Study of vine stilbenes neuroprotective effects on Parkinson’s disease
Identifieur interne : 000A50 ( Hal/Corpus ); précédent : 000A49; suivant : 000A51Study of vine stilbenes neuroprotective effects on Parkinson’s disease
Auteurs : Hamza TemsamaniSource :
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Abstract
Parkinson’s disease is one of the most spread neurodegenerative diseases in the world. Post mortem analyses have put in evidence small inclusion bodies in patient’s brain, composed of α-synuclein fibrils. Several studies attempted then to identify compounds that could inhibit α-synuclein aggregation, as its aggregation is linked to its toxicity. Still, numerous active compounds need to be identified in order to put on relief shared active structures that could lead to a potent drug design. Stilbenes are phenolic compounds that often display interesting health-related biological activities. In this study, the anti-aggregative behavior of stilbenes monomers (resveratrol, piceatannol) and oligomers such as ampelopsin and isohopeaphenol was assessed. The results put on evidence stilbene propensity to inhibit α-synuclein aggregation and provide an insight into their inhibition mechanisms.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Study of vine stilbenes neuroprotective effects on Parkinson’s disease</title><title xml:lang="fr">Etude des effets neuroprotecteurs des stilbènes de la vigne sur la maladie de Parkinson</title><author><name sortKey="Temsamani, Hamza" sort="Temsamani, Hamza" uniqKey="Temsamani H" first="Hamza" last="Temsamani">Hamza Temsamani</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-51092" status="INCOMING"><orgName>Groupe d'Etude des Substances Végétales à Activité Biologique</orgName><orgName type="acronym">GESVAB - EA 3675</orgName><desc><address><addrLine>Université Victor Segalen Bordeaux 2</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-91134" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-91134" type="direct"><org type="institution" xml:id="struct-91134" status="OLD"><orgName>Université Bordeaux Segalen - Bordeaux 2</orgName><desc><address><addrLine>146 rue Léo Saignat - 33076 Bordeaux cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-bordeauxsegalen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:tel-01290204</idno><idno type="halId">tel-01290204</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01290204</idno><idno type="url">https://tel.archives-ouvertes.fr/tel-01290204</idno><date when="2015-12-18">2015-12-18</date><idno type="wicri:Area/Hal/Corpus">000A50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Study of vine stilbenes neuroprotective effects on Parkinson’s disease</title><title xml:lang="fr">Etude des effets neuroprotecteurs des stilbènes de la vigne sur la maladie de Parkinson</title><author><name sortKey="Temsamani, Hamza" sort="Temsamani, Hamza" uniqKey="Temsamani H" first="Hamza" last="Temsamani">Hamza Temsamani</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-51092" status="INCOMING"><orgName>Groupe d'Etude des Substances Végétales à Activité Biologique</orgName><orgName type="acronym">GESVAB - EA 3675</orgName><desc><address><addrLine>Université Victor Segalen Bordeaux 2</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-91134" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-91134" type="direct"><org type="institution" xml:id="struct-91134" status="OLD"><orgName>Université Bordeaux Segalen - Bordeaux 2</orgName><desc><address><addrLine>146 rue Léo Saignat - 33076 Bordeaux cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-bordeauxsegalen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Neuroprotection</term><term>Parkinson’s disease</term><term>Polyphenol</term><term>Stilbene</term><term>Α-synuclein</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Maladie de Parkinson</term><term>Α-synucléine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson’s disease is one of the most spread neurodegenerative diseases in the world. Post mortem analyses have put in evidence small inclusion bodies in patient’s brain, composed of α-synuclein fibrils. Several studies attempted then to identify compounds that could inhibit α-synuclein aggregation, as its aggregation is linked to its toxicity. Still, numerous active compounds need to be identified in order to put on relief shared active structures that could lead to a potent drug design. Stilbenes are phenolic compounds that often display interesting health-related biological activities. In this study, the anti-aggregative behavior of stilbenes monomers (resveratrol, piceatannol) and oligomers such as ampelopsin and isohopeaphenol was assessed. The results put on evidence stilbene propensity to inhibit α-synuclein aggregation and provide an insight into their inhibition mechanisms.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Study of vine stilbenes neuroprotective effects on Parkinson’s disease</title><title xml:lang="fr">Etude des effets neuroprotecteurs des stilbènes de la vigne sur la maladie de Parkinson</title><author role="aut"><persName><forename type="first">Hamza</forename><surname>Temsamani</surname></persName><idno type="halauthorid">828494</idno><idno type="IdRef">http://www.idref.fr/192007742</idno><affiliation ref="#struct-51092"></affiliation></author><editor role="depositor"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2016-03-17 16:52:30</date><date type="whenModified">2016-05-25 04:09:04</date><date type="whenReleased">2016-03-18 09:47:16</date><date type="whenProduced">2015-12-18</date><date type="whenEndEmbargoed">2016-03-17</date><ref type="file" target="https://tel.archives-ouvertes.fr/tel-01290204/document"><date notBefore="2016-03-17"></date></ref><ref type="file" subtype="author" n="1" target="https://tel.archives-ouvertes.fr/tel-01290204/file/TEMSAMANI_HAMZA_2015.pdf"><date notBefore="2016-03-17"></date></ref></edition><respStmt><resp>contributor</resp><name key="131274"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">tel-01290204</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01290204</idno><idno type="halBibtex">temsamani:tel-01290204</idno><idno type="halRefHtml">Médecine humaine et pathologie. Université de Bordeaux, 2015. Français. <NNT : 2015BORD0433></idno><idno type="halRef">Médecine humaine et pathologie. Université de Bordeaux, 2015. Français. <NNT : 2015BORD0433></idno></publicationStmt><seriesStmt><idno type="stamp" n="STAR">STAR - Dépôt national des thèses électroniques</idno><idno type="stamp" n="U-BORDEAUX">Université de Bordeaux</idno></seriesStmt><notesStmt></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Study of vine stilbenes neuroprotective effects on Parkinson’s disease</title><title xml:lang="fr">Etude des effets neuroprotecteurs des stilbènes de la vigne sur la maladie de Parkinson</title><author role="aut"><persName><forename type="first">Hamza</forename><surname>Temsamani</surname></persName><idno type="halauthorid">828494</idno><idno type="IdRef">http://www.idref.fr/192007742</idno><affiliation ref="#struct-51092"></affiliation></author></analytic><monogr><idno type="nnt">2015BORD0433</idno><imprint><date type="dateDefended">2015-12-18</date></imprint><authority type="institution">Université de Bordeaux</authority><authority type="school">École doctorale Sciences de la vie et de la santé (Bordeaux)</authority><authority type="supervisor">Tristan Richard</authority><authority type="jury">Stéphanie Krisa [Président]</authority><authority type="jury">Dominique Delmas [Rapporteur]</authority><authority type="jury">Cédric Saucier [Rapporteur]</authority></monogr></biblStruct></sourceDesc><profileDesc><langUsage><language ident="fr">French</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Parkinson’s disease</term><term xml:lang="en">Α-synuclein</term><term xml:lang="en">Polyphenol</term><term xml:lang="en">Stilbene</term><term xml:lang="en">Neuroprotection</term><term xml:lang="fr">Maladie de Parkinson</term><term xml:lang="fr">Α-synucléine</term></keywords><classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode><classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode><classCode scheme="halTypology" n="THESE">Theses</classCode></textClass><abstract xml:lang="en">Parkinson’s disease is one of the most spread neurodegenerative diseases in the world. Post mortem analyses have put in evidence small inclusion bodies in patient’s brain, composed of α-synuclein fibrils. Several studies attempted then to identify compounds that could inhibit α-synuclein aggregation, as its aggregation is linked to its toxicity. Still, numerous active compounds need to be identified in order to put on relief shared active structures that could lead to a potent drug design. Stilbenes are phenolic compounds that often display interesting health-related biological activities. In this study, the anti-aggregative behavior of stilbenes monomers (resveratrol, piceatannol) and oligomers such as ampelopsin and isohopeaphenol was assessed. The results put on evidence stilbene propensity to inhibit α-synuclein aggregation and provide an insight into their inhibition mechanisms.</abstract><abstract xml:lang="fr">La maladie de Parkinson est l’une des plus répandue dans le monde. Des analyses post mortem ont mis en évidences des inclusions dans les cerveaux des patients, composées d’α-synucléine. Plusieurs études ont visé à identifier des composés capables d’inhiber l’agrégation de cette protéine, étant donné que cette agrégation est liée à sa toxicité. Néanmoins, de nombreux composés restent encore à être identifiés afin de mettre en évidence des structures moléculaires actives partagées qui pourrait mener à la synthèse d’un principe actif. Les stilbènes sont des composés phénoliques démontrant régulièrement des activités biologiques intéressantes pour la santé. Dans cette étude, nous étudions le comportement anti-agrégatif des stilbènes monomériques (resvératrol, picéatannol) et oligomèriques (ampélopsine, viniférine, et isohopeaphénol). Les résultats présentés mettent en évidence la capacité des stilbènes à inhiber l’agrégation de l’α-synucléine et fournissent des éléments pour comprendre ce mécanisme.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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