Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.
Identifieur interne : 000527 ( Hal/Curation ); précédent : 000526; suivant : 000528Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.
Auteurs : Claudine Fayard [France] ; Audrey Bonaventure [France] ; Isabelle Benatru [France] ; Emmanuel Roze [France] ; Julien Dumurgier [France] ; Frédéric Moisan [France] ; Aïcha Soumaré [France] ; Jean Houssinot [France] ; Jean-Luc Dupupet [France] ; Jean-Louis Mazurie [France] ; Irina Balaboi [France] ; Jean-Luc Houeto [France] ; Elsa Krim [France] ; Danièle Ranoux [France] ; Marcel Goldberg [France] ; Ellen Imbernon [France] ; Thibault Moreau [France] ; Maurice Giroud [France] ; Christophe Tzourio [France] ; Alexis Elbaz [France]Source :
Abstract
Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.
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DOI: 10.1016/j.parkreldis.2011.04.020
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14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/neurologie-generale-vasculaire-degenerative-sip-1</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Giroud, Maurice" sort="Giroud, Maurice" uniqKey="Giroud M" first="Maurice" last="Giroud">Maurice Giroud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444681" status="VALID"> <orgName>Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)</orgName> <desc> <address> <addrLine>CHU de Dijon - 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Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00598387</idno><idno type="halId">inserm-00598387</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00598387</idno><idno type="url">http://www.hal.inserm.fr/inserm-00598387</idno><idno type="doi">10.1016/j.parkreldis.2011.04.020</idno><date when="2011-08">2011-08</date><idno type="wicri:Area/Hal/Corpus">000550</idno><idno type="wicri:Area/Hal/Curation">000550</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.</title><author><name sortKey="Fayard, Claudine" sort="Fayard, Claudine" uniqKey="Fayard C" first="Claudine" last="Fayard">Claudine Fayard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444681" status="VALID"> <orgName>Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/neurologie-generale-vasculaire-degenerative-sip-1</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bonaventure, Audrey" sort="Bonaventure, Audrey" uniqKey="Bonaventure A" first="Audrey" last="Bonaventure">Audrey Bonaventure</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Benatru">Isabelle Benatru</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444681" status="VALID"> <orgName>Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/neurologie-generale-vasculaire-degenerative-sip-1</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-43171" status="VALID"> <orgName>Fédération des Maladies du Système Nerveux</orgName> <desc> <address> <addrLine>47-83, boulevard de l'Hôpital - 75651 PARIS Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dumurgier, Julien" sort="Dumurgier, Julien" uniqKey="Dumurgier J" first="Julien" last="Dumurgier">Julien Dumurgier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Soumare, Aicha" sort="Soumare, Aicha" uniqKey="Soumare A" first="Aïcha" last="Soumaré">Aïcha Soumaré</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Houssinot, Jean" sort="Houssinot, Jean" uniqKey="Houssinot J" first="Jean" last="Houssinot">Jean Houssinot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-136524" status="INCOMING"> <orgName>Caisse centrale</orgName> <desc> <address> <addrLine>F-93547, Bagnolet</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-313137" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-313137" type="direct"><org type="institution" xml:id="struct-313137" status="INCOMING"> <orgName>Mutualité sociale agricole</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dupupet, Jean Luc" sort="Dupupet, Jean Luc" uniqKey="Dupupet J" first="Jean-Luc" last="Dupupet">Jean-Luc Dupupet</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-136524" status="INCOMING"> <orgName>Caisse centrale</orgName> <desc> <address> <addrLine>F-93547, Bagnolet</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-313137" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-313137" type="direct"><org type="institution" xml:id="struct-313137" status="INCOMING"> <orgName>Mutualité sociale agricole</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mazurie, Jean Louis" sort="Mazurie, Jean Louis" uniqKey="Mazurie J" first="Jean-Louis" last="Mazurie">Jean-Louis Mazurie</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-136525" status="INCOMING"> <orgName>Caisse départementale de la Gironde</orgName> <desc> <address> <addrLine>F-33052, Bordeaux</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-313137" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-313137" type="direct"><org type="institution" xml:id="struct-313137" status="INCOMING"> <orgName>Mutualité sociale agricole</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Balaboi, Irina" sort="Balaboi, Irina" uniqKey="Balaboi I" first="Irina" last="Balaboi">Irina Balaboi</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-93187" status="VALID"> <orgName>Service de neurologie [Poitiers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-54493" type="direct"></relation> <relation active="#struct-300170" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName> <desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 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86034 Poitiers Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-poitiers.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300170" type="direct"><org type="institution" xml:id="struct-300170" status="VALID"> <orgName>CHU de Poitiers</orgName> <desc> <address> <addrLine>2 Rue de la Milétrie, 86021 Poitiers</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-poitiers.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Poitiers</settlement><region type="region" nuts="2">Poitou-Charentes</region></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Krim, Elsa" sort="Krim, Elsa" uniqKey="Krim E" first="Elsa" last="Krim">Elsa Krim</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-157289" status="INCOMING"> <orgName>Service de neurologie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-310501" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-310501" type="direct"><org type="institution" xml:id="struct-310501" status="INCOMING"> <orgName>CHG Pau</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ranoux, Daniele" sort="Ranoux, Daniele" uniqKey="Ranoux D" first="Danièle" last="Ranoux">Danièle Ranoux</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-60000" status="INCOMING"> <orgName>Services de neurologie, neurochirurgie et soins palliatifs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300906" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300906" type="direct"><org type="institution" xml:id="struct-300906" status="VALID"> <orgName>CHU Limoges</orgName> <desc> <address> <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-limoges.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106188" status="VALID"> <idno type="IdRef">156182254</idno> <idno type="ISNI">0000 0004 0638 6872 </idno> <idno type="RNSR">201019083D</idno> <orgName>Centre de recherche en épidémiologie et santé des populations</orgName> <orgName type="acronym">CESP</orgName> <desc> <address> <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation active="#struct-81173" type="direct"></relation> <relation name="U1018" active="#struct-303623" type="direct"></relation> <relation active="#struct-300153" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc></org></tutelle><tutelle active="#struct-81173" type="direct"><org type="institution" xml:id="struct-81173" status="VALID"> <idno type="IdRef">03082057X</idno> <idno type="ISNI">0000 0001 2323 0229 </idno> <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName> <orgName type="acronym">UVSQ</orgName> <date type="start">1991-07-22</date> <desc> <address> <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.uvsq.fr/</ref> </desc></org></tutelle><tutelle name="U1018" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle active="#struct-300153" type="direct"><org type="institution" xml:id="struct-300153" status="VALID"> <orgName>Hôpital Paul Brousse</orgName> <desc> <address> <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName></affiliation></author><author><name sortKey="Imbernon, Ellen" sort="Imbernon, Ellen" uniqKey="Imbernon E" first="Ellen" last="Imbernon">Ellen Imbernon</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-22546" status="VALID"> <orgName>Département santé travail</orgName> <orgName type="acronym">DST-InVS</orgName> <desc> <address> <addrLine>12, rue du Val d'Osne 94415 Saint-Maurice Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.invs.sante.fr</ref> </desc> <listRelation> <relation active="#struct-305680" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-305680" type="direct"><org type="institution" xml:id="struct-305680" status="INCOMING"> <orgName>Institut de Veille Sanitaire</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Moreau, Thibault" sort="Moreau, Thibault" uniqKey="Moreau T" first="Thibault" last="Moreau">Thibault Moreau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444681" status="VALID"> <orgName>Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/neurologie-generale-vasculaire-degenerative-sip-1</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Giroud, Maurice" sort="Giroud, Maurice" uniqKey="Giroud M" first="Maurice" last="Giroud">Maurice Giroud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444681" status="VALID"> <orgName>Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)</orgName> <desc> <address> <addrLine>CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr/service/neurologie-generale-vasculaire-degenerative-sip-1</ref> </desc> <listRelation> <relation active="#struct-300924" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300924" type="direct"><org type="institution" xml:id="struct-300924" status="VALID"> <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName> <orgName type="acronym">CHU Dijon</orgName> <desc> <address> <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-dijon.fr/fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"> <orgName>Neuroépidémiologie</orgName> <desc> <address> <addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U708" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U708" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.parkreldis.2011.04.020</idno></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="es"><term>Epidemiology</term><term>Guidelines</term><term>Medical practice</term><term>Parkinson's disease</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.</div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.</title> <author role="aut"> <persName> <forename type="first">Claudine</forename> <surname>Fayard</surname> </persName> <idno type="halauthorid">614835</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Audrey</forename> <surname>Bonaventure</surname> </persName> <idno type="halauthorid">614836</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Benatru</surname> </persName> <idno type="halauthorid">604645</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Emmanuel</forename> <surname>Roze</surname> </persName> <idno type="halauthorid">217010</idno> <affiliation ref="#struct-43171"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Julien</forename> <surname>Dumurgier</surname> </persName> <idno type="halauthorid">614837</idno> <affiliation ref="#struct-3066"></affiliation> <affiliation ref="#struct-157288"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Moisan</surname> </persName> <idno type="halauthorid">361186</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aïcha</forename> <surname>Soumaré</surname> </persName> <idno type="halauthorid">614838</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean</forename> <surname>Houssinot</surname> </persName> <idno type="halauthorid">614839</idno> <affiliation ref="#struct-136524"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Luc</forename> <surname>Dupupet</surname> </persName> <idno type="halauthorid">560283</idno> <affiliation ref="#struct-136524"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Louis</forename> <surname>Mazurie</surname> </persName> <idno type="halauthorid">560285</idno> <affiliation ref="#struct-136525"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Irina</forename> <surname>Balaboi</surname> </persName> <idno type="halauthorid">614840</idno> <affiliation ref="#struct-93187"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Luc</forename> <surname>Houeto</surname> </persName> <idno type="halauthorid">214478</idno> <affiliation ref="#struct-93187"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Elsa</forename> <surname>Krim</surname> </persName> <idno type="halauthorid">614841</idno> <affiliation ref="#struct-157289"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Danièle</forename> <surname>Ranoux</surname> </persName> <idno type="halauthorid">315773</idno> <affiliation ref="#struct-60000"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marcel</forename> <surname>Goldberg</surname> </persName> <idno type="halauthorid">112736</idno> <affiliation ref="#struct-106188"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ellen</forename> <surname>Imbernon</surname> </persName> <idno type="halauthorid">139576</idno> <affiliation ref="#struct-22546"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thibault</forename> <surname>Moreau</surname> </persName> <idno type="halauthorid">564521</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maurice</forename> <surname>Giroud</surname> </persName> <idno type="halauthorid">454055</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Tzourio</surname> </persName> <idno type="halauthorid">205118</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Alexis</forename> <surname>Elbaz</surname> </persName> <email type="md5">dbddf5e2cdc0c668b7f6baa5a6407f4b</email> <email type="domain">upmc.fr</email> <idno type="halauthorid">560286</idno> <affiliation ref="#struct-3066"></affiliation> <affiliation ref="#struct-22546"></affiliation> </author> <editor role="depositor"> <persName> <forename>Annie</forename> <surname>Schmaus</surname> </persName> <email type="md5">2b5c7455c3506864c2d144aee0b90da1</email> <email type="domain">inserm.fr</email> </editor> <funder>This work was funded by Institut national de la santé et de la recherche médicale (Inserm), Agence Nationale de la Recherche (ANR Santé-environnement et santé-travail), Agence française de sécurité sanitaire de l'environnement et du travail (Afsset), and France Parkinson. FM was supported by a scholarship from the Ministère de l'enseignement supérieur et de la recherche.</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2011-06-06 14:08:58</date> <date type="whenModified">2017-02-09 14:57:25</date> <date type="whenReleased">2011-06-06 15:46:30</date> <date type="whenProduced">2011-08</date> <date type="whenEndEmbargoed">9999-12-31</date> <ref type="file" target="http://www.hal.inserm.fr/inserm-00598387/document"> <date notBefore="9999-12-31"></date> </ref> <ref type="file" subtype="greenPublisher" n="1" target="http://www.hal.inserm.fr/inserm-00598387/file/Fayard_et_al_Parkinsonism_and_Related_Disorders_2011.pdf"> <date notBefore="9999-12-31"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="159747"> <persName> <forename>Annie</forename> <surname>Schmaus</surname> </persName> <email type="md5">2b5c7455c3506864c2d144aee0b90da1</email> <email type="domain">inserm.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">inserm-00598387</idno> <idno type="halUri">http://www.hal.inserm.fr/inserm-00598387</idno> <idno type="halBibtex">fayard:inserm-00598387</idno> <idno type="halRefHtml">Parkinsonism & Related Disorders, 2011, 17 (7), pp.543-6. <10.1016/j.parkreldis.2011.04.020></idno> <idno type="halRef">Parkinsonism & Related Disorders, 2011, 17 (7), pp.543-6. <10.1016/j.parkreldis.2011.04.020></idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="SANTE_PUB_INSERM" p="INSERM">Santé Publique à l'Inserm</idno> <idno type="stamp" n="CESP" p="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno> <idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno> <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno> <idno type="stamp" n="UNIV-PSUD">Université Paris Sud - Paris XI</idno> <idno type="stamp" n="INVS">Institut de veille sanitaire</idno> <idno type="stamp" n="APHP" p="INSERM">AP-HP</idno> <idno type="stamp" n="UNIV-POITIERS">Université de Poitiers</idno> <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.</title> <author role="aut"> <persName> <forename type="first">Claudine</forename> <surname>Fayard</surname> </persName> <idno type="halauthorid">614835</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Audrey</forename> <surname>Bonaventure</surname> </persName> <idno type="halauthorid">614836</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Benatru</surname> </persName> <idno type="halauthorid">604645</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Emmanuel</forename> <surname>Roze</surname> </persName> <idno type="halauthorid">217010</idno> <affiliation ref="#struct-43171"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Julien</forename> <surname>Dumurgier</surname> </persName> <idno type="halauthorid">614837</idno> <affiliation ref="#struct-3066"></affiliation> <affiliation ref="#struct-157288"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Frédéric</forename> <surname>Moisan</surname> </persName> <idno type="halauthorid">361186</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Aïcha</forename> <surname>Soumaré</surname> </persName> <idno type="halauthorid">614838</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean</forename> <surname>Houssinot</surname> </persName> <idno type="halauthorid">614839</idno> <affiliation ref="#struct-136524"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Luc</forename> <surname>Dupupet</surname> </persName> <idno type="halauthorid">560283</idno> <affiliation ref="#struct-136524"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Louis</forename> <surname>Mazurie</surname> </persName> <idno type="halauthorid">560285</idno> <affiliation ref="#struct-136525"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Irina</forename> <surname>Balaboi</surname> </persName> <idno type="halauthorid">614840</idno> <affiliation ref="#struct-93187"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Luc</forename> <surname>Houeto</surname> </persName> <idno type="halauthorid">214478</idno> <affiliation ref="#struct-93187"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Elsa</forename> <surname>Krim</surname> </persName> <idno type="halauthorid">614841</idno> <affiliation ref="#struct-157289"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Danièle</forename> <surname>Ranoux</surname> </persName> <idno type="halauthorid">315773</idno> <affiliation ref="#struct-60000"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marcel</forename> <surname>Goldberg</surname> </persName> <idno type="halauthorid">112736</idno> <affiliation ref="#struct-106188"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ellen</forename> <surname>Imbernon</surname> </persName> <idno type="halauthorid">139576</idno> <affiliation ref="#struct-22546"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thibault</forename> <surname>Moreau</surname> </persName> <idno type="halauthorid">564521</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maurice</forename> <surname>Giroud</surname> </persName> <idno type="halauthorid">454055</idno> <affiliation ref="#struct-444681"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christophe</forename> <surname>Tzourio</surname> </persName> <idno type="halauthorid">205118</idno> <affiliation ref="#struct-3066"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Alexis</forename> <surname>Elbaz</surname> </persName> <email type="md5">dbddf5e2cdc0c668b7f6baa5a6407f4b</email> <email type="domain">upmc.fr</email> <idno type="halauthorid">560286</idno> <affiliation ref="#struct-3066"></affiliation> <affiliation ref="#struct-22546"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="INCOMING">70482</idno> <title level="j">Parkinsonism & Related Disorders</title> <imprint> <biblScope unit="volume">17</biblScope> <biblScope unit="issue">7</biblScope> <biblScope unit="pp">543-6</biblScope> <date type="datePub">2011-08</date> <date type="dateEpub">2011-05-25</date> </imprint> </monogr> <idno type="doi">10.1016/j.parkreldis.2011.04.020</idno> <idno type="pubmed">21612970</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="es">Parkinson's disease</term> <term xml:lang="es">Guidelines</term> <term xml:lang="es">Epidemiology</term> <term xml:lang="es">Medical practice</term> </keywords> <classCode scheme="mesh">Aged</classCode> <classCode scheme="mesh">Antiparkinson Agents</classCode> <classCode scheme="mesh">Middle Aged</classCode> <classCode scheme="mesh">Parkinson Disease</classCode> <classCode scheme="mesh">Physician's Practice Patterns</classCode> <classCode scheme="mesh">Practice Guidelines as Topic</classCode> <classCode scheme="mesh">Consensus Development Conferences as Topic</classCode> <classCode scheme="mesh">Dopamine Agonists</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="mesh">France</classCode> <classCode scheme="mesh">Guideline Adherence</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Levodopa</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en">Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.</abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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