F. Cassim</name>
</json:item>
<json:item><name>C. Monaca</name>
</json:item>
<json:item><name>W. Szurhaj</name>
</json:item>
<json:item><name>J.L. Bourriez</name>
</json:item>
<json:item><name>L. Defebvre</name>
</json:item>
<json:item><name>P. Derambure</name>
</json:item>
<json:item><name>J.D. Guieu</name>
</json:item>
</author>
<host><volume>12</volume>
<pages><last>3863</last>
<first>3859</first>
</pages>
<author></author>
<title>Neuroreport</title>
</host>
<title>Does post movement beta synchronization reflect an ‘idling’ motor cortex?</title>
</json:item>
<json:item><author><json:item><name>F.C. Cassim</name>
</json:item>
<json:item><name>W. Szurhaj</name>
</json:item>
<json:item><name>H. Sediri</name>
</json:item>
<json:item><name>D. Devos</name>
</json:item>
<json:item><name>J.L. Bourriez</name>
</json:item>
<json:item><name>I. Poirot</name>
</json:item>
<json:item><name>Ph Derambure</name>
</json:item>
<json:item><name>L. Defebvre</name>
</json:item>
<json:item><name>J.D. Guieu</name>
</json:item>
</author>
<host><volume>111</volume>
<pages><last>2039</last>
<first>2032</first>
</pages>
<author></author>
<title>Clin. Neurophysiol.</title>
</host>
<title>Brief and sustained movements: differences in event‐related (de) synchronization (ERD/ERS) patterns</title>
</json:item>
<json:item><author><json:item><name>R. Chen</name>
</json:item>
<json:item><name>Z. Yassen</name>
</json:item>
<json:item><name>L.G. Cohen</name>
</json:item>
<json:item><name>M. Hallett</name>
</json:item>
</author>
<host><volume>44</volume>
<pages><last>325</last>
<first>317</first>
</pages>
<author></author>
<title>Ann. Neurol.</title>
</host>
<title>The time course of corticospinal excitability in reaction time and self‐paced movements</title>
</json:item>
<json:item><author><json:item><name>W.J. Conover</name>
</json:item>
<json:item><name>R.L. Iman</name>
</json:item>
</author>
<host><volume>35</volume>
<pages><last>129</last>
<first>124</first>
</pages>
<author></author>
<title>Am. Statistician Assoc</title>
</host>
<title>Rank transformation as a bridge between parametric and nonparametric statistics</title>
</json:item>
<json:item><author><json:item><name>J.L. Contreras‐Vidal</name>
</json:item>
<json:item><name>C.E. Stelmach</name>
</json:item>
</author>
<host><volume>73</volume>
<pages><last>476</last>
<first>467</first>
</pages>
<author></author>
<title>Biol. Cybern.</title>
</host>
<title>A neural model of basal ganglia–thalamocortical relations in normal and parkinsonian movement</title>
</json:item>
<json:item><author><json:item><name>D. Cunic</name>
</json:item>
<json:item><name>L. Roshan</name>
</json:item>
<json:item><name>F.I. Khan</name>
</json:item>
<json:item><name>A.M. Lozano</name>
</json:item>
<json:item><name>A.E. Lang</name>
</json:item>
<json:item><name>R. Chen</name>
</json:item>
</author>
<host><volume>58</volume>
<pages><last>1672</last>
<first>1665</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>R. Cunnington</name>
</json:item>
<json:item><name>R. Iansek</name>
</json:item>
<json:item><name>K. Johnson</name>
</json:item>
<json:item><name>J.L. Bradshaw</name>
</json:item>
</author>
<host><volume>120</volume>
<pages><last>1353</last>
<first>1339</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Movement‐related potentials in Parkinson's disease. Motor imagery and movement preparation</title>
</json:item>
<json:item><author><json:item><name>D. Devos</name>
</json:item>
<json:item><name>P. Derambure</name>
</json:item>
<json:item><name>J.L. Bourriez</name>
</json:item>
<json:item><name>D.F. Cassim</name>
</json:item>
<json:item><name>S. Blond</name>
</json:item>
<json:item><name>J.D. Guieu</name>
</json:item>
<json:item><name>A. Destee</name>
</json:item>
<json:item><name>L. Defebvre</name>
</json:item>
</author>
<host><volume>113</volume>
<pages><last>1120</last>
<first>1110</first>
</pages>
<author></author>
<title>Clin. Neurophysiol.</title>
</host>
<title>Influence of internal globus pallidus stimulation on motor cortex activation pattern in Parkinson's disease</title>
</json:item>
<json:item><host><author></author>
<title>Devos, D., Labyt, E., Derambure, P., Bourriez, J.L., Cassim, D.F., Blond, S., Guieu, J.D., Destee, A. & Defebvre, L. (2002a) Cortical activation improvement obtained by subthalamic nucleus stimulation in Parkinson's disease and its relation to bradykinesia. In Neurology 2002 Proceedings of the 54th Meeting of the American Academy of Neurology Congress, Denver, 2002, 58 (Suppl. 3), p. A56.</title>
</host>
</json:item>
<json:item><author><json:item><name>W. Gerschlager</name>
</json:item>
<json:item><name>F. Alesch</name>
</json:item>
<json:item><name>R. Cunnington</name>
</json:item>
<json:item><name>L. Deecke</name>
</json:item>
<json:item><name>G. Dirnberger</name>
</json:item>
<json:item><name>W. Endl</name>
</json:item>
<json:item><name>G. Lindinger</name>
</json:item>
<json:item><name>W. Lang</name>
</json:item>
</author>
<host><volume>122</volume>
<pages><last>2373</last>
<first>2365</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Bilateral subthalamic nucleus stimulation improves frontal cortex function in Parkinson's disease. An electrophysiological study of the contingent negative variation</title>
</json:item>
<json:item><author><json:item><name>J.D. Guieu</name>
</json:item>
<json:item><name>J.L. Bourriez</name>
</json:item>
<json:item><name>Ph Derambure</name>
</json:item>
<json:item><name>L. Defebvre</name>
</json:item>
<json:item><name>F. Cassim</name>
</json:item>
</author>
<host><pages><last>290</last>
<first>279</first>
</pages>
<author></author>
<title>Event‐Related Desynchronization. Handbook of Electroencephalography and Clinical Neurophysiology. Revised Series</title>
</host>
<title>Temporal and spatial aspects of event‐related desynchronization and movement‐related cortical potential</title>
</json:item>
<json:item><author><json:item><name>T. Hashimoto</name>
</json:item>
<json:item><name>C.M. Elder</name>
</json:item>
<json:item><name>M.S. Okun</name>
</json:item>
<json:item><name>S.K. Patrick</name>
</json:item>
<json:item><name>J.L. Vitek</name>
</json:item>
</author>
<host><volume>23</volume>
<pages><last>1923</last>
<first>1916</first>
</pages>
<author></author>
<title>J. Neurosci.</title>
</host>
<title>Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons</title>
</json:item>
<json:item><author><json:item><name>P. Limousin</name>
</json:item>
<json:item><name>J. Greene</name>
</json:item>
<json:item><name>P. Pollak</name>
</json:item>
<json:item><name>J. Rothwell</name>
</json:item>
<json:item><name>A.L. Benabid</name>
</json:item>
<json:item><name>R. Frackowiak</name>
</json:item>
</author>
<host><volume>42</volume>
<pages><last>291</last>
<first>283</first>
</pages>
<author></author>
<title>Ann. Neurol.</title>
</host>
<title>Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>J.A. Obeso</name>
</json:item>
<json:item><name>M.C. Rodriguez‐Oroz</name>
</json:item>
<json:item><name>M. Rodriguez</name>
</json:item>
<json:item><name>R. Macias</name>
</json:item>
<json:item><name>L. Alvarez</name>
</json:item>
<json:item><name>J. Guridi</name>
</json:item>
<json:item><name>J. Vitek</name>
</json:item>
<json:item><name>M.R. DeLong</name>
</json:item>
</author>
<host><volume>55</volume>
<pages><last>12</last>
<first>7</first>
</pages>
<issue>Suppl. 6</issue>
<author></author>
<title>Neurology</title>
</host>
<title>Pathophysiologic basis of surgery for Parkinson's disease</title>
</json:item>
<json:item><host><author></author>
<title>Event‐related synchronization of beta rhythms in idiopathic Parkinson's diseaseEvent‐Related Desynchronization.</title>
</host>
</json:item>
<json:item><author><json:item><name>G. Pfürtscheller</name>
</json:item>
<json:item><name>K. Pichler‐Zalaudek</name>
</json:item>
<json:item><name>B. Ortmayr</name>
</json:item>
<json:item><name>J. Diez</name>
</json:item>
<json:item><name>F. Reisecker</name>
</json:item>
</author>
<host><volume>15</volume>
<pages><last>250</last>
<first>243</first>
</pages>
<author></author>
<title>J. Clin. Neurophysiol.</title>
</host>
<title>Post‐movement beta synchronization in patients with Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>A. Stancak Jr</name>
</json:item>
<json:item><name>G. Pfürtscheller</name>
</json:item>
</author>
<host><volume>4</volume>
<pages><last>183</last>
<first>171</first>
</pages>
<author></author>
<title>Cognitive Brain Res.</title>
</host>
<title>Event‐related desynchronisation of central beta‐rhythms during brisk and slow self‐paced finger movements</title>
</json:item>
<json:item><author><json:item><name> </name>
</json:item>
</author>
<host><volume>345</volume>
<pages><last>963</last>
<first>956</first>
</pages>
<author></author>
<title>N. Engl. J. Med.</title>
</host>
<title>Deep‐brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>R.L. Watts</name>
</json:item>
<json:item><name>A.S. Mandir</name>
</json:item>
</author>
<host><volume>10</volume>
<pages><last>469</last>
<first>451</first>
</pages>
<author></author>
<title>Neurol. Clin.</title>
</host>
<title>The role of motor cortex in the pathophysiology of voluntary movement deficits associated with parkinsonism</title>
</json:item>
</refBibs>
<genre><json:string>article</json:string>
</genre>
<host><volume>18</volume>
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</publisherId>
<pages><last>1888</last>
<first>1884</first>
</pages>
<issn><json:string>0953-816X</json:string>
</issn>
<issue>7</issue>
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<language><json:string>unknown</json:string>
</language>
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<namePart type="family">Defebvre</namePart>
<affiliation>Department of Neurology, EA2683, Lille University Medical Centre, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="article" displayLabel="article"></genre>
<originInfo><publisher>Blackwell Science, Ltd</publisher>
<place><placeTerm type="text">Oxford, UK</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2003-10</dateIssued>
<edition>Received 20 May 2003, revised 21 July 2003, accepted 25 July 2003</edition>
<copyrightDate encoding="w3cdtf">2003</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
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<extent unit="figures">1</extent>
<extent unit="tables">2</extent>
<extent unit="references">23</extent>
<extent unit="words">4632</extent>
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<abstract lang="en">In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement‐related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l‐dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self‐paced wrist flexion in four conditions according to the presence or not of stimulation and l‐dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l‐dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l‐dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement‐related somatosensory processing at the end of the movement through the basal ganglia into the cortex.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>advanced Parkinsonian</topic>
<topic>EEG</topic>
<topic>event‐related synchronization</topic>
<topic>human</topic>
<topic>l‐dopa</topic>
<topic>movement</topic>
</subject>
<relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title>
</titleInfo>
<genre type="journal">journal</genre>
<identifier type="ISSN">0953-816X</identifier>
<identifier type="eISSN">1460-9568</identifier>
<identifier type="DOI">10.1111/(ISSN)1460-9568</identifier>
<identifier type="PublisherID">EJN</identifier>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>1884</start>
<end>1888</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">FC5D8CA50AAB4EFF904A1ACC8E4490C219FBE3B2</identifier>
<identifier type="DOI">10.1046/j.1460-9568.2003.02925.x</identifier>
<identifier type="ArticleID">EJN2925</identifier>
<recordInfo><recordContentSource>WILEY</recordContentSource>
<recordOrigin>Blackwell Science, Ltd</recordOrigin>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
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