ParkinsonFranceV1, Hal, Curation, bibRecord, 000387

Epidemiologic studies of environmental exposures in Parkinson's disease.

Identifieur interne : 000387 ( Hal/Curation ); précédent : 000386; suivant : 000388

Epidemiologic studies of environmental exposures in Parkinson's disease.

Auteurs : Alexis Elbaz [France] ; Christine Tranchant [France]

Source :

Journal of the Neurological Sciences [ 0022-510X ] ; 2007-11-15.

RBID : Hal:inserm-00177220

Descripteurs français

mix :
- Environment, Gene-environment interaction, Parkinson's disease, Risk factors.

Abstract

Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Because of the ageing of Western populations, an increasing number of persons will be affected with PD in the future and neither curative treatments nor preventive measures have been identified. PD is considered as a multifactorial disease, resulting from the effect of environmental factors and genetic susceptibility. Increasing age and male sex appear to be associated with an increased risk of PD. In addition, recent epidemiological studies have identified environmental exposures that influence the risk of PD. This review provides an overview of the epidemiologic evidence for environmental etiologies in PD; we will focus on two environmental exposures that have been quite consistently associated with PD - cigarette smoking and pesticide exposure - and will summarize briefly the findings for other exposures. Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs.

Url:

http://www.hal.inserm.fr/inserm-00177220

DOI: 10.1016/j.jns.2007.06.024

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Le document en format XML

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Epidemiologic studies of environmental exposures in Parkinson's disease.

Epidemiologic studies of environmental exposures in Parkinson's disease.

Source :

Descripteurs français

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri