[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors
Identifieur interne : 000E32 ( Istex/Corpus ); précédent : 000E31; suivant : 000E33[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors
Auteurs : Bernard Maziere ; Christian Loc'H ; Oscar Stulzaft ; Philippe Hantraye ; Michele Ottaviani ; Dominique Comar ; Mariannick MaziereSource :
- European Journal of Pharmacology [ 0014-2999 ] ; 1986.
Abstract
Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.
Url:
DOI: 10.1016/0014-2999(86)90370-5
Links to Exploration step
ISTEX:CEE9E5B656782783E7866CB197160F4BF1CAA249Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
<author><name sortKey="Maziere, Bernard" sort="Maziere, Bernard" uniqKey="Maziere B" first="Bernard" last="Maziere">Bernard Maziere</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>To whom all correspondence should be addressed.</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Loc H, Christian" sort="Loc H, Christian" uniqKey="Loc H C" first="Christian" last="Loc'H">Christian Loc'H</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Stulzaft, Oscar" sort="Stulzaft, Oscar" uniqKey="Stulzaft O" first="Oscar" last="Stulzaft">Oscar Stulzaft</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
<affiliation><mods:affiliation>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Ottaviani, Michele" sort="Ottaviani, Michele" uniqKey="Ottaviani M" first="Michele" last="Ottaviani">Michele Ottaviani</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Comar, Dominique" sort="Comar, Dominique" uniqKey="Comar D" first="Dominique" last="Comar">Dominique Comar</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Maziere, Mariannick" sort="Maziere, Mariannick" uniqKey="Maziere M" first="Mariannick" last="Maziere">Mariannick Maziere</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CEE9E5B656782783E7866CB197160F4BF1CAA249</idno>
<date when="1986" year="1986">1986</date>
<idno type="doi">10.1016/0014-2999(86)90370-5</idno>
<idno type="url">https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000E32</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E32</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
<author><name sortKey="Maziere, Bernard" sort="Maziere, Bernard" uniqKey="Maziere B" first="Bernard" last="Maziere">Bernard Maziere</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>To whom all correspondence should be addressed.</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Loc H, Christian" sort="Loc H, Christian" uniqKey="Loc H C" first="Christian" last="Loc'H">Christian Loc'H</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Stulzaft, Oscar" sort="Stulzaft, Oscar" uniqKey="Stulzaft O" first="Oscar" last="Stulzaft">Oscar Stulzaft</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
<affiliation><mods:affiliation>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Ottaviani, Michele" sort="Ottaviani, Michele" uniqKey="Ottaviani M" first="Michele" last="Ottaviani">Michele Ottaviani</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Comar, Dominique" sort="Comar, Dominique" uniqKey="Comar D" first="Dominique" last="Comar">Dominique Comar</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Maziere, Mariannick" sort="Maziere, Mariannick" uniqKey="Maziere M" first="Mariannick" last="Maziere">Mariannick Maziere</name>
<affiliation><mods:affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Pharmacology</title>
<title level="j" type="abbrev">EJP</title>
<idno type="ISSN">0014-2999</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1986">1986</date>
<biblScope unit="volume">127</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="239">239</biblScope>
<biblScope unit="page" to="247">247</biblScope>
</imprint>
<idno type="ISSN">0014-2999</idno>
</series>
<idno type="istex">CEE9E5B656782783E7866CB197160F4BF1CAA249</idno>
<idno type="DOI">10.1016/0014-2999(86)90370-5</idno>
<idno type="PII">0014-2999(86)90370-5</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0014-2999</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</div>
</front>
</TEI>
<istex><corpusName>elsevier</corpusName>
<author><json:item><name>Bernard Maziere</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
<json:string>To whom all correspondence should be addressed.</json:string>
<json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
<json:item><name>Christian Loc'h</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
<json:item><name>Oscar Stulzaft</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
<json:item><name>Philippe Hantraye</name>
<affiliations><json:string>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</json:string>
</affiliations>
</json:item>
<json:item><name>Michele Ottaviani</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
<json:item><name>Dominique Comar</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
<json:item><name>Mariannick Maziere</name>
<affiliations><json:string>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>D-2 dopamine receptors</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>Positron tomography</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>[76Br]Bromolisuride</value>
</json:item>
</subject>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>Full-length article</json:string>
</originalGenre>
<abstract>Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</abstract>
<qualityIndicators><score>5.918</score>
<pdfVersion>1.4</pdfVersion>
<pdfPageSize>540 x 741 pts</pdfPageSize>
<refBibsNative>true</refBibsNative>
<keywordCount>3</keywordCount>
<abstractCharCount>634</abstractCharCount>
<pdfWordCount>4254</pdfWordCount>
<pdfCharCount>22924</pdfCharCount>
<pdfPageCount>9</pdfPageCount>
<abstractWordCount>97</abstractWordCount>
</qualityIndicators>
<title>[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
<pii><json:string>0014-2999(86)90370-5</json:string>
</pii>
<refBibs><json:item><author><json:item><name>J.C. Baron</name>
</json:item>
<json:item><name>B. Mazière</name>
</json:item>
<json:item><name>C. Loc'h</name>
</json:item>
<json:item><name>P. Sgouropoulos</name>
</json:item>
<json:item><name>A.M. Bonnet</name>
</json:item>
<json:item><name>Y. Agid</name>
</json:item>
</author>
<host><volume>ii</volume>
<pages><first>1163</first>
</pages>
<author></author>
<title>Lancet</title>
</host>
<title>Progressive supranuclear palsy: Loss of striatal dopamine receptors demonstrated in vivo by positron emission tomography</title>
</json:item>
<json:item><author><json:item><name>H. Bernheimer</name>
</json:item>
<json:item><name>W. Birkmayer</name>
</json:item>
<json:item><name>O. Hornykiewicz</name>
</json:item>
<json:item><name>K. Jellinger</name>
</json:item>
<json:item><name>F. Seitelberger</name>
</json:item>
</author>
<host><volume>20</volume>
<pages><first>415</first>
</pages>
<author></author>
<title>J. Neurol. Sci.</title>
</host>
<title>Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations</title>
</json:item>
<json:item><author><json:item><name>B. Bokobza</name>
</json:item>
<json:item><name>M. Ruberg</name>
</json:item>
<json:item><name>B. Scatton</name>
</json:item>
<json:item><name>F. Javoy-Agid</name>
</json:item>
<json:item><name>Y. Agid</name>
</json:item>
</author>
<host><volume>99</volume>
<pages><first>167</first>
</pages>
<author></author>
<title>European J. Pharmacol.</title>
</host>
<title>[3H]Spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy</title>
</json:item>
<json:item><author><json:item><name>J.A. Clémens</name>
</json:item>
<json:item><name>E.B. Smalstig</name>
</json:item>
<json:item><name>C.J. Schaar</name>
</json:item>
</author>
<host><volume>79</volume>
<pages><first>230</first>
</pages>
<author></author>
<title>Acta Endocrinol.</title>
</host>
<title>Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action</title>
</json:item>
<json:item><author><json:item><name>M.J. Cronin</name>
</json:item>
<json:item><name>R.I. Wener</name>
</json:item>
</author>
<host><volume>104</volume>
<pages><first>307</first>
</pages>
<author></author>
<title>Endocrinology</title>
</host>
<title>[3H]Spiroperidol binding to a putative dopamine receptor in sheep and steer pituitary and stalk median eminence</title>
</json:item>
<json:item><author><json:item><name>L. Farde</name>
</json:item>
<json:item><name>E. Ehrin</name>
</json:item>
<json:item><name>L. Ericksson</name>
</json:item>
<json:item><name>T. Greitz</name>
</json:item>
<json:item><name>H. Hall</name>
</json:item>
<json:item><name>C.G. Hedstrom</name>
</json:item>
<json:item><name>J.E. Litton</name>
</json:item>
<json:item><name>G. Sedvall</name>
</json:item>
</author>
<host><author></author>
<title>Proc. Natl. Acad. Sci. U.S.A.</title>
</host>
<serie><author></author>
<title>Proc. Natl. Acad. Sci. U.S.A.</title>
</serie>
<title>Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography</title>
</json:item>
<json:item><author><json:item><name>J.Z. Fields</name>
</json:item>
<json:item><name>T.D. Reisine</name>
</json:item>
<json:item><name>H.I. Yamamura</name>
</json:item>
</author>
<host><volume>136</volume>
<pages><first>578</first>
</pages>
<author></author>
<title>Brain Res.</title>
</host>
<title>Biochemical demonstration of dopaminergic receptors in rat and human brain using [3H]spiroperidol</title>
</json:item>
<json:item><author><json:item><name>R.H. Fuller</name>
</json:item>
<json:item><name>J.A. Clémens</name>
</json:item>
<json:item><name>E.C. Kornfeld</name>
</json:item>
<json:item><name>H.R. Snoddy</name>
</json:item>
<json:item><name>E.B. Smalstig</name>
</json:item>
<json:item><name>N.J. Bach</name>
</json:item>
</author>
<host><volume>24</volume>
<pages><first>375</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Effects of (8-β)-8-methyl-thiomethyl-6-propylergoline on dopaminergic function and brain dopamine turnover in rats</title>
</json:item>
<json:item><author><json:item><name>J. Glowinski</name>
</json:item>
<json:item><name>L.L. Iversen</name>
</json:item>
</author>
<host><volume>13</volume>
<pages><first>1011</first>
</pages>
<author></author>
<title>I.J. Neurochem.</title>
</host>
<title>Regional studies of catecholamines in the rat brain</title>
</json:item>
<json:item><author><json:item><name>E.J. Hartley</name>
</json:item>
<json:item><name>P. Seeman</name>
</json:item>
</author>
<host><volume>23</volume>
<pages><first>513</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>The effect of varying [3H]spiperone concentration on its binding parameters</title>
</json:item>
<json:item><author><json:item><name>R. Horowski</name>
</json:item>
<json:item><name>H. Wachtel</name>
</json:item>
</author>
<host><volume>36</volume>
<pages><first>373</first>
</pages>
<author></author>
<title>European J. Pharmacol.</title>
</host>
<title>Direct dopaminergic action of lisuride hydrogen maleate, an ergot derivative, in mice</title>
</json:item>
<json:item><author><json:item><name>M.J. Kuhar</name>
</json:item>
<json:item><name>L.C. Murrin</name>
</json:item>
<json:item><name>A.T. Malouf</name>
</json:item>
<json:item><name>N. Klemm</name>
</json:item>
</author>
<host><volume>22</volume>
<pages><first>203</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Dopamine receptor binding in vivo: the feasability of autoradiographic studies</title>
</json:item>
<json:item><author><json:item><name>M.P. Martres</name>
</json:item>
<json:item><name>M.L. Bouthenet</name>
</json:item>
<json:item><name>N. Sales</name>
</json:item>
<json:item><name>P. Sokoloff</name>
</json:item>
<json:item><name>J.C. Schwartz</name>
</json:item>
</author>
<host><volume>228</volume>
<pages><first>752</first>
</pages>
<author></author>
<title>Science</title>
</host>
<title>Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand</title>
</json:item>
<json:item><author><json:item><name>B. Mazière</name>
</json:item>
<json:item><name>C. Loc'h</name>
</json:item>
<json:item><name>P. Hantraye</name>
</json:item>
<json:item><name>R. Guillon</name>
</json:item>
<json:item><name>N. Duquesnoy</name>
</json:item>
<json:item><name>F. Soussaline</name>
</json:item>
<json:item><name>R. Naquet</name>
</json:item>
<json:item><name>D. Comar</name>
</json:item>
<json:item><name>M. Mazière</name>
</json:item>
</author>
<host><volume>35</volume>
<pages><first>1349</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>[76Br]-Bromospiroperidol: A new tool for quantitative in vivo imaging of neuroleptic receptors</title>
</json:item>
<json:item><author><json:item><name>T.D. Reisine</name>
</json:item>
<json:item><name>J.Z. Fields</name>
</json:item>
<json:item><name>L.Z. Stern</name>
</json:item>
<json:item><name>P.C. Johnson</name>
</json:item>
<json:item><name>E.D. Bird</name>
</json:item>
<json:item><name>H.I. Yamamura</name>
</json:item>
</author>
<host><volume>21</volume>
<pages><first>1223</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Alterations in dopaminergic receptors in Huntington's disease</title>
</json:item>
<json:item><author><json:item><name>T.D. Reisine</name>
</json:item>
<json:item><name>J.Z. Fields</name>
</json:item>
<json:item><name>H.I. Yamamura</name>
</json:item>
<json:item><name>E.D. Bird</name>
</json:item>
<json:item><name>E. Spokes</name>
</json:item>
<json:item><name>P.S. Schreiner</name>
</json:item>
<json:item><name>S.J. Enna</name>
</json:item>
</author>
<host><volume>21</volume>
<pages><first>335</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Neurotransmitter receptor alterations in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>M.O. Thorner</name>
</json:item>
<json:item><name>E. Fluckiger</name>
</json:item>
<json:item><name>D.B. Calne</name>
</json:item>
</author>
<host><pages><first>56</first>
</pages>
<author></author>
</host>
<title>Bromocriptine: A Clinical and Pharmacological Review</title>
</json:item>
<json:item><author><json:item><name>E.S. Tolosa</name>
</json:item>
<json:item><name>S.B. Sparber</name>
</json:item>
</author>
<host><volume>15</volume>
<pages><first>1371</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Apomorphine in Huntington's chorea: clinical observations and theoretical considerations</title>
</json:item>
<json:item><author><json:item><name>H. Wachtel</name>
</json:item>
<json:item><name>W. Kehr</name>
</json:item>
<json:item><name>G. Sauer</name>
</json:item>
</author>
<host><volume>33</volume>
<pages><first>2583</first>
</pages>
<author></author>
<title>Life Sci.</title>
</host>
<title>Central anti-dopaminergic properties of 2-bromolisuride, an analogue of the ergot dopamine agonist lisuride</title>
</json:item>
<json:item><author><json:item><name>H.N. Wagner</name>
</json:item>
<json:item><name>H.D. Burns</name>
</json:item>
<json:item><name>R.F. Dannals</name>
</json:item>
<json:item><name>D.F. Wong</name>
</json:item>
<json:item><name>B. Langstrom</name>
</json:item>
<json:item><name>T. Duelfer</name>
</json:item>
<json:item><name>J.J. Frost</name>
</json:item>
<json:item><name>H.T. Ravert</name>
</json:item>
<json:item><name>J.M. Links</name>
</json:item>
<json:item><name>S. Rosenbloom</name>
</json:item>
<json:item><name>S.E. Lukas</name>
</json:item>
<json:item><name>A.V. Kramer</name>
</json:item>
<json:item><name>M.J. Kuhar</name>
</json:item>
</author>
<host><pages><first>251</first>
</pages>
<author></author>
<title>The Metabolism of the Human Brain Studied with Positron Emission Tomography</title>
</host>
<title>Imaging of dopamine receptors in human brain by positron emission tomography</title>
</json:item>
</refBibs>
<genre><json:string>research-article</json:string>
</genre>
<serie><volume>82</volume>
<pages><first>3863</first>
</pages>
<language><json:string>unknown</json:string>
</language>
<title>Proc. Natl. Acad. Sci. U.S.A.</title>
</serie>
<host><volume>127</volume>
<pii><json:string>S0014-2999(00)X0485-2</json:string>
</pii>
<pages><last>247</last>
<first>239</first>
</pages>
<issn><json:string>0014-2999</json:string>
</issn>
<issue>3</issue>
<genre><json:string>journal</json:string>
</genre>
<language><json:string>unknown</json:string>
</language>
<title>European Journal of Pharmacology</title>
<publicationDate>1986</publicationDate>
</host>
<publicationDate>1986</publicationDate>
<copyrightDate>1986</copyrightDate>
<doi><json:string>10.1016/0014-2999(86)90370-5</json:string>
</doi>
<id>CEE9E5B656782783E7866CB197160F4BF1CAA249</id>
<score>0.13402405</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>ELSEVIER</publisher>
<availability><p>ELSEVIER</p>
</availability>
<date>1986</date>
</publicationStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a">[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
<author xml:id="author-1"><persName><forename type="first">Bernard</forename>
<surname>Maziere</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<affiliation>To whom all correspondence should be addressed.</affiliation>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
<author xml:id="author-2"><persName><forename type="first">Christian</forename>
<surname>Loc'h</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
<author xml:id="author-3"><persName><forename type="first">Oscar</forename>
<surname>Stulzaft</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
<author xml:id="author-4"><persName><forename type="first">Philippe</forename>
<surname>Hantraye</surname>
</persName>
<affiliation>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</affiliation>
</author>
<author xml:id="author-5"><persName><forename type="first">Michele</forename>
<surname>Ottaviani</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
<author xml:id="author-6"><persName><forename type="first">Dominique</forename>
<surname>Comar</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
<author xml:id="author-7"><persName><forename type="first">Mariannick</forename>
<surname>Maziere</surname>
</persName>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
</author>
</analytic>
<monogr><title level="j">European Journal of Pharmacology</title>
<title level="j" type="abbrev">EJP</title>
<idno type="pISSN">0014-2999</idno>
<idno type="PII">S0014-2999(00)X0485-2</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1986"></date>
<biblScope unit="volume">127</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="239">239</biblScope>
<biblScope unit="page" to="247">247</biblScope>
</imprint>
</monogr>
<idno type="istex">CEE9E5B656782783E7866CB197160F4BF1CAA249</idno>
<idno type="DOI">10.1016/0014-2999(86)90370-5</idno>
<idno type="PII">0014-2999(86)90370-5</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>1986</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="en"><p>Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</p>
</abstract>
<textClass><keywords scheme="keyword"><list><head>Keywords</head>
<item><term>D-2 dopamine receptors</term>
</item>
<item><term>Positron tomography</term>
</item>
<item><term>[76Br]Bromolisuride</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="1986-05-07">Modified</change>
<change when="1986">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/document/CEE9E5B656782783E7866CB197160F4BF1CAA249/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType>
<istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>EJP</jid>
<aid>86903705</aid>
<ce:pii>0014-2999(86)90370-5</ce:pii>
<ce:doi>10.1016/0014-2999(86)90370-5</ce:doi>
<ce:copyright type="unknown" year="1986"></ce:copyright>
</item-info>
<head><ce:title>[<ce:sup loc="pre">76</ce:sup>
Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</ce:title>
<ce:author-group><ce:author><ce:given-name>Bernard</ce:given-name>
<ce:surname>Maziere</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Christian</ce:given-name>
<ce:surname>Loc'h</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Oscar</ce:given-name>
<ce:surname>Stulzaft</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Philippe</ce:given-name>
<ce:surname>Hantraye</ce:surname>
<ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Michele</ce:given-name>
<ce:surname>Ottaviani</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Dominique</ce:given-name>
<ce:surname>Comar</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Mariannick</ce:given-name>
<ce:surname>Maziere</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:affiliation id="AFF1"><ce:label>a</ce:label>
<ce:textfn>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF2"><ce:label>‡</ce:label>
<ce:textfn>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</ce:textfn>
</ce:affiliation>
<ce:correspondence id="COR1"><ce:label>∗</ce:label>
<ce:text>To whom all correspondence should be addressed.</ce:text>
</ce:correspondence>
</ce:author-group>
<ce:date-received day="27" month="2" year="1986"></ce:date-received>
<ce:date-revised day="7" month="5" year="1986"></ce:date-revised>
<ce:date-accepted day="27" month="5" year="1986"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (K<ce:inf>D</ce:inf>
= 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [<ce:sup loc="pre">76</ce:sup>
Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>D-2 dopamine receptors</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Positron tomography</ce:text>
</ce:keyword>
<ce:keyword><ce:text>[<ce:sup loc="pre">76</ce:sup>
Br]Bromolisuride</ce:text>
</ce:keyword>
</ce:keywords>
</head>
</converted-article>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo><title>[76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>[</title>
</titleInfo>
<name type="personal"><namePart type="given">Bernard</namePart>
<namePart type="family">Maziere</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<affiliation>To whom all correspondence should be addressed.</affiliation>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Christian</namePart>
<namePart type="family">Loc'h</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Oscar</namePart>
<namePart type="family">Stulzaft</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Philippe</namePart>
<namePart type="family">Hantraye</namePart>
<affiliation>Laboratoire de Physiologie Nerveuse, CNRS, 91190 Gif/Yvette, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Michele</namePart>
<namePart type="family">Ottaviani</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Dominique</namePart>
<namePart type="family">Comar</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Mariannick</namePart>
<namePart type="family">Maziere</namePart>
<affiliation>Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="Full-length article"></genre>
<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1986</dateIssued>
<dateModified encoding="w3cdtf">1986-05-07</dateModified>
<copyrightDate encoding="w3cdtf">1986</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="iso639-2b">eng</languageTerm>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
</physicalDescription>
<abstract lang="en">Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (KD = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of [76Br]bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in humain brain.</abstract>
<subject><genre>Keywords</genre>
<topic>D-2 dopamine receptors</topic>
<topic>Positron tomography</topic>
<topic>[76Br]Bromolisuride</topic>
</subject>
<relatedItem type="host"><titleInfo><title>European Journal of Pharmacology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>EJP</title>
</titleInfo>
<genre type="journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">19860815</dateIssued>
</originInfo>
<identifier type="ISSN">0014-2999</identifier>
<identifier type="PII">S0014-2999(00)X0485-2</identifier>
<part><date>19860815</date>
<detail type="volume"><number>127</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>3</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>165</start>
<end>306</end>
</extent>
<extent unit="pages"><start>239</start>
<end>247</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">CEE9E5B656782783E7866CB197160F4BF1CAA249</identifier>
<identifier type="DOI">10.1016/0014-2999(86)90370-5</identifier>
<identifier type="PII">0014-2999(86)90370-5</identifier>
<recordInfo><recordContentSource>ELSEVIER</recordContentSource>
</recordInfo>
</mods>
</metadata>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000E32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:CEE9E5B656782783E7866CB197160F4BF1CAA249 |texte= [76Br]Bromolisuride: A new tool for quantitative in vivo imaging of D-2 dopamine receptors }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |