ParkinsonFranceV1, Hal, Corpus, bibRecord, 000608

L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.

Identifieur interne : 000608 ( Hal/Corpus ); précédent : 000607; suivant : 000609

L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.

Auteurs : Sylvia Navailles ; Manolo Carta ; Martin Guthrie ; Philippe De Deurwaerdère

Source :

Central Nervous System Agents in Medicinal Chemistry [ 1871-5249 ] ; 2011-12-01.

RBID : Hal:hal-01178542

Abstract

L-DOPA is the gold standard medication of Parkinson's disease, a neurological disorder consequent upon the degeneration of mesencephalic dopaminergic neurons. The therapeutic efficacy of L-DOPA has been related to its ability to restore dopamine (DA) extracellular levels in the Parkinsonian brain. The origin of the L-DOPA-induced rise in DA has been the object of numerous studies and controversies but the data collectively point to serotonergic (5-HT) neurons as being most significant in the release. Here, we review biochemical and behavioral evidence supporting serotonergic neurons as playing the main role in the actions of L-DOPA, considered from two points of view. The main aspect concerns the biochemical demonstration that 5-HT neurons are almost solely implicated in the release of DA induced by L-DOPA. The mechanism of action of L-DOPA inside 5-HT neurons will be thoroughly dissected on the basis of L-DOPA effects on extracellular versus tissue DA levels. The unique contribution of 5-HT neurons in mediating the release of newly synthesised DA from L-DOPA will be discussed in parallel with DA-dependent behaviors induced by L-DOPA. The other, and neglected, aspect concerns the possible deleterious impact of the presence of L-DOPA inside 5-HT neurons on 5-HT neuronal function. Overall, the fact that 5-HT neurons release the newly synthesised DA from L-DOPA in multiple brain regions beyond the striatum gives new insight into the large impact of L-DOPA in the Parkinsonian brain and strengthens therapeutic perspectives targeting the 5-HT system to reduce both motor and non-motor complications of L-DOPA medication.

Url:

https://hal.archives-ouvertes.fr/hal-01178542

Links to Exploration step

Hal:hal-01178542

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.</title>
<author><name sortKey="Navailles, Sylvia" sort="Navailles, Sylvia" uniqKey="Navailles S" first="Sylvia" last="Navailles">Sylvia Navailles</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Carta, Manolo" sort="Carta, Manolo" uniqKey="Carta M" first="Manolo" last="Carta">Manolo Carta</name>
</author>
<author><name sortKey="Guthrie, Martin" sort="Guthrie, Martin" uniqKey="Guthrie M" first="Martin" last="Guthrie">Martin Guthrie</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="De Deurwaerdere, Philippe" sort="De Deurwaerdere, Philippe" uniqKey="De Deurwaerdere P" first="Philippe" last="De Deurwaerdère">Philippe De Deurwaerdère</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01178542</idno>
<idno type="halId">hal-01178542</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01178542</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01178542</idno>
<date when="2011-12-01">2011-12-01</date>
<idno type="wicri:Area/Hal/Corpus">000608</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.</title>
<author><name sortKey="Navailles, Sylvia" sort="Navailles, Sylvia" uniqKey="Navailles S" first="Sylvia" last="Navailles">Sylvia Navailles</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Carta, Manolo" sort="Carta, Manolo" uniqKey="Carta M" first="Manolo" last="Carta">Manolo Carta</name>
</author>
<author><name sortKey="Guthrie, Martin" sort="Guthrie, Martin" uniqKey="Guthrie M" first="Martin" last="Guthrie">Martin Guthrie</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="De Deurwaerdere, Philippe" sort="De Deurwaerdere, Philippe" uniqKey="De Deurwaerdere P" first="Philippe" last="De Deurwaerdère">Philippe De Deurwaerdère</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Central Nervous System Agents in Medicinal Chemistry</title>
<idno type="ISSN">1871-5249</idno>
<imprint><date type="datePub">2011-12-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">L-DOPA is the gold standard medication of Parkinson's disease, a neurological disorder consequent upon the degeneration of mesencephalic dopaminergic neurons. The therapeutic efficacy of L-DOPA has been related to its ability to restore dopamine (DA) extracellular levels in the Parkinsonian brain. The origin of the L-DOPA-induced rise in DA has been the object of numerous studies and controversies but the data collectively point to serotonergic (5-HT) neurons as being most significant in the release. Here, we review biochemical and behavioral evidence supporting serotonergic neurons as playing the main role in the actions of L-DOPA, considered from two points of view. The main aspect concerns the biochemical demonstration that 5-HT neurons are almost solely implicated in the release of DA induced by L-DOPA. The mechanism of action of L-DOPA inside 5-HT neurons will be thoroughly dissected on the basis of L-DOPA effects on extracellular versus tissue DA levels. The unique contribution of 5-HT neurons in mediating the release of newly synthesised DA from L-DOPA will be discussed in parallel with DA-dependent behaviors induced by L-DOPA. The other, and neglected, aspect concerns the possible deleterious impact of the presence of L-DOPA inside 5-HT neurons on 5-HT neuronal function. Overall, the fact that 5-HT neurons release the newly synthesised DA from L-DOPA in multiple brain regions beyond the striatum gives new insight into the large impact of L-DOPA in the Parkinsonian brain and strengthens therapeutic perspectives targeting the 5-HT system to reduce both motor and non-motor complications of L-DOPA medication.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.</title>
            <author role="aut">              <persName>                <forename type="first">Sylvia</forename>
                <surname>Navailles</surname>
              </persName>
              <idno type="halauthorid">1167834</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Manolo</forename>
                <surname>Carta</surname>
              </persName>
              <idno type="halauthorid">1190816</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Martin</forename>
                <surname>Guthrie</surname>
              </persName>
              <idno type="halauthorid">858146</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Philippe</forename>
                <surname>De Deurwaerdère</surname>
              </persName>
              <idno type="halauthorid">1169525</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Philippe</forename>
                <surname>De Deurwaerdere</surname>
              </persName>
              <email type="md5">ea9841169841792cc22b5da7df57965f</email>
              <email type="domain">u-bordeaux.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2015-07-20 13:16:26</date>
              <date type="whenModified">2015-07-21 01:00:17</date>
              <date type="whenReleased">2015-07-20 13:16:26</date>
              <date type="whenProduced">2011-12-01</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="318954">                <persName>                  <forename>Philippe</forename>
                  <surname>De Deurwaerdere</surname>
                </persName>
                <email type="md5">ea9841169841792cc22b5da7df57965f</email>
                <email type="domain">u-bordeaux.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-01178542</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01178542</idno>
            <idno type="halBibtex">navailles:hal-01178542</idno>
            <idno type="halRefHtml">Central Nervous System Agents in Medicinal Chemistry, Bentham Science Publishers, 2011, 11 (4), pp.305-20</idno>
            <idno type="halRef">Central Nervous System Agents in Medicinal Chemistry, Bentham Science Publishers, 2011, 11 (4), pp.305-20</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.</title>
                <author role="aut">                  <persName>                    <forename type="first">Sylvia</forename>
                    <surname>Navailles</surname>
                  </persName>
                  <idno type="halauthorid">1167834</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Manolo</forename>
                    <surname>Carta</surname>
                  </persName>
                  <idno type="halauthorid">1190816</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Martin</forename>
                    <surname>Guthrie</surname>
                  </persName>
                  <idno type="halauthorid">858146</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Philippe</forename>
                    <surname>De Deurwaerdère</surname>
                  </persName>
                  <idno type="halauthorid">1169525</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">38559</idno>
                <idno type="issn">1871-5249</idno>
                <title level="j">Central Nervous System Agents in Medicinal Chemistry</title>
                <imprint>                  <publisher>Bentham Science Publishers</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">305-20</biblScope>
                  <date type="datePub">2011-12-01</date>
                </imprint>
              </monogr>
              <idno type="pubmed">22117594</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">L-DOPA is the gold standard medication of Parkinson's disease, a neurological disorder consequent upon the degeneration of mesencephalic dopaminergic neurons. The therapeutic efficacy of L-DOPA has been related to its ability to restore dopamine (DA) extracellular levels in the Parkinsonian brain. The origin of the L-DOPA-induced rise in DA has been the object of numerous studies and controversies but the data collectively point to serotonergic (5-HT) neurons as being most significant in the release. Here, we review biochemical and behavioral evidence supporting serotonergic neurons as playing the main role in the actions of L-DOPA, considered from two points of view. The main aspect concerns the biochemical demonstration that 5-HT neurons are almost solely implicated in the release of DA induced by L-DOPA. The mechanism of action of L-DOPA inside 5-HT neurons will be thoroughly dissected on the basis of L-DOPA effects on extracellular versus tissue DA levels. The unique contribution of 5-HT neurons in mediating the release of newly synthesised DA from L-DOPA will be discussed in parallel with DA-dependent behaviors induced by L-DOPA. The other, and neglected, aspect concerns the possible deleterious impact of the presence of L-DOPA inside 5-HT neurons on 5-HT neuronal function. Overall, the fact that 5-HT neurons release the newly synthesised DA from L-DOPA in multiple brain regions beyond the striatum gives new insight into the large impact of L-DOPA in the Parkinsonian brain and strengthens therapeutic perspectives targeting the 5-HT system to reduce both motor and non-motor complications of L-DOPA medication.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000608 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000608 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-01178542
   |texte=   L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.

L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri