Motor neuron disease, parkinsonism and dementia
Identifieur interne : 000604 ( Istex/Corpus ); précédent : 000603; suivant : 000605Motor neuron disease, parkinsonism and dementia
Auteurs : M. B. Delisle ; P. Gorce ; E. Hirsch ; J. J. Hauw ; A. Rascol ; H. BouissouSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1987-01-01.
Abstract
Summary: The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.
Url:
DOI: 10.1007/BF00686799
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ISTEX:0E5F6C4B89C2B11462E419D6D051BC897918787ELe document en format XML
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Hirsch</name><affiliation><mods:affiliation>INSERM U. 289, Hôpital de la Salpétrière, F-75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J. J." last="Hauw">J. J. Hauw</name><affiliation><mods:affiliation>Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpétrière, F-75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name><affiliation><mods:affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bouissou, H" sort="Bouissou, H" uniqKey="Bouissou H" first="H." last="Bouissou">H. Bouissou</name><affiliation><mods:affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0E5F6C4B89C2B11462E419D6D051BC897918787E</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1007/BF00686799</idno><idno type="url">https://api.istex.fr/document/0E5F6C4B89C2B11462E419D6D051BC897918787E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000604</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000604</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Motor neuron disease, parkinsonism and dementia</title><author><name sortKey="Delisle, M B" sort="Delisle, M B" uniqKey="Delisle M" first="M. B." last="Delisle">M. B. Delisle</name><affiliation><mods:affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Gorce, P" sort="Gorce, P" uniqKey="Gorce P" first="P." last="Gorce">P. Gorce</name><affiliation><mods:affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, E" sort="Hirsch, E" uniqKey="Hirsch E" first="E." last="Hirsch">E. Hirsch</name><affiliation><mods:affiliation>INSERM U. 289, Hôpital de la Salpétrière, F-75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J. J." last="Hauw">J. J. Hauw</name><affiliation><mods:affiliation>Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpétrière, F-75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name><affiliation><mods:affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bouissou, H" sort="Bouissou, H" uniqKey="Bouissou H" first="H." last="Bouissou">H. Bouissou</name><affiliation><mods:affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1987-01-01">1987-01-01</date><biblScope unit="volume">75</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="104">104</biblScope><biblScope unit="page" to="108">108</biblScope></imprint><idno type="ISSN">0001-6322</idno></series><idno type="istex">0E5F6C4B89C2B11462E419D6D051BC897918787E</idno><idno type="DOI">10.1007/BF00686799</idno><idno type="ArticleID">BF00686799</idno><idno type="ArticleID">Art15</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>M. B. Delisle</name><affiliations><json:string>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</json:string></affiliations></json:item><json:item><name>P. Gorce</name><affiliations><json:string>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</json:string></affiliations></json:item><json:item><name>E. Hirsch</name><affiliations><json:string>INSERM U. 289, Hôpital de la Salpétrière, F-75005, Paris, France</json:string></affiliations></json:item><json:item><name>J. J. Hauw</name><affiliations><json:string>Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpétrière, F-75005, Paris, France</json:string></affiliations></json:item><json:item><name>A. Rascol</name><affiliations><json:string>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</json:string></affiliations></json:item><json:item><name>H. Bouissou</name><affiliations><json:string>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</json:string></affiliations></json:item></author><articleId><json:string>BF00686799</json:string><json:string>Art15</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</abstract><qualityIndicators><score>4.022</score><pdfVersion>1.3</pdfVersion><pdfPageSize>597.28 x 785 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>876</abstractCharCount><pdfWordCount>2534</pdfWordCount><pdfCharCount>14435</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>124</abstractWordCount></qualityIndicators><title>Motor neuron disease, parkinsonism and dementia</title><refBibs><json:item><author><json:item><name>P Castaigne</name></json:item><json:item><name>J Cambier</name></json:item><json:item><name>R Escourolle</name></json:item><json:item><name>P Brunet</name></json:item><json:item><name>T Guilleminau</name></json:item></author><host><volume>122</volume><pages><last>320</last><first>313</first></pages><author></author><title>Rev Neurol (Paris)</title><publicationDate>1970</publicationDate></host><title>D6gSn~rescence subaigu~ des neurones moteurs p6riph6riques avec inclusions neuronales et 16sions des cordons post6rieurs: les limites de la scl6rose lat6rale amyotrophique</title><publicationDate>1970</publicationDate></json:item><json:item><author><json:item><name>Mb Delisle</name></json:item><json:item><name>S Carpenter</name></json:item></author><host><volume>63</volume><pages><last>250</last><first>241</first></pages><author></author><title>J Neurol Sci</title><publicationDate>1984</publicationDate></host><title>Neurofibrillary axonal swellings and amyotrophic lateral sclerosis</title><publicationDate>1984</publicationDate></json:item><json:item><author><json:item><name>B Dubois</name></json:item><json:item><name>J,J Hauw</name></json:item><json:item><name>M Ruberg</name></json:item><json:item><name>M Serdaru</name></json:item><json:item><name>F Javoy-Agid</name></json:item><json:item><name>Y Agid</name></json:item></author><host><volume>141</volume><pages><last>193</last><first>184</first></pages><author></author><title>Rev Neurol (Paris)</title><publicationDate>1985</publicationDate></host><title>D6mence et maladie de Parkinson: correlation biochimique et anatomoclinique</title><publicationDate>1985</publicationDate></json:item><json:item><author><json:item><name>De Eggerston</name></json:item><json:item><name>Aaf Sima</name></json:item></author><host><volume>43</volume><pages><last>527</last><first>524</first></pages><author></author><title>Arch Neurol</title><publicationDate>1986</publicationDate></host><title>Dementia with cerebral Lewy bodies. 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Histochemical and electron microscopic study of hyaline inclusions in motor neurons</title><publicationDate>1972</publicationDate></json:item><json:item><author><json:item><name>M Tomonaga</name></json:item></author><host><volume>53</volume><pages><last>168</last><first>165</first></pages><author></author><title>Aeta Neuropathol (Berl)</title><publicationDate>1981</publicationDate></host><title>Neurofibrillary tangles and Lewy bodies in the locus caeruleus neurons of the aged brain</title><publicationDate>1981</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>75</volume><pages><last>108</last><first>104</first></pages><issn><json:string>0001-6322</json:string></issn><issue>1</issue><subject><json:item><value>Pathology</value></json:item></subject><journalId><json:string>401</json:string></journalId><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1432-0533</json:string></eissn><title>Acta Neuropathologica</title><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate><doi><json:string>10.1007/BF00686799</json:string></doi><id>0E5F6C4B89C2B11462E419D6D051BC897918787E</id><score>0.2281178</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/0E5F6C4B89C2B11462E419D6D051BC897918787E/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/0E5F6C4B89C2B11462E419D6D051BC897918787E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0E5F6C4B89C2B11462E419D6D051BC897918787E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Motor neuron disease, parkinsonism and dementia</title><title level="a" type="sub" xml:lang="en">Report of a case with diffuse Lewy body-like intracytoplasmic inclusions</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1987</p></availability><date>1986-12-23</date></publicationStmt><notesStmt><note>Case Report</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Motor neuron disease, parkinsonism and dementia</title><title level="a" type="sub" xml:lang="en">Report of a case with diffuse Lewy body-like intracytoplasmic inclusions</title><author xml:id="author-1" corresp="yes"><persName><forename type="first">M.</forename><surname>Delisle</surname></persName><affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">P.</forename><surname>Gorce</surname></persName><affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">E.</forename><surname>Hirsch</surname></persName><affiliation>INSERM U. 289, Hôpital de la Salpétrière, F-75005, Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">J.</forename><surname>Hauw</surname></persName><affiliation>Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpétrière, F-75005, Paris, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">A.</forename><surname>Rascol</surname></persName><affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">H.</forename><surname>Bouissou</surname></persName><affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</affiliation></author></analytic><monogr><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="journal-ID">401</idno><idno type="pISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><idno type="issue-article-count">15</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1987-01-01"></date><biblScope unit="volume">75</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="104">104</biblScope><biblScope unit="page" to="108">108</biblScope></imprint></monogr><idno type="istex">0E5F6C4B89C2B11462E419D6D051BC897918787E</idno><idno type="DOI">10.1007/BF00686799</idno><idno type="ArticleID">BF00686799</idno><idno type="ArticleID">Art15</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1986-12-23</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1986-12-23">Created</change><change when="1987-01-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-22">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-20">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/0E5F6C4B89C2B11462E419D6D051BC897918787E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>401</JournalID><JournalPrintISSN>0001-6322</JournalPrintISSN><JournalElectronicISSN>1432-0533</JournalElectronicISSN><JournalTitle>Acta Neuropathologica</JournalTitle><JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>75</VolumeIDStart><VolumeIDEnd>75</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>15</IssueArticleCount><IssueHistory><CoverDate><DateString>1987</DateString><Year>1987</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag GmbH & Co. KG</CopyrightHolderName><CopyrightYear>1987</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art15"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00686799</ArticleID><ArticleDOI>10.1007/BF00686799</ArticleDOI><ArticleSequenceNumber>15</ArticleSequenceNumber><ArticleTitle Language="En">Motor neuron disease, parkinsonism and dementia</ArticleTitle><ArticleSubTitle Language="En">Report of a case with diffuse Lewy body-like intracytoplasmic inclusions</ArticleSubTitle><ArticleCategory>Case Report</ArticleCategory><ArticleFirstPage>104</ArticleFirstPage><ArticleLastPage>108</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>8</Day></RegistrationDate><Received><Year>1986</Year><Month>12</Month><Day>23</Day></Received><Accepted><Year>1987</Year><Month>7</Month><Day>9</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1987</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>75</VolumeIDStart><VolumeIDEnd>75</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>B.</GivenName><FamilyName>Delisle</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>P.</GivenName><FamilyName>Gorce</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Hirsch</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>J.</GivenName><GivenName>J.</GivenName><FamilyName>Hauw</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Rascol</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Bouissou</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Laboratoire d'Anatomie Pathologique</OrgDivision><OrgName>CHU Rangueil</OrgName><OrgAddress><Postcode>F-31054</Postcode><City>Toulouse Cedex</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Service de Neurologie</OrgDivision><OrgName>CHU Purpan</OrgName><OrgAddress><Postcode>F-31054</Postcode><City>Toulouse Cedex</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>INSERM U. 289</OrgDivision><OrgName>Hôpital de la Salpétrière</OrgName><OrgAddress><Postcode>F-75005</Postcode><City>Paris</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Laboratoire de Neuropathologie R. Escourolle</OrgDivision><OrgName>Hôpital de la Salpétrière</OrgName><OrgAddress><Postcode>F-75005</Postcode><City>Paris</City><Country>France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Motor neuron disease</Keyword><Keyword>Parkinsonism</Keyword><Keyword>Dementia</Keyword><Keyword>Lewy body</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Motor neuron disease, parkinsonism and dementia</title><subTitle>Report of a case with diffuse Lewy body-like intracytoplasmic inclusions</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Motor neuron disease, parkinsonism and dementia</title><subTitle>Report of a case with diffuse Lewy body-like intracytoplasmic inclusions</subTitle></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">M.</namePart><namePart type="given">B.</namePart><namePart type="family">Delisle</namePart><affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Gorce</namePart><affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Hirsch</namePart><affiliation>INSERM U. 289, Hôpital de la Salpétrière, F-75005, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="given">J.</namePart><namePart type="family">Hauw</namePart><affiliation>Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpétrière, F-75005, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rascol</namePart><affiliation>Service de Neurologie, CHU Purpan, F-31054, Toulouse Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Bouissou</namePart><affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, F-31054, Toulouse Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1986-12-23</dateCreated><dateIssued encoding="w3cdtf">1987-01-01</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: The clinicopathological finding in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. 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