Asymmetric influences of pointing on saccade latency in hemi-Parkinson's disease
Identifieur interne : 000F67 ( Istex/Checkpoint ); précédent : 000F66; suivant : 000F68Asymmetric influences of pointing on saccade latency in hemi-Parkinson's disease
Auteurs : Jocelyne Ventre-Dominey [France] ; Peter Ford Dominey [France] ; Emmanuel Broussolle [France]Source :
- Neuropsychologia [ 0028-3932 ] ; 2001.
English descriptors
Abstract
The objective of this study was to investigate whether eye–hand coupling was preserved or not in PD. We studied predictive saccade performance during hand pointing in six Parkinson's disease (PD) patients with asymmetrical motor signs compared to nine age-matched healthy subjects. The motor responses (saccades and hand pointing) were elicited under open loop conditions (without vision of the hand), by a visual target stepping at a predictable location (10° right and left from the centre) and time. The subjects had to simultaneously move the eyes and point with the finger to the visual target alternating at one of three fixed frequencies (0.25, 0.5 and 1 Hz), for 30 cycles. This task was performed in two sessions balanced over the subjects: one session of ocular saccades only and another session of combined ocular saccades and manual pointing. In the PD group, motor performance was perturbed particularly in terms of increased latencies of hand movements. Interestingly, during pointing, associated predictive saccade disorders were tightly related to the defects of the pointing hand. Indeed, with respect to the latency of predictive saccades alone, the predictive saccade latency during hand pointing significantly decreased in the control group and in the PD group when using the non-affected hand. In contrast, for the PD group when using the affected hand, the saccade latency was increased from the latency values of predictive saccades induced without pointing. Moreover, in the control and in the PD groups, the correlation between eye and hand latencies was highly significant, suggesting an intact eye–hand coupling. No saccadic amplitude disorders were found in either condition. These results demonstrate that eye–hand coupling is preserved in PD, as revealed by the possible beneficial or adverse effects on the ocular saccades, respectively, of the less- or more-affected hand motor responses. This eye–hand coupling mechanism likely involves regions other than the nigro-striatal pathways affected in PD.
Url:
DOI: 10.1016/S0028-3932(00)00133-0
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:60CC54E2986172783C493DD68B4C4F5283BB73E9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Asymmetric influences of pointing on saccade latency in hemi-Parkinson's disease</title>
<author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
</author>
<author><name sortKey="Ford Dominey, Peter" sort="Ford Dominey, Peter" uniqKey="Ford Dominey P" first="Peter" last="Ford Dominey">Peter Ford Dominey</name>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:60CC54E2986172783C493DD68B4C4F5283BB73E9</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1016/S0028-3932(00)00133-0</idno>
<idno type="url">https://api.istex.fr/document/60CC54E2986172783C493DD68B4C4F5283BB73E9/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B36</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B36</idno>
<idno type="wicri:Area/Istex/Curation">001B34</idno>
<idno type="wicri:Area/Istex/Checkpoint">000F67</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Asymmetric influences of pointing on saccade latency in hemi-Parkinson's disease</title>
<author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM-Unit 94, 16 avenue Doyen Lépine, 69500 Bron</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Bron</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ford Dominey, Peter" sort="Ford Dominey, Peter" uniqKey="Ford Dominey P" first="Peter" last="Ford Dominey">Peter Ford Dominey</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS-Cognitive Sciences Institute, 69500 Bron</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Bron</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurology Unit, Neurology Hospital, 69003 Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Neuropsychologia</title>
<title level="j" type="abbrev">NSY</title>
<idno type="ISSN">0028-3932</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="2001">2001</date>
<biblScope unit="volume">39</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="470">470</biblScope>
<biblScope unit="page" to="477">477</biblScope>
</imprint>
<idno type="ISSN">0028-3932</idno>
</series>
<idno type="istex">60CC54E2986172783C493DD68B4C4F5283BB73E9</idno>
<idno type="DOI">10.1016/S0028-3932(00)00133-0</idno>
<idno type="PII">S0028-3932(00)00133-0</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0028-3932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Eye–hand coordination</term>
<term>Hand pointing</term>
<term>Ocular saccade</term>
<term>Parkinson's disease</term>
<term>Prediction</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The objective of this study was to investigate whether eye–hand coupling was preserved or not in PD. We studied predictive saccade performance during hand pointing in six Parkinson's disease (PD) patients with asymmetrical motor signs compared to nine age-matched healthy subjects. The motor responses (saccades and hand pointing) were elicited under open loop conditions (without vision of the hand), by a visual target stepping at a predictable location (10° right and left from the centre) and time. The subjects had to simultaneously move the eyes and point with the finger to the visual target alternating at one of three fixed frequencies (0.25, 0.5 and 1 Hz), for 30 cycles. This task was performed in two sessions balanced over the subjects: one session of ocular saccades only and another session of combined ocular saccades and manual pointing. In the PD group, motor performance was perturbed particularly in terms of increased latencies of hand movements. Interestingly, during pointing, associated predictive saccade disorders were tightly related to the defects of the pointing hand. Indeed, with respect to the latency of predictive saccades alone, the predictive saccade latency during hand pointing significantly decreased in the control group and in the PD group when using the non-affected hand. In contrast, for the PD group when using the affected hand, the saccade latency was increased from the latency values of predictive saccades induced without pointing. Moreover, in the control and in the PD groups, the correlation between eye and hand latencies was highly significant, suggesting an intact eye–hand coupling. No saccadic amplitude disorders were found in either condition. These results demonstrate that eye–hand coupling is preserved in PD, as revealed by the possible beneficial or adverse effects on the ocular saccades, respectively, of the less- or more-affected hand motor responses. This eye–hand coupling mechanism likely involves regions other than the nigro-striatal pathways affected in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Bron</li>
<li>Lyon</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
</noRegion>
<name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<name sortKey="Ford Dominey, Peter" sort="Ford Dominey, Peter" uniqKey="Ford Dominey P" first="Peter" last="Ford Dominey">Peter Ford Dominey</name>
<name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 000F67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:60CC54E2986172783C493DD68B4C4F5283BB73E9 |texte= Asymmetric influences of pointing on saccade latency in hemi-Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |