ParkinsonFranceV1, Hal, Corpus, bibRecord, 000516

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

Identifieur interne : 000516 ( Hal/Corpus ); précédent : 000515; suivant : 000517

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

Auteurs : Mathieu Schmitt ; Benjamin Dehay ; Erwan Bezard ; F. Javier Garcia-Ladona

Source :

Synapse [ 0887-4476 ] ; 2016-03.

RBID : Hal:hal-01286611

Abstract

The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that induces parkinsonism in both human and primate, has prompted the search for environmental toxins potentially responsible for idiopathic Parkinson's disease (PD). The present study reports the ultimate effects of MPTP intoxication of a female macaque monkey, which unraveled to be pregnant after parkinsonism had developed, upon its fetus. Detailed examination of the offpsring nigrostriatal pathway showed that tyrosine hydroxylase immunoreactivity in caudate-putamen nuclei and substantia nigra compacta (SNc) was not different from an age-matched control. Biochemical analysis of the tissue content of dopaminergic markers further suggested modification of metabolism in the MPTP-exposed monkey. These data suggest that early prenatal intoxication does not destroy nigrostriatal neurons, most likely because dopamine neurons had not developed yet when exposed to MPTP. Synapse 70:52-56, 2016. © 2015 Wiley Periodicals, Inc.

Url:

https://hal.archives-ouvertes.fr/hal-01286611

DOI: 10.1002/syn.21881

Links to Exploration step

Hal:hal-01286611

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line</title>
<author><name sortKey="Schmitt, Mathieu" sort="Schmitt, Mathieu" uniqKey="Schmitt M" first="Mathieu" last="Schmitt">Mathieu Schmitt</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-67360" status="INCOMING">  <orgName>Institute of Ecology</orgName>
  <desc>    <address>      <country key="AT"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-63989" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-63989" type="direct"><org type="institution" xml:id="struct-63989" status="VALID">  <orgName>University of Innsbruck</orgName>
  <desc>    <address>      <addrLine>University of Innsbruck, Innrain 52, A-6020 Innsbruck</addrLine>
      <country key="AT"></country>
    </address>
    <ref type="url">http://www.uibk.ac.at/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Ladona, F Javier" sort="Garcia Ladona, F Javier" uniqKey="Garcia Ladona F" first="F. Javier" last="Garcia-Ladona">F. Javier Garcia-Ladona</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-452778" status="INCOMING">  <orgName>Neuroscience Therapeutic Area, New Medicines</orgName>
  <desc>    <address>      <addrLine>1420 Braine L'alleud</addrLine>
      <country key="BE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-452777" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-452777" type="direct"><org type="institution" xml:id="struct-452777" status="INCOMING">  <orgName> UCB Biopharma SPRL</orgName>
  <desc>    <address>      <addrLine>1420 Braine L'alleud</addrLine>
      <country key="BE"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01286611</idno>
<idno type="halId">hal-01286611</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01286611</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01286611</idno>
<idno type="doi">10.1002/syn.21881</idno>
<date when="2016-03">2016-03</date>
<idno type="wicri:Area/Hal/Corpus">000516</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line</title>
<author><name sortKey="Schmitt, Mathieu" sort="Schmitt, Mathieu" uniqKey="Schmitt M" first="Mathieu" last="Schmitt">Mathieu Schmitt</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-67360" status="INCOMING">  <orgName>Institute of Ecology</orgName>
  <desc>    <address>      <country key="AT"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-63989" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-63989" type="direct"><org type="institution" xml:id="struct-63989" status="VALID">  <orgName>University of Innsbruck</orgName>
  <desc>    <address>      <addrLine>University of Innsbruck, Innrain 52, A-6020 Innsbruck</addrLine>
      <country key="AT"></country>
    </address>
    <ref type="url">http://www.uibk.ac.at/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID">  <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
  <orgName type="acronym">IMN</orgName>
  <desc>    <address>      <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://imn-bordeaux.org/</ref>
  </desc>
  <listRelation>    <relation active="#struct-259761" type="direct"></relation>
    <relation name="UMR5293" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">  <orgName>Université de Bordeaux</orgName>
  <orgName type="acronym">UB</orgName>
  <desc>    <address>      <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.u-bordeaux.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Ladona, F Javier" sort="Garcia Ladona, F Javier" uniqKey="Garcia Ladona F" first="F. Javier" last="Garcia-Ladona">F. Javier Garcia-Ladona</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-452778" status="INCOMING">  <orgName>Neuroscience Therapeutic Area, New Medicines</orgName>
  <desc>    <address>      <addrLine>1420 Braine L'alleud</addrLine>
      <country key="BE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-452777" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-452777" type="direct"><org type="institution" xml:id="struct-452777" status="INCOMING">  <orgName> UCB Biopharma SPRL</orgName>
  <desc>    <address>      <addrLine>1420 Braine L'alleud</addrLine>
      <country key="BE"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1002/syn.21881</idno>
<series><title level="j">Synapse</title>
<idno type="ISSN">0887-4476</idno>
<imprint><date type="datePub">2016-03</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that induces parkinsonism in both human and primate, has prompted the search for environmental toxins potentially responsible for idiopathic Parkinson's disease (PD). The present study reports the ultimate effects of MPTP intoxication of a female macaque monkey, which unraveled to be pregnant after parkinsonism had developed, upon its fetus. Detailed examination of the offpsring nigrostriatal pathway showed that tyrosine hydroxylase immunoreactivity in caudate-putamen nuclei and substantia nigra compacta (SNc) was not different from an age-matched control. Biochemical analysis of the tissue content of dopaminergic markers further suggested modification of metabolism in the MPTP-exposed monkey. These data suggest that early prenatal intoxication does not destroy nigrostriatal neurons, most likely because dopamine neurons had not developed yet when exposed to MPTP. Synapse 70:52-56, 2016. © 2015 Wiley Periodicals, Inc.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line</title>
            <author role="aut">              <persName>                <forename type="first">Mathieu</forename>
                <surname>Schmitt</surname>
              </persName>
              <idno type="halauthorid">795855</idno>
              <affiliation ref="#struct-67360"></affiliation>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Benjamin</forename>
                <surname>Dehay</surname>
              </persName>
              <idno type="halauthorid">159357</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Erwan</forename>
                <surname>Bezard</surname>
              </persName>
              <idno type="halauthorid">537314</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">F. Javier</forename>
                <surname>Garcia-Ladona</surname>
              </persName>
              <idno type="halauthorid">1308268</idno>
              <affiliation ref="#struct-452778"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Chantal</forename>
                <surname>GUERIN</surname>
              </persName>
              <email type="md5">eb4bde61f74652335183b0bd05630b2c</email>
              <email type="domain">u-bordeaux.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2016-03-11 10:40:56</date>
              <date type="whenModified">2016-03-12 01:00:19</date>
              <date type="whenReleased">2016-03-11 10:40:56</date>
              <date type="whenProduced">2016-03</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="321070">                <persName>                  <forename>Chantal</forename>
                  <surname>GUERIN</surname>
                </persName>
                <email type="md5">eb4bde61f74652335183b0bd05630b2c</email>
                <email type="domain">u-bordeaux.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-01286611</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01286611</idno>
            <idno type="halBibtex">schmitt:hal-01286611</idno>
            <idno type="halRefHtml">Synapse, Wiley-Blackwell, 2016, 70 (3), pp.52-6. <10.1002/syn.21881></idno>
            <idno type="halRef">Synapse, Wiley-Blackwell, 2016, 70 (3), pp.52-6. <10.1002/syn.21881></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line</title>
                <author role="aut">                  <persName>                    <forename type="first">Mathieu</forename>
                    <surname>Schmitt</surname>
                  </persName>
                  <idno type="halauthorid">795855</idno>
                  <affiliation ref="#struct-67360"></affiliation>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Benjamin</forename>
                    <surname>Dehay</surname>
                  </persName>
                  <idno type="halauthorid">159357</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Erwan</forename>
                    <surname>Bezard</surname>
                  </persName>
                  <idno type="halauthorid">537314</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">F. Javier</forename>
                    <surname>Garcia-Ladona</surname>
                  </persName>
                  <idno type="halauthorid">1308268</idno>
                  <affiliation ref="#struct-452778"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">19270</idno>
                <idno type="issn">0887-4476</idno>
                <idno type="eissn">1098-2396</idno>
                <title level="j">Synapse</title>
                <imprint>                  <publisher>Wiley-Blackwell</publisher>
                  <biblScope unit="volume">70</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">52-6</biblScope>
                  <date type="datePub">2016-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/syn.21881</idno>
              <idno type="pubmed">26695835</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that induces parkinsonism in both human and primate, has prompted the search for environmental toxins potentially responsible for idiopathic Parkinson's disease (PD). The present study reports the ultimate effects of MPTP intoxication of a female macaque monkey, which unraveled to be pregnant after parkinsonism had developed, upon its fetus. Detailed examination of the offpsring nigrostriatal pathway showed that tyrosine hydroxylase immunoreactivity in caudate-putamen nuclei and substantia nigra compacta (SNc) was not different from an age-matched control. Biochemical analysis of the tissue content of dopaminergic markers further suggested modification of metabolism in the MPTP-exposed monkey. These data suggest that early prenatal intoxication does not destroy nigrostriatal neurons, most likely because dopamine neurons had not developed yet when exposed to MPTP. Synapse 70:52-56, 2016. © 2015 Wiley Periodicals, Inc.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000516 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000516 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-01286611
   |texte=   Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri