The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom.
Identifieur interne : 000B26 ( Hal/Corpus ); précédent : 000B25; suivant : 000B27The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom.
Auteurs : Paul Mccrone ; Christine Anne Mary Payan ; Martin Knapp ; Albert Ludolph ; Yves Agid ; P Nigel Leigh ; Gilbert Bensimon ; Nnipps Study GroupSource :
- Plant Methods [ 1746-4811 ] ; 2011.
Abstract
Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are progressive disabling neurological conditions usually fatal within 10 years of onset. Little is known about the economic costs of these conditions. This paper reports service use and costs from France, Germany and the UK and identifies patient characteristics that are associated with cost. 767 patients were recruited, and 760 included in the study, from 44 centres as part of the NNIPPS trial. Service use during the previous six months was measured at entry to the study and costs calculated. Mean six-month costs were calculated for 742 patients. Data on patient sociodemographic and clinical characteristics were recorded and used in regression models to identify predictors of service costs and unpaid care costs (i.e., care from family and friends). The mean six-month service costs of PSP were €24,491 in France, €30,643 in Germany and €25,655 in the UK. The costs for MSA were €28,924, €25,645 and €19,103 respectively. Unpaid care accounted for 68-76%. Formal and unpaid costs were significantly higher the more severe the illness, as indicated by the Parkinson's Plus Symptom scale. There was a significant inverse relationship between service and unpaid care costs.
Url:
DOI: 10.1371/journal.pone.0024369
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<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are progressive disabling neurological conditions usually fatal within 10 years of onset. Little is known about the economic costs of these conditions. This paper reports service use and costs from France, Germany and the UK and identifies patient characteristics that are associated with cost. 767 patients were recruited, and 760 included in the study, from 44 centres as part of the NNIPPS trial. Service use during the previous six months was measured at entry to the study and costs calculated. Mean six-month costs were calculated for 742 patients. Data on patient sociodemographic and clinical characteristics were recorded and used in regression models to identify predictors of service costs and unpaid care costs (i.e., care from family and friends). The mean six-month service costs of PSP were €24,491 in France, €30,643 in Germany and €25,655 in the UK. The costs for MSA were €28,924, €25,645 and €19,103 respectively. Unpaid care accounted for 68-76%. Formal and unpaid costs were significantly higher the more severe the illness, as indicated by the Parkinson's Plus Symptom scale. There was a significant inverse relationship between service and unpaid care costs.</div>
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<idno type="halRefHtml">Plant Methods, BioMed Central, 2011, 6 (9), pp.e24369. <10.1371/journal.pone.0024369></idno>
<idno type="halRef">Plant Methods, BioMed Central, 2011, 6 (9), pp.e24369. <10.1371/journal.pone.0024369></idno>
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<seriesStmt> <idno type="stamp" n="UNILIM">Université de Limoges</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
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<idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
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<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom.</title>
<author role="crp"> <persName> <forename type="first">Paul</forename>
<surname>Mccrone</surname>
</persName>
<email type="md5">073f7a325d0651ce71ab3118337285bc</email>
<email type="domain">kcl.ac.uk</email>
<idno type="halauthorid">965555</idno>
<affiliation ref="#struct-161214"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Christine Anne Mary</forename>
<surname>Payan</surname>
</persName>
<idno type="halauthorid">965556</idno>
</author>
<author role="aut"> <persName> <forename type="first">Martin</forename>
<surname>Knapp</surname>
</persName>
<idno type="halauthorid">965557</idno>
</author>
<author role="aut"> <persName> <forename type="first">Albert</forename>
<surname>Ludolph</surname>
</persName>
<idno type="halauthorid">620647</idno>
<affiliation ref="#struct-174362"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Yves</forename>
<surname>Agid</surname>
</persName>
<idno type="halauthorid">217013</idno>
<affiliation ref="#struct-43171"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">P Nigel</forename>
<surname>Leigh</surname>
</persName>
<idno type="halauthorid">620649</idno>
<affiliation ref="#struct-138540"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Gilbert</forename>
<surname>Bensimon</surname>
</persName>
<idno type="halauthorid">538699</idno>
<affiliation ref="#struct-210917"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Nnipps</forename>
<surname>Study Group</surname>
</persName>
<idno type="halauthorid">968357</idno>
<affiliation ref="#struct-55201"></affiliation>
</author>
</analytic>
<monogr> <idno type="localRef">IF: 2.153</idno>
<idno type="halJournalId" status="VALID">1948</idno>
<idno type="issn">1746-4811</idno>
<title level="j">Plant Methods</title>
<imprint> <publisher>BioMed Central</publisher>
<biblScope unit="volume">6</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="pp">e24369</biblScope>
<date type="datePub">2011</date>
<date type="dateEpub">2011-09-08</date>
</imprint>
</monogr>
<idno type="doi">10.1371/journal.pone.0024369</idno>
<idno type="pubmed">21931694</idno>
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<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="mesh">Multiple System Atrophy</classCode>
<classCode scheme="mesh">Severity of Illness Index</classCode>
<classCode scheme="mesh">Supranuclear Palsy, Progressive</classCode>
<classCode scheme="mesh">France</classCode>
<classCode scheme="mesh">Germany</classCode>
<classCode scheme="mesh">Great Britain</classCode>
<classCode scheme="mesh">Health Services</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are progressive disabling neurological conditions usually fatal within 10 years of onset. Little is known about the economic costs of these conditions. This paper reports service use and costs from France, Germany and the UK and identifies patient characteristics that are associated with cost. 767 patients were recruited, and 760 included in the study, from 44 centres as part of the NNIPPS trial. Service use during the previous six months was measured at entry to the study and costs calculated. Mean six-month costs were calculated for 742 patients. Data on patient sociodemographic and clinical characteristics were recorded and used in regression models to identify predictors of service costs and unpaid care costs (i.e., care from family and friends). The mean six-month service costs of PSP were €24,491 in France, €30,643 in Germany and €25,655 in the UK. The costs for MSA were €28,924, €25,645 and €19,103 respectively. Unpaid care accounted for 68-76%. Formal and unpaid costs were significantly higher the more severe the illness, as indicated by the Parkinson's Plus Symptom scale. There was a significant inverse relationship between service and unpaid care costs.</abstract>
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