Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B
Identifieur interne : 000302 ( Istex/Corpus ); précédent : 000301; suivant : 000303Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B
Auteurs : Neil Vasdev ; Oleg Sadovski ; Armando Garcia ; Frédéric Dollé ; Jeffrey H. Meyer ; Sylvain Houle ; Alan A. WilsonSource :
- Journal of Labelled Compounds and Radiopharmaceuticals [ 0362-4803 ] ; 2011-08.
Abstract
Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.
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DOI: 10.1002/jlcr.1908
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Meyer</name><affiliation><mods:affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation><mods:affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. 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Meyer</name><affiliation><mods:affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation><mods:affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name><affiliation><mods:affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Labelled Compounds and Radiopharmaceuticals</title><title level="j" type="abbrev">J. Label Compd. Radiopharm</title><idno type="ISSN">0362-4803</idno><idno type="eISSN">1099-1344</idno><imprint><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-08">2011-08</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="678">678</biblScope><biblScope unit="page" to="680">680</biblScope></imprint><idno type="ISSN">0362-4803</idno></series><idno type="istex">72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951</idno><idno type="DOI">10.1002/jlcr.1908</idno><idno type="ArticleID">JLCR1908</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0362-4803</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Neil Vasdev</name><affiliations><json:string>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</json:string><json:string>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</json:string><json:string>Correspondence to: Neil Vasdev, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8.E‐mail:</json:string><json:string>E-mail: neil.vasdev@utoronto.ca</json:string></affiliations></json:item><json:item><name>Oleg Sadovski</name><affiliations><json:string>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Armando Garcia</name><affiliations><json:string>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Frédéric Dollé</name><affiliations><json:string>CEA, I²BM, Service Hospitalier Frédéric Joliot, Orsay, France</json:string></affiliations></json:item><json:item><name>Jeffrey H. 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chemistry</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/jlcr.1908</json:string></doi><id>72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951</id><score>0.08719134</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>Copyright © 2011 John Wiley & Sons, Ltd.Copyright © 2011 John Wiley & Sons, Ltd.</p></availability><date>2011-06-24</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B</title><author xml:id="author-1"><persName><forename type="first">Neil</forename><surname>Vasdev</surname></persName><email>neil.vasdev@utoronto.ca</email><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><affiliation>Correspondence to: Neil Vasdev, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8.E‐mail:</affiliation></author><author xml:id="author-2"><persName><forename type="first">Oleg</forename><surname>Sadovski</surname></persName><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation></author><author xml:id="author-3"><persName><forename type="first">Armando</forename><surname>Garcia</surname></persName><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation></author><author xml:id="author-4"><persName><forename type="first">Frédéric</forename><surname>Dollé</surname></persName><affiliation>CEA, I²BM, Service Hospitalier Frédéric Joliot, Orsay, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Jeffrey H.</forename><surname>Meyer</surname></persName><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation></author><author xml:id="author-6"><persName><forename type="first">Sylvain</forename><surname>Houle</surname></persName><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation></author><author xml:id="author-7"><persName><forename type="first">Alan A.</forename><surname>Wilson</surname></persName><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation></author></analytic><monogr><title level="j">Journal of Labelled Compounds and Radiopharmaceuticals</title><title level="j" type="abbrev">J. Label Compd. Radiopharm</title><idno type="pISSN">0362-4803</idno><idno type="eISSN">1099-1344</idno><idno type="DOI">10.1002/(ISSN)1099-1344</idno><imprint><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-08"></date><biblScope unit="volume">54</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="678">678</biblScope><biblScope unit="page" to="680">680</biblScope></imprint></monogr><idno type="istex">72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951</idno><idno type="DOI">10.1002/jlcr.1908</idno><idno type="ArticleID">JLCR1908</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011-06-24</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.</p></abstract><abstract style="graphical"><p>Carbon‐11‐labelled SL2511.88, a promising radiotracer for imaging central MAO‐B, has been labelled in one‐step using [11C]CO2. The reaction was effectively carried out at room temperature in solution by fixation chemistry thereby precluding the use of [11C]COCl2.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>PET</term></item><item><term>carbon‐11</term></item><item><term>CO2 fixation</term></item><item><term>monoamine oxidase B</term></item><item><term>SL25.1188</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Note</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-04-13">Received</change><change when="2011-06-02">Registration</change><change when="2011-06-24">Created</change><change when="2011-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:lang="en" xml:id="jlcr1908"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi>10.1002/(ISSN)1099-1344</doi><issn type="print">0362-4803</issn><issn type="electronic">1099-1344</issn><idGroup><id type="product" value="JLCR"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS">Journal of Labelled Compounds and Radiopharmaceuticals</title><title type="short">J. Label Compd. Radiopharm</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi>10.1002/jlcr.v54.10</doi><copyright ownership="publisher">Copyright © 2011 John Wiley & Sons, Ltd.</copyright><numberingGroup><numbering type="journalVolume" number="54">54</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2011-08">August 2011</coverDate></publicationMeta><publicationMeta level="unit" position="7" type="article" status="forIssue"><doi>10.1002/jlcr.1908</doi><idGroup><id type="unit" value="JLCR1908"></id></idGroup><countGroup><count type="pageTotal" number="3"></count></countGroup><titleGroup><title type="articleCategory">Note</title><title type="tocHeading1">Notes</title></titleGroup><copyright ownership="publisher">Copyright © 2011 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2011-04-13"></event><event type="manuscriptRevised" date="2011-05-03"></event><event type="manuscriptAccepted" date="2011-06-02"></event><event type="xmlCreated" agent="SPi Global" date="2011-06-24"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-07-19"></event><event type="firstOnline" date="2011-07-19"></event><event type="publishedOnlineFinalForm" date="2011-09-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">678</numbering><numbering type="pageLast">680</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence to: Neil Vasdev, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8.</line><line>E‐mail: <email>neil.vasdev@utoronto.ca</email></line></lineatedText></correspondenceTo><objectNameGroup><objectName elementName="figure">Scheme</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:JLCR.JLCR1908.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Radiosynthesis of [<sup>11</sup>C]SL25.1188 via [<sup>11</sup>C]CO<sub>2</sub> fixation for imaging monoamine oxidase B</title><title type="shortAuthors">N. Vasdev <i>et al.</i></title></titleGroup><creators><creator creatorRole="author" xml:id="jlcr1908-cr-0001" affiliationRef="#jlcr1908-aff-0001 #jlcr1908-aff-0002" corresponding="yes"><personName><givenNames>Neil</givenNames><familyName>Vasdev</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0002" affiliationRef="#jlcr1908-aff-0001"><personName><givenNames>Oleg</givenNames><familyName>Sadovski</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0003" affiliationRef="#jlcr1908-aff-0001"><personName><givenNames>Armando</givenNames><familyName>Garcia</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0004" affiliationRef="#jlcr1908-aff-0003"><personName><givenNames>Frédéric</givenNames><familyName>Dollé</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0005" affiliationRef="#jlcr1908-aff-0001 #jlcr1908-aff-0002"><personName><givenNames>Jeffrey H.</givenNames><familyName>Meyer</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0006" affiliationRef="#jlcr1908-aff-0001 #jlcr1908-aff-0002"><personName><givenNames>Sylvain</givenNames><familyName>Houle</familyName></personName></creator><creator creatorRole="author" xml:id="jlcr1908-cr-0007" affiliationRef="#jlcr1908-aff-0001 #jlcr1908-aff-0002"><personName><givenNames>Alan A.</givenNames><familyName>Wilson</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="jlcr1908-aff-0001" countryCode="CA" type="organization"><orgDiv>PET Centre</orgDiv><orgName>Centre for Addiction and Mental Health</orgName><address><street>250 College Street</street><city>Toronto</city><countryPart>Ontario</countryPart><country>Canada</country><postCode>M5T 1R8</postCode></address></affiliation><affiliation xml:id="jlcr1908-aff-0002" countryCode="CA" type="organization"><orgDiv>Department of Psychiatry</orgDiv><orgName>University of Toronto</orgName><address><street>250 College Street</street><city>Toronto</city><countryPart>Ontario</countryPart><country>Canada</country><postCode>M5T 1R8</postCode></address></affiliation><affiliation xml:id="jlcr1908-aff-0003" countryCode="FR" type="organization"><orgDiv>CEA, I²BM</orgDiv><orgName>Service Hospitalier Frédéric Joliot</orgName><address><city>Orsay</city><country>France</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jlcr1908-kwd-0001">PET</keyword><keyword xml:id="jlcr1908-kwd-0002">carbon‐11</keyword><keyword xml:id="jlcr1908-kwd-0003">CO<sub>2</sub> fixation</keyword><keyword xml:id="jlcr1908-kwd-0004">monoamine oxidase B</keyword><keyword xml:id="jlcr1908-kwd-0005">SL25.1188</keyword></keywordGroup><abstractGroup><abstract type="main"><p>Carbon‐11‐labelled (<i>S</i>)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[<i>d</i>]isoxazol‐3‐yl]oxazolidin‐2‐[<sup>11</sup>C]‐one ([<sup>11</sup>C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [<sup>11</sup>C]CO<sub>2</sub>, thereby precluding the use of [<sup>11</sup>C]COCl<sub>2</sub>. Formulated [<sup>11</sup>C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [<sup>11</sup>C]CO<sub>2</sub>, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; <i>n</i> = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [<sup>11</sup>C]SL25.1188 at ambient temperature and is suitable for human imaging studies.</p></abstract><abstract type="graphical" xml:id="jlcr1908-abs-0002"><p>Carbon‐11‐labelled SL2511.88, a promising radiotracer for imaging central MAO‐B, has been labelled in one‐step using [<sup>11</sup>C]CO<sub>2</sub>. The reaction was effectively carried out at room temperature in solution by fixation chemistry thereby precluding the use of [<sup>11</sup>C]COCl<sub>2</sub>. <blockFixed type="graphic" xml:id="jlcr1908-blkfxd-0001"><mediaResourceGroup><mediaResource alt="image" href="urn:x-wiley:10991344:media:jlcr1908:jlcr1908-toc-0001"></mediaResource><mediaResource mimeType="image/gif" rendition="webOriginal" alt="image" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B</title></titleInfo><name type="personal"><namePart type="given">Neil</namePart><namePart type="family">Vasdev</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><affiliation>Correspondence to: Neil Vasdev, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8.E‐mail:</affiliation><affiliation>E-mail: neil.vasdev@utoronto.ca</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Oleg</namePart><namePart type="family">Sadovski</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Armando</namePart><namePart type="family">Garcia</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frédéric</namePart><namePart type="family">Dollé</namePart><affiliation>CEA, I²BM, Service Hospitalier Frédéric Joliot, Orsay, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey H.</namePart><namePart type="family">Meyer</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvain</namePart><namePart type="family">Houle</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alan A.</namePart><namePart type="family">Wilson</namePart><affiliation>PET Centre, Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ontario, Canada</affiliation><affiliation>Department of Psychiatry, University of Toronto, 250 College Street, Ontario, M5T 1R8, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-08</dateIssued><dateCreated encoding="w3cdtf">2011-06-24</dateCreated><dateCaptured encoding="w3cdtf">2011-04-13</dateCaptured><dateValid encoding="w3cdtf">2011-06-02</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Carbon‐11‐labelled (S)‐5‐methoxymethyl‐3‐[6‐(4,4,4‐trifluorobutoxy)benzo[d]isoxazol‐3‐yl]oxazolidin‐2‐[11C]‐one ([11C]SL25.1188), a promising reversibly binding radiotracer for imaging central monoamine oxidase B, was rapidly prepared via an intramolecular cyclization reaction in an automated one‐pot procedure directly from [11C]CO2, thereby precluding the use of [11C]COCl2. Formulated [11C]SL25.1188 was isolated in 12 ± 1% uncorrected radiochemical yield, based on starting [11C]CO2, with a specific activity of 37 ± 2 GBq/µmol at the end of synthesis (30 min; n = 3). Radiochemical and enantiomeric purities were both >99%. The methodology described herein offers an efficient production of [11C]SL25.1188 at ambient temperature and is suitable for human imaging studies.</abstract><abstract type="graphical">Carbon‐11‐labelled SL2511.88, a promising radiotracer for imaging central MAO‐B, has been labelled in one‐step using [11C]CO2. The reaction was effectively carried out at room temperature in solution by fixation chemistry thereby precluding the use of [11C]COCl2.</abstract><subject><genre>keywords</genre><topic>PET</topic><topic>carbon‐11</topic><topic>CO2 fixation</topic><topic>monoamine oxidase B</topic><topic>SL25.1188</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Labelled Compounds and Radiopharmaceuticals</title></titleInfo><titleInfo type="abbreviated"><title>J. Label Compd. Radiopharm</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Note</topic></subject><identifier type="ISSN">0362-4803</identifier><identifier type="eISSN">1099-1344</identifier><identifier type="DOI">10.1002/(ISSN)1099-1344</identifier><identifier type="PublisherID">JLCR</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>678</start><end>680</end><total>3</total></extent></part></relatedItem><identifier type="istex">72E33E45E4BB7A9B3D56F08E0CEE2BEF984EC951</identifier><identifier type="DOI">10.1002/jlcr.1908</identifier><identifier type="ArticleID">JLCR1908</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 John Wiley & Sons, Ltd.Copyright © 2011 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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