Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method
Identifieur interne : 000636 ( Hal/Corpus ); précédent : 000635; suivant : 000637Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method
Auteurs : Jérôme Yelnik ; P. Damier ; S. Demeret ; D. Gervais ; Eric Bardinet ; B. P. Bejjani ; C. François ; J. L. Houeto ; I. Arnule ; Didier Dormont ; Damien Galanaud ; Bernard Pidoux ; Philippe Cornu ; Yves AgidSource :
- Journal of Neurosurgery [ 0022-3085 ] ; 2003.
Abstract
OBJECT: The aim of this study was to correlate the clinical improvement in patients with Parkinson disease (PD) treated using deep brain stimulation (DBS) of the subthalamic nucleus (STN) with the precise anatomical localization of stimulating electrodes. METHODS: Localization was determined by superimposing figures from an anatomical atlas with postoperative magnetic resonance (MR) images obtained in each patient. This approach was validated by an analysis of experimental and clinical MR images of the electrode, and the development of a three-dimensional (3D) atlas-MR imaging coregistration method. The PD motor score was assessed through two contacts for each of two electrodes implanted in 10 patients: the "therapeutic contact" and the "distant contact" (that is, the next but one to the therapeutic contact). Seventeen therapeutic contacts were located within or on the border of the STN, most of which were associated with significant improvement of the four PD symptoms tested. Therapeutic contacts located in other structures (zona incerta, lenticular fasciculus, or midbrain reticular formation) were also linked to a significant positive effect. Stimulation applied through distant contacts located in the STN improved symptoms of PD, whereas that delivered through distant contacts in the remaining structures had variable effects ranging from worsening of symptoms to their improvement. CONCLUSIONS: The authors have demonstrated that 3D atlas-MR imaging coregistration is a reliable method for the precise localization of DBS electrodes on postoperative MR images. In addition, they have confirmed that although the STN is the main target during DBS treatment for PD, stimulation of surrounding regions, particularly the zona incerta or the lenticular fasciculus, can also improve symptoms of PD.
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Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"> <orgName>IFR70</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="U679" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inria-00615635</idno><idno type="halId">inria-00615635</idno><idno type="halUri">https://hal.inria.fr/inria-00615635</idno><idno type="url">https://hal.inria.fr/inria-00615635</idno><date when="2003">2003</date><idno type="wicri:Area/Hal/Corpus">000636</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method</title><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"> <orgName>Neurologie et thérapeutique expérimentale</orgName> <desc> <address> <addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300636" type="direct"></relation> <relation name="U679" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"> <orgName>IFR70</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="U679" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-111538" status="VALID"><orgName>Clinique neurologique</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-305392" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-305392" type="direct"><org type="institution" xml:id="struct-305392" status="INCOMING"><orgName>Hôpital Laennec</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S." last="Demeret">S. Demeret</name><affiliation><hal:affiliation type="department" xml:id="struct-18479" status="VALID"><orgName>Service de neurologie 1 [CHU Pitié-Salpétrière]</orgName><desc><address><addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300068" type="direct"></relation><relation active="#struct-353778" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"><orgName>CHU Pitié-Salpêtrière [APHP]</orgName><desc><address><addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Gervais, D" sort="Gervais, D" uniqKey="Gervais D" first="D." last="Gervais">D. Gervais</name></author><author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"> <orgName>Neurologie et thérapeutique expérimentale</orgName> <desc> <address> <addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300636" type="direct"></relation> <relation name="U679" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"> <orgName>IFR70</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="U679" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bejjani, B P" sort="Bejjani, B P" uniqKey="Bejjani B" first="B. P." last="Bejjani">B. P. Bejjani</name></author><author><name sortKey="Francois, C" sort="Francois, C" uniqKey="Francois C" first="C." last="François">C. François</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName><orgName type="acronym">IBCP</orgName><desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine><country key="FR"></country></address><ref type="url">http://www.ibcp.fr</ref></desc><listRelation><relation active="#struct-194495" type="direct"></relation><relation name="UMR5086" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName><orgName type="acronym">UCBL</orgName><desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lyon1.fr/</ref></desc></org></tutelle><tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno><idno type="ISNI">0000000122597504</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name></author><author><name sortKey="Arnule, I" sort="Arnule, I" uniqKey="Arnule I" first="I." last="Arnule">I. Arnule</name></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-81470" status="OLD"><orgName>Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière</orgName><orgName type="acronym">CRICM</orgName><desc><address><addrLine>GH Pitié-Salpêtrière 47, boulevard de l'Hôpital 75651 Paris cedex 13</addrLine><country key="FR"></country></address><ref type="url">http://www.cricm.upmc.fr/</ref></desc><listRelation><relation active="#struct-93591" type="direct"></relation><relation name="U975" active="#struct-303623" type="direct"></relation><relation name="UMR7225" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U975" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno><idno type="ISNI">0000000122597504</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name><affiliation><hal:affiliation type="department" xml:id="struct-41020" status="VALID"><orgName>Service de neuro-radiologie [CHU Pitié-Salpêtrière]</orgName><desc><address><addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-353778" type="direct"></relation><relation active="#struct-300068" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"><orgName>CHU Pitié-Salpêtrière [APHP]</orgName><desc><address><addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref></desc></org></tutelle><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation><hal:affiliation type="department" xml:id="struct-455092" status="VALID"><orgName>Service de Neurochirurgie [CHU Pitié-Salpêtrière]</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-300068" type="direct"></relation><relation active="#struct-353778" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"><orgName>CHU Pitié-Salpêtrière [APHP]</orgName><desc><address><addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><affiliation><hal:affiliation type="department" xml:id="struct-455092" status="VALID"><orgName>Service de Neurochirurgie [CHU Pitié-Salpêtrière]</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-300068" type="direct"></relation><relation active="#struct-353778" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"><orgName>CHU Pitié-Salpêtrière [APHP]</orgName><desc><address><addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"> <orgName>Neurologie et thérapeutique expérimentale</orgName> <desc> <address> <addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300636" type="direct"></relation> <relation name="U679" active="#struct-303623" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"> <orgName>IFR70</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="U679" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><series><title level="j">Journal of Neurosurgery</title><idno type="ISSN">0022-3085</idno><imprint><date type="datePub">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECT: The aim of this study was to correlate the clinical improvement in patients with Parkinson disease (PD) treated using deep brain stimulation (DBS) of the subthalamic nucleus (STN) with the precise anatomical localization of stimulating electrodes. METHODS: Localization was determined by superimposing figures from an anatomical atlas with postoperative magnetic resonance (MR) images obtained in each patient. This approach was validated by an analysis of experimental and clinical MR images of the electrode, and the development of a three-dimensional (3D) atlas-MR imaging coregistration method. The PD motor score was assessed through two contacts for each of two electrodes implanted in 10 patients: the "therapeutic contact" and the "distant contact" (that is, the next but one to the therapeutic contact). Seventeen therapeutic contacts were located within or on the border of the STN, most of which were associated with significant improvement of the four PD symptoms tested. Therapeutic contacts located in other structures (zona incerta, lenticular fasciculus, or midbrain reticular formation) were also linked to a significant positive effect. Stimulation applied through distant contacts located in the STN improved symptoms of PD, whereas that delivered through distant contacts in the remaining structures had variable effects ranging from worsening of symptoms to their improvement. CONCLUSIONS: The authors have demonstrated that 3D atlas-MR imaging coregistration is a reliable method for the precise localization of DBS electrodes on postoperative MR images. In addition, they have confirmed that although the STN is the main target during DBS treatment for PD, stimulation of surrounding regions, particularly the zona incerta or the lenticular fasciculus, can also improve symptoms of PD.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method</title><author role="aut"><persName><forename type="first">Jérôme</forename><surname>Yelnik</surname></persName><idno type="halauthorid">404202</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-353778"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-95919"></affiliation></author><author role="aut"><persName><forename type="first">P.</forename><surname>Damier</surname></persName><idno type="halauthorid">112525</idno><affiliation ref="#struct-111538"></affiliation></author><author role="aut"><persName><forename type="first">S.</forename><surname>Demeret</surname></persName><idno type="halauthorid">301328</idno><affiliation ref="#struct-18479"></affiliation></author><author role="aut"><persName><forename type="first">D.</forename><surname>Gervais</surname></persName><idno type="halauthorid">634604</idno></author><author role="aut"><persName><forename type="first">Eric</forename><surname>Bardinet</surname></persName><idno type="halauthorid">98501</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-422"></affiliation><affiliation ref="#struct-2459"></affiliation></author><author role="aut"><persName><forename type="first">B.P.</forename><surname>Bejjani</surname></persName><idno type="halauthorid">634605</idno></author><author role="aut"><persName><forename type="first">C.</forename><surname>François</surname></persName><idno type="halauthorid">317176</idno><affiliation ref="#struct-581"></affiliation><affiliation ref="#struct-1230"></affiliation></author><author role="aut"><persName><forename type="first">J.L.</forename><surname>Houeto</surname></persName><idno type="halauthorid">112531</idno></author><author role="aut"><persName><forename type="first">I.</forename><surname>Arnule</surname></persName><idno type="halauthorid">634606</idno></author><author role="aut"><persName><forename type="first">Didier</forename><surname>Dormont</surname></persName><idno type="halauthorid">98507</idno><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-422"></affiliation><affiliation ref="#struct-41020"></affiliation><affiliation ref="#struct-3036"></affiliation></author><author role="crp"><persName><forename type="first">Damien</forename><surname>Galanaud</surname></persName><email type="md5">4179a5f00eceac608cc170e2d54934f2</email><email type="domain">gmail.com</email><idno type="halauthorid">499123</idno><affiliation ref="#struct-41020"></affiliation><affiliation ref="#struct-480402"></affiliation></author><author role="aut"><persName><forename type="first">Bernard</forename><surname>Pidoux</surname></persName><idno type="halauthorid">403865</idno><affiliation ref="#struct-455092"></affiliation></author><author role="aut"><persName><forename type="first">Philippe</forename><surname>Cornu</surname></persName><idno type="halauthorid">385265</idno><affiliation ref="#struct-455092"></affiliation></author><author role="aut"><persName><forename type="first">Yves</forename><surname>Agid</surname></persName><idno type="halauthorid">217013</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-95919"></affiliation><affiliation ref="#struct-18479"></affiliation><affiliation ref="#struct-455092"></affiliation><affiliation ref="#struct-2623"></affiliation><affiliation ref="#struct-23330"></affiliation><affiliation ref="#struct-16845"></affiliation></author><editor role="depositor"><persName><forename>Project-Team</forename><surname>Asclepios</surname></persName><email type="md5">153d489f712c736f0e518aaa23216ea6</email><email type="domain">inria.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2011-08-19 18:06:09</date><date type="whenWritten">2003</date><date type="whenModified">2017-01-04 16:21:45</date><date type="whenReleased">2011-08-19 18:06:09</date><date type="whenProduced">2003</date></edition><respStmt><resp>contributor</resp><name key="167080"><persName><forename>Project-Team</forename><surname>Asclepios</surname></persName><email type="md5">153d489f712c736f0e518aaa23216ea6</email><email type="domain">inria.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inria-00615635</idno><idno type="halUri">https://hal.inria.fr/inria-00615635</idno><idno type="halBibtex">yelnik:inria-00615635</idno><idno type="halRefHtml">Journal of Neurosurgery, American Association of Neurological Surgeons, 2003, 99 (1), pp.89--99</idno><idno type="halRef">Journal of Neurosurgery, American Association of Neurological Surgeons, 2003, 99 (1), pp.89--99</idno></publicationStmt><seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno><idno type="stamp" n="INRIA-SOPHIA">INRIA Sophia Antipolis - Méditerranée</idno><idno type="stamp" n="INRIASO">INRIA-SOPHIA</idno><idno type="stamp" n="AGROPARISTECH">AgroParisTech</idno><idno type="stamp" n="PARISTECH">ParisTech</idno><idno type="stamp" n="UPMC-LIF">Laboratoire d'Imagerie Fonctionnelle</idno><idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno><idno type="stamp" n="LIB" p="UPMC">Laboratoire d'Imagerie Biomédicale</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno><idno type="stamp" n="ICM" p="UPMC">Institut du Cerveau et de la Moëlle Epinière</idno><idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno><idno type="stamp" n="APHP" p="INSERM">AP-HP</idno><idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno><idno type="stamp" n="ESE" p="AGROPARISTECH">Laboratoire d'Ecologie, Systématique et Evolution</idno><idno type="stamp" n="CRMBM">Centre de Résonance Magnétique Biologique et Médicale</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method</title><author role="aut"><persName><forename type="first">Jérôme</forename><surname>Yelnik</surname></persName><idno type="halauthorid">404202</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-353778"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-95919"></affiliation></author><author role="aut"><persName><forename type="first">P.</forename><surname>Damier</surname></persName><idno type="halauthorid">112525</idno><affiliation ref="#struct-111538"></affiliation></author><author role="aut"><persName><forename type="first">S.</forename><surname>Demeret</surname></persName><idno type="halauthorid">301328</idno><affiliation ref="#struct-18479"></affiliation></author><author role="aut"><persName><forename type="first">D.</forename><surname>Gervais</surname></persName><idno type="halauthorid">634604</idno></author><author role="aut"><persName><forename type="first">Eric</forename><surname>Bardinet</surname></persName><idno type="halauthorid">98501</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-422"></affiliation><affiliation ref="#struct-2459"></affiliation></author><author role="aut"><persName><forename type="first">B.P.</forename><surname>Bejjani</surname></persName><idno type="halauthorid">634605</idno></author><author role="aut"><persName><forename type="first">C.</forename><surname>François</surname></persName><idno type="halauthorid">317176</idno><affiliation ref="#struct-581"></affiliation><affiliation ref="#struct-1230"></affiliation></author><author role="aut"><persName><forename type="first">J.L.</forename><surname>Houeto</surname></persName><idno type="halauthorid">112531</idno></author><author role="aut"><persName><forename type="first">I.</forename><surname>Arnule</surname></persName><idno type="halauthorid">634606</idno></author><author role="aut"><persName><forename type="first">Didier</forename><surname>Dormont</surname></persName><idno type="halauthorid">98507</idno><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-422"></affiliation><affiliation ref="#struct-41020"></affiliation><affiliation ref="#struct-3036"></affiliation></author><author role="crp"><persName><forename type="first">Damien</forename><surname>Galanaud</surname></persName><email type="md5">4179a5f00eceac608cc170e2d54934f2</email><email type="domain">gmail.com</email><idno type="halauthorid">499123</idno><affiliation ref="#struct-41020"></affiliation><affiliation ref="#struct-480402"></affiliation></author><author role="aut"><persName><forename type="first">Bernard</forename><surname>Pidoux</surname></persName><idno type="halauthorid">403865</idno><affiliation ref="#struct-455092"></affiliation></author><author role="aut"><persName><forename type="first">Philippe</forename><surname>Cornu</surname></persName><idno type="halauthorid">385265</idno><affiliation ref="#struct-455092"></affiliation></author><author role="aut"><persName><forename type="first">Yves</forename><surname>Agid</surname></persName><idno type="halauthorid">217013</idno><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-81470"></affiliation><affiliation ref="#struct-95919"></affiliation><affiliation ref="#struct-18479"></affiliation><affiliation ref="#struct-455092"></affiliation><affiliation ref="#struct-2623"></affiliation><affiliation ref="#struct-23330"></affiliation><affiliation ref="#struct-16845"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">21871</idno><idno type="issn">0022-3085</idno><title level="j">Journal of Neurosurgery</title><imprint><publisher>American Association of Neurological Surgeons</publisher><biblScope unit="volume">99</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="pp">89--99</biblScope><date type="datePub">2003</date></imprint></monogr></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="info.info-im">Computer Science [cs]/Medical Imaging</classCode><classCode scheme="halDomain" n="info.info-mo">Computer Science [cs]/Modeling and Simulation</classCode><classCode scheme="halDomain" n="sdv.ib.ima">Life Sciences [q-bio]/Bioengineering/Imaging</classCode><classCode scheme="halDomain" n="spi.signal">Engineering Sciences [physics]/Signal and Image processing</classCode><classCode scheme="halDomain" n="info.info-ts">Computer Science [cs]/Signal and Image Processing</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">OBJECT: The aim of this study was to correlate the clinical improvement in patients with Parkinson disease (PD) treated using deep brain stimulation (DBS) of the subthalamic nucleus (STN) with the precise anatomical localization of stimulating electrodes. METHODS: Localization was determined by superimposing figures from an anatomical atlas with postoperative magnetic resonance (MR) images obtained in each patient. This approach was validated by an analysis of experimental and clinical MR images of the electrode, and the development of a three-dimensional (3D) atlas-MR imaging coregistration method. The PD motor score was assessed through two contacts for each of two electrodes implanted in 10 patients: the "therapeutic contact" and the "distant contact" (that is, the next but one to the therapeutic contact). Seventeen therapeutic contacts were located within or on the border of the STN, most of which were associated with significant improvement of the four PD symptoms tested. Therapeutic contacts located in other structures (zona incerta, lenticular fasciculus, or midbrain reticular formation) were also linked to a significant positive effect. Stimulation applied through distant contacts located in the STN improved symptoms of PD, whereas that delivered through distant contacts in the remaining structures had variable effects ranging from worsening of symptoms to their improvement. CONCLUSIONS: The authors have demonstrated that 3D atlas-MR imaging coregistration is a reliable method for the precise localization of DBS electrodes on postoperative MR images. In addition, they have confirmed that although the STN is the main target during DBS treatment for PD, stimulation of surrounding regions, particularly the zona incerta or the lenticular fasciculus, can also improve symptoms of PD.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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