Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study.
Identifieur interne : 000604 ( Hal/Curation ); précédent : 000603; suivant : 000605Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study.
Auteurs : Audrey Maillet [France] ; Alexandre Krainik [France] ; Bettina Debû [France] ; Irène Troprès [France] ; Christelle Lagrange [France] ; Stéphane Thobois [France] ; Pierre Pollak [France] ; Serge Pinto [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson's disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient's population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.
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DOI: 10.1371/journal.pone.0046541
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Aix Marseille Université5 avenue Pasteur13100 Aix-en-Provence</addrLine><country key="FR"></country></address><ref type="url">http://www.lpl-aix.fr/</ref></desc><listRelation><relation name="UMR7309" active="#struct-198056" type="direct"></relation><relation name="UMR6057" active="#struct-92823" type="direct"></relation><relation name="UMR7309" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle name="UMR7309" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno><idno type="ISNI">0000 0001 2176 4817</idno><orgName>Aix Marseille Université</orgName><orgName type="acronym">AMU</orgName><date type="start">2012-01-01</date><desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-amu.fr/</ref></desc></org></tutelle><tutelle name="UMR6057" active="#struct-92823" type="direct"><org type="institution" xml:id="struct-92823" status="OLD"><idno type="IdRef">026403781</idno><orgName>Université de Provence - Aix-Marseille 1</orgName><date type="end">2011-12-31</date><desc><address><addrLine>3, place Victor Hugo - 13331 Marseille Cedex 03</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-provence.fr/</ref></desc></org></tutelle><tutelle name="UMR7309" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><idno type="DOI">10.1371/journal.pone.0046541</idno><series><title level="j">PLoS ONE</title><idno type="ISSN">1932-6203</idno><imprint><date type="datePub">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson's disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient's population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.</div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study.</title> <author role="aut"> <persName> <forename type="first">Audrey</forename> <surname>Maillet</surname> </persName> <idno type="halauthorid">886871</idno> <affiliation ref="#struct-392013"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alexandre</forename> <surname>Krainik</surname> </persName> <idno type="halauthorid">197196</idno> <affiliation ref="#struct-404316"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bettina</forename> <surname>Debû</surname> </persName> <idno type="halauthorid">407445</idno> <affiliation ref="#struct-390086"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Irène</forename> <surname>Troprès</surname> </persName> <idno type="halauthorid">397549</idno> <affiliation ref="#struct-86972"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christelle</forename> <surname>Lagrange</surname> </persName> <idno type="halauthorid">403201</idno> <affiliation ref="#struct-14242"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Stéphane</forename> <surname>Thobois</surname> </persName> <idno type="halauthorid">233621</idno> <affiliation ref="#struct-234038"></affiliation> <affiliation ref="#struct-24477"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pierre</forename> <surname>Pollak</surname> </persName> <idno type="halauthorid">233619</idno> <affiliation ref="#struct-14242"></affiliation> <affiliation ref="#struct-234039"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Serge</forename> <surname>Pinto</surname> </persName> <email type="md5">e79dbeb284de490e0e22c8dc9cbab539</email> <email type="domain">lpl-aix.fr</email> <idno type="idhal" notation="string">sergepinto</idno> <idno type="idhal" notation="numeric">8359</idno> <idno type="halauthorid">296409</idno> <idno type="ORCID">http://orcid.org/0000-0002-3375-4787</idno> <affiliation ref="#struct-199923"></affiliation> </author> <editor role="depositor"> <persName> <forename>Olivier</forename> <surname>David</surname> </persName> <email type="md5">8c7e32b95ee0bf9d400da48fae10cb58</email> <email type="domain">ujf-grenoble.fr</email> </editor> <funder>French Health Ministry (PHRC 2005)</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2013-10-18 11:04:30</date> <date type="whenModified">2016-02-12 01:06:04</date> <date type="whenReleased">2013-10-18 11:57:58</date> <date type="whenProduced">2012</date> <date type="whenEndEmbargoed">2013-10-18</date> <ref type="file" target="http://www.hal.inserm.fr/inserm-00874568/document"> <date notBefore="2013-10-18"></date> </ref> <ref type="file" subtype="author" n="1" target="http://www.hal.inserm.fr/inserm-00874568/file/Maillet-2012_Levodopa_AO.pdf"> <date notBefore="2013-10-18"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="162566"> <persName> <forename>Olivier</forename> <surname>David</surname> </persName> <email type="md5">8c7e32b95ee0bf9d400da48fae10cb58</email> <email type="domain">ujf-grenoble.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">inserm-00874568</idno> <idno type="halUri">http://www.hal.inserm.fr/inserm-00874568</idno> <idno type="halBibtex">maillet:inserm-00874568</idno> <idno type="halRefHtml">PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e46541. <10.1371/journal.pone.0046541></idno> <idno type="halRef">PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e46541. <10.1371/journal.pone.0046541></idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno> <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno> <idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno> <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno> <idno type="stamp" n="U836" p="INSERM">Grenoble Institut des Neurosciences</idno> <idno type="stamp" n="LPL-AIX">Laboratoire Parole et Langage</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study.</title> <author role="aut"> <persName> <forename type="first">Audrey</forename> <surname>Maillet</surname> </persName> <idno type="halauthorid">886871</idno> <affiliation ref="#struct-392013"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alexandre</forename> <surname>Krainik</surname> </persName> <idno type="halauthorid">197196</idno> <affiliation ref="#struct-404316"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bettina</forename> <surname>Debû</surname> </persName> <idno type="halauthorid">407445</idno> <affiliation ref="#struct-390086"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Irène</forename> <surname>Troprès</surname> </persName> <idno type="halauthorid">397549</idno> <affiliation ref="#struct-86972"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christelle</forename> <surname>Lagrange</surname> </persName> <idno type="halauthorid">403201</idno> <affiliation ref="#struct-14242"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Stéphane</forename> <surname>Thobois</surname> </persName> <idno type="halauthorid">233621</idno> <affiliation ref="#struct-234038"></affiliation> <affiliation ref="#struct-24477"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Pierre</forename> <surname>Pollak</surname> </persName> <idno type="halauthorid">233619</idno> <affiliation ref="#struct-14242"></affiliation> <affiliation ref="#struct-234039"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Serge</forename> <surname>Pinto</surname> </persName> <email type="md5">e79dbeb284de490e0e22c8dc9cbab539</email> <email type="domain">lpl-aix.fr</email> <idno type="idhal" notation="string">sergepinto</idno> <idno type="idhal" notation="numeric">8359</idno> <idno type="halauthorid">296409</idno> <idno type="ORCID">http://orcid.org/0000-0002-3375-4787</idno> <affiliation ref="#struct-199923"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">28700</idno> <idno type="issn">1932-6203</idno> <title level="j">PLoS ONE</title> <imprint> <publisher>Public Library of Science</publisher> <biblScope unit="volume">7</biblScope> <biblScope unit="issue">10</biblScope> <biblScope unit="pp">e46541</biblScope> <date type="datePub">2012</date> <date type="dateEpub">2012-10-09</date> </imprint> </monogr> <idno type="pubmed">23056337</idno> <idno type="doi">10.1371/journal.pone.0046541</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="mesh">Aged</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Levodopa</classCode> <classCode scheme="mesh">Magnetic Resonance Imaging</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="mesh">Middle Aged</classCode> <classCode scheme="mesh">Movement</classCode> <classCode scheme="mesh">Parkinson Disease</classCode> <classCode scheme="mesh">Speech</classCode> <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en">Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson's disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient's population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.</abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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