New perspectives in stem cell research: beyond embryonic stem cells
Identifieur interne : 000B73 ( Istex/Corpus ); précédent : 000B72; suivant : 000B74New perspectives in stem cell research: beyond embryonic stem cells
Auteurs : C. Leeb ; M. Jurga ; C. Mcguckin ; N. Forraz ; C. Thallinger ; R. Moriggl ; L. KennerSource :
- Cell Proliferation [ 0960-7722 ] ; 2011-04.
Abstract
Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.
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DOI: 10.1111/j.1365-2184.2010.00725.x
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ISTEX:6B8E0FE2B20C4BB3584497AAB37B6354741381E1Le document en format XML
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Mcguckin</name><affiliation><mods:affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</mods:affiliation></affiliation></author><author><name sortKey="Forraz, N" sort="Forraz, N" uniqKey="Forraz N" first="N." last="Forraz">N. Forraz</name><affiliation><mods:affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</mods:affiliation></affiliation></author><author><name sortKey="Thallinger, C" sort="Thallinger, C" uniqKey="Thallinger C" first="C." last="Thallinger">C. Thallinger</name><affiliation><mods:affiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Moriggl, R" sort="Moriggl, R" uniqKey="Moriggl R" first="R." last="Moriggl">R. 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Leeb</name><affiliation><mods:affiliation>Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Jurga, M" sort="Jurga, M" uniqKey="Jurga M" first="M." last="Jurga">M. Jurga</name><affiliation><mods:affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</mods:affiliation></affiliation></author><author><name sortKey="Mcguckin, C" sort="Mcguckin, C" uniqKey="Mcguckin C" first="C." last="Mcguckin">C. Mcguckin</name><affiliation><mods:affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</mods:affiliation></affiliation></author><author><name sortKey="Forraz, N" sort="Forraz, N" uniqKey="Forraz N" first="N." last="Forraz">N. Forraz</name><affiliation><mods:affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</mods:affiliation></affiliation></author><author><name sortKey="Thallinger, C" sort="Thallinger, C" uniqKey="Thallinger C" first="C." last="Thallinger">C. Thallinger</name><affiliation><mods:affiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Moriggl, R" sort="Moriggl, R" uniqKey="Moriggl R" first="R." last="Moriggl">R. Moriggl</name><affiliation><mods:affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Kenner, L" sort="Kenner, L" uniqKey="Kenner L" first="L." last="Kenner">L. Kenner</name><affiliation><mods:affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell Proliferation</title><idno type="ISSN">0960-7722</idno><idno type="eISSN">1365-2184</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="volume">44</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="14">14</biblScope></imprint><idno type="ISSN">0960-7722</idno></series><idno type="istex">6B8E0FE2B20C4BB3584497AAB37B6354741381E1</idno><idno type="DOI">10.1111/j.1365-2184.2010.00725.x</idno><idno type="ArticleID">CPR725</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0960-7722</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>C. Leeb</name><affiliations><json:string>Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>M. Jurga</name><affiliations><json:string>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</json:string></affiliations></json:item><json:item><name>C. McGuckin</name><affiliations><json:string>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</json:string></affiliations></json:item><json:item><name>N. Forraz</name><affiliations><json:string>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</json:string></affiliations></json:item><json:item><name>C. Thallinger</name><affiliations><json:string>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>R. Moriggl</name><affiliations><json:string>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</json:string></affiliations></json:item><json:item><name>L. Kenner</name><affiliations><json:string>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</json:string><json:string>Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria</json:string></affiliations></json:item></author><articleId><json:string>CPR725</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. 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Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria</affiliation></author><author xml:id="author-2"><persName><forename type="first">M.</forename><surname>Jurga</surname></persName><affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">C.</forename><surname>McGuckin</surname></persName><affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">N.</forename><surname>Forraz</surname></persName><affiliation>Cell Therapy Research Institute CTI‐LYON, Parc Technologique de Lyon‐Saint Priest, Saint Priest, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">C.</forename><surname>Thallinger</surname></persName><affiliation>Department of Internal Medicine, Medical University of Vienna, Vienna, Austria</affiliation></author><author xml:id="author-6"><persName><forename type="first">R.</forename><surname>Moriggl</surname></persName><affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</affiliation></author><author xml:id="author-7"><persName><forename type="first">L.</forename><surname>Kenner</surname></persName><affiliation>Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria</affiliation><affiliation>Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria</affiliation></author></analytic><monogr><title level="j">Cell Proliferation</title><idno type="pISSN">0960-7722</idno><idno type="eISSN">1365-2184</idno><idno type="DOI">10.1111/(ISSN)1365-2184</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-04"></date><biblScope unit="volume">44</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="14">14</biblScope></imprint></monogr><idno type="istex">6B8E0FE2B20C4BB3584497AAB37B6354741381E1</idno><idno type="DOI">10.1111/j.1365-2184.2010.00725.x</idno><idno type="ArticleID">CPR725</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells to drastically increase quality of life through repairing aging and diseased organs. Nevertheless, the essence of stem cell research is to understand how tissues are maintained during adult life. In this article, we summarize the various types of stem cells and their differentiation potential in vivo and in vitro. We review current clinical applications of stem cells and highlight problems encountered when going from animal studies to clinical practice. Furthermore, we describe the current state of induced pluripotent stem cell technology and applications for disease modelling and cell replacement therapy.</p></abstract></profileDesc><revisionDesc><change when="2011-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6B8E0FE2B20C4BB3584497AAB37B6354741381E1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2184</doi><issn type="print">0960-7722</issn><issn type="electronic">1365-2184</issn><idGroup><id type="product" value="CPR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CELL PROLIFERATION">Cell Proliferation</title></titleGroup></publicationMeta><publicationMeta level="part" position="04001"><doi origin="wiley">10.1111/cpr.2011.44.issue-s1</doi><titleGroup><title type="specialIssueTitle">2nd International Congress on Responsible Stem Cell Research: Adult Somatic Stem Cells: New perspectives</title></titleGroup><numberingGroup><numbering type="journalVolume" number="44">44</numbering><numbering type="supplement">s1</numbering></numberingGroup><coverDate startDate="2011-04">April 2011</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="2" status="forIssue"><doi origin="wiley">10.1111/j.1365-2184.2010.00725.x</doi><idGroup><id type="unit" value="CPR725"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Review Articles</title></titleGroup><copyright>© 2011 Blackwell Publishing Ltd</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.8 mode:FullText" date="2011-04-10"></event><event type="firstOnline" date="2011-04-11"></event><event type="publishedOnlineFinalForm" date="2011-04-11"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="9">9</numbering><numbering type="pageLast" number="14">14</numbering></numberingGroup><correspondenceTo>L. Kenner, Ludwig Boltzmann Institute for Cancer Research, Währingerstrasse 13A, Vienna, Austria. Tel.:+43‐1‐4277‐64111; Fax: +43‐1‐4277‐9641; E‐mail: <email>lukas.kenner@lbicr.lbg.ac.at</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CPR.CPR725.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory><i>Received</i> 4 <i>June</i> 2010; <i>revision accepted</i> 19 <i>July</i> 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">New perspectives in stem cell research: beyond embryonic stem cells</title><title type="shortAuthors"><i>C. Leeb</i> et al.</title><title type="short"><i>New perspectives in stem cell research</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>C.</givenNames><familyName>Leeb</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>M.</givenNames><familyName>Jurga</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>C.</givenNames><familyName>McGuckin</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>N.</givenNames><familyName>Forraz</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>C.</givenNames><familyName>Thallinger</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a4"><personName><givenNames>R.</givenNames><familyName>Moriggl</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a4 #a5"><personName><givenNames>L.</givenNames><familyName>Kenner</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Max F. 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