Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP
Identifieur interne : 000E29 ( Istex/Corpus ); précédent : 000E28; suivant : 000E30Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP
Auteurs : C. Chassain ; A. Eschalier ; F. DurifSource :
- Journal of Neuroscience Methods [ 0165-0270 ] ; 2001.
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Abstract
The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).
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DOI: 10.1016/S0165-0270(01)00425-3
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Eschalier</name><affiliation><mods:affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name><affiliation><mods:affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0A44555E08059FDB0955CD896FABD271A07AE00</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0165-0270(01)00425-3</idno><idno type="url">https://api.istex.fr/document/D0A44555E08059FDB0955CD896FABD271A07AE00/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E29</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title><author><name sortKey="Chassain, C" sort="Chassain, C" uniqKey="Chassain C" first="C" last="Chassain">C. Chassain</name><affiliation><mods:affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: fdurif@chu.clermontferrand.fr</mods:affiliation></affiliation></author><author><name sortKey="Eschalier, A" sort="Eschalier, A" uniqKey="Eschalier A" first="A" last="Eschalier">A. Eschalier</name><affiliation><mods:affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name><affiliation><mods:affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroscience Methods</title><title level="j" type="abbrev">NSM</title><idno type="ISSN">0165-0270</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">111</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="16">16</biblScope></imprint><idno type="ISSN">0165-0270</idno></series><idno type="istex">D0A44555E08059FDB0955CD896FABD271A07AE00</idno><idno type="DOI">10.1016/S0165-0270(01)00425-3</idno><idno type="PII">S0165-0270(01)00425-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-0270</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical rating scales</term><term>Levodopa</term><term>MPTP</term><term>Monkey</term><term>Motor behavior assessment</term><term>Video image analyzer system</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C Chassain</name><affiliations><json:string>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</json:string><json:string>E-mail: fdurif@chu.clermontferrand.fr</json:string></affiliations></json:item><json:item><name>A Eschalier</name><affiliations><json:string>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</json:string></affiliations></json:item><json:item><name>F Durif</name><affiliations><json:string>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Monkey</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Video image analyzer system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Clinical rating scales</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Motor behavior assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MPTP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Levodopa</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).</abstract><qualityIndicators><score>5.913</score><pdfVersion>1.2</pdfVersion><pdfPageSize>552 x 752 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1043</abstractCharCount><pdfWordCount>4209</pdfWordCount><pdfCharCount>25587</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>142</abstractWordCount></qualityIndicators><title>Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title><pii><json:string>S0165-0270(01)00425-3</json:string></pii><refBibs><json:item><author><json:item><name>G.E. 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Neurochem.</title></host><title>Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>111</volume><pii><json:string>S0165-0270(00)X0090-8</json:string></pii><pages><last>16</last><first>9</first></pages><issn><json:string>0165-0270</json:string></issn><issue>1</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of Neuroscience Methods</title><publicationDate>2001</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>biochemical research methods</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1016/S0165-0270(01)00425-3</json:string></doi><id>D0A44555E08059FDB0955CD896FABD271A07AE00</id><score>0.13150671</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D0A44555E08059FDB0955CD896FABD271A07AE00/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D0A44555E08059FDB0955CD896FABD271A07AE00/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D0A44555E08059FDB0955CD896FABD271A07AE00/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2001</date></publicationStmt><notesStmt><note type="content">Fig. 1: Picture of the video system. Locomotor activity of primates was assessed from video cameras located in front of the animals. Each camera was able to assess two primates separately. The green rectangles corresponded to the acquisition windows (1: global locomotor activity, 2: climbing, 3: social interactions, 4: eating, 5: drinking). The curve of activity corresponding to the global locomotor activity of the primates appears in real time in the lower part of the picture (red: hyperactivity, green: normal activity, white: inactivity). The thresholds between the three states, and the detection sensitivity could be set using the software.</note><note type="content">Fig. 2: Comparison of global locomotor activity evaluated by the video system between controls (n=4) and MPTP monkeys (n=3). Animals were assessed for 30 min each day for 6 days. Values represented the mean of time spent in each state of activity (inactivity, normal activity, hyperactivity) on 6 days of assessment. ***P<0.001 compared with controls.</note><note type="content">Fig. 3: Comparison of specific activities (climbing, social interactions, eating and drinking behaviors) and of the sum of the four specific activities evaluated by the video system between controls (n=4) and MPTP monkeys (n=3). Animals were assessed for 30 min each day for 6 days. Values represented the mean on 6 days of assessment. *P<0.05; **P<0.01; ***P<0.001 compared with controls.</note><note type="content">Fig. 4: Motor activities of MPTP monkeys (n=3) after daily MPTP administrations (0.5 mg/kg). Animals were assessed by the video system for 30 min before MPTP administration (day 0), for 4 days just before the following MPTP administration (day 1, 2, 3, 4), and the fourth day after the last MPTP administration (day 8). Values were means of three animals for global locomotor activity (A) and for the sum of specific activities (climbing, social interactions; eating, drinking) (B). *P<0.05; **P<0.01; ***P<0.001: day 1, 2, 3, 4 vs. day 0 and #P<0.05; ##P<0.01; ###P<0.001: day 0, 1, 2, 3, 4 vs. day 8 (ANOVA with repeated measures with post hoc tests).</note><note type="content">Fig. 5: Gomez-Mancilla clinical rating scale after daily MPTP administrations. Animals were assessed by the clinical rating scale for 30 min before MPTP administration (day 0), for 4 days just before the following MPTP administration (day 1, 2, 3, 4), and the fourth day after the last MPTP administration (day 8). Values were means for three animals. ***P<0.001: day 1, 2, 3, 4, 8 vs. day 0 and #P<0.05; ##P<0.01: day 1, 2, 3, 4 vs. day 8 (ANOVA with repeated measures with post hoc tests).</note><note type="content">Fig. 6: Motor activities assessed by the video system recorded daily for 4 h for 3 days in MPTP monkeys (n=3) and MPTP+levodopa monkeys (n=3). Values were means ±S.D. (A) global locomotor activity, B: specific activities (climbing, social interactions, eating and drinking behaviors) and sum of the specific activities. *P<0.05; **P<0.01 compared with MPTP monkeys.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title><author xml:id="author-1"><persName><forename type="first">C</forename><surname>Chassain</surname></persName><email>fdurif@chu.clermontferrand.fr</email><note type="correspondence"><p>Corresponding author. Tel.: +33-4-7375-1600; fax: +33-4-7375-1596</p></note><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">A</forename><surname>Eschalier</surname></persName><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">F</forename><surname>Durif</surname></persName><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation></author></analytic><monogr><title level="j">Journal of Neuroscience Methods</title><title level="j" type="abbrev">NSM</title><idno type="pISSN">0165-0270</idno><idno type="PII">S0165-0270(00)X0090-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">111</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="16">16</biblScope></imprint></monogr><idno type="istex">D0A44555E08059FDB0955CD896FABD271A07AE00</idno><idno type="DOI">10.1016/S0165-0270(01)00425-3</idno><idno type="PII">S0165-0270(01)00425-3</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Monkey</term></item><item><term>Video image analyzer system</term></item><item><term>Clinical rating scales</term></item><item><term>Motor behavior assessment</term></item><item><term>MPTP</term></item><item><term>Levodopa</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-06-11">Modified</change><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D0A44555E08059FDB0955CD896FABD271A07AE00/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="gr3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="gr4"></istex:entity><istex:entity SYSTEM="gr5" NDATA="IMAGE" name="gr5"></istex:entity><istex:entity SYSTEM="gr6" NDATA="IMAGE" name="gr6"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>NSM</jid><aid>3065</aid><ce:pii>S0165-0270(01)00425-3</ce:pii><ce:doi>10.1016/S0165-0270(01)00425-3</ce:doi><ce:copyright type="unknown" year="2001"></ce:copyright></item-info><head><ce:title>Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</ce:title><ce:author-group><ce:author><ce:given-name>C</ce:given-name><ce:surname>Chassain</ce:surname><ce:cross-ref refid="COR1">*</ce:cross-ref><ce:e-address type="email">fdurif@chu.clermontferrand.fr</ce:e-address></ce:author><ce:author><ce:given-name>A</ce:given-name><ce:surname>Eschalier</ce:surname></ce:author><ce:author><ce:given-name>F</ce:given-name><ce:surname>Durif</ce:surname></ce:author><ce:affiliation><ce:textfn>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +33-4-7375-1600; fax: +33-4-7375-1596</ce:text></ce:correspondence></ce:author-group><ce:date-received day="27" month="4" year="2001"></ce:date-received><ce:date-revised day="11" month="6" year="2001"></ce:date-revised><ce:date-accepted day="29" month="6" year="2001"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require <ce:italic>clinical rating scales</ce:italic> that measure <ce:italic>motor behavior</ce:italic> with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The <ce:italic>video image analyzer system</ce:italic>, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by <ce:italic>levodopa</ce:italic>: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Monkey</ce:text></ce:keyword><ce:keyword><ce:text>Video image analyzer system</ce:text></ce:keyword><ce:keyword><ce:text>Clinical rating scales</ce:text></ce:keyword><ce:keyword><ce:text>Motor behavior assessment</ce:text></ce:keyword><ce:keyword><ce:text>MPTP</ce:text></ce:keyword><ce:keyword><ce:text>Levodopa</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Chassain</namePart><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation><affiliation>E-mail: fdurif@chu.clermontferrand.fr</affiliation><description>Corresponding author. Tel.: +33-4-7375-1600; fax: +33-4-7375-1596</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Eschalier</namePart><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Durif</namePart><affiliation>Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2001</dateIssued><dateModified encoding="w3cdtf">2001-06-11</dateModified><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).</abstract><note type="content">Fig. 1: Picture of the video system. Locomotor activity of primates was assessed from video cameras located in front of the animals. Each camera was able to assess two primates separately. The green rectangles corresponded to the acquisition windows (1: global locomotor activity, 2: climbing, 3: social interactions, 4: eating, 5: drinking). The curve of activity corresponding to the global locomotor activity of the primates appears in real time in the lower part of the picture (red: hyperactivity, green: normal activity, white: inactivity). The thresholds between the three states, and the detection sensitivity could be set using the software.</note><note type="content">Fig. 2: Comparison of global locomotor activity evaluated by the video system between controls (n=4) and MPTP monkeys (n=3). Animals were assessed for 30 min each day for 6 days. Values represented the mean of time spent in each state of activity (inactivity, normal activity, hyperactivity) on 6 days of assessment. ***P<0.001 compared with controls.</note><note type="content">Fig. 3: Comparison of specific activities (climbing, social interactions, eating and drinking behaviors) and of the sum of the four specific activities evaluated by the video system between controls (n=4) and MPTP monkeys (n=3). Animals were assessed for 30 min each day for 6 days. Values represented the mean on 6 days of assessment. *P<0.05; **P<0.01; ***P<0.001 compared with controls.</note><note type="content">Fig. 4: Motor activities of MPTP monkeys (n=3) after daily MPTP administrations (0.5 mg/kg). Animals were assessed by the video system for 30 min before MPTP administration (day 0), for 4 days just before the following MPTP administration (day 1, 2, 3, 4), and the fourth day after the last MPTP administration (day 8). Values were means of three animals for global locomotor activity (A) and for the sum of specific activities (climbing, social interactions; eating, drinking) (B). *P<0.05; **P<0.01; ***P<0.001: day 1, 2, 3, 4 vs. day 0 and #P<0.05; ##P<0.01; ###P<0.001: day 0, 1, 2, 3, 4 vs. day 8 (ANOVA with repeated measures with post hoc tests).</note><note type="content">Fig. 5: Gomez-Mancilla clinical rating scale after daily MPTP administrations. Animals were assessed by the clinical rating scale for 30 min before MPTP administration (day 0), for 4 days just before the following MPTP administration (day 1, 2, 3, 4), and the fourth day after the last MPTP administration (day 8). Values were means for three animals. ***P<0.001: day 1, 2, 3, 4, 8 vs. day 0 and #P<0.05; ##P<0.01: day 1, 2, 3, 4 vs. day 8 (ANOVA with repeated measures with post hoc tests).</note><note type="content">Fig. 6: Motor activities assessed by the video system recorded daily for 4 h for 3 days in MPTP monkeys (n=3) and MPTP+levodopa monkeys (n=3). Values were means ±S.D. (A) global locomotor activity, B: specific activities (climbing, social interactions, eating and drinking behaviors) and sum of the specific activities. *P<0.05; **P<0.01 compared with MPTP monkeys.</note><subject lang="en"><genre>Keywords</genre><topic>Monkey</topic><topic>Video image analyzer system</topic><topic>Clinical rating scales</topic><topic>Motor behavior assessment</topic><topic>MPTP</topic><topic>Levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroscience Methods</title></titleInfo><titleInfo type="abbreviated"><title>NSM</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20011015</dateIssued></originInfo><identifier type="ISSN">0165-0270</identifier><identifier type="PII">S0165-0270(00)X0090-8</identifier><part><date>20011015</date><detail type="volume"><number>111</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>81</end></extent><extent unit="pages"><start>9</start><end>16</end></extent></part></relatedItem><identifier type="istex">D0A44555E08059FDB0955CD896FABD271A07AE00</identifier><identifier type="DOI">10.1016/S0165-0270(01)00425-3</identifier><identifier type="PII">S0165-0270(01)00425-3</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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