Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study
Identifieur interne : 001087 ( Istex/Corpus ); précédent : 001086; suivant : 001088Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study
Auteurs : Christine Brefel-Courbon ; Pierre Payoux ; Claire Thalamas ; Fabienne Ory ; Isabelle Quelven ; François Chollet ; Jean Louis Montastruc ; Olivier RascolSource :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
English descriptors
Abstract
Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20629
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society</div>
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<abstract xml:lang="en"><p>Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society</p>
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. We performed H<sub>2</sub>
<sup>15</sup>
O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during <i>off</i>
and <i>on</i>
conditions. In <i>off</i>
condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During <i>off</i>
condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society</p>
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<mods version="3.6"><titleInfo lang="en"><title>Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Levodopa Effect on Pain Threshold in PD</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study</title>
</titleInfo>
<name type="personal"><namePart type="given">Christine</namePart>
<namePart type="family">Brefel‐Courbon</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation>
<affiliation>Service de Neurologie, Purpan Hospital, Toulouse, France</affiliation>
<affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France</affiliation>
<affiliation>Service de Pharmacologie Clinique, Faculté de Medecine, 37 Allées Jules Guesde, 31073 Toulouse Cedex, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Pierre</namePart>
<namePart type="family">Payoux</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Claire</namePart>
<namePart type="family">Thalamas</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Fabienne</namePart>
<namePart type="family">Ory</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Service de Neurologie, Purpan Hospital, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Isabelle</namePart>
<namePart type="family">Quelven</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">François</namePart>
<namePart type="family">Chollet</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Service de Neurologie, Purpan Hospital, Toulouse, France</affiliation>
<affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jean Louis</namePart>
<namePart type="family">Montastruc</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Olivier</namePart>
<namePart type="family">Rascol</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Service de Pharmacologie Clinique, University Hospital, Toulouse, France</affiliation>
<affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France</affiliation>
<affiliation>Centre d'Investigation Clinique, Purpan Hospital, Toulouse, France</affiliation>
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<dateIssued encoding="w3cdtf">2005-12</dateIssued>
<dateCaptured encoding="w3cdtf">2004-11-12</dateCaptured>
<dateValid encoding="w3cdtf">2005-03-08</dateValid>
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<abstract lang="en">Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society</abstract>
<note type="funding">Clinical Research Hospital Program from the French Ministry of Health - No. PHRC no. 0104103; </note>
<note type="funding">France Parkinson Association</note>
<subject lang="en"><genre>keywords</genre>
<topic>Parkinson's disease</topic>
<topic>pain threshold</topic>
<topic>levodopa</topic>
<topic>H215O positron emission tomography</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<genre type="journal">journal</genre>
<subject><genre>article-category</genre>
<topic>Research Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>12</number>
</detail>
<extent unit="pages"><start>1557</start>
<end>1563</end>
<total>7</total>
</extent>
</part>
</relatedItem>
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<identifier type="DOI">10.1002/mds.20629</identifier>
<identifier type="ArticleID">MDS20629</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition>
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