La maladie de Parkinson en France (serveur d'exploration)

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Editorial Familial Parkinson's Disease/Parkinsonism

Identifieur interne : 000349 ( Hal/Corpus ); précédent : 000348; suivant : 000350

Editorial Familial Parkinson's Disease/Parkinsonism

Auteurs : Hiroyuki Tomiyama ; Suzanne Lesage ; Eng-King Tan ; Beom S. Jeon

Source :

RBID : Hal:hal-01211612

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD. Indeed, PARK 1-20 loci have been identified in typical and atypical parkinsonism. Furthermore, a new causative gene for PD was identified in Japanese families very recently. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients.

Url:
DOI: 10.1155/2015/736915

Links to Exploration step

Hal:hal-01211612

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<div type="abstract" xml:lang="en">Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD. Indeed, PARK 1-20 loci have been identified in typical and atypical parkinsonism. Furthermore, a new causative gene for PD was identified in Japanese families very recently. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients.</div>
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