New perspectives in stem cell research: beyond embryonic stem cells
Identifieur interne : 000B73 ( Istex/Corpus ); précédent : 000B72; suivant : 000B74New perspectives in stem cell research: beyond embryonic stem cells
Auteurs : C. Leeb ; M. Jurga ; C. Mcguckin ; N. Forraz ; C. Thallinger ; R. Moriggl ; L. KennerSource :
- Cell Proliferation [ 0960-7722 ] ; 2011-04.
Abstract
Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.
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DOI: 10.1111/j.1365-2184.2010.00725.x
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<surname>Leeb</surname>
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<affiliation>Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</affiliation>
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<author xml:id="author-2"><persName><forename type="first">M.</forename>
<surname>Jurga</surname>
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<affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation>
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<author xml:id="author-3"><persName><forename type="first">C.</forename>
<surname>McGuckin</surname>
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<author xml:id="author-4"><persName><forename type="first">N.</forename>
<surname>Forraz</surname>
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<affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation>
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<author xml:id="author-5"><persName><forename type="first">C.</forename>
<surname>Thallinger</surname>
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<affiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</affiliation>
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<author xml:id="author-6"><persName><forename type="first">R.</forename>
<surname>Moriggl</surname>
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<affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</affiliation>
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<author xml:id="author-7"><persName><forename type="first">L.</forename>
<surname>Kenner</surname>
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<abstract xml:lang="en"><p>Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.</p>
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<correspondenceTo>L. Kenner, Ludwig Boltzmann Institute for Cancer Research, Währingerstrasse 13A, Vienna, Austria. Tel.:+43‐1‐4277‐64111; Fax: +43‐1‐4277‐9641; E‐mail: <email>lukas.kenner@lbicr.lbg.ac.at</email>
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<affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</unparsedAffiliation>
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<affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</unparsedAffiliation>
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<affiliation xml:id="a3" countryCode="AT"><unparsedAffiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</unparsedAffiliation>
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<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential <i>in vivo</i>
and <i>in vitro</i>
. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.</p>
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<mods version="3.6"><titleInfo lang="en"><title>New perspectives in stem cell research: beyond embryonic stem cells</title>
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<titleInfo type="abbreviated" lang="en"><title>New perspectives in stem cell research</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>New perspectives in stem cell research: beyond embryonic stem cells</title>
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<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Leeb</namePart>
<affiliation>Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M.</namePart>
<namePart type="family">Jurga</namePart>
<affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">McGuckin</namePart>
<affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N.</namePart>
<namePart type="family">Forraz</namePart>
<affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Thallinger</namePart>
<affiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R.</namePart>
<namePart type="family">Moriggl</namePart>
<affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
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<name type="personal"><namePart type="given">L.</namePart>
<namePart type="family">Kenner</namePart>
<affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</affiliation>
<affiliation>Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria</affiliation>
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<dateIssued encoding="w3cdtf">2011-04</dateIssued>
<edition>Received 4 June 2010; revision accepted 19 July 2010</edition>
<copyrightDate encoding="w3cdtf">2011</copyrightDate>
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<abstract lang="en">Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.</abstract>
<relatedItem type="host"><titleInfo><title>Cell Proliferation</title>
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<genre type="journal">journal</genre>
<identifier type="ISSN">0960-7722</identifier>
<identifier type="eISSN">1365-2184</identifier>
<identifier type="DOI">10.1111/(ISSN)1365-2184</identifier>
<identifier type="PublisherID">CPR</identifier>
<part><date>2011</date>
<detail type="title"><title>2nd International Congress on Responsible Stem Cell Research: Adult Somatic Stem Cells: New perspectives</title>
</detail>
<detail type="volume"><caption>vol.</caption>
<number>44</number>
</detail>
<detail type="supplement"><caption>Suppl. no.</caption>
<number>s1</number>
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<extent unit="pages"><start>9</start>
<end>14</end>
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<identifier type="DOI">10.1111/j.1365-2184.2010.00725.x</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">© 2011 Blackwell Publishing Ltd</accessCondition>
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