Rewiring the brain with cell transplantation in Parkinson's disease.
Identifieur interne : 000890 ( Hal/Curation ); précédent : 000889; suivant : 000891Rewiring the brain with cell transplantation in Parkinson's disease.
Auteurs : Afsaneh Gaillard [France] ; Mohamed Jaber [France]Source :
- Trends in Neurosciences [ 0166-2236 ] ; 2011-03.
Abstract
Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.
Url:
DOI: 10.1016/j.tins.2011.01.003
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000967
Links to Exploration step
Hal:hal-00582383Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author><name sortKey="Gaillard, Afsaneh" sort="Gaillard, Afsaneh" uniqKey="Gaillard A" first="Afsaneh" last="Gaillard">Afsaneh Gaillard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-877" status="OLD"> <orgName>Institut de physiologie et biologie cellulaires</orgName>
<orgName type="acronym">IPBC</orgName>
<desc> <address> <addrLine>bat. physiologie 40 avenue du recteur Pineau 86022 POITIERS CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54493" type="direct"></relation>
<relation name="UMR6187" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName>
<desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-poitiers.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6187" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
<region type="region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
<author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-877" status="OLD"> <orgName>Institut de physiologie et biologie cellulaires</orgName>
<orgName type="acronym">IPBC</orgName>
<desc> <address> <addrLine>bat. physiologie 40 avenue du recteur Pineau 86022 POITIERS CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54493" type="direct"></relation>
<relation name="UMR6187" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName>
<desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-poitiers.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6187" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
<region type="region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00582383</idno>
<idno type="halId">hal-00582383</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00582383</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00582383</idno>
<idno type="doi">10.1016/j.tins.2011.01.003</idno>
<date when="2011-03">2011-03</date>
<idno type="wicri:Area/Hal/Corpus">000967</idno>
<idno type="wicri:Area/Hal/Curation">000967</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author><name sortKey="Gaillard, Afsaneh" sort="Gaillard, Afsaneh" uniqKey="Gaillard A" first="Afsaneh" last="Gaillard">Afsaneh Gaillard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-877" status="OLD"> <orgName>Institut de physiologie et biologie cellulaires</orgName>
<orgName type="acronym">IPBC</orgName>
<desc> <address> <addrLine>bat. physiologie 40 avenue du recteur Pineau 86022 POITIERS CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54493" type="direct"></relation>
<relation name="UMR6187" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName>
<desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-poitiers.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6187" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
<region type="region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
<author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-877" status="OLD"> <orgName>Institut de physiologie et biologie cellulaires</orgName>
<orgName type="acronym">IPBC</orgName>
<desc> <address> <addrLine>bat. physiologie 40 avenue du recteur Pineau 86022 POITIERS CEDEX</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54493" type="direct"></relation>
<relation name="UMR6187" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName>
<desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-poitiers.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6187" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Poitiers</settlement>
<region type="region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.tins.2011.01.003</idno>
<series><title level="j">Trends in Neurosciences</title>
<idno type="ISSN">0166-2236</idno>
<imprint><date type="datePub">2011-03</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.</div>
</front>
</TEI>
<hal api="V3"> <titleStmt> <title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author role="aut"> <persName> <forename type="first">Afsaneh</forename>
<surname>Gaillard</surname>
</persName>
<idno type="halauthorid">420355</idno>
<affiliation ref="#struct-877"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Mohamed</forename>
<surname>Jaber</surname>
</persName>
<idno type="halauthorid">159452</idno>
<affiliation ref="#struct-877"></affiliation>
</author>
<editor role="depositor"> <persName> <forename>Christelle</forename>
<surname>Morillon</surname>
</persName>
<email type="md5">7fc9b48947d40525a994b67ea9f35fe1</email>
<email type="domain">univ-poitiers.fr</email>
</editor>
</titleStmt>
<editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2011-04-01 11:47:23</date>
<date type="whenModified">2011-04-01 11:47:23</date>
<date type="whenReleased">2011-04-01 11:47:23</date>
<date type="whenProduced">2011-03</date>
</edition>
<respStmt> <resp>contributor</resp>
<name key="140725"> <persName> <forename>Christelle</forename>
<surname>Morillon</surname>
</persName>
<email type="md5">7fc9b48947d40525a994b67ea9f35fe1</email>
<email type="domain">univ-poitiers.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt> <distributor>CCSD</distributor>
<idno type="halId">hal-00582383</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00582383</idno>
<idno type="halBibtex">gaillard:hal-00582383</idno>
<idno type="halRefHtml">Trends in Neurosciences, Elsevier, 2011, 34 (3), pp.124-33. <10.1016/j.tins.2011.01.003></idno>
<idno type="halRef">Trends in Neurosciences, Elsevier, 2011, 34 (3), pp.124-33. <10.1016/j.tins.2011.01.003></idno>
</publicationStmt>
<seriesStmt> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
</seriesStmt>
<notesStmt> <note type="commentary">IF : 12,81</note>
<note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author role="aut"> <persName> <forename type="first">Afsaneh</forename>
<surname>Gaillard</surname>
</persName>
<idno type="halauthorid">420355</idno>
<affiliation ref="#struct-877"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Mohamed</forename>
<surname>Jaber</surname>
</persName>
<idno type="halauthorid">159452</idno>
<affiliation ref="#struct-877"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">9000</idno>
<idno type="issn">0166-2236</idno>
<idno type="eissn">1878-108X</idno>
<title level="j">Trends in Neurosciences</title>
<imprint> <publisher>Elsevier</publisher>
<biblScope unit="volume">34</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="pp">124-33</biblScope>
<date type="datePub">2011-03</date>
</imprint>
</monogr>
<idno type="doi">10.1016/j.tins.2011.01.003</idno>
<idno type="pubmed">21316770</idno>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000890 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000890 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Hal |étape= Curation |type= RBID |clé= Hal:hal-00582383 |texte= Rewiring the brain with cell transplantation in Parkinson's disease. }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |