ParkinsonFranceV1, Istex, Corpus, bibRecord, 000D68

Adrenergic receptors in frontal cortex in human brain

Identifieur interne : 000D68 ( Istex/Corpus ); précédent : 000D67; suivant : 000D69

Adrenergic receptors in frontal cortex in human brain

Auteurs : Roland Cash ; Rita Raisman ; Merle Ruberg ; Yves Agid

Source :

European Journal of Pharmacology [ 0014-2999 ] ; 1985.

RBID : ISTEX:DD98F5B3D3BBE5BBAF2413688BF70C1AB3FB79C6

Abstract

The binding of three adrenergic ligands ([3H]prazosin, [3H]clonidine, [3H]dihydroalprenolol) was studied in the frontal cortex of human brain. α1-Receptors, labeled by [3H]prazosin, predominated. [3H]Clonidine bound to two classes of sites, one of high affinity and one of low affinity. Guanosine triphosphate appeared to lower the affinity of [3H]clonidine for its receptor. [3H]Dihydroalprenolol bound to three classes of sites: the β1-receptor, the β2- receptor and a receptor with low affinity which represented about 40% of the total binding, but which was probably a non-specific site; the β1/β2 ratio was 12.

Url:

https://api.istex.fr/document/DD98F5B3D3BBE5BBAF2413688BF70C1AB3FB79C6/fulltext/pdf

DOI: 10.1016/0014-2999(85)90444-3

Links to Exploration step

ISTEX:DD98F5B3D3BBE5BBAF2413688BF70C1AB3FB79C6

Le document en format XML

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<front><div type="abstract" xml:lang="en">The binding of three adrenergic ligands ([3H]prazosin, [3H]clonidine, [3H]dihydroalprenolol) was studied in the frontal cortex of human brain. α1-Receptors, labeled by [3H]prazosin, predominated. [3H]Clonidine bound to two classes of sites, one of high affinity and one of low affinity. Guanosine triphosphate appeared to lower the affinity of [3H]clonidine for its receptor. [3H]Dihydroalprenolol bound to three classes of sites: the β1-receptor, the β2- receptor and a receptor with low affinity which represented about 40% of the total binding, but which was probably a non-specific site; the β1/β2 ratio was 12.</div>
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<abstract lang="en">The binding of three adrenergic ligands ([3H]prazosin, [3H]clonidine, [3H]dihydroalprenolol) was studied in the frontal cortex of human brain. α1-Receptors, labeled by [3H]prazosin, predominated. [3H]Clonidine bound to two classes of sites, one of high affinity and one of low affinity. Guanosine triphosphate appeared to lower the affinity of [3H]clonidine for its receptor. [3H]Dihydroalprenolol bound to three classes of sites: the β1-receptor, the β2- receptor and a receptor with low affinity which represented about 40% of the total binding, but which was probably a non-specific site; the β1/β2 ratio was 12.</abstract>
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Adrenergic receptors in frontal cortex in human brain

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