ParkinsonFranceV1, Hal, Corpus, bibRecord, 000387

Emerging dysfunctions consequent to combined monoaminergic depletions in Parkinsonism.

Identifieur interne : 000387 ( Hal/Corpus ); précédent : 000386; suivant : 000388

Emerging dysfunctions consequent to combined monoaminergic depletions in Parkinsonism.

Auteurs : Claire Delaville ; Jonathan Chetrit ; Khaled Abdallah ; Stéphanie Morin ; Laura Cardoit ; Philippe De Deurwaerdère ; Abdelhamid Benazzouz

Source :

Neurobiology of Disease [ 0969-9961 ] ; 2012-01-31.

RBID : Hal:hal-01178540

Abstract

The loss of dopamine (DA) neurons has been the pathophysiological focus of the devastating conditions of Parkinson's disease, but depletion of DA alone in animal models has failed to simultaneously elicit both the motor and non-motor deficits of PD. The present study aimed to investigate, in rats, the respective role of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) depletions on motor and non-motor behaviors and on subthalamic (STN) neuronal activity. We show that NA or DA depletion significantly decreased locomotor activity and enhanced the proportion of bursty and irregular STN neurons. Anxiety-like states required DA depletion plus the depletion of 5-HT or NA. Anhedonia and "depressive-like" behavior emerged only from the combined depletion of all three monoamines, an effect paralleled by an increase in the firing rate and the proportion of bursty and irregular STN neurons. Here, we provide evidence for the exacerbation of behavioral deficits when NA and/or 5-HT depletions are combined with DA depletion, bringing new insight into the combined roles of the three monoamines in PD.

Url:

https://hal.archives-ouvertes.fr/hal-01178540

DOI: 10.1016/j.nbd.2011.10.023

Links to Exploration step

Hal:hal-01178540

Le document en format XML

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<front><div type="abstract" xml:lang="en">The loss of dopamine (DA) neurons has been the pathophysiological focus of the devastating conditions of Parkinson's disease, but depletion of DA alone in animal models has failed to simultaneously elicit both the motor and non-motor deficits of PD. The present study aimed to investigate, in rats, the respective role of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) depletions on motor and non-motor behaviors and on subthalamic (STN) neuronal activity. We show that NA or DA depletion significantly decreased locomotor activity and enhanced the proportion of bursty and irregular STN neurons. Anxiety-like states required DA depletion plus the depletion of 5-HT or NA. Anhedonia and "depressive-like" behavior emerged only from the combined depletion of all three monoamines, an effect paralleled by an increase in the firing rate and the proportion of bursty and irregular STN neurons. Here, we provide evidence for the exacerbation of behavioral deficits when NA and/or 5-HT depletions are combined with DA depletion, bringing new insight into the combined roles of the three monoamines in PD.</div>
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   |étape=   Corpus
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   |texte=   Emerging dysfunctions consequent to combined monoaminergic depletions in Parkinsonism.
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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Emerging dysfunctions consequent to combined monoaminergic depletions in Parkinsonism.

Emerging dysfunctions consequent to combined monoaminergic depletions in Parkinsonism.

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