ParkinsonFranceV1, Hal, Corpus, bibRecord, 000052

Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations

Identifieur interne : 000052 ( Hal/Corpus ); précédent : 000051; suivant : 000053

Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations

Auteurs : B. Mollereau ; N. M. Rzechorzek ; B. D. Roussel ; M. Sedru ; D. Brink ; B. Bailly-Maitre ; F. Palladino ; D. B. Medinas ; P. M. Domingos ; S. Hunot ; S. Chandran ; S. Birman ; T. Baron ; D. Vivien ; C. B. Duarte ; H. D. Ryoo ; H. Steller ; F. Urano ; E. Chevet ; G. Kroemer ; A. Ciechanover ; E. J. Calabrese ; R. J. Kaufman ; C. Hetz

Source :

Brain Research [ 0006-8993 ] ; 2016-02.

RBID : Hal:hal-01282346

English descriptors

mix :
- ER stress, Hormesis, Ischemia, Parkinson, Proteasome, Autophagy.

Abstract

In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interestingly, several recent studies have shown that these adaptive responses can be stimulated by preconditioning treatments, which confer resistance to a subsequent toxic challenge - the phenomenon known as hormesis. In this review we discuss the impact of adaptive stress responses stimulated in diverse human neuropathologies including Parkinson´s disease, Wolfram syndrome, brain ischemia, and brain cancer. Further, we examine how these responses - and the molecular pathways they recruit - might be exploited for therapeutic gain

Url:

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282346

DOI: 10.1016/j.brainres.2016.02.033

Links to Exploration step

Hal:hal-01282346

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations</title>
<author><name sortKey="Mollereau, B" sort="Mollereau, B" uniqKey="Mollereau B" first="B." last="Mollereau">B. Mollereau</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID"><orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
<orgName type="acronym">LBMC</orgName>
<desc><address><addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
</desc>
<listRelation><relation active="#struct-6818" type="direct"></relation>
<relation active="#struct-194495" type="direct"></relation>
<relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
<relation name="U1210" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Rzechorzek, N M" sort="Rzechorzek, N M" uniqKey="Rzechorzek N" first="N. M." last="Rzechorzek">N. M. Rzechorzek</name>
</author>
<author><name sortKey="Roussel, B D" sort="Roussel, B D" uniqKey="Roussel B" first="B. D." last="Roussel">B. D. Roussel</name>
</author>
<author><name sortKey="Sedru, M" sort="Sedru, M" uniqKey="Sedru M" first="M." last="Sedru">M. Sedru</name>
</author>
<author><name sortKey="Brink, D" sort="Brink, D" uniqKey="Brink D" first="D." last="Brink">D. Brink</name>
</author>
<author><name sortKey="Bailly Maitre, B" sort="Bailly Maitre, B" uniqKey="Bailly Maitre B" first="B." last="Bailly-Maitre">B. Bailly-Maitre</name>
</author>
<author><name sortKey="Palladino, F" sort="Palladino, F" uniqKey="Palladino F" first="F." last="Palladino">F. Palladino</name>
</author>
<author><name sortKey="Medinas, D B" sort="Medinas, D B" uniqKey="Medinas D" first="D. B." last="Medinas">D. B. Medinas</name>
</author>
<author><name sortKey="Domingos, P M" sort="Domingos, P M" uniqKey="Domingos P" first="P. M." last="Domingos">P. M. Domingos</name>
</author>
<author><name sortKey="Hunot, S" sort="Hunot, S" uniqKey="Hunot S" first="S." last="Hunot">S. Hunot</name>
</author>
<author><name sortKey="Chandran, S" sort="Chandran, S" uniqKey="Chandran S" first="S." last="Chandran">S. Chandran</name>
</author>
<author><name sortKey="Birman, S" sort="Birman, S" uniqKey="Birman S" first="S." last="Birman">S. Birman</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID">  <idno type="IdRef">149374186</idno>
  <idno type="RNSR">201220316K</idno>
  <orgName>Institut de Biologie du Développement de Marseille</orgName>
  <orgName type="acronym">IBDM</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ibdm.univ-mrs.fr</ref>
  </desc>
  <listRelation>    <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
    <relation name="UMR7288" active="#struct-198056" type="direct"></relation>
    <relation name="UMR7288" active="#struct-441569" type="direct"></relation>
    <relation active="#struct-5033" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">  <idno type="IdRef">15863621X</idno>
  <idno type="ISNI">0000 0001 2176 4817</idno>
  <orgName>Aix Marseille Université</orgName>
  <orgName type="acronym">AMU</orgName>
  <date type="start">2012-01-01</date>
  <desc>    <address>      <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-amu.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD">  <idno type="IdRef">026402882</idno>
  <orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
  <date type="start">1969</date>
  <date type="end">2011</date>
  <desc>    <address>      <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univmed.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Baron, T" sort="Baron, T" uniqKey="Baron T" first="T." last="Baron">T. Baron</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-616" status="VALID">  <orgName>Laboratoire des technologies de la microélectronique</orgName>
  <orgName type="acronym">LTM</orgName>
  <desc>    <address>      <addrLine>LETI/DTS 17 rue des martyrs 38054 GRENOBLE CEDEX 9</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="UMR5129" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5129" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Vivien, D" sort="Vivien, D" uniqKey="Vivien D" first="D." last="Vivien">D. Vivien</name>
</author>
<author><name sortKey="Duarte, C B" sort="Duarte, C B" uniqKey="Duarte C" first="C. B." last="Duarte">C. B. Duarte</name>
</author>
<author><name sortKey="Ryoo, H D" sort="Ryoo, H D" uniqKey="Ryoo H" first="H. D." last="Ryoo">H. D. Ryoo</name>
</author>
<author><name sortKey="Steller, H" sort="Steller, H" uniqKey="Steller H" first="H." last="Steller">H. Steller</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-247629" status="INCOMING">  <orgName>Laboratory of Apoptosis and Cancer Biology</orgName>
  <desc>    <address>      <addrLine>Howard Hughes Medical Institute New York,</addrLine>
      <country key="US"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-410360" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-410360" type="direct"><org type="institution" xml:id="struct-410360" status="INCOMING">  <orgName>The Rockefeller University</orgName>
  <desc>    <address>      <country key="US"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Urano, F" sort="Urano, F" uniqKey="Urano F" first="F." last="Urano">F. Urano</name>
</author>
<author><name sortKey="Chevet, E" sort="Chevet, E" uniqKey="Chevet E" first="E." last="Chevet">E. Chevet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-418267" status="OLD">  <idno type="IdRef">192863495</idno>
  <idno type="RNSR">201521288D</idno>
  <orgName>Oncogenesis Stress Signaling</orgName>
  <orgName type="acronym">OSS</orgName>
  <date type="start">2015</date>
  <date type="end">2016-12-31</date>
  <desc>    <address>      <addrLine>Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque Bat D35042 Rennes</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="ERL 440" active="#struct-105160" type="direct"></relation>
    <relation active="#struct-301510" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="ERL 440" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"><orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc><address><addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301510" type="direct"><org type="institution" xml:id="struct-301510" status="VALID">  <orgName>CRLCC Eugène Marquis</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G." last="Kroemer">G. Kroemer</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-246994" status="VALID">  <idno type="ISNI">0000 0004 0620 5824 </idno>
  <idno type="RNSR">200716512X</idno>
  <orgName>Centre de Recherche des Cordeliers</orgName>
  <orgName type="acronym">CRC</orgName>
  <desc>    <address>      <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.crc.jussieu.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-93591" type="direct"></relation>
    <relation active="#struct-110691" type="direct"></relation>
    <relation active="#struct-300301" type="direct"></relation>
    <relation active="#struct-301664" type="direct"></relation>
    <relation name="U1138" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-110691" type="direct"><org type="institution" xml:id="struct-110691" status="VALID">  <orgName>École pratique des hautes études</orgName>
  <orgName type="acronym">EPHE</orgName>
  <desc>    <address>      <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ephe.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID">  <orgName>Université Paris Diderot - Paris 7</orgName>
  <orgName type="acronym">UPD7</orgName>
  <desc>    <address>      <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-paris-diderot.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="VALID"><idno type="IdRef">026404788</idno>
<idno type="ISNI">0000 0001 2188 0914 </idno>
<orgName>Université Paris Descartes - Paris 5</orgName>
<orgName type="acronym">UPD5</orgName>
<desc><address><addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.parisdescartes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1138" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Ciechanover, A" sort="Ciechanover, A" uniqKey="Ciechanover A" first="A." last="Ciechanover">A. Ciechanover</name>
</author>
<author><name sortKey="Calabrese, E J" sort="Calabrese, E J" uniqKey="Calabrese E" first="E. J." last="Calabrese">E. J. Calabrese</name>
</author>
<author><name sortKey="Kaufman, R J" sort="Kaufman, R J" uniqKey="Kaufman R" first="R. J." last="Kaufman">R. J. Kaufman</name>
</author>
<author><name sortKey="Hetz, C" sort="Hetz, C" uniqKey="Hetz C" first="C" last="Hetz">C. Hetz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01282346</idno>
<idno type="halId">hal-01282346</idno>
<idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282346</idno>
<idno type="url">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282346</idno>
<idno type="doi">10.1016/j.brainres.2016.02.033</idno>
<date when="2016-02">2016-02</date>
<idno type="wicri:Area/Hal/Corpus">000052</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations</title>
<author><name sortKey="Mollereau, B" sort="Mollereau, B" uniqKey="Mollereau B" first="B." last="Mollereau">B. Mollereau</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID"><orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
<orgName type="acronym">LBMC</orgName>
<desc><address><addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
</desc>
<listRelation><relation active="#struct-6818" type="direct"></relation>
<relation active="#struct-194495" type="direct"></relation>
<relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
<relation name="U1210" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Rzechorzek, N M" sort="Rzechorzek, N M" uniqKey="Rzechorzek N" first="N. M." last="Rzechorzek">N. M. Rzechorzek</name>
</author>
<author><name sortKey="Roussel, B D" sort="Roussel, B D" uniqKey="Roussel B" first="B. D." last="Roussel">B. D. Roussel</name>
</author>
<author><name sortKey="Sedru, M" sort="Sedru, M" uniqKey="Sedru M" first="M." last="Sedru">M. Sedru</name>
</author>
<author><name sortKey="Brink, D" sort="Brink, D" uniqKey="Brink D" first="D." last="Brink">D. Brink</name>
</author>
<author><name sortKey="Bailly Maitre, B" sort="Bailly Maitre, B" uniqKey="Bailly Maitre B" first="B." last="Bailly-Maitre">B. Bailly-Maitre</name>
</author>
<author><name sortKey="Palladino, F" sort="Palladino, F" uniqKey="Palladino F" first="F." last="Palladino">F. Palladino</name>
</author>
<author><name sortKey="Medinas, D B" sort="Medinas, D B" uniqKey="Medinas D" first="D. B." last="Medinas">D. B. Medinas</name>
</author>
<author><name sortKey="Domingos, P M" sort="Domingos, P M" uniqKey="Domingos P" first="P. M." last="Domingos">P. M. Domingos</name>
</author>
<author><name sortKey="Hunot, S" sort="Hunot, S" uniqKey="Hunot S" first="S." last="Hunot">S. Hunot</name>
</author>
<author><name sortKey="Chandran, S" sort="Chandran, S" uniqKey="Chandran S" first="S." last="Chandran">S. Chandran</name>
</author>
<author><name sortKey="Birman, S" sort="Birman, S" uniqKey="Birman S" first="S." last="Birman">S. Birman</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID">  <idno type="IdRef">149374186</idno>
  <idno type="RNSR">201220316K</idno>
  <orgName>Institut de Biologie du Développement de Marseille</orgName>
  <orgName type="acronym">IBDM</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ibdm.univ-mrs.fr</ref>
  </desc>
  <listRelation>    <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
    <relation name="UMR7288" active="#struct-198056" type="direct"></relation>
    <relation name="UMR7288" active="#struct-441569" type="direct"></relation>
    <relation active="#struct-5033" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">  <idno type="IdRef">15863621X</idno>
  <idno type="ISNI">0000 0001 2176 4817</idno>
  <orgName>Aix Marseille Université</orgName>
  <orgName type="acronym">AMU</orgName>
  <date type="start">2012-01-01</date>
  <desc>    <address>      <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-amu.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD">  <idno type="IdRef">026402882</idno>
  <orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
  <date type="start">1969</date>
  <date type="end">2011</date>
  <desc>    <address>      <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univmed.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Baron, T" sort="Baron, T" uniqKey="Baron T" first="T." last="Baron">T. Baron</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-616" status="VALID">  <orgName>Laboratoire des technologies de la microélectronique</orgName>
  <orgName type="acronym">LTM</orgName>
  <desc>    <address>      <addrLine>LETI/DTS 17 rue des martyrs 38054 GRENOBLE CEDEX 9</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="UMR5129" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR5129" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Vivien, D" sort="Vivien, D" uniqKey="Vivien D" first="D." last="Vivien">D. Vivien</name>
</author>
<author><name sortKey="Duarte, C B" sort="Duarte, C B" uniqKey="Duarte C" first="C. B." last="Duarte">C. B. Duarte</name>
</author>
<author><name sortKey="Ryoo, H D" sort="Ryoo, H D" uniqKey="Ryoo H" first="H. D." last="Ryoo">H. D. Ryoo</name>
</author>
<author><name sortKey="Steller, H" sort="Steller, H" uniqKey="Steller H" first="H." last="Steller">H. Steller</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-247629" status="INCOMING">  <orgName>Laboratory of Apoptosis and Cancer Biology</orgName>
  <desc>    <address>      <addrLine>Howard Hughes Medical Institute New York,</addrLine>
      <country key="US"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-410360" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-410360" type="direct"><org type="institution" xml:id="struct-410360" status="INCOMING">  <orgName>The Rockefeller University</orgName>
  <desc>    <address>      <country key="US"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Urano, F" sort="Urano, F" uniqKey="Urano F" first="F." last="Urano">F. Urano</name>
</author>
<author><name sortKey="Chevet, E" sort="Chevet, E" uniqKey="Chevet E" first="E." last="Chevet">E. Chevet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-418267" status="OLD">  <idno type="IdRef">192863495</idno>
  <idno type="RNSR">201521288D</idno>
  <orgName>Oncogenesis Stress Signaling</orgName>
  <orgName type="acronym">OSS</orgName>
  <date type="start">2015</date>
  <date type="end">2016-12-31</date>
  <desc>    <address>      <addrLine>Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque Bat D35042 Rennes</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="ERL 440" active="#struct-105160" type="direct"></relation>
    <relation active="#struct-301510" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="ERL 440" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"><orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc><address><addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301510" type="direct"><org type="institution" xml:id="struct-301510" status="VALID">  <orgName>CRLCC Eugène Marquis</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G." last="Kroemer">G. Kroemer</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-246994" status="VALID">  <idno type="ISNI">0000 0004 0620 5824 </idno>
  <idno type="RNSR">200716512X</idno>
  <orgName>Centre de Recherche des Cordeliers</orgName>
  <orgName type="acronym">CRC</orgName>
  <desc>    <address>      <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.crc.jussieu.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-93591" type="direct"></relation>
    <relation active="#struct-110691" type="direct"></relation>
    <relation active="#struct-300301" type="direct"></relation>
    <relation active="#struct-301664" type="direct"></relation>
    <relation name="U1138" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-110691" type="direct"><org type="institution" xml:id="struct-110691" status="VALID">  <orgName>École pratique des hautes études</orgName>
  <orgName type="acronym">EPHE</orgName>
  <desc>    <address>      <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ephe.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID">  <orgName>Université Paris Diderot - Paris 7</orgName>
  <orgName type="acronym">UPD7</orgName>
  <desc>    <address>      <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-paris-diderot.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="VALID"><idno type="IdRef">026404788</idno>
<idno type="ISNI">0000 0001 2188 0914 </idno>
<orgName>Université Paris Descartes - Paris 5</orgName>
<orgName type="acronym">UPD5</orgName>
<desc><address><addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.parisdescartes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1138" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Ciechanover, A" sort="Ciechanover, A" uniqKey="Ciechanover A" first="A." last="Ciechanover">A. Ciechanover</name>
</author>
<author><name sortKey="Calabrese, E J" sort="Calabrese, E J" uniqKey="Calabrese E" first="E. J." last="Calabrese">E. J. Calabrese</name>
</author>
<author><name sortKey="Kaufman, R J" sort="Kaufman, R J" uniqKey="Kaufman R" first="R. J." last="Kaufman">R. J. Kaufman</name>
</author>
<author><name sortKey="Hetz, C" sort="Hetz, C" uniqKey="Hetz C" first="C" last="Hetz">C. Hetz</name>
</author>
</analytic>
<idno type="DOI">10.1016/j.brainres.2016.02.033</idno>
<series><title level="j">Brain Research</title>
<idno type="ISSN">0006-8993</idno>
<imprint><date type="datePub">2016-02</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> ER stress</term>
<term> Hormesis</term>
<term> Ischemia</term>
<term> Parkinson</term>
<term> Proteasome</term>
<term>Autophagy</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interestingly, several recent studies have shown that these adaptive responses can be stimulated by preconditioning treatments, which confer resistance to a subsequent toxic challenge - the phenomenon known as hormesis. In this review we discuss the impact of adaptive stress responses stimulated in diverse human neuropathologies including Parkinson´s disease, Wolfram syndrome, brain ischemia, and brain cancer. Further, we examine how these responses - and the molecular pathways they recruit - might be exploited for therapeutic gain</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations</title>
            <author role="aut">              <persName>                <forename type="first">B.</forename>
                <surname>Mollereau</surname>
              </persName>
              <idno type="halauthorid">529956</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">N. M.</forename>
                <surname>Rzechorzek</surname>
              </persName>
              <idno type="halauthorid">1303188</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">B. D.</forename>
                <surname>Roussel</surname>
              </persName>
              <idno type="halauthorid">1303189</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">M.</forename>
                <surname>Sedru</surname>
              </persName>
              <idno type="halauthorid">1303190</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">D.</forename>
                <forename type="middle">Van den</forename>
                <surname>Brink</surname>
              </persName>
              <idno type="halauthorid">1303191</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">B.</forename>
                <surname>Bailly-Maitre</surname>
              </persName>
              <idno type="halauthorid">1303192</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">F.</forename>
                <surname>Palladino</surname>
              </persName>
              <idno type="halauthorid">1303193</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">D. B.</forename>
                <surname>Medinas</surname>
              </persName>
              <idno type="halauthorid">1303194</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">P. M.</forename>
                <surname>Domingos</surname>
              </persName>
              <idno type="halauthorid">1303195</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Hunot</surname>
              </persName>
              <idno type="halauthorid">1303196</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Chandran</surname>
              </persName>
              <idno type="halauthorid">1303197</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Birman</surname>
              </persName>
              <idno type="halauthorid">116884</idno>
              <affiliation ref="#struct-199397"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">T.</forename>
                <surname>Baron</surname>
              </persName>
              <idno type="halauthorid">94228</idno>
              <affiliation ref="#struct-616"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">D.</forename>
                <surname>Vivien</surname>
              </persName>
              <idno type="halauthorid">145538</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">C. B.</forename>
                <surname>Duarte</surname>
              </persName>
              <idno type="halauthorid">1303198</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">H. D.</forename>
                <surname>Ryoo</surname>
              </persName>
              <idno type="halauthorid">1303199</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">H.</forename>
                <surname>Steller</surname>
              </persName>
              <idno type="halauthorid">1466196</idno>
              <affiliation ref="#struct-247629"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">F.</forename>
                <surname>Urano</surname>
              </persName>
              <idno type="halauthorid">1303200</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">E.</forename>
                <surname>Chevet</surname>
              </persName>
              <idno type="halauthorid">401106</idno>
              <affiliation ref="#struct-418267"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">G.</forename>
                <surname>Kroemer</surname>
              </persName>
              <idno type="halauthorid">105566</idno>
              <affiliation ref="#struct-246994"></affiliation>
              <affiliation ref="#struct-418262"></affiliation>
              <affiliation ref="#struct-150182"></affiliation>
              <affiliation ref="#struct-434437"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">A.</forename>
                <surname>Ciechanover</surname>
              </persName>
              <idno type="halauthorid">1303201</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">E. J.</forename>
                <surname>Calabrese</surname>
              </persName>
              <idno type="halauthorid">1303202</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">R. J.</forename>
                <surname>Kaufman</surname>
              </persName>
              <idno type="halauthorid">1303203</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">C</forename>
                <surname>Hetz</surname>
              </persName>
              <idno type="halauthorid">1303204</idno>
            </author>
            <editor role="depositor">              <persName>                <forename>Nelly</forename>
                <surname>Brenner</surname>
              </persName>
              <email type="md5">8503b29898396526c56d96d8ae07e3e5</email>
              <email type="domain">univ-rennes1.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2016-03-03 15:40:53</date>
              <date type="whenModified">2017-01-23 13:41:03</date>
              <date type="whenReleased">2016-03-03 15:40:53</date>
              <date type="whenProduced">2016-02</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="322814">                <persName>                  <forename>Nelly</forename>
                  <surname>Brenner</surname>
                </persName>
                <email type="md5">8503b29898396526c56d96d8ae07e3e5</email>
                <email type="domain">univ-rennes1.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-01282346</idno>
            <idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282346</idno>
            <idno type="halBibtex">mollereau:hal-01282346</idno>
            <idno type="halRefHtml">Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. <10.1016/j.brainres.2016.02.033></idno>
            <idno type="halRef">Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. <10.1016/j.brainres.2016.02.033></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="MARQUIS" p="FNCLCC">Centre Eugène Marquis</idno>
            <idno type="stamp" n="CORDELIERS" p="UPMC">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="APHP" p="INSERM">AP-HP</idno>
            <idno type="stamp" n="LTM" p="FMNT">Laboratoire des technologies de la microélectronique</idno>
            <idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="ENS-LYON">École Normale Supérieure de Lyon</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="OSS">Chemistry Oncogenesis Stress Signaling</idno>
            <idno type="stamp" n="FNCLCC" p="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" p="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="BIOSIT">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="PSL">Paris Sciences et Lettres (PSL) Research University</idno>
            <idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="EPHE">Ecole Pratique des Hautes Etudes</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations</title>
                <author role="aut">                  <persName>                    <forename type="first">B.</forename>
                    <surname>Mollereau</surname>
                  </persName>
                  <idno type="halauthorid">529956</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">N. M.</forename>
                    <surname>Rzechorzek</surname>
                  </persName>
                  <idno type="halauthorid">1303188</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">B. D.</forename>
                    <surname>Roussel</surname>
                  </persName>
                  <idno type="halauthorid">1303189</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">M.</forename>
                    <surname>Sedru</surname>
                  </persName>
                  <idno type="halauthorid">1303190</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">D.</forename>
                    <forename type="middle">Van den</forename>
                    <surname>Brink</surname>
                  </persName>
                  <idno type="halauthorid">1303191</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">B.</forename>
                    <surname>Bailly-Maitre</surname>
                  </persName>
                  <idno type="halauthorid">1303192</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">F.</forename>
                    <surname>Palladino</surname>
                  </persName>
                  <idno type="halauthorid">1303193</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">D. B.</forename>
                    <surname>Medinas</surname>
                  </persName>
                  <idno type="halauthorid">1303194</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">P. M.</forename>
                    <surname>Domingos</surname>
                  </persName>
                  <idno type="halauthorid">1303195</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Hunot</surname>
                  </persName>
                  <idno type="halauthorid">1303196</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Chandran</surname>
                  </persName>
                  <idno type="halauthorid">1303197</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Birman</surname>
                  </persName>
                  <idno type="halauthorid">116884</idno>
                  <affiliation ref="#struct-199397"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">T.</forename>
                    <surname>Baron</surname>
                  </persName>
                  <idno type="halauthorid">94228</idno>
                  <affiliation ref="#struct-616"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">D.</forename>
                    <surname>Vivien</surname>
                  </persName>
                  <idno type="halauthorid">145538</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">C. B.</forename>
                    <surname>Duarte</surname>
                  </persName>
                  <idno type="halauthorid">1303198</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">H. D.</forename>
                    <surname>Ryoo</surname>
                  </persName>
                  <idno type="halauthorid">1303199</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">H.</forename>
                    <surname>Steller</surname>
                  </persName>
                  <idno type="halauthorid">1466196</idno>
                  <affiliation ref="#struct-247629"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">F.</forename>
                    <surname>Urano</surname>
                  </persName>
                  <idno type="halauthorid">1303200</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">E.</forename>
                    <surname>Chevet</surname>
                  </persName>
                  <idno type="halauthorid">401106</idno>
                  <affiliation ref="#struct-418267"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G.</forename>
                    <surname>Kroemer</surname>
                  </persName>
                  <idno type="halauthorid">105566</idno>
                  <affiliation ref="#struct-246994"></affiliation>
                  <affiliation ref="#struct-418262"></affiliation>
                  <affiliation ref="#struct-150182"></affiliation>
                  <affiliation ref="#struct-434437"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">A.</forename>
                    <surname>Ciechanover</surname>
                  </persName>
                  <idno type="halauthorid">1303201</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">E. J.</forename>
                    <surname>Calabrese</surname>
                  </persName>
                  <idno type="halauthorid">1303202</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">R. J.</forename>
                    <surname>Kaufman</surname>
                  </persName>
                  <idno type="halauthorid">1303203</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">C</forename>
                    <surname>Hetz</surname>
                  </persName>
                  <idno type="halauthorid">1303204</idno>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">11284</idno>
                <idno type="issn">0006-8993</idno>
                <idno type="eissn">0006-8993</idno>
                <title level="j">Brain Research</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">1648</biblScope>
                  <biblScope unit="issue">B</biblScope>
                  <biblScope unit="pp">603–616</biblScope>
                  <date type="datePub">2016-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.brainres.2016.02.033</idno>
              <idno type="pubmed">26923166</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en"> Parkinson</term>
                <term xml:lang="en"> Hormesis</term>
                <term xml:lang="en"> Ischemia</term>
                <term xml:lang="en">Autophagy</term>
                <term xml:lang="en"> ER stress</term>
                <term xml:lang="en"> Proteasome</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interestingly, several recent studies have shown that these adaptive responses can be stimulated by preconditioning treatments, which confer resistance to a subsequent toxic challenge - the phenomenon known as hormesis. In this review we discuss the impact of adaptive stress responses stimulated in diverse human neuropathologies including Parkinson´s disease, Wolfram syndrome, brain ischemia, and brain cancer. Further, we examine how these responses - and the molecular pathways they recruit - might be exploited for therapeutic gain</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000052 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000052 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Corpus
   |type=    RBID
   |clé=     Hal:hal-01282346
   |texte=   Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations

Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri