Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys
Identifieur interne : 001140 ( Istex/Corpus ); précédent : 001139; suivant : 001141Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys
Auteurs : M. T. Herrero ; S. J. Augood ; H. Asensi ; E. C. Hirsch ; Y. Agid ; J. A. Obeso ; P. C. EmsonSource :
- Molecular Brain Research [ 0169-328X ] ; 1996.
Abstract
The cellular expression of dopamine D2 receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 Macaca fascicularis monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific 35S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor l-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D2 receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D2 receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D2 receptor mRNA was observed in (dyskinetic) l-DOPA-treated monkeys suggesting that levodopa-therapy normalises D2 receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D2 receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. The implications of these findings for the development of levodopa-induced dyskinesias is discussed.
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DOI: 10.1016/S0169-328X(96)00157-X
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Asensi</name><affiliation><mods:affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation><mods:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</mods:affiliation></affiliation></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. 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Herrero</name><affiliation><mods:affiliation>E-mail: mtherrer@fcu.um.es</mods:affiliation></affiliation><affiliation><mods:affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Augood, S J" sort="Augood, S J" uniqKey="Augood S" first="S. J." last="Augood">S. J. Augood</name><affiliation><mods:affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</mods:affiliation></affiliation></author><author><name sortKey="Asensi, H" sort="Asensi, H" uniqKey="Asensi H" first="H." last="Asensi">H. Asensi</name><affiliation><mods:affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation><mods:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</mods:affiliation></affiliation></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name><affiliation><mods:affiliation>Centro de Neurologia y Neurocirugia Fanctional, Clínica Quirón Donostia, Parque Alcolea, s/n, 20012 San Sebastian, Spain</mods:affiliation></affiliation></author><author><name sortKey="Emson, P C" sort="Emson, P C" uniqKey="Emson P" first="P. C." last="Emson">P. C. Emson</name><affiliation><mods:affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Brain Research</title><title level="j" type="abbrev">BRESM</title><idno type="ISSN">0169-328X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">42</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="155">155</biblScope></imprint><idno type="ISSN">0169-328X</idno></series><idno type="istex">1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3</idno><idno type="DOI">10.1016/S0169-328X(96)00157-X</idno><idno type="PII">S0169-328X(96)00157-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-328X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cellular expression of dopamine D2 receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 Macaca fascicularis monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific 35S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor l-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D2 receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D2 receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D2 receptor mRNA was observed in (dyskinetic) l-DOPA-treated monkeys suggesting that levodopa-therapy normalises D2 receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D2 receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. The implications of these findings for the development of levodopa-induced dyskinesias is discussed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M.T. Herrero</name><affiliations><json:string>E-mail: mtherrer@fcu.um.es</json:string><json:string>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</json:string></affiliations></json:item><json:item><name>S.J. Augood</name><affiliations><json:string>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</json:string></affiliations></json:item><json:item><name>H. Asensi</name><affiliations><json:string>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</json:string></affiliations></json:item><json:item><name>E.C. Hirsch</name><affiliations><json:string>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</json:string></affiliations></json:item><json:item><name>Y. Agid</name><affiliations><json:string>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</json:string></affiliations></json:item><json:item><name>J.A. Obeso</name><affiliations><json:string>Centro de Neurologia y Neurocirugia Fanctional, Clínica Quirón Donostia, Parque Alcolea, s/n, 20012 San Sebastian, Spain</json:string></affiliations></json:item><json:item><name>P.C. Emson</name><affiliations><json:string>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Dopamine D2 receptor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hybridization, in situ</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Monkey</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MPTP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>l-DOPA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dyskinesia</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>The cellular expression of dopamine D2 receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 Macaca fascicularis monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific 35S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor l-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D2 receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D2 receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D2 receptor mRNA was observed in (dyskinetic) l-DOPA-treated monkeys suggesting that levodopa-therapy normalises D2 receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D2 receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. 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Levey</name></json:item></author><host><volume>65</volume><pages><last>730</last><first>709</first></pages><author></author><title>Neuroscience</title></host><title>Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: light and electron microscopy</title></json:item></refBibs><genre><json:string>brief-communication</json:string></genre><serie><volume>Vol. 99</volume><pages><last>199</last><first>181</first></pages><language><json:string>unknown</json:string></language><title>Progress in Brain Research</title></serie><host><volume>42</volume><pii><json:string>S0169-328X(00)X0022-8</json:string></pii><pages><last>155</last><first>149</first></pages><issn><json:string>0169-328X</json:string></issn><issue>1</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Molecular Brain Research</title><publicationDate>1996</publicationDate></host><categories><wos></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/S0169-328X(96)00157-X</json:string></doi><id>1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3</id><score>0.14918722</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1996</date></publicationStmt><notesStmt><note type="content">Section title: Short communication</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys</title><author xml:id="author-1"><persName><forename type="first">M.T.</forename><surname>Herrero</surname></persName><email>mtherrer@fcu.um.es</email><note type="correspondence"><p>Corresponding author. Fax: +34 (68) 36-3955</p></note><affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</affiliation></author><author xml:id="author-2"><persName><forename type="first">S.J.</forename><surname>Augood</surname></persName><affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</affiliation></author><author xml:id="author-3"><persName><forename type="first">H.</forename><surname>Asensi</surname></persName><affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</affiliation></author><author xml:id="author-4"><persName><forename type="first">E.C.</forename><surname>Hirsch</surname></persName><affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Y.</forename><surname>Agid</surname></persName><affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">J.A.</forename><surname>Obeso</surname></persName><affiliation>Centro de Neurologia y Neurocirugia Fanctional, Clínica Quirón Donostia, Parque Alcolea, s/n, 20012 San Sebastian, Spain</affiliation></author><author xml:id="author-7"><persName><forename type="first">P.C.</forename><surname>Emson</surname></persName><affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</affiliation></author></analytic><monogr><title level="j">Molecular Brain Research</title><title level="j" type="abbrev">BRESM</title><idno type="pISSN">0169-328X</idno><idno type="PII">S0169-328X(00)X0022-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">42</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="155">155</biblScope></imprint></monogr><idno type="istex">1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3</idno><idno type="DOI">10.1016/S0169-328X(96)00157-X</idno><idno type="PII">S0169-328X(96)00157-X</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The cellular expression of dopamine D2 receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 Macaca fascicularis monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific 35S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor l-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D2 receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D2 receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D2 receptor mRNA was observed in (dyskinetic) l-DOPA-treated monkeys suggesting that levodopa-therapy normalises D2 receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D2 receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. The implications of these findings for the development of levodopa-induced dyskinesias is discussed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Dopamine D2 receptor</term></item><item><term>Hybridization, in situ</term></item><item><term>Monkey</term></item><item><term>MPTP</term></item><item><term>Parkinson's disease</term></item><item><term>l-DOPA</term></item><item><term>Dyskinesia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco"><item-info><jid>BRESM</jid><aid>9600157X</aid><ce:pii>S0169-328X(96)00157-X</ce:pii><ce:doi>10.1016/S0169-328X(96)00157-X</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>Effects of <ce:small-caps>l</ce:small-caps>-DOPA-therapy on dopamine D<ce:inf>2</ce:inf> receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys</ce:title><ce:author-group><ce:author><ce:given-name>M.T.</ce:given-name><ce:surname>Herrero</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:e-address>mtherrer@fcu.um.es</ce:e-address></ce:author><ce:author><ce:given-name>S.J.</ce:given-name><ce:surname>Augood</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Asensi</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:surname>Hirsch</ce:surname><ce:given-name>E.C.</ce:given-name><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Agid</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.A.</ce:given-name><ce:surname>Obeso</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.C.</ce:given-name><ce:surname>Emson</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Centro de Neurologia y Neurocirugia Fanctional, Clínica Quirón Donostia, Parque Alcolea, s/n, 20012 San Sebastian, Spain</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Fax: +34 (68) 36-3955</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="18" month="6" year="1996"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The cellular expression of dopamine D<ce:inf>2</ce:inf> receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 <ce:italic>Macaca fascicularis</ce:italic> monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific <ce:sup loc="pre">35</ce:sup>S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor <ce:small-caps>l</ce:small-caps>-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D<ce:inf>2</ce:inf> receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D<ce:inf>2</ce:inf> receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D<ce:inf>2</ce:inf> receptor mRNA was observed in (dyskinetic) <ce:small-caps>l</ce:small-caps>-DOPA-treated monkeys suggesting that levodopa-therapy normalises D<ce:inf>2</ce:inf> receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D<ce:inf>2</ce:inf> receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. The implications of these findings for the development of levodopa-induced dyskinesias is discussed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Dopamine D<ce:inf>2</ce:inf> receptor</ce:text></ce:keyword><ce:keyword><ce:text>Hybridization, in situ</ce:text></ce:keyword><ce:keyword><ce:text>Monkey</ce:text></ce:keyword><ce:keyword><ce:text>MPTP</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text><ce:small-caps>l</ce:small-caps>-DOPA</ce:text></ce:keyword><ce:keyword><ce:text>Dyskinesia</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effects of</title></titleInfo><name type="personal"><namePart type="given">M.T.</namePart><namePart type="family">Herrero</namePart><affiliation>E-mail: mtherrer@fcu.um.es</affiliation><affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</affiliation><description>Corresponding author. Fax: +34 (68) 36-3955</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.J.</namePart><namePart type="family">Augood</namePart><affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Asensi</namePart><affiliation>Departamento de Anatomía, Facultad de Medicina, Universidad de Murcia, 30071 Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.C.</namePart><namePart type="family">Hirsch</namePart><affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Agid</namePart><affiliation>INSERM U289, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris 13, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.A.</namePart><namePart type="family">Obeso</namePart><affiliation>Centro de Neurologia y Neurocirugia Fanctional, Clínica Quirón Donostia, Parque Alcolea, s/n, 20012 San Sebastian, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.C.</namePart><namePart type="family">Emson</namePart><affiliation>MRC Molecular Neuroscience Group, Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The cellular expression of dopamine D2 receptor mRNA was examined in striatal (caudate nucleus and putamen) neurones of 9 Macaca fascicularis monkeys rendered parkinsonian by systemic injection of MPTP. Messenger RNA abundance was determined by quantitative in situ hybridization using human-specific 35S-labelled oligonucleotides. Control monkeys were untreated and received neither MPTP nor l-DOPA while the rest were rendered parkinsonian and received chronic levodopa therapy to induce dyskinesia. In the control brains a strong dopamine D2 receptor hybridization signal was detected overlying medium-sized and some large neurons in both the caudate nucleus and putamen. Neurons from the lateral and medial regions of the caudate nucleus, and from the dorsal and ventral regions of the putamen were analysed separately. A significant increase in the cellular abundance of dopamine D2 receptor mRNA was seen in the striatum of MPTP-treated monkeys: this increase being restricted to the population of medium-sized striatal cells. No such increase in dopamine D2 receptor mRNA was observed in (dyskinetic) l-DOPA-treated monkeys suggesting that levodopa-therapy normalises D2 receptor expression in post-synaptic striatal cells. The cellular abundance of dopamine D2 receptor mRNA expressed by large striatal neurons (putative cholinergic cells) was unaffected by either MPTP treatment or levodopa therapy. The implications of these findings for the development of levodopa-induced dyskinesias is discussed.</abstract><note type="content">Section title: Short communication</note><subject><genre>Keywords</genre><topic>Dopamine D2 receptor</topic><topic>Hybridization, in situ</topic><topic>Monkey</topic><topic>MPTP</topic><topic>Parkinson's disease</topic><topic>l-DOPA</topic><topic>Dyskinesia</topic></subject><relatedItem type="host"><titleInfo><title>Molecular Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRESM</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199611</dateIssued></originInfo><identifier type="ISSN">0169-328X</identifier><identifier type="PII">S0169-328X(00)X0022-8</identifier><part><date>199611</date><detail type="volume"><number>42</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>179</end></extent><extent unit="pages"><start>149</start><end>155</end></extent></part></relatedItem><identifier type="istex">1B5F0BAAE6C29F3B00156403D1D8A06D5178E5E3</identifier><identifier type="DOI">10.1016/S0169-328X(96)00157-X</identifier><identifier type="PII">S0169-328X(96)00157-X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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