Effects of prototypic PCBs on benzo[ a ]pyrene mutagenic activity related to vitamin A intake
Identifieur interne : 001F17 ( Istex/Checkpoint ); précédent : 001F16; suivant : 001F18Effects of prototypic PCBs on benzo[ a ]pyrene mutagenic activity related to vitamin A intake
Auteurs : P. Grolier [France] ; P. Cassand [France] ; E. Antignac [France] ; J. F. Narbonne [France] ; R. Albrecht [France] ; V. Azais [France] ; L. W. Robertson [États-Unis] ; F. Oesch [Allemagne]Source :
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis [ 0027-5107 ] ; 1989.
Abstract
The effects of vitamin A dietary intake (2 and 20 IU∗/g of food) on the mutagenic activity of benzo[a]pyrene (B(a)P) toward Salmonella typhimurium (TA98) were studied either in control rats or in animals treated by the PCB congeners 2,4,5,2′,4′,5′-hexachlorobiphenyl ((2,4,5)2Cl) and 3,4,3′,4′-tetrachlorobiphenyl ((3,4)2Cl). (3,4)2Cl (a planar compound) strongly increased B(a)P monooxygenase (B(a)PMO) activity and glutathione transferase, (2,4,5)2Cl (a non-planar PCB) was a strong inducer of epoxide hydrolase and a weak inducer of B(a)PMO. Enzyme induction was not modified by changes in vitamin A dietary intake. A higher mutagenic effect was observed in the (3,4)2Cl group than in the (2,4,5)2Cl one. This could be related to the specific form of cytochrome P-450 induced by (3,4)2Cl. In the untreated animals, the activation of B(a)P was higher in the 2-IU group than in the 20-IU one. Conversely, in PCB-treated rats the mutagenic activity of B(a)P was higher in the 20-IU group than in the 2-IU one. PCB induction increased the liver content of vitamin C in both the 2-IU and the 20-IU groups but only increased the glutathione levels in the 2-IU groups. This suggests that glutathione content in cellular fractions may be one of the determining parameters for the mutagenic activity of B(a)P.
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DOI: 10.1016/0027-5107(89)90114-0
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<front><div type="abstract" xml:lang="en">The effects of vitamin A dietary intake (2 and 20 IU∗/g of food) on the mutagenic activity of benzo[a]pyrene (B(a)P) toward Salmonella typhimurium (TA98) were studied either in control rats or in animals treated by the PCB congeners 2,4,5,2′,4′,5′-hexachlorobiphenyl ((2,4,5)2Cl) and 3,4,3′,4′-tetrachlorobiphenyl ((3,4)2Cl). (3,4)2Cl (a planar compound) strongly increased B(a)P monooxygenase (B(a)PMO) activity and glutathione transferase, (2,4,5)2Cl (a non-planar PCB) was a strong inducer of epoxide hydrolase and a weak inducer of B(a)PMO. Enzyme induction was not modified by changes in vitamin A dietary intake. A higher mutagenic effect was observed in the (3,4)2Cl group than in the (2,4,5)2Cl one. This could be related to the specific form of cytochrome P-450 induced by (3,4)2Cl. In the untreated animals, the activation of B(a)P was higher in the 2-IU group than in the 20-IU one. Conversely, in PCB-treated rats the mutagenic activity of B(a)P was higher in the 20-IU group than in the 2-IU one. PCB induction increased the liver content of vitamin C in both the 2-IU and the 20-IU groups but only increased the glutathione levels in the 2-IU groups. This suggests that glutathione content in cellular fractions may be one of the determining parameters for the mutagenic activity of B(a)P.</div>
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