ParkinsonFranceV1, Hal, Curation, bibRecord, 000975

Subthalamic stimulation improves orienting gaze movements in Parkinson's disease.

Identifieur interne : 000975 ( Hal/Curation ); précédent : 000974; suivant : 000976

Subthalamic stimulation improves orienting gaze movements in Parkinson's disease.

Auteurs : Paul Sauleau [France] ; Pierre Pollak [France] ; Paul Krack [France] ; Jean-Hubert Courjon [France] ; Alain Vighetto [France] ; Alim-Louis Benabid [France] ; Denis Pélisson [France] ; Caroline Tilikete [France]

Source :

Clinical Neurophysiology [ 1388-2457 ] ; 2008-08.

RBID : Hal:inserm-00391539

Abstract

OBJECTIVE: To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD). METHODS: We compared the gain and latency of visually triggered eye and head movements in 12 patients bilaterally implanted into the subthalamic nucleus (STN) for severe PD and six age-matched control subjects. Visually triggered movements of eye (head restrained), and of eye and head (head unrestrained) were recorded in the absence of dopaminergic medication. Bilateral stimulation was turned OFF and then turned ON with voltage and contact used in chronic setting. The latency was determined from the beginning of initial horizontal eye movements relative to the target onset, and the gain was defined as the ratio of the amplitude of the initial movement to the amplitude of the target movement. RESULTS: Without stimulation, the initiation of the head movement was significantly delayed in patients and the gain of head movement was reduced. Our patients also presented significantly prolonged latencies and hypometry of visually triggered saccades in the head-fixed condition and of gaze in head-free condition. Bilateral STN stimulation with therapeutic parameters improved performance of orienting gaze, eye and head movements towards the controls' level CONCLUSIONS: These results demonstrate that visually triggered saccades and orienting eye-head movements are impaired in the advanced stage of PD. In addition, subthalamic stimulation enhances amplitude and shortens latency of these movements. SIGNIFICANCE: These results are likely explained by alteration of the information processed by the superior colliculus (SC), a pivotal visuomotor structure involved in both voluntary and reflexive saccades. Improvement of movements with stimulation of the STN may be related to its positive input either on the STN-Substantia Nigra-SC pathway or on the parietal cortex-SC pathway.

Url:

http://www.hal.inserm.fr/inserm-00391539

DOI: 10.1016/j.clinph.2008.04.013

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<idno type="DOI">10.1016/j.clinph.2008.04.013</idno>
<series><title level="j">Clinical Neurophysiology</title>
<idno type="ISSN">1388-2457</idno>
<imprint><date type="datePub">2008-08</date>
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<front><div type="abstract" xml:lang="en">OBJECTIVE: To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD). METHODS: We compared the gain and latency of visually triggered eye and head movements in 12 patients bilaterally implanted into the subthalamic nucleus (STN) for severe PD and six age-matched control subjects. Visually triggered movements of eye (head restrained), and of eye and head (head unrestrained) were recorded in the absence of dopaminergic medication. Bilateral stimulation was turned OFF and then turned ON with voltage and contact used in chronic setting. The latency was determined from the beginning of initial horizontal eye movements relative to the target onset, and the gain was defined as the ratio of the amplitude of the initial movement to the amplitude of the target movement. RESULTS: Without stimulation, the initiation of the head movement was significantly delayed in patients and the gain of head movement was reduced. Our patients also presented significantly prolonged latencies and hypometry of visually triggered saccades in the head-fixed condition and of gaze in head-free condition. Bilateral STN stimulation with therapeutic parameters improved performance of orienting gaze, eye and head movements towards the controls' level CONCLUSIONS: These results demonstrate that visually triggered saccades and orienting eye-head movements are impaired in the advanced stage of PD. In addition, subthalamic stimulation enhances amplitude and shortens latency of these movements. SIGNIFICANCE: These results are likely explained by alteration of the information processed by the superior colliculus (SC), a pivotal visuomotor structure involved in both voluntary and reflexive saccades. Improvement of movements with stimulation of the STN may be related to its positive input either on the STN-Substantia Nigra-SC pathway or on the parietal cortex-SC pathway.</div>
</front>
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                  <affiliation ref="#struct-2812"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Denis</forename>
                    <surname>Pélisson</surname>
                  </persName>
                  <idno type="halauthorid">403857</idno>
                  <affiliation ref="#struct-27736"></affiliation>
                  <affiliation ref="#struct-95949"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Caroline</forename>
                    <surname>Tilikete</surname>
                  </persName>
                  <idno type="halauthorid">352563</idno>
                  <affiliation ref="#struct-27736"></affiliation>
                  <affiliation ref="#struct-95949"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">11801</idno>
                <idno type="issn">1388-2457</idno>
                <title level="j">Clinical Neurophysiology</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">119</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1857-63</biblScope>
                  <date type="datePub">2008-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.clinph.2008.04.013</idno>
              <idno type="pubmed">18567536</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Movement</classCode>
              <classCode scheme="mesh">Orientation</classCode>
              <classCode scheme="mesh">Parkinson Disease</classCode>
              <classCode scheme="mesh">Photic Stimulation</classCode>
              <classCode scheme="mesh">Psychophysics</classCode>
              <classCode scheme="mesh">Subthalamus</classCode>
              <classCode scheme="mesh">Analysis of Variance</classCode>
              <classCode scheme="mesh">Case-Control Studies</classCode>
              <classCode scheme="mesh">Electric Stimulation Therapy</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Fixation, Ocular</classCode>
              <classCode scheme="mesh">Head Movements</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">OBJECTIVE: To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD). METHODS: We compared the gain and latency of visually triggered eye and head movements in 12 patients bilaterally implanted into the subthalamic nucleus (STN) for severe PD and six age-matched control subjects. Visually triggered movements of eye (head restrained), and of eye and head (head unrestrained) were recorded in the absence of dopaminergic medication. Bilateral stimulation was turned OFF and then turned ON with voltage and contact used in chronic setting. The latency was determined from the beginning of initial horizontal eye movements relative to the target onset, and the gain was defined as the ratio of the amplitude of the initial movement to the amplitude of the target movement. RESULTS: Without stimulation, the initiation of the head movement was significantly delayed in patients and the gain of head movement was reduced. Our patients also presented significantly prolonged latencies and hypometry of visually triggered saccades in the head-fixed condition and of gaze in head-free condition. Bilateral STN stimulation with therapeutic parameters improved performance of orienting gaze, eye and head movements towards the controls' level CONCLUSIONS: These results demonstrate that visually triggered saccades and orienting eye-head movements are impaired in the advanced stage of PD. In addition, subthalamic stimulation enhances amplitude and shortens latency of these movements. SIGNIFICANCE: These results are likely explained by alteration of the information processed by the superior colliculus (SC), a pivotal visuomotor structure involved in both voluntary and reflexive saccades. Improvement of movements with stimulation of the STN may be related to its positive input either on the STN-Substantia Nigra-SC pathway or on the parietal cortex-SC pathway.</abstract>
            <particDesc>              <org type="consortium">Collaboration</org>
            </particDesc>
          </profileDesc>
        </hal>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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Subthalamic stimulation improves orienting gaze movements in Parkinson's disease.

Subthalamic stimulation improves orienting gaze movements in Parkinson's disease.

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