ParkinsonFranceV1, Istex, Corpus, bibRecord, 000E32

[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors

Identifieur interne : 000E32 ( Istex/Corpus ); précédent : 000E31; suivant : 000E33

[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors

Auteurs : Bernard Maziere ; Christian Loc'H ; Oscar Stulzaft ; Philippe Hantraye ; Michele Ottaviani ; Dominique Comar ; Mariannick Maziere

Source :

European Journal of Pharmacology [ 0014-2999 ] ; 1986.

RBID : ISTEX:CEE9E5B656782783E7866CB197160F4BF1CAA249

Abstract

Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.

Url:

https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/pdf

DOI: 10.1016/0014-2999(86)90370-5

Links to Exploration step

ISTEX:CEE9E5B656782783E7866CB197160F4BF1CAA249

Le document en format XML

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<front><div type="abstract" xml:lang="en">Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</div>
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[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors

[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors

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