ParkinsonFranceV1, Hal, Corpus, bibRecord, 000249

D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism

Identifieur interne : 000249 ( Hal/Corpus ); précédent : 000248; suivant : 000250

D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism

Auteurs : Carole Hyacinthe ; Quentin Barraud ; François Tison ; Erwan Bezard ; Imad Ghorayeb

Source :

Neurobiology of Disease [ 0969-9961 ] ; 2014-03-03.

RBID : Hal:hal-01048645

Abstract

Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.

Url:

https://hal.archives-ouvertes.fr/hal-01048645

DOI: 10.1016/j.nbd.2013.10.029

Links to Exploration step

Hal:hal-01048645

Le document en format XML

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<front><div type="abstract" xml:lang="en">Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.</div>
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              <date type="whenProduced">2014-03-03</date>
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              <name key="194354">                <persName>                  <forename>Catherine</forename>
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            <idno type="halRefHtml">Neurobiology of Disease, Elsevier, 2014, 63, pp.20. <10.1016/j.nbd.2013.10.029></idno>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism</title>
                <author role="aut">                  <persName>                    <forename type="first">Carole</forename>
                    <surname>Hyacinthe</surname>
                  </persName>
                  <idno type="halauthorid">600721</idno>
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                  <affiliation ref="#struct-244085"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Quentin</forename>
                    <surname>Barraud</surname>
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                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">François</forename>
                    <surname>Tison</surname>
                  </persName>
                  <idno type="halauthorid">224383</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Erwan</forename>
                    <surname>Bezard</surname>
                  </persName>
                  <email type="md5">b0deb6c343e8d1ae022cfd4a58cecc43</email>
                  <email type="domain">u-bordeaux2.fr</email>
                  <idno type="halauthorid">506531</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">Imad</forename>
                    <surname>Ghorayeb</surname>
                  </persName>
                  <email type="md5">0e29adf391ab4782c9207181c2c3022a</email>
                  <email type="domain">u-bordeaux2.fr</email>
                  <idno type="halauthorid">1059420</idno>
                  <affiliation ref="#struct-244085"></affiliation>
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              <monogr>                <idno type="halJournalId" status="VALID">13277</idno>
                <idno type="issn">0969-9961</idno>
                <idno type="eissn">1095-953X</idno>
                <title level="j">Neurobiology of Disease</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">63</biblScope>
                  <biblScope unit="pp">20</biblScope>
                  <date type="datePub">2014-03-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.nbd.2013.10.029</idno>
              <idno type="pubmed">24211719</idno>
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            <abstract xml:lang="en">Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.</abstract>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism

D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism

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