Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine
Identifieur interne : 000832 ( Istex/Corpus ); précédent : 000831; suivant : 000833Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine
Auteurs : C. Saligaut ; M. Daoust ; N. Moore ; F. BoismareSource :
- Neuropharmacology [ 0028-3908 ] ; 1987.
Abstract
A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l-DOPA.
Url:
DOI: 10.1016/0028-3908(87)90093-1
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ISTEX:43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25Le document en format XML
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Moore</name><affiliation><mods:affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</mods:affiliation></affiliation></author><author><name sortKey="Boismare, F" sort="Boismare, F" uniqKey="Boismare F" first="F." last="Boismare">F. 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Saligaut</name><affiliation><mods:affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</mods:affiliation></affiliation></author><author><name sortKey="Daoust, M" sort="Daoust, M" uniqKey="Daoust M" first="M." last="Daoust">M. Daoust</name><affiliation><mods:affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</mods:affiliation></affiliation></author><author><name sortKey="Moore, N" sort="Moore, N" uniqKey="Moore N" first="N." last="Moore">N. Moore</name><affiliation><mods:affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</mods:affiliation></affiliation></author><author><name sortKey="Boismare, F" sort="Boismare, F" uniqKey="Boismare F" first="F." last="Boismare">F. Boismare</name><affiliation><mods:affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropharmacology</title><title level="j" type="abbrev">NP</title><idno type="ISSN">0028-3908</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1315">1315</biblScope><biblScope unit="page" to="1319">1319</biblScope></imprint><idno type="ISSN">0028-3908</idno></series><idno type="istex">43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25</idno><idno type="DOI">10.1016/0028-3908(87)90093-1</idno><idno type="PII">0028-3908(87)90093-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-3908</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l-DOPA.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C. Saligaut</name><affiliations><json:string>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</json:string></affiliations></json:item><json:item><name>M. Daoust</name><affiliations><json:string>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</json:string></affiliations></json:item><json:item><name>N. Moore</name><affiliations><json:string>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</json:string></affiliations></json:item><json:item><name>F. Boismare</name><affiliations><json:string>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>apomorphine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>l-DOPA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>amphetamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>circling behaviour</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l-DOPA.</abstract><qualityIndicators><score>4.77</score><pdfVersion>1.2</pdfVersion><pdfPageSize>504 x 756 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>985</abstractCharCount><pdfWordCount>3138</pdfWordCount><pdfCharCount>21030</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>136</abstractWordCount></qualityIndicators><title>Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</title><pii><json:string>0028-3908(87)90093-1</json:string></pii><refBibs><json:item><author><json:item><name>J. 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Pharmac.</title></host><title>The relationship between amphetamine antagonism and depletion of brain catecholamines by alpha-methyl-p-tyrosine in rats</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>26</volume><pii><json:string>S0028-3908(00)X0122-0</json:string></pii><pages><last>1319</last><first>1315</first></pages><issn><json:string>0028-3908</json:string></issn><issue>9</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Neuropharmacology</title><publicationDate>1987</publicationDate></host><categories><wos><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>neurosciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate><doi><json:string>10.1016/0028-3908(87)90093-1</json:string></doi><id>43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25</id><score>0.1533442</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1987</date></publicationStmt><notesStmt><note>This work was presented in part of the 4th European Workshop on Clinical Neuropharmacology, Pamplona, Spain, June 1986.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</title><author xml:id="author-1"><persName><forename type="first">C.</forename><surname>Saligaut</surname></persName><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">M.</forename><surname>Daoust</surname></persName><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">N.</forename><surname>Moore</surname></persName><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">F.</forename><surname>Boismare</surname></persName><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation></author></analytic><monogr><title level="j">Neuropharmacology</title><title level="j" type="abbrev">NP</title><idno type="pISSN">0028-3908</idno><idno type="PII">S0028-3908(00)X0122-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1315">1315</biblScope><biblScope unit="page" to="1319">1319</biblScope></imprint></monogr><idno type="istex">43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25</idno><idno type="DOI">10.1016/0028-3908(87)90093-1</idno><idno type="PII">0028-3908(87)90093-1</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l-DOPA.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>apomorphine</term></item><item><term>l-DOPA</term></item><item><term>amphetamine</term></item><item><term>circling behaviour</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1987">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>NP</jid><aid>87900931</aid><ce:pii>0028-3908(87)90093-1</ce:pii><ce:doi>10.1016/0028-3908(87)90093-1</ce:doi><ce:copyright type="unknown" year="1987"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was presented in part of the 4th European Workshop on Clinical Neuropharmacology, Pamplona, Spain, June 1986.</ce:note-para></ce:article-footnote><ce:title>Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</ce:title><ce:author-group><ce:author><ce:given-name>C.</ce:given-name><ce:surname>Saligaut</ce:surname></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Daoust</ce:surname></ce:author><ce:author><ce:given-name>N.</ce:given-name><ce:surname>Moore</ce:surname></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Boismare</ce:surname></ce:author><ce:affiliation><ce:textfn>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</ce:textfn></ce:affiliation></ce:author-group><ce:date-accepted day="16" month="3" year="1987"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to <ce:small-caps>l</ce:small-caps>-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by <ce:small-caps>l</ce:small-caps>-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of <ce:small-caps>l</ce:small-caps>-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous <ce:small-caps>l</ce:small-caps>-DOPA.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>apomorphine</ce:text></ce:keyword><ce:keyword><ce:text><ce:small-caps>l</ce:small-caps>-DOPA</ce:text></ce:keyword><ce:keyword><ce:text>amphetamine</ce:text></ce:keyword><ce:keyword><ce:text>circling behaviour</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine</title></titleInfo><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Saligaut</namePart><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Daoust</namePart><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Moore</namePart><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Boismare</namePart><affiliation>Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, B.P. 97, 76800 St-Etienne-du-Rouvray, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1987</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l-DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l-DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l-DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l-DOPA.</abstract><note>This work was presented in part of the 4th European Workshop on Clinical Neuropharmacology, Pamplona, Spain, June 1986.</note><subject><genre>Keywords</genre><topic>apomorphine</topic><topic>l-DOPA</topic><topic>amphetamine</topic><topic>circling behaviour</topic></subject><relatedItem type="host"><titleInfo><title>Neuropharmacology</title></titleInfo><titleInfo type="abbreviated"><title>NP</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198709</dateIssued></originInfo><identifier type="ISSN">0028-3908</identifier><identifier type="PII">S0028-3908(00)X0122-0</identifier><part><date>198709</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="issue pages"><start>1247</start><end>1451</end></extent><extent unit="pages"><start>1315</start><end>1319</end></extent></part></relatedItem><identifier type="istex">43A4C5BADFB7ADF8793EFB2936710BBDC99D8D25</identifier><identifier type="DOI">10.1016/0028-3908(87)90093-1</identifier><identifier type="PII">0028-3908(87)90093-1</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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