Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects
Identifieur interne : 000854 ( Istex/Corpus ); précédent : 000853; suivant : 000855Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects
Auteurs : P. Delay-Goyet ; J.-M. Zajac ; F. Javoy-Agid ; Y. Agid ; B. P. RoquesSource :
- Brain Research [ 0006-8993 ] ; 1987.
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Abstract
Abstract: The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [3H]Tyr-d-Ala-Gly-(Me)Phe-Gly-ol and [3H]Tyr-d-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [3H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.
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DOI: 10.1016/0006-8993(87)91321-7
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ISTEX:EDD390816A43E3D1CC016367C64F5C952B9B9ECELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects</title><author><name sortKey="Delay Goyet, P" sort="Delay Goyet, P" uniqKey="Delay Goyet P" first="P." last="Delay-Goyet">P. Delay-Goyet</name><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Zajac, J M" sort="Zajac, J M" uniqKey="Zajac J" first="J.-M." last="Zajac">J.-M. Zajac</name><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation><mods:affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B. P." last="Roques">B. P. Roques</name><affiliation><mods:affiliation>Correspondence: B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</mods:affiliation></affiliation><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EDD390816A43E3D1CC016367C64F5C952B9B9ECE</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1016/0006-8993(87)91321-7</idno><idno type="url">https://api.istex.fr/document/EDD390816A43E3D1CC016367C64F5C952B9B9ECE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000854</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000854</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects</title><author><name sortKey="Delay Goyet, P" sort="Delay Goyet, P" uniqKey="Delay Goyet P" first="P." last="Delay-Goyet">P. Delay-Goyet</name><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Zajac, J M" sort="Zajac, J M" uniqKey="Zajac J" first="J.-M." last="Zajac">J.-M. Zajac</name><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation><mods:affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Y. Agid</name><affiliation><mods:affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</mods:affiliation></affiliation></author><author><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B. P." last="Roques">B. P. Roques</name><affiliation><mods:affiliation>Correspondence: B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</mods:affiliation></affiliation><affiliation><mods:affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">414</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="8">8</biblScope><biblScope unit="page" to="14">14</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">EDD390816A43E3D1CC016367C64F5C952B9B9ECE</idno><idno type="DOI">10.1016/0006-8993(87)91321-7</idno><idno type="PII">0006-8993(87)91321-7</idno><idno type="ArticleID">87913217</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Discriminative binding property</term><term>Human brain</term><term>Opioid receptor</term><term>Parkinson's disease</term><term>Selective ligand</term><term>δ-Enkephalin analogue</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [3H]Tyr-d-Ala-Gly-(Me)Phe-Gly-ol and [3H]Tyr-d-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [3H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>P. Delay-Goyet</name><affiliations><json:string>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</json:string></affiliations></json:item><json:item><name>J.-M. Zajac</name><affiliations><json:string>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</json:string></affiliations></json:item><json:item><name>F. Javoy-Agid</name><affiliations><json:string>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</json:string></affiliations></json:item><json:item><name>Y. Agid</name><affiliations><json:string>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</json:string></affiliations></json:item><json:item><name>B.P. Roques</name><affiliations><json:string>Correspondence: B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</json:string><json:string>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Opioid receptor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Selective ligand</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>δ-Enkephalin analogue</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Discriminative binding property</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Human brain</value></json:item></subject><articleId><json:string>87913217</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [3H]Tyr-d-Ala-Gly-(Me)Phe-Gly-ol and [3H]Tyr-d-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [3H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.</abstract><qualityIndicators><score>4.826</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 771 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>635</abstractCharCount><pdfWordCount>3782</pdfWordCount><pdfCharCount>22916</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>87</abstractWordCount></qualityIndicators><title>Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects</title><pii><json:string>0006-8993(87)91321-7</json:string></pii><refBibs><json:item><author><json:item><name>Y. Agid</name></json:item><json:item><name>F. 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(Biomedical Division)</p></availability><date>1987</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects</title><author xml:id="author-1"><persName><forename type="first">P.</forename><surname>Delay-Goyet</surname></persName><affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</affiliation></author><author xml:id="author-2"><persName><forename type="first">J.-M.</forename><surname>Zajac</surname></persName><affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</affiliation></author><author xml:id="author-3"><persName><forename type="first">F.</forename><surname>Javoy-Agid</surname></persName><affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Y.</forename><surname>Agid</surname></persName><affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</affiliation></author><author xml:id="author-5"><persName><forename type="first">B.P.</forename><surname>Roques</surname></persName><affiliation>Correspondence: B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</affiliation><affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X1162-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987"></date><biblScope unit="volume">414</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="8">8</biblScope><biblScope unit="page" to="14">14</biblScope></imprint></monogr><idno type="istex">EDD390816A43E3D1CC016367C64F5C952B9B9ECE</idno><idno type="DOI">10.1016/0006-8993(87)91321-7</idno><idno type="PII">0006-8993(87)91321-7</idno><idno type="ArticleID">87913217</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [3H]Tyr-d-Ala-Gly-(Me)Phe-Gly-ol and [3H]Tyr-d-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [3H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Opioid receptor</term></item><item><term>Selective ligand</term></item><item><term>δ-Enkephalin analogue</term></item><item><term>Discriminative binding property</term></item><item><term>Parkinson's disease</term></item><item><term>Human brain</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1987">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/EDD390816A43E3D1CC016367C64F5C952B9B9ECE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>BRES</jid><aid>87913217</aid><ce:pii>0006-8993(87)91321-7</ce:pii><ce:doi>10.1016/0006-8993(87)91321-7</ce:doi><ce:copyright type="unknown" year="1987">Elsevier Science Publishers B.V. (Biomedical Division)</ce:copyright></item-info><head><ce:title>Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects</ce:title><ce:author-group><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Delay-Goyet</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.-M.</ce:given-name><ce:surname>Zajac</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Javoy-Agid</ce:surname><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Agid</ce:surname><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>B.P.</ce:given-name><ce:surname>Roques</ce:surname><ce:cross-ref refid="cor1"><ce:sup loc="post">*</ce:sup></ce:cross-ref><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>a</ce:label><ce:textfn>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>b</ce:label><ce:textfn>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text><ce:italic>Correspondence:</ce:italic> B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="4" month="11" year="1986"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [<ce:sup loc="pre">3</ce:sup>H]Tyr-<ce:small-caps>d</ce:small-caps>-Ala-Gly-(Me)Phe-Gly-ol and [<ce:sup loc="pre">3</ce:sup>H]Tyr-<ce:small-caps>d</ce:small-caps>-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [<ce:sup loc="pre">3</ce:sup>H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Opioid receptor</ce:text></ce:keyword><ce:keyword><ce:text>Selective ligand</ce:text></ce:keyword><ce:keyword><ce:text>δ-Enkephalin analogue</ce:text></ce:keyword><ce:keyword><ce:text>Discriminative binding property</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Human brain</ce:text></ce:keyword></ce:keywords></head><tail view="all"><ce:bibliography view="all" id="bibliography.0010"><ce:section-title>Reference</ce:section-title><ce:bibliography-sec id="bibliography-sec.0010"><ce:bib-reference id="bib1"><ce:label>1</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Agid</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Javoy-Agid</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Ruberg</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The neurobiochemistry of Parkinson's disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Marsden</ce:surname><ce:given-name>C.D.</ce:given-name></sb:editor><sb:editor><ce:surname>Fahn</ce:surname><ce:given-name>S.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>Movement Disorders-2</sb:maintitle></sb:title><sb:date>1986</sb:date><sb:publisher><sb:name>BIMR Neurology, Butterworths</sb:name></sb:publisher></sb:edited-book></sb:host><sb:comment>in press</sb:comment></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Attali</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Gouaederes</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Mazarguil</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Audigier</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Cros</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evidence of multiple kappa binding sites by use of opioid peptides in the guinea pig lumbo-sacral cord</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuropeptides</sb:maintitle></sb:title><sb:volume-nr>3</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>53</sb:first-page><sb:last-page>64</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bokobza</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Ruberg</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Scatton</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Javoy-Agid</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Agid</ce:surname><ce:given-name>Y.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>[<ce:sup loc="pre">3</ce:sup>H]Spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Eur. 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Pitie´-Salpeˆtrie`re, Paris ,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Agid</namePart><affiliation>Laboratoire de Me´decine Expe´rimentale, U.289 INSERM, U.E.R. Pitie´-Salpeˆtrie`re, Paris ,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.P.</namePart><namePart type="family">Roques</namePart><affiliation>Correspondence: B.P. Roques, De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris ,France</affiliation><affiliation>De´partement de Chimie Organique, U.266 INSERM, U.A. 498 C.N.R.S., U.E.R. des Sciences Pharmaceutiques et Biologiques, Paris ,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1987</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: The binding properties of μ and δ opioid receptors were investigated in several areas of human brain by using [3H]Tyr-d-Ala-Gly-(Me)Phe-Gly-ol and [3H]Tyr-d-Thr-Gly-Phe-Leu-Thr as respective selective ligands, while the totality of opioid receptors was measured by using [3H]etorphine as a non-selective agonist. Receptor densities were highest in cerebral cortex, amygdala and striatum, and lowest in the substantia nigra (pars compacta). In the different brain areas of patients with Parkinson's disease, the density and the proportion of the various opioid receptors were not significantly different from control subjects.</abstract><subject lang="en"><genre>Keywords</genre><topic>Opioid receptor</topic><topic>Selective ligand</topic><topic>δ-Enkephalin analogue</topic><topic>Discriminative binding property</topic><topic>Parkinson's disease</topic><topic>Human brain</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19870623</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X1162-6</identifier><part><date>19870623</date><detail type="volume"><number>414</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>204</end></extent><extent unit="pages"><start>8</start><end>14</end></extent></part></relatedItem><identifier type="istex">EDD390816A43E3D1CC016367C64F5C952B9B9ECE</identifier><identifier type="DOI">10.1016/0006-8993(87)91321-7</identifier><identifier type="PII">0006-8993(87)91321-7</identifier><identifier type="ArticleID">87913217</identifier><accessCondition type="use and reproduction" contentType="copyright">©1987 Elsevier Science Publishers B.V. 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