Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease
Identifieur interne : 000C79 ( Istex/Corpus ); précédent : 000C78; suivant : 000C80Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease
Auteurs : T. Zalla ; A. Sirigu ; B. Pillon ; B. Dubois ; J. Grafman ; Y. AgidSource :
- Cortex [ 0010-9452 ] ; 1998.
Abstract
The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script syntax knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.
Url:
DOI: 10.1016/S0010-9452(08)70519-7
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Zalla</name><affiliation><mods:affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</mods:affiliation></affiliation><affiliation><mods:affiliation>Crea Ecole Polytechnique, Paris, France;</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Tiziana Zalla, Institut des Sciences Cognitives 67, boulevard Pinel 69675 Bron Cedex France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: zalla@ext.jussieu.fr</mods:affiliation></affiliation></author><author><name sortKey="Sirigu, A" sort="Sirigu, A" uniqKey="Sirigu A" first="A." last="Sirigu">A. Sirigu</name><affiliation><mods:affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</mods:affiliation></affiliation></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B." last="Pillon">B. Pillon</name><affiliation><mods:affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</mods:affiliation></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><affiliation><mods:affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</mods:affiliation></affiliation></author><author><name sortKey="Grafman, J" sort="Grafman, J" uniqKey="Grafman J" first="J." last="Grafman">J. Grafman</name><affiliation><mods:affiliation>Cognitive Neuroscience Section NINDS, NIH, Bethesda, USA</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cortex</title><title level="j" type="abbrev">CORTEX</title><idno type="ISSN">0010-9452</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">34</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="621">621</biblScope><biblScope unit="page" to="627">627</biblScope></imprint><idno type="ISSN">0010-9452</idno></series><idno type="istex">84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F</idno><idno type="DOI">10.1016/S0010-9452(08)70519-7</idno><idno type="PII">S0010-9452(08)70519-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0010-9452</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script syntax knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>T. Zalla</name><affiliations><json:string>Inserm U. 289, Hpital de la Salptrire, Paris, France;</json:string><json:string>Crea Ecole Polytechnique, Paris, France;</json:string><json:string>Dr. Tiziana Zalla, Institut des Sciences Cognitives 67, boulevard Pinel 69675 Bron Cedex France</json:string><json:string>E-mail: zalla@ext.jussieu.fr</json:string></affiliations></json:item><json:item><name>A. Sirigu</name><affiliations><json:string>Inserm U. 289, Hpital de la Salptrire, Paris, France;</json:string></affiliations></json:item><json:item><name>B. Pillon</name><affiliations><json:string>Inserm U. 289, Hpital de la Salptrire, Paris, France;</json:string></affiliations></json:item><json:item><name>B. Dubois</name><affiliations><json:string>Inserm U. 289, Hpital de la Salptrire, Paris, France;</json:string></affiliations></json:item><json:item><name>J. Grafman</name><affiliations><json:string>Cognitive Neuroscience Section NINDS, NIH, Bethesda, USA</json:string></affiliations></json:item><json:item><name>Y. Agid</name><affiliations><json:string>Inserm U. 289, Hpital de la Salptrire, Paris, France;</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>script event sequence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>shifting ability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script syntax knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</abstract><qualityIndicators><score>5.618</score><pdfVersion>1.4</pdfVersion><pdfPageSize>481 x 682 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>783</abstractCharCount><pdfWordCount>3666</pdfWordCount><pdfCharCount>22166</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>121</abstractWordCount></qualityIndicators><title>Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</title><pii><json:string>S0010-9452(08)70519-7</json:string></pii><refBibs><json:item><author><json:item><name>G.E. Alexander</name></json:item><json:item><name>M.R. De Long</name></json:item><json:item><name>P.L. 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Lang</name></json:item></author><host><volume>13</volume><pages><last>232</last><first>211</first></pages><author></author><title>Brain and Cognition</title></host><title>Memory and learning in early Parkinson's disease: Evidence for a frontal lobe syndrome</title></json:item><json:item><host><author></author></host></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>34</volume><pii><json:string>S0010-9452(08)X7030-3</json:string></pii><pages><last>627</last><first>621</first></pages><issn><json:string>0010-9452</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Cortex</title><publicationDate>1998</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>behavioral sciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>psychology & cognitive sciences</json:string><json:string>experimental psychology</json:string></scienceMetrix></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S0010-9452(08)70519-7</json:string></doi><id>84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F</id><score>0.1526827</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1998 Elsevier Masson Srl</p></availability><date>1998</date></publicationStmt><notesStmt><note type="content">Section title: Note</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</title><author xml:id="author-1"><persName><forename type="first">T.</forename><surname>Zalla</surname></persName><email>zalla@ext.jussieu.fr</email><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><affiliation>Crea Ecole Polytechnique, Paris, France;</affiliation><affiliation>Dr. Tiziana Zalla, Institut des Sciences Cognitives 67, boulevard Pinel 69675 Bron Cedex France</affiliation></author><author xml:id="author-2"><persName><forename type="first">A.</forename><surname>Sirigu</surname></persName><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation></author><author xml:id="author-3"><persName><forename type="first">B.</forename><surname>Pillon</surname></persName><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation></author><author xml:id="author-4"><persName><forename type="first">B.</forename><surname>Dubois</surname></persName><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation></author><author xml:id="author-5"><persName><forename type="first">J.</forename><surname>Grafman</surname></persName><affiliation>Cognitive Neuroscience Section NINDS, NIH, Bethesda, USA</affiliation></author><author xml:id="author-6"><persName><forename type="first">Y.</forename><surname>Agid</surname></persName><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation></author></analytic><monogr><title level="j">Cortex</title><title level="j" type="abbrev">CORTEX</title><idno type="pISSN">0010-9452</idno><idno type="PII">S0010-9452(08)X7030-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">34</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="621">621</biblScope><biblScope unit="page" to="627">627</biblScope></imprint></monogr><idno type="istex">84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F</idno><idno type="DOI">10.1016/S0010-9452(08)70519-7</idno><idno type="PII">S0010-9452(08)70519-7</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script syntax knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</p></abstract><textClass><keywords scheme="keyword"><list><head>Key Words</head><item><term>script event sequence</term></item><item><term>shifting ability</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.2//EN//XML" URI="art502.dtd" name="istex:docType"></istex:docType><istex:document><article docsubtype="fla"> <item-info> <jid>CORTEX</jid> <aid>70519</aid> <ce:pii>S0010-9452(08)70519-7</ce:pii> <ce:doi>10.1016/S0010-9452(08)70519-7</ce:doi> <ce:copyright type="full-transfer" year="1998">Elsevier Masson Srl</ce:copyright> </item-info> <head> <ce:dochead> <ce:textfn>Note</ce:textfn> </ce:dochead> <ce:title>Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</ce:title> <ce:author-group> <ce:author> <ce:given-name>T.</ce:given-name> <ce:surname>Zalla</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref> <ce:e-address type="email">zalla@ext.jussieu.fr</ce:e-address> </ce:author> <ce:author> <ce:given-name>A.</ce:given-name> <ce:surname>Sirigu</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:author> <ce:given-name>B.</ce:given-name> <ce:surname>Pillon</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:author> <ce:given-name>B.</ce:given-name> <ce:surname>Dubois</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:author> <ce:given-name>J.</ce:given-name> <ce:surname>Grafman</ce:surname><ce:cross-ref refid="aff3"><ce:sup>c</ce:sup></ce:cross-ref> </ce:author> <ce:author> <ce:given-name>Y.</ce:given-name> <ce:surname>Agid</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:affiliation id="aff1"> <ce:label>a</ce:label> <ce:textfn>Inserm U. 289, Hôpital de la Salpêtrière, Paris, France;</ce:textfn> </ce:affiliation> <ce:affiliation id="aff2"> <ce:label>b</ce:label> <ce:textfn>Crea – Ecole Polytechnique, Paris, France;</ce:textfn> </ce:affiliation> <ce:affiliation id="aff3"> <ce:label>c</ce:label> <ce:textfn>Cognitive Neuroscience Section NINDS, NIH, Bethesda, USA</ce:textfn> </ce:affiliation> <ce:correspondence id="cor1"> <ce:label>*</ce:label> <ce:text>Dr. Tiziana Zalla, Institut des Sciences Cognitives 67, boulevard Pinel 69675 Bron Cedex France</ce:text> </ce:correspondence> </ce:author-group> <ce:date-received day="5" month="3" year="1998"></ce:date-received> <ce:date-accepted day="30" month="4" year="1998"></ce:date-accepted> <ce:abstract> <ce:section-title>Abstract</ce:section-title> <ce:abstract-sec> <ce:simple-para>The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script “syntax” knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</ce:simple-para> </ce:abstract-sec> </ce:abstract> <ce:keywords> <ce:section-title>Key Words</ce:section-title> <ce:keyword> <ce:text>script event sequence</ce:text> </ce:keyword> <ce:keyword> <ce:text>shifting ability</ce:text> </ce:keyword> <ce:keyword> <ce:text>Parkinson's disease</ce:text> </ce:keyword> </ce:keywords> </head> <tail> <ce:bibliography> <ce:section-title>References</ce:section-title> <ce:bibliography-sec> <ce:bib-reference id="bib1"> <ce:label>Alexander et al., 1986</ce:label> <sb:reference> <sb:contribution> <sb:authors> <sb:author> <ce:given-name>G.E.</ce:given-name> <ce:surname>Alexander</ce:surname> </sb:author> <sb:author> <ce:given-name>M.R.</ce:given-name> <ce:surname>De Long</ce:surname> </sb:author> 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How patients with Parkinson's disease retrieve and manage script knowledge, 1998 (<ce:italic>Submitted</ce:italic>).</ce:textref> </ce:other-ref> </ce:bib-reference> </ce:bibliography-sec> </ce:bibliography> </tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Deficit in Evaluating Pre-Determinated Sequences of Script Events in Patients with Parkinson's Disease</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Zalla</namePart><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><affiliation>Crea Ecole Polytechnique, Paris, France;</affiliation><affiliation>Dr. Tiziana Zalla, Institut des Sciences Cognitives 67, boulevard Pinel 69675 Bron Cedex France</affiliation><affiliation>E-mail: zalla@ext.jussieu.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sirigu</namePart><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Pillon</namePart><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Dubois</namePart><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Grafman</namePart><affiliation>Cognitive Neuroscience Section NINDS, NIH, Bethesda, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Agid</namePart><affiliation>Inserm U. 289, Hpital de la Salptrire, Paris, France;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script syntax knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</abstract><note type="content">Section title: Note</note><subject><genre>Key Words</genre><topic>script event sequence</topic><topic>shifting ability</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Cortex</title></titleInfo><titleInfo type="abbreviated"><title>CORTEX</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">0010-9452</identifier><identifier type="PII">S0010-9452(08)X7030-3</identifier><part><date>1998</date><detail type="volume"><number>34</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>471</start><end>634</end></extent><extent unit="pages"><start>621</start><end>627</end></extent></part></relatedItem><identifier type="istex">84DD175AACF6EA5E7E2E426D0B9F7CF21ED7588F</identifier><identifier type="DOI">10.1016/S0010-9452(08)70519-7</identifier><identifier type="PII">S0010-9452(08)70519-7</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 Elsevier Masson Srl</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Masson Srl, ©1998</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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