The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity
Identifieur interne : 000F14 ( Istex/Corpus ); précédent : 000F13; suivant : 000F15The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity
Auteurs : Françoise Esclaire ; Glen Kisby ; Peter Spencer ; John Milne ; Mathieu Lesort ; Jacques HugonSource :
- Experimental Neurology [ 0014-4886 ] ; 1999.
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Abstract
As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. ElevatedTaugene expressionin vitrois coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.
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DOI: 10.1006/exnr.1998.6962
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ISTEX:323884908E5863433D366DDA5E1935E0E217BF55Le document en format XML
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sort="Esclaire, Francoise" uniqKey="Esclaire F" first="Françoise" last="Esclaire">Françoise Esclaire</name><affiliation><mods:affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</mods:affiliation></affiliation></author><author><name sortKey="Kisby, Glen" sort="Kisby, Glen" uniqKey="Kisby G" first="Glen" last="Kisby">Glen Kisby</name><affiliation><mods:affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</mods:affiliation></affiliation></author><author><name sortKey="Spencer, Peter" sort="Spencer, Peter" uniqKey="Spencer P" first="Peter" last="Spencer">Peter Spencer</name><affiliation><mods:affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</mods:affiliation></affiliation></author><author><name sortKey="Milne, John" sort="Milne, John" uniqKey="Milne J" first="John" last="Milne">John Milne</name><affiliation><mods:affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</mods:affiliation></affiliation></author><author><name sortKey="Lesort, Mathieu" sort="Lesort, Mathieu" uniqKey="Lesort M" first="Mathieu" last="Lesort">Mathieu Lesort</name><affiliation><mods:affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</mods:affiliation></affiliation></author><author><name sortKey="Hugon, Jacques" sort="Hugon, Jacques" uniqKey="Hugon J" first="Jacques" last="Hugon">Jacques Hugon</name><affiliation><mods:affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="ISSN">0014-4886</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">155</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="11">11</biblScope><biblScope unit="page" to="21">21</biblScope></imprint><idno type="ISSN">0014-4886</idno></series><idno type="istex">323884908E5863433D366DDA5E1935E0E217BF55</idno><idno type="DOI">10.1006/exnr.1998.6962</idno><idno type="PII">S0014-4886(98)96962-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA adducts</term><term>DNA repair</term><term>Guam ALS/PDC.</term><term>glutamate</term><term>tau</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. ElevatedTaugene expressionin vitrois coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Françoise Esclaire</name><affiliations><json:string>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</json:string></affiliations></json:item><json:item><name>Glen Kisby</name><affiliations><json:string>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</json:string></affiliations></json:item><json:item><name>Peter Spencer</name><affiliations><json:string>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</json:string></affiliations></json:item><json:item><name>John Milne</name><affiliations><json:string>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</json:string></affiliations></json:item><json:item><name>Mathieu Lesort</name><affiliations><json:string>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</json:string></affiliations></json:item><json:item><name>Jacques Hugon</name><affiliations><json:string>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>DNA adducts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DNA repair</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tau</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>glutamate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Guam ALS/PDC.</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. ElevatedTaugene expressionin vitrois coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.</abstract><qualityIndicators><score>6.056</score><pdfVersion>1.2</pdfVersion><pdfPageSize>554 x 734 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>709</abstractCharCount><pdfWordCount>6561</pdfWordCount><pdfCharCount>40713</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>88</abstractWordCount></qualityIndicators><title>The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</title><pii><json:string>S0014-4886(98)96962-X</json:string></pii><refBibs><json:item><author><json:item><name>A.J. Anderson</name></json:item><json:item><name>J.H. Su</name></json:item><json:item><name>C.W. Cotman</name></json:item></author><host><volume>16</volume><pages><last>1719</last><first>1710</first></pages><author></author><title>J. 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Scand.</title></host><title>Motor neuron disease on Guam: geographic and familial occurrence, 1956–85</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>155</volume><pii><json:string>S0014-4886(00)X0035-0</json:string></pii><pages><last>21</last><first>11</first></pages><issn><json:string>0014-4886</json:string></issn><issue>1</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Experimental Neurology</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1006/exnr.1998.6962</json:string></doi><id>323884908E5863433D366DDA5E1935E0E217BF55</id><score>0.10302545</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/323884908E5863433D366DDA5E1935E0E217BF55/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/323884908E5863433D366DDA5E1935E0E217BF55/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/323884908E5863433D366DDA5E1935E0E217BF55/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1999 Academic Press</p></availability><date>1999</date></publicationStmt><notesStmt><note>M. Manson</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</title><author xml:id="author-1"><persName><forename type="first">Françoise</forename><surname>Esclaire</surname></persName><note type="biography">The first two authors contributed equally.</note><affiliation>The first two authors contributed equally.</affiliation><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Glen</forename><surname>Kisby</surname></persName><note type="biography">The first two authors contributed equally.</note><affiliation>The first two authors contributed equally.</affiliation><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation></author><author xml:id="author-3"><persName><forename type="first">Peter</forename><surname>Spencer</surname></persName><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation></author><author xml:id="author-4"><persName><forename type="first">John</forename><surname>Milne</surname></persName><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation></author><author xml:id="author-5"><persName><forename type="first">Mathieu</forename><surname>Lesort</surname></persName><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Jacques</forename><surname>Hugon</surname></persName><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation></author></analytic><monogr><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="pISSN">0014-4886</idno><idno type="PII">S0014-4886(00)X0035-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">155</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="11">11</biblScope><biblScope unit="page" to="21">21</biblScope></imprint></monogr><idno type="istex">323884908E5863433D366DDA5E1935E0E217BF55</idno><idno type="DOI">10.1006/exnr.1998.6962</idno><idno type="PII">S0014-4886(98)96962-X</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. ElevatedTaugene expressionin vitrois coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>DNA adducts</term></item><item><term>DNA repair</term></item><item><term>tau</term></item><item><term>glutamate</term></item><item><term>Guam ALS/PDC.</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/323884908E5863433D366DDA5E1935E0E217BF55/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YEXNR</jid><aid>96962</aid><ce:pii>S0014-4886(98)96962-X</ce:pii><ce:doi>10.1006/exnr.1998.6962</ce:doi><ce:copyright type="full-transfer" year="1999">Academic Press</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>M. Manson</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</ce:title><ce:author-group><ce:author><ce:given-name>Françoise</ce:given-name><ce:surname>Esclaire</ce:surname><ce:cross-ref refid="QA1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="QFN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Glen</ce:given-name><ce:surname>Kisby</ce:surname><ce:cross-ref refid="QA2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="QFN1">1</ce:cross-ref></ce:author><ce:author><ce:given-name>Peter</ce:given-name><ce:surname>Spencer</ce:surname><ce:cross-ref refid="QA2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="QA3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>John</ce:given-name><ce:surname>Milne</ce:surname><ce:cross-ref refid="QA2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mathieu</ce:given-name><ce:surname>Lesort</ce:surname><ce:cross-ref refid="QA1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jacques</ce:given-name><ce:surname>Hugon</ce:surname><ce:cross-ref refid="QA1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="QA1"><ce:label>a</ce:label><ce:textfn>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</ce:textfn></ce:affiliation><ce:affiliation id="QA2"><ce:label>b</ce:label><ce:textfn>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</ce:textfn></ce:affiliation><ce:affiliation id="QA3"><ce:label>c</ce:label><ce:textfn>Department of Neurology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</ce:textfn></ce:affiliation><ce:footnote id="QFN1"><ce:label>1</ce:label><ce:note-para>The first two authors contributed equally.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="26" month="6" year="1997"></ce:date-received><ce:date-accepted day="18" month="9" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. Elevated<ce:italic>Tau</ce:italic>gene expression<ce:italic>in vitro</ce:italic>is coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>DNA adducts</ce:text></ce:keyword><ce:keyword><ce:text>DNA repair</ce:text></ce:keyword><ce:keyword><ce:text>tau</ce:text></ce:keyword><ce:keyword><ce:text>glutamate</ce:text></ce:keyword><ce:keyword><ce:text>Guam ALS/PDC.</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>The Guam Cycad Toxin Methylazoxymethanol Damages Neuronal DNA and Modulates Tau mRNA Expression and Excitotoxicity</title></titleInfo><name type="personal"><namePart type="given">Françoise</namePart><namePart type="family">Esclaire</namePart><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation><description>The first two authors contributed equally.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Glen</namePart><namePart type="family">Kisby</namePart><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation><description>The first two authors contributed equally.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Spencer</namePart><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Milne</namePart><affiliation>Center for Research on Occupational and Environmental Toxicology, School of Medicine, Oregon Health Sciences University, Portland, Oregon, 97201</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mathieu</namePart><namePart type="family">Lesort</namePart><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacques</namePart><namePart type="family">Hugon</namePart><affiliation>Department of Histology and Cell Biology, ERS CNRS 6101, Faculty of Medicine, University of Limoges, 87025 Limoges, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism–dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures—normally modulated by glutamate—increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. ElevatedTaugene expressionin vitrois coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC.</abstract><note>M. Manson</note><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>DNA adducts</topic><topic>DNA repair</topic><topic>tau</topic><topic>glutamate</topic><topic>Guam ALS/PDC.</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Neurology</title></titleInfo><titleInfo type="abbreviated"><title>YEXNR</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199901</dateIssued></originInfo><identifier type="ISSN">0014-4886</identifier><identifier type="PII">S0014-4886(00)X0035-0</identifier><part><date>199901</date><detail type="volume"><number>155</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>155</end></extent><extent unit="pages"><start>11</start><end>21</end></extent></part></relatedItem><identifier type="istex">323884908E5863433D366DDA5E1935E0E217BF55</identifier><identifier type="DOI">10.1006/exnr.1998.6962</identifier><identifier type="PII">S0014-4886(98)96962-X</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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