Blood vessels change in the mesencephalon of patients with Parkinson's disease
Identifieur interne : 000128 ( Istex/Corpus ); précédent : 000127; suivant : 000129Blood vessels change in the mesencephalon of patients with Parkinson's disease
Auteurs : Baptiste A. Faucheux ; Yves Agid ; Etienne C. Hirsch ; Anne-Marie BonnetSource :
- The Lancet [ 0140-6736 ] ; 1999.
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DOI: 10.1016/S0140-6736(99)00641-8
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Blood vessels change in the mesencephalon of patients with Parkinson's disease</title><author><name sortKey="Faucheux, Baptiste A" sort="Faucheux, Baptiste A" uniqKey="Faucheux B" first="Baptiste A" last="Faucheux">Baptiste A. Faucheux</name><affiliation><mods:affiliation>E-mail: faucheux@ccr.jussieu.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name><affiliation><mods:affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A99CE814670BE07B9D6D203531D85EF86158E74B</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0140-6736(99)00641-8</idno><idno type="url">https://api.istex.fr/document/A99CE814670BE07B9D6D203531D85EF86158E74B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000128</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000128</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Blood vessels change in the mesencephalon of patients with Parkinson's disease</title><author><name sortKey="Faucheux, Baptiste A" sort="Faucheux, Baptiste A" uniqKey="Faucheux B" first="Baptiste A" last="Faucheux">Baptiste A. Faucheux</name><affiliation><mods:affiliation>E-mail: faucheux@ccr.jussieu.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. 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Hirsch</name></json:item><json:item><name>AM Graybiel</name></json:item><json:item><name>Y Agid</name></json:item></author><host><volume>334</volume><pages><last>347</last><first>345</first></pages><author></author><title>Nature</title></host><title>Melanized dopaminergic neurones are differentially susceptible to degeneration in Parkinson's disease</title></json:item><json:item><host><author></author><title>Atlas of histology: normal microscopic anatomy of man</title></host></json:item><json:item><author><json:item><name>MR Issidorides</name></json:item></author><host><volume>25</volume><pages><last>299</last><first>289</first></pages><author></author><title>Brain Res</title></host><title>Neuronal vascular relationships in the zona compacta of normal and parkinsonian substantia nigra</title></json:item><json:item><author><json:item><name>B Leveugle</name></json:item><json:item><name>BA Faucheux</name></json:item><json:item><name>C Bouras</name></json:item></author><host><volume>91</volume><pages><last>572</last><first>566</first></pages><author></author><title>Acta Neuropathol</title></host><title>Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases</title></json:item><json:item><author><json:item><name>BA Faucheux</name></json:item><json:item><name>N Nillesse</name></json:item><json:item><name>P Damier</name></json:item></author><host><volume>92</volume><pages><last>9607</last><first>9603</first></pages><author></author><title>Proc Natl Acad Sci USA</title></host><title>Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>353</volume><pii><json:string>S0140-6736(00)X0133-X</json:string></pii><pages><last>982</last><first>981</first></pages><issn><json:string>0140-6736</json:string></issn><issue>9157</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>The 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disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1999 Elsevier Ltd</p></availability><date>1999</date></publicationStmt><notesStmt><note type="content">Section title: Research Letters</note><note type="content">Table: Mean number (SE) of nuclei of non-melanised neurons, melanised neurons, and blood vessel endothelial cells</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Blood vessels change in the mesencephalon of patients with Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Baptiste A</forename><surname>Faucheux</surname></persName><email>faucheux@ccr.jussieu.fr</email><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Yves</forename><surname>Agid</surname></persName><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Etienne C</forename><surname>Hirsch</surname></persName><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Anne-Marie</forename><surname>Bonnet</surname></persName><affiliation></affiliation></author></analytic><monogr><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="pISSN">0140-6736</idno><idno type="PII">S0140-6736(00)X0133-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">353</biblScope><biblScope unit="issue">9157</biblScope><biblScope unit="page" from="981">981</biblScope><biblScope unit="page" to="982">982</biblScope></imprint></monogr><idno type="istex">A99CE814670BE07B9D6D203531D85EF86158E74B</idno><idno type="DOI">10.1016/S0140-6736(99)00641-8</idno><idno 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name="istex:docType"></istex:docType><istex:document><article docsubtype="fla"> <item-info> <jid>LANCET</jid> <aid>641</aid> <ce:pii>S0140-6736(99)00641-8</ce:pii> <ce:doi>10.1016/S0140-6736(99)00641-8</ce:doi> <ce:copyright type="full-transfer" year="1999">Elsevier Ltd</ce:copyright> <ce:doctopics> <ce:doctopic> <ce:text>Primary Research</ce:text> </ce:doctopic> <ce:doctopic> <ce:text>Research Letters</ce:text> </ce:doctopic> </ce:doctopics> </item-info> <ce:floats> <ce:table id="tbl1" frame="topbot" rowsep="0" colsep="0"> <ce:label>Table</ce:label> <ce:caption> <ce:simple-para id="spara10" role="caption">Mean number (SE) of nuclei of non-melanised neurons, melanised neurons, and blood vessel endothelial cells</ce:simple-para> </ce:caption> <tgroup cols="7" altimg="si1.gif"> <colspec colnum="1" colname="col1"></colspec> <colspec colnum="2" colname="col2"></colspec> <colspec colnum="3" colname="col3"></colspec> <colspec colnum="4" colname="col4"></colspec> <colspec colnum="5" colname="col5"></colspec> <colspec colnum="6" colname="col6"></colspec> <colspec colnum="7" colname="col7"></colspec> <thead> <row valign="top"> <entry align="left"><ce:bold>Mesencephalon sub-region</ce:bold></entry> <entry align="left" namest="col2" nameend="col3" rowsep="1"><ce:bold>Non-melanised neurons</ce:bold></entry> <entry align="left" namest="col4" nameend="col5" rowsep="1"><ce:bold>Melanised neurons</ce:bold></entry> <entry align="left" namest="col6" nameend="col7" rowsep="1"><ce:bold>Endothelial cells</ce:bold></entry> </row> <row valign="top"> <entry rowsep="1"></entry> <entry align="left" rowsep="1">Controls (n=10)</entry> <entry align="left" rowsep="1">PD patients (n=6)</entry> <entry align="left" rowsep="1">Controls (n=10)</entry> <entry align="left" rowsep="1">PD patients (n=6)</entry> <entry align="left" rowsep="1">Controls (n=10)</entry> <entry align="left" rowsep="1">PD patients (n=6)</entry> </row> </thead> <tbody> <row valign="top"> <entry align="left">CGS</entry> <entry align="left">57 (7)</entry> <entry align="left">55 (11)</entry> <entry align="left">0</entry> <entry align="left">0</entry> <entry align="left">12 (3)</entry> <entry align="left">18 (3)</entry> </row> <row valign="top"> <entry align="left">A8</entry> <entry align="left">38 (4)</entry> <entry align="left">39 (3)</entry> <entry align="left">0·3 (0·2)</entry> <entry align="left">0·5 (0·2)</entry> <entry align="left">13 (3)</entry> <entry align="left">16 (9)</entry> </row> <row valign="top"> <entry align="left">VTA-Mv</entry> <entry align="left">9 (2)</entry> <entry align="left">11 (3)</entry> <entry align="left">20 (3)</entry> <entry align="left">17 (3)</entry> <entry align="left">10 (2)</entry> <entry align="left">12 (5)</entry> </row> <row valign="bottom"> <entry align="left">SNpc</entry> <entry align="left">6 (1)</entry> <entry align="left">7 (1)</entry> <entry align="left">19 (2)</entry> <entry align="left">6 (1)<ce:cross-ref refid="tbl1fn1"><ce:sup>*</ce:sup></ce:cross-ref></entry> <entry align="left">13 (3)</entry> <entry align="left">32 (11)<ce:cross-ref refid="tbl1fn2"><ce:sup>†</ce:sup></ce:cross-ref></entry> </row> </tbody> </tgroup> <ce:legend> <ce:simple-para id="spara20">Quantified in 20 randomly distributed fields in the mesencephalon subregions of patients with Parkinson's disease and controls (number per 0·25 mm<ce:cross-ref refid="bib2"><ce:sup>2</ce:sup></ce:cross-ref> of 20 μm thick sections).</ce:simple-para> </ce:legend> <ce:table-footnote id="tbl1fn1"> <ce:label>*</ce:label> <ce:note-para>p>0·001 for Mann-Whitney rank sum test.</ce:note-para> </ce:table-footnote> <ce:table-footnote id="tbl1fn2"> <ce:label>†</ce:label> <ce:note-para>p>0·05 for Student's t-test.</ce:note-para> </ce:table-footnote> </ce:table> </ce:floats> <head> <ce:dochead> <ce:textfn>Research Letters</ce:textfn> </ce:dochead> <ce:title>Blood vessels change in the mesencephalon of patients with Parkinson's disease</ce:title> <ce:author-group> <ce:author> <ce:given-name>Baptiste A</ce:given-name> <ce:surname>Faucheux</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> <ce:e-address type="email">faucheux@ccr.jussieu.fr</ce:e-address> </ce:author> <ce:author> <ce:given-name>Yves</ce:given-name> <ce:surname>Agid</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:author> <ce:given-name>Etienne C</ce:given-name> <ce:surname>Hirsch</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref> </ce:author> <ce:affiliation id="aff1"> <ce:label>a</ce:label> <ce:textfn>INSERM U 289, Hôpital de la Salpêtrière, 75013 Paris, France</ce:textfn> </ce:affiliation> </ce:author-group> <ce:author-group> <ce:author> <ce:given-name>Anne-Marie</ce:given-name> <ce:surname>Bonnet</ce:surname> </ce:author> </ce:author-group> </head> <body> <ce:sections> <ce:para id="para10">The proportion of dopaminergic neurons that degenerates in Parkinson's disease varies between sub-populations of dopaminergic neurons in the mesencephalon.<ce:cross-ref refid="bib1"><ce:sup>1</ce:sup></ce:cross-ref> Neurotrophic and neurotoxic factors could be involved in neurodegeneration, and local factors such as changes in the vascular system and blood supply might be associated with the differential vulnerability of nigral dopaminergic neurons.</ce:para> <ce:para id="para20">We have compared the numbers of nuclei of blood vessel endothelial cells, melanised neurons, non-melanised neurons, and glial cells<ce:cross-ref refid="bib2"><ce:sup>2</ce:sup></ce:cross-ref> in mesencephalon sections from six patients with Parkinson's disease (mean age 74 years [SE 5, range 62–94], mean necropsy delay 21 [4] hours) and ten control patients (mean age 84 [3, range 65–94] years, mean necropsy delay 20 [2] hours). Frozen tissue sections (20 μm) mounted on gelatin-coated glass slides were fixed for 7 weeks in 4% paraformaldehyde and processed for Nissl's staining. Endothelial cell nuclei were identified by both their shapes and location in blood vessels. Quantifications were done in 20 circular fields (125 μm in diameter; randomly distributed throughout the analysed regions and recorded by a computerised plotting system [Histo200 program, Biocom, France]) within four midbrain subregions containing dopaminergic neurons and identified from acetylcholinesterase histochemistry:<ce:cross-ref refid="bib1"><ce:sup>1</ce:sup></ce:cross-ref> SNpc, medioventral part of ventral tegmental area (VTA-Mv, A10 cell group), retrorubral area containing A8 cell group (A8), and central grey substance (CGS).<ce:cross-ref refid="bib1"><ce:sup>1</ce:sup></ce:cross-ref></ce:para> <ce:para id="para30">42752 cell nuclei were counted. Mean numbers of nuclei located in the four midbrain subregions were very close in patients with Parkinson's disease and controls (SNpc: 433 [SE 27] <ce:italic>vs</ce:italic> 427 [38] nuclei per 0·25 mm<ce:cross-ref refid="bib2"><ce:sup>2</ce:sup></ce:cross-ref>; VTA-Mv: 443 [21] <ce:italic>vs</ce:italic> 427 [36]; A8: 523 [28] <ce:italic>vs</ce:italic> 557 [47]; CGS: 518 [23] <ce:italic>vs</ce:italic> 531 [47]). Mean numbers of identified non-melanised neurons were nearly identical in the two groups, whereas those of melanised neurons were decreased in the VTA (−19%) and SNpc (−68%) of patients with Parkinson's disease (<ce:cross-ref refid="tbl1">table</ce:cross-ref><ce:float-anchor refid="tbl1"></ce:float-anchor>) together with a slight increase for glial cells. Mean numbers of nuclei of blood vessel endothelial cells were very similar in the four subregions for control subjects, both for their mean values and variabilities. In patients with Parkinson's disease, they were multiplied by a factor of × 2·5 in the SNpc and only slightly augmented in the VTA, A8, and CGS (+20% to +40%).</ce:para> <ce:para id="para40">Whether the higher number of endothelial cell nuclei in the SNpc of patients with Parkinson's disease reflects an increase in the number and density of blood vessels or changes in the thickness of vascular walls, or both, needs further investigation. Regional differences in the vascular system and blood supply may be important factors in the pathogenesis of brain diseases. In a study of the associations between neurons and capillaries, Issidorides<ce:cross-ref refid="bib3"><ce:sup>3</ce:sup></ce:cross-ref> has shown that the melanin-containing neurons of the SNpc have a close relation with capillary walls in control patients, whereas close contacts are lost in patients with Parkinson's disease. Modifications of the vascular microenvironment of dopaminergic neurons may alter the drawing and transferring of nutrients or toxic compounds. Among others, changes in vascularisation density could concur to iron accumulation, as an increase in lactotransferrin and lactotransferrin receptor expressions have been observed on blood vessels in the SNpc of patients with Parkinson's disease.<ce:cross-refs refid="bib4 bib5"><ce:sup>4,5</ce:sup></ce:cross-refs></ce:para> <ce:para id="para50" role="acknowledgement">This study was supported, in part, by INSERM, the Association Claude Bernard pour le développement des recherches biologiques et médicales dans les hôpitaux de l'Assistance Publique à Paris, and the National Parkinson Foundation Inc, Miami. We would like to thank C Duyckaerts, J J Hauw, M Laurent, F Piette, D Seilhean, A Sachet, V Sazdovitch, and M Verny for their cooperation in providing the brain specimens.</ce:para> </ce:sections> </body> <tail> <ce:bibliography id="bibl10"> <ce:section-title>References</ce:section-title> <ce:bibliography-sec id="cebibsec10"> <ce:bib-reference id="bib1"> <ce:label>1</ce:label> <sb:reference> <sb:contribution> <sb:authors> <sb:author> <ce:surname>Hirsch</ce:surname> <ce:given-name>E</ce:given-name> </sb:author> <sb:author> <ce:surname>Graybiel</ce:surname> <ce:given-name>AM</ce:given-name> </sb:author> <sb:author> <ce:surname>Agid</ce:surname> <ce:given-name>Y</ce:given-name> </sb:author> </sb:authors> <sb:title> <sb:maintitle>Melanized dopaminergic neurones are differentially susceptible to degeneration in Parkinson's disease</sb:maintitle> </sb:title> </sb:contribution> <sb:host> <sb:issue> <sb:series> <sb:title> <sb:maintitle>Nature</sb:maintitle> </sb:title> 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lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease</sb:maintitle> </sb:title> </sb:contribution> <sb:host> <sb:issue> <sb:series> <sb:title> <sb:maintitle>Proc Natl Acad Sci USA</sb:maintitle> </sb:title> <sb:volume-nr>92</sb:volume-nr> </sb:series> <sb:date>1995</sb:date> </sb:issue> <sb:pages> <sb:first-page>9603</sb:first-page> <sb:last-page>9607</sb:last-page> </sb:pages> </sb:host> </sb:reference> </ce:bib-reference> </ce:bibliography-sec> </ce:bibliography> </tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Blood vessels change in the mesencephalon of patients with Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Blood vessels change in the mesencephalon of patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Baptiste A</namePart><namePart type="family">Faucheux</namePart><affiliation>E-mail: faucheux@ccr.jussieu.fr</affiliation><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Agid</namePart><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Etienne C</namePart><namePart type="family">Hirsch</namePart><affiliation>INSERM U 289, Hpital de la Salptrire, 75013 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne-Marie</namePart><namePart type="family">Bonnet</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><note type="content">Section title: Research Letters</note><note type="content">Table: Mean number (SE) of nuclei of non-melanised neurons, melanised neurons, and blood vessel endothelial cells</note><subject><genre>article-category</genre><topic>Primary Research</topic><topic>Research Letters</topic></subject><relatedItem type="host"><titleInfo><title>The Lancet</title></titleInfo><titleInfo type="abbreviated"><title>LANCET</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19990320</dateIssued></originInfo><identifier type="ISSN">0140-6736</identifier><identifier type="PII">S0140-6736(00)X0133-X</identifier><part><date>19990320</date><detail type="volume"><number>353</number><caption>vol.</caption></detail><detail type="issue"><number>9157</number><caption>no.</caption></detail><extent unit="issue pages"><start>939</start><end>1026</end></extent><extent unit="pages"><start>981</start><end>982</end></extent></part></relatedItem><identifier type="istex">A99CE814670BE07B9D6D203531D85EF86158E74B</identifier><identifier type="DOI">10.1016/S0140-6736(99)00641-8</identifier><identifier type="PII">S0140-6736(99)00641-8</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Elsevier Ltd</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Ltd, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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