Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801
Identifieur interne : 000D42 ( Istex/Checkpoint ); précédent : 000D41; suivant : 000D43Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801
Auteurs : Lionel Bert [France] ; Daniel Rodier [France] ; Isabelle Bougault [France] ; Nathalie Allouard [France] ; Gérard Le-Fur [France] ; Philippe Soubrié [France] ; Régis Steinberg [France]Source :
- Synapse [ 0887-4476 ] ; 2002-01.
English descriptors
- KwdEn :
Abstract
The present experiments investigated the role of neurokinin‐1 (NK1) and neurokinin‐3 (NK3) receptors on the activity of the locus coeruleus (LC)‐noradrenergic system by using a dual probe microdialysis technique in anesthetized guinea pigs. The local application in the LC of the selective NK1 receptor agonists [SAR9,Met(O2)11]‐SP (10 μM) and septide (1 μM) as well as the selective NK3 receptor agonist senktide (1 μM), enhanced the extracellular norepinephrine (NE) levels in the prefrontal cortex. The enhancing effect of [SAR9,Met(O2)11]‐SP was completely blocked by the peripheral administration of the selective non peptide NK1 and NK3 receptor antagonists, GR 205171 (1 mg/kg, i.p.) and SR 142801 (0.1 mg/kg, i.p.), respectively, whereas SR 142806 (0.1 mg/kg, i.p.) the inactive enantiomer of SR 142801 had no effect. Moreover, the [SAR9,Met(O2)11]‐SP‐induced increase in LC DOPAC concentrations, is only antagonized by GR 205171. In contrast, only SR 142801 (0.3 mg/kg, i.p.) could block stereoselectively the senktide‐evoked increase in NE levels. Both [SAR9,Met(O2)11]‐SP and senktide effects were blocked by local infusion into the LC of SR 142801 (10−9 M). These results demonstrate that stimulation of NK1 and NK3 receptors located in the LC area modulates the activity of the LC‐NE system, and that the excitatory effects of NK1 receptor agonists require NKB/NK3 receptor activation in the LC. Synapse 43:62–69, 2002. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/syn.10021
Affiliations:
- France
- Auvergne-Rhône-Alpes, Languedoc-Roussillon, Occitanie (région administrative), Rhône-Alpes
- LYON, Montpellier
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:FEF08F0BC4EDFB435E530D688DE2B5B4C9E7C38ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801</title>
<author><name sortKey="Bert, Lionel" sort="Bert, Lionel" uniqKey="Bert L" first="Lionel" last="Bert">Lionel Bert</name>
</author>
<author><name sortKey="Rodier, Daniel" sort="Rodier, Daniel" uniqKey="Rodier D" first="Daniel" last="Rodier">Daniel Rodier</name>
</author>
<author><name sortKey="Bougault, Isabelle" sort="Bougault, Isabelle" uniqKey="Bougault I" first="Isabelle" last="Bougault">Isabelle Bougault</name>
</author>
<author><name sortKey="Allouard, Nathalie" sort="Allouard, Nathalie" uniqKey="Allouard N" first="Nathalie" last="Allouard">Nathalie Allouard</name>
</author>
<author><name sortKey="Le Ur, Gerard" sort="Le Ur, Gerard" uniqKey="Le Ur G" first="Gérard" last="Le-Fur">Gérard Le-Fur</name>
</author>
<author><name sortKey="Soubrie, Philippe" sort="Soubrie, Philippe" uniqKey="Soubrie P" first="Philippe" last="Soubrié">Philippe Soubrié</name>
</author>
<author><name sortKey="Steinberg, Regis" sort="Steinberg, Regis" uniqKey="Steinberg R" first="Régis" last="Steinberg">Régis Steinberg</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FEF08F0BC4EDFB435E530D688DE2B5B4C9E7C38A</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/syn.10021</idno>
<idno type="url">https://api.istex.fr/document/FEF08F0BC4EDFB435E530D688DE2B5B4C9E7C38A/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001988</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001988</idno>
<idno type="wicri:Area/Istex/Curation">001986</idno>
<idno type="wicri:Area/Istex/Checkpoint">000D42</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D42</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801</title>
<author><name sortKey="Bert, Lionel" sort="Bert, Lionel" uniqKey="Bert L" first="Lionel" last="Bert">Lionel Bert</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Current Address: Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, UCBL, Faculté de Pharmacie, 8, av. Rockefeller, 69373 LYON Cedex 08</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">LYON</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodier, Daniel" sort="Rodier, Daniel" uniqKey="Rodier D" first="Daniel" last="Rodier">Daniel Rodier</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bougault, Isabelle" sort="Bougault, Isabelle" uniqKey="Bougault I" first="Isabelle" last="Bougault">Isabelle Bougault</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allouard, Nathalie" sort="Allouard, Nathalie" uniqKey="Allouard N" first="Nathalie" last="Allouard">Nathalie Allouard</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Ur, Gerard" sort="Le Ur, Gerard" uniqKey="Le Ur G" first="Gérard" last="Le-Fur">Gérard Le-Fur</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soubrie, Philippe" sort="Soubrie, Philippe" uniqKey="Soubrie P" first="Philippe" last="Soubrié">Philippe Soubrié</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steinberg, Regis" sort="Steinberg, Regis" uniqKey="Steinberg R" first="Régis" last="Steinberg">Régis Steinberg</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Sanofi‐Synthélabo, Central Nervous System Department, 371, rue du Prof. Blayac, 34184 Montpellier Cedex 04</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Synapse</title>
<title level="j" type="abbrev">Synapse</title>
<idno type="ISSN">0887-4476</idno>
<idno type="eISSN">1098-2396</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2002-01">2002-01</date>
<biblScope unit="volume">43</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="62">62</biblScope>
<biblScope unit="page" to="69">69</biblScope>
</imprint>
<idno type="ISSN">0887-4476</idno>
</series>
<idno type="istex">FEF08F0BC4EDFB435E530D688DE2B5B4C9E7C38A</idno>
<idno type="DOI">10.1002/syn.10021</idno>
<idno type="ArticleID">SYN10021</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0887-4476</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>dual probe microdialysis</term>
<term>guinea pig</term>
<term>norepinephrine</term>
<term>prefrontal cortex</term>
<term>tachykinin antagonists</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The present experiments investigated the role of neurokinin‐1 (NK1) and neurokinin‐3 (NK3) receptors on the activity of the locus coeruleus (LC)‐noradrenergic system by using a dual probe microdialysis technique in anesthetized guinea pigs. The local application in the LC of the selective NK1 receptor agonists [SAR9,Met(O2)11]‐SP (10 μM) and septide (1 μM) as well as the selective NK3 receptor agonist senktide (1 μM), enhanced the extracellular norepinephrine (NE) levels in the prefrontal cortex. The enhancing effect of [SAR9,Met(O2)11]‐SP was completely blocked by the peripheral administration of the selective non peptide NK1 and NK3 receptor antagonists, GR 205171 (1 mg/kg, i.p.) and SR 142801 (0.1 mg/kg, i.p.), respectively, whereas SR 142806 (0.1 mg/kg, i.p.) the inactive enantiomer of SR 142801 had no effect. Moreover, the [SAR9,Met(O2)11]‐SP‐induced increase in LC DOPAC concentrations, is only antagonized by GR 205171. In contrast, only SR 142801 (0.3 mg/kg, i.p.) could block stereoselectively the senktide‐evoked increase in NE levels. Both [SAR9,Met(O2)11]‐SP and senktide effects were blocked by local infusion into the LC of SR 142801 (10−9 M). These results demonstrate that stimulation of NK1 and NK3 receptors located in the LC area modulates the activity of the LC‐NE system, and that the excitatory effects of NK1 receptor agonists require NKB/NK3 receptor activation in the LC. Synapse 43:62–69, 2002. © 2001 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>LYON</li>
<li>Montpellier</li>
</settlement>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Bert, Lionel" sort="Bert, Lionel" uniqKey="Bert L" first="Lionel" last="Bert">Lionel Bert</name>
</region>
<name sortKey="Allouard, Nathalie" sort="Allouard, Nathalie" uniqKey="Allouard N" first="Nathalie" last="Allouard">Nathalie Allouard</name>
<name sortKey="Bert, Lionel" sort="Bert, Lionel" uniqKey="Bert L" first="Lionel" last="Bert">Lionel Bert</name>
<name sortKey="Bougault, Isabelle" sort="Bougault, Isabelle" uniqKey="Bougault I" first="Isabelle" last="Bougault">Isabelle Bougault</name>
<name sortKey="Le Ur, Gerard" sort="Le Ur, Gerard" uniqKey="Le Ur G" first="Gérard" last="Le-Fur">Gérard Le-Fur</name>
<name sortKey="Rodier, Daniel" sort="Rodier, Daniel" uniqKey="Rodier D" first="Daniel" last="Rodier">Daniel Rodier</name>
<name sortKey="Soubrie, Philippe" sort="Soubrie, Philippe" uniqKey="Soubrie P" first="Philippe" last="Soubrié">Philippe Soubrié</name>
<name sortKey="Steinberg, Regis" sort="Steinberg, Regis" uniqKey="Steinberg R" first="Régis" last="Steinberg">Régis Steinberg</name>
<name sortKey="Steinberg, Regis" sort="Steinberg, Regis" uniqKey="Steinberg R" first="Régis" last="Steinberg">Régis Steinberg</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 000D42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:FEF08F0BC4EDFB435E530D688DE2B5B4C9E7C38A |texte= Permissive role of neurokinin NK3 receptors in NK1 receptor‐mediated activation of the locus coeruleus revealed by SR 142801 }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |