Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease
Identifieur interne : 000655 ( Istex/Corpus ); précédent : 000654; suivant : 000656Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease
Auteurs : David Maltête ; Stéphane Derrey ; Nathalie Chastan ; Bertrand Debono ; Emmanuel Gérardin ; Pierre Fréger ; Bruno Mihout ; Jean François Menard ; Didier HannequinSource :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
English descriptors
Abstract
A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22054
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ISTEX:52DAE76E4C18228DECEB23D90A25C1AF940DCF5FLe document en format XML
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Maltête</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, 76031 Rouen, Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name><affiliation><mods:affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name><affiliation><mods:affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name><affiliation><mods:affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name><affiliation><mods:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Freger, Pierre" sort="Freger, Pierre" uniqKey="Freger P" first="Pierre" last="Fréger">Pierre Fréger</name><affiliation><mods:affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean François" last="Menard">Jean François Menard</name><affiliation><mods:affiliation>Department of Biostatistics, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><mods:affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1047">1047</biblScope><biblScope unit="page" to="1050">1050</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">52DAE76E4C18228DECEB23D90A25C1AF940DCF5F</idno><idno type="DOI">10.1002/mds.22054</idno><idno type="ArticleID">MDS22054</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>deep brain stimulation</term><term>microsubthalamotomy</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>David Maltête MD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string><json:string>INSERM U614, Rouen Faculty of Medicine Rouen, France</json:string><json:string>Department of Neurology, Rouen University Hospital, 76031 Rouen, Cedex, France</json:string></affiliations></json:item><json:item><name>Stéphane Derrey MD</name><affiliations><json:string>Department of Neurosurgery, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Nathalie Chastan MD</name><affiliations><json:string>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Bertrand Debono MD</name><affiliations><json:string>Department of Neurosurgery, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Emmanuel Gérardin MD, PhD</name><affiliations><json:string>Department of Radiology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Pierre Fréger MD, PhD</name><affiliations><json:string>Department of Neurosurgery, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Bruno Mihout MD, PhD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Jean François Menard MD, PhD</name><affiliations><json:string>Department of Biostatistics, Rouen University Hospital, Rouen, France</json:string></affiliations></json:item><json:item><name>Didier Hannequin MD, PhD</name><affiliations><json:string>Department of Neurology, Rouen University Hospital, Rouen, France</json:string><json:string>INSERM U614, Rouen Faculty of Medicine Rouen, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>microsubthalamotomy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item></subject><articleId><json:string>MDS22054</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>4.194</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1094</abstractCharCount><pdfWordCount>2298</pdfWordCount><pdfCharCount>15871</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>158</abstractWordCount></qualityIndicators><title>Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease</title><refBibs><json:item><author><json:item><name>ML Welter</name></json:item><json:item><name>JL Houeto</name></json:item><json:item><name>S Tezenas du 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disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2008 Movement Disorder Society</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease</title><author xml:id="author-1"><persName><forename type="first">David</forename><surname>Maltête</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</affiliation><affiliation>Department of Neurology, Rouen University Hospital, 76031 Rouen, Cedex, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Stéphane</forename><surname>Derrey</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Nathalie</forename><surname>Chastan</surname></persName><roleName type="degree">MD</roleName><affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Bertrand</forename><surname>Debono</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Emmanuel</forename><surname>Gérardin</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Pierre</forename><surname>Fréger</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Bruno</forename><surname>Mihout</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Jean François</forename><surname>Menard</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Biostatistics, Rouen University Hospital, Rouen, France</affiliation></author><author xml:id="author-9"><persName><forename type="first">Didier</forename><surname>Hannequin</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1047">1047</biblScope><biblScope unit="page" to="1050">1050</biblScope></imprint></monogr><idno type="istex">52DAE76E4C18228DECEB23D90A25C1AF940DCF5F</idno><idno type="DOI">10.1002/mds.22054</idno><idno type="ArticleID">MDS22054</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>microsubthalamotomy</term></item><item><term>subthalamic nucleus</term></item><item><term>deep brain stimulation</term></item><item><term>Parkinson disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-01-10">Received</change><change when="2008-03-01">Registration</change><change when="2008-05-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/52DAE76E4C18228DECEB23D90A25C1AF940DCF5F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi origin="wiley" registered="yes">10.1002/mds.v23:7</doi><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2008-05-15">15 May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="200" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22054</doi><idGroup><id type="unit" value="MDS22054"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-01-10"></event><event type="manuscriptRevised" date="2008-02-28"></event><event type="manuscriptAccepted" 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type="figureTotal" number="1"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="21"></count><count type="wordTotal" number="2415"></count></countGroup><titleGroup><title type="main" xml:lang="en">Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease</title><title type="short" xml:lang="en">Microsubthalamotomy</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>David</givenNames><familyName>Maltête</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="david.maltete@chu-rouen.fr">david.maltete@chu‐rouen.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Stéphane</givenNames><familyName>Derrey</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Nathalie</givenNames><familyName>Chastan</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Bertrand</givenNames><familyName>Debono</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Emmanuel</givenNames><familyName>Gérardin</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Pierre</givenNames><familyName>Fréger</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Bruno</givenNames><familyName>Mihout</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Jean François</givenNames><familyName>Menard</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Didier</givenNames><familyName>Hannequin</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Department of Radiology, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="FR" type="organization"><unparsedAffiliation>Department of Biostatistics, Rouen University Hospital, Rouen, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">microsubthalamotomy</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">deep brain stimulation</keyword><keyword xml:id="kwd4">Parkinson disease</keyword></keywordGroup><supportingInformation><p> This article contains supplementary material available via the Internet at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url> . </p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (<i>P</i> = 0.005) and global mean intensity of stimulation (<i>P</i> = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the <i>off</i>‐drug/<i>on</i>‐stimulation condition. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Microsubthalamotomy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease</title></titleInfo><name type="personal"><namePart type="given">David</namePart><namePart type="family">Maltête</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</affiliation><affiliation>Department of Neurology, Rouen University Hospital, 76031 Rouen, Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stéphane</namePart><namePart type="family">Derrey</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nathalie</namePart><namePart type="family">Chastan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratory of Neurophysiology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bertrand</namePart><namePart type="family">Debono</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emmanuel</namePart><namePart type="family">Gérardin</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Fréger</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurosurgery, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Mihout</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean François</namePart><namePart type="family">Menard</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Biostatistics, Rouen University Hospital, Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Didier</namePart><namePart type="family">Hannequin</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Rouen University Hospital, Rouen, France</affiliation><affiliation>INSERM U614, Rouen Faculty of Medicine Rouen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-05-15</dateIssued><dateCaptured encoding="w3cdtf">2008-01-10</dateCaptured><dateValid encoding="w3cdtf">2008-03-01</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="references">21</extent><extent unit="words">2415</extent></physicalDescription><abstract lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>keywords</genre><topic>microsubthalamotomy</topic><topic>subthalamic nucleus</topic><topic>deep brain stimulation</topic><topic>Parkinson disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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