Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases
Identifieur interne : 000734 ( Hal/Checkpoint ); précédent : 000733; suivant : 000735Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases
Auteurs : Paolo Gubellini [France] ; Barbara Picconi [Italie] ; Massimiliano Di Filippo [France] ; Paolo Calabresi [Italie]Source :
- BBA - Biochimica et Biophysica Acta [ 0006-3002 ] ; 2010-01.
English descriptors
- mix :
Abstract
Mitochondrial dysfunctions have been implicated in the cellular processes underlying several neurodegenerative disorders affecting the basal ganglia. These include Huntington's chorea and Parkinson's disease, two highly debilitating motor disorders for which recent research has also involved gene mutation linked to mitochondrial deficits. Experimental models of basal ganglia diseases have been developed by using toxins able to disrupt mitochondrial function: these molecules act by selectively inhibiting mitochondrial respiratory complexes, uncoupling cellular respiration. This in turn leads to oxidative stress and energy deficit that trigger critical downstream mechanisms, ultimately resulting in neuronal vulnerability and loss. Here we review the molecular and cellular downstream effects triggered by mitochondrial dysfunction, and the different experimental models that are obtained by the administration of selective mitochondrial toxins or by the expression of mutant genes.
Url:
DOI: 10.1016/j.bbadis.2009.08.001
Links toward previous steps (curation, corpus...)
Links to Exploration step
Hal:hal-00848870Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases</title>
<author><name sortKey="Gubellini, Paolo" sort="Gubellini, Paolo" uniqKey="Gubellini P" first="Paolo" last="Gubellini">Paolo Gubellini</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID"> <idno type="IdRef">149374186</idno>
<idno type="RNSR">201220316K</idno>
<orgName>Institut de Biologie du Développement de Marseille</orgName>
<orgName type="acronym">IBDM</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibdm.univ-mrs.fr</ref>
</desc>
<listRelation> <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
<relation name="UMR7288" active="#struct-198056" type="direct"></relation>
<relation name="UMR7288" active="#struct-441569" type="direct"></relation>
<relation active="#struct-5033" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD"> <idno type="IdRef">026402882</idno>
<orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
<date type="start">1969</date>
<date type="end">2011</date>
<desc> <address> <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univmed.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Picconi, Barbara" sort="Picconi, Barbara" uniqKey="Picconi B" first="Barbara" last="Picconi">Barbara Picconi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-265431" status="VALID"> <orgName>Fondazione Santa Lucia [IRCCS]</orgName>
<desc> <address> <addrLine>Roma</addrLine>
<country key="IT"></country>
</address>
<ref type="url">http://www.hsantalucia.it/</ref>
</desc>
<listRelation> <relation active="#struct-303621" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-303621" type="direct"><org type="institution" xml:id="struct-303621" status="VALID"> <orgName>Clinical and Behavioral Neurology [IRCCS Santa Lucia]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Di Filippo, Massimiliano" sort="Di Filippo, Massimiliano" uniqKey="Di Filippo M" first="Massimiliano" last="Di Filippo">Massimiliano Di Filippo</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-344454" status="INCOMING"> <orgName>Ospedale Santa Maria della Misericordia</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-265431" status="VALID"> <orgName>Fondazione Santa Lucia [IRCCS]</orgName>
<desc> <address> <addrLine>Roma</addrLine>
<country key="IT"></country>
</address>
<ref type="url">http://www.hsantalucia.it/</ref>
</desc>
<listRelation> <relation active="#struct-303621" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-303621" type="direct"><org type="institution" xml:id="struct-303621" status="VALID"> <orgName>Clinical and Behavioral Neurology [IRCCS Santa Lucia]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00848870</idno>
<idno type="halId">hal-00848870</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00848870</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00848870</idno>
<idno type="doi">10.1016/j.bbadis.2009.08.001</idno>
<date when="2010-01">2010-01</date>
<idno type="wicri:Area/Hal/Corpus">000334</idno>
<idno type="wicri:Area/Hal/Curation">000334</idno>
<idno type="wicri:Area/Hal/Checkpoint">000734</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000734</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases</title>
<author><name sortKey="Gubellini, Paolo" sort="Gubellini, Paolo" uniqKey="Gubellini P" first="Paolo" last="Gubellini">Paolo Gubellini</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID"> <idno type="IdRef">149374186</idno>
<idno type="RNSR">201220316K</idno>
<orgName>Institut de Biologie du Développement de Marseille</orgName>
<orgName type="acronym">IBDM</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibdm.univ-mrs.fr</ref>
</desc>
<listRelation> <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
<relation name="UMR7288" active="#struct-198056" type="direct"></relation>
<relation name="UMR7288" active="#struct-441569" type="direct"></relation>
<relation active="#struct-5033" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD"> <idno type="IdRef">026402882</idno>
<orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
<date type="start">1969</date>
<date type="end">2011</date>
<desc> <address> <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univmed.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Picconi, Barbara" sort="Picconi, Barbara" uniqKey="Picconi B" first="Barbara" last="Picconi">Barbara Picconi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-265431" status="VALID"> <orgName>Fondazione Santa Lucia [IRCCS]</orgName>
<desc> <address> <addrLine>Roma</addrLine>
<country key="IT"></country>
</address>
<ref type="url">http://www.hsantalucia.it/</ref>
</desc>
<listRelation> <relation active="#struct-303621" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-303621" type="direct"><org type="institution" xml:id="struct-303621" status="VALID"> <orgName>Clinical and Behavioral Neurology [IRCCS Santa Lucia]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Di Filippo, Massimiliano" sort="Di Filippo, Massimiliano" uniqKey="Di Filippo M" first="Massimiliano" last="Di Filippo">Massimiliano Di Filippo</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-344454" status="INCOMING"> <orgName>Ospedale Santa Maria della Misericordia</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-265431" status="VALID"> <orgName>Fondazione Santa Lucia [IRCCS]</orgName>
<desc> <address> <addrLine>Roma</addrLine>
<country key="IT"></country>
</address>
<ref type="url">http://www.hsantalucia.it/</ref>
</desc>
<listRelation> <relation active="#struct-303621" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-303621" type="direct"><org type="institution" xml:id="struct-303621" status="VALID"> <orgName>Clinical and Behavioral Neurology [IRCCS Santa Lucia]</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.bbadis.2009.08.001</idno>
<series><title level="j">BBA - Biochimica et Biophysica Acta</title>
<idno type="ISSN">0006-3002</idno>
<imprint><date type="datePub">2010-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Animal</term>
<term> Basal Ganglia/*metabolism/physiopathology</term>
<term> Cell Death</term>
<term> Disease Models</term>
<term> Huntington Disease/metabolism</term>
<term> Mitochondria/*metabolism</term>
<term> Neurodegenerative Diseases/*metabolism</term>
<term> Parkinson Disease/metabolism</term>
<term>Animals</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mitochondrial dysfunctions have been implicated in the cellular processes underlying several neurodegenerative disorders affecting the basal ganglia. These include Huntington's chorea and Parkinson's disease, two highly debilitating motor disorders for which recent research has also involved gene mutation linked to mitochondrial deficits. Experimental models of basal ganglia diseases have been developed by using toxins able to disrupt mitochondrial function: these molecules act by selectively inhibiting mitochondrial respiratory complexes, uncoupling cellular respiration. This in turn leads to oxidative stress and energy deficit that trigger critical downstream mechanisms, ultimately resulting in neuronal vulnerability and loss. Here we review the molecular and cellular downstream effects triggered by mitochondrial dysfunction, and the different experimental models that are obtained by the administration of selective mitochondrial toxins or by the expression of mutant genes.</div>
</front>
</TEI>
<hal api="V3"> <titleStmt> <title xml:lang="en">Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases</title>
<author role="aut"> <persName> <forename type="first">Paolo</forename>
<surname>Gubellini</surname>
</persName>
<idno type="halauthorid">410381</idno>
<affiliation ref="#struct-199397"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Barbara</forename>
<surname>Picconi</surname>
</persName>
<idno type="halauthorid">554311</idno>
<affiliation ref="#struct-265431"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Massimiliano</forename>
<surname>Di Filippo</surname>
</persName>
<idno type="halauthorid">554312</idno>
<affiliation ref="#struct-344454"></affiliation>
<affiliation ref="#struct-265431"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Paolo</forename>
<surname>Calabresi</surname>
</persName>
<idno type="halauthorid">523226</idno>
<affiliation ref="#struct-265431"></affiliation>
<affiliation ref="#struct-344454"></affiliation>
</author>
<editor role="depositor"> <persName> <forename>Lydia</forename>
<surname>Nelsom</surname>
</persName>
<email type="md5">bba8ce8b7a76814561866cfe35712816</email>
<email type="domain">univ-amu.fr</email>
</editor>
</titleStmt>
<editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2013-07-29 14:18:58</date>
<date type="whenModified">2016-10-14 16:28:27</date>
<date type="whenReleased">2013-07-29 14:18:58</date>
<date type="whenProduced">2010-01</date>
</edition>
<respStmt> <resp>contributor</resp>
<name key="112288"> <persName> <forename>Lydia</forename>
<surname>Nelsom</surname>
</persName>
<email type="md5">bba8ce8b7a76814561866cfe35712816</email>
<email type="domain">univ-amu.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt> <distributor>CCSD</distributor>
<idno type="halId">hal-00848870</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00848870</idno>
<idno type="halBibtex">gubellini:hal-00848870</idno>
<idno type="halRefHtml">BBA - Biochimica et Biophysica Acta, Elsevier, 2010, 1802 (1), pp.151-61. <http://www.sciencedirect.com/science/article/pii/S0925443909001689>. <10.1016/j.bbadis.2009.08.001></idno>
<idno type="halRef">BBA - Biochimica et Biophysica Acta, Elsevier, 2010, 1802 (1), pp.151-61. <http://www.sciencedirect.com/science/article/pii/S0925443909001689>. <10.1016/j.bbadis.2009.08.001></idno>
</publicationStmt>
<seriesStmt> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
<idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
</seriesStmt>
<notesStmt> <note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases</title>
<author role="aut"> <persName> <forename type="first">Paolo</forename>
<surname>Gubellini</surname>
</persName>
<idno type="halauthorid">410381</idno>
<affiliation ref="#struct-199397"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Barbara</forename>
<surname>Picconi</surname>
</persName>
<idno type="halauthorid">554311</idno>
<affiliation ref="#struct-265431"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Massimiliano</forename>
<surname>Di Filippo</surname>
</persName>
<idno type="halauthorid">554312</idno>
<affiliation ref="#struct-344454"></affiliation>
<affiliation ref="#struct-265431"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Paolo</forename>
<surname>Calabresi</surname>
</persName>
<idno type="halauthorid">523226</idno>
<affiliation ref="#struct-265431"></affiliation>
<affiliation ref="#struct-344454"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">11108</idno>
<idno type="issn">0006-3002</idno>
<title level="j">BBA - Biochimica et Biophysica Acta</title>
<imprint> <publisher>Elsevier</publisher>
<biblScope unit="volume">1802</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="pp">151-61</biblScope>
<date type="datePub">2010-01</date>
<date type="dateEpub">2009-08-14</date>
</imprint>
</monogr>
<idno type="doi">10.1016/j.bbadis.2009.08.001</idno>
<idno type="pubmed">19683569</idno>
<ref type="publisher">http://www.sciencedirect.com/science/article/pii/S0925443909001689</ref>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <keywords scheme="author"> <term xml:lang="en"> Neurodegenerative Diseases/*metabolism</term>
<term xml:lang="en"> Parkinson Disease/metabolism</term>
<term xml:lang="en">Animals</term>
<term xml:lang="en"> Basal Ganglia/*metabolism/physiopathology</term>
<term xml:lang="en"> Cell Death</term>
<term xml:lang="en"> Disease Models</term>
<term xml:lang="en"> Animal</term>
<term xml:lang="en"> Huntington Disease/metabolism</term>
<term xml:lang="en"> Mitochondria/*metabolism</term>
</keywords>
<classCode scheme="mesh">Animals</classCode>
<classCode scheme="mesh">Basal Ganglia</classCode>
<classCode scheme="mesh">Cell Death</classCode>
<classCode scheme="mesh">Disease Models, Animal</classCode>
<classCode scheme="mesh">Huntington Disease</classCode>
<classCode scheme="mesh">Mitochondria</classCode>
<classCode scheme="mesh">Neurodegenerative Diseases</classCode>
<classCode scheme="mesh">Parkinson Disease</classCode>
<classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Mitochondrial dysfunctions have been implicated in the cellular processes underlying several neurodegenerative disorders affecting the basal ganglia. These include Huntington's chorea and Parkinson's disease, two highly debilitating motor disorders for which recent research has also involved gene mutation linked to mitochondrial deficits. Experimental models of basal ganglia diseases have been developed by using toxins able to disrupt mitochondrial function: these molecules act by selectively inhibiting mitochondrial respiratory complexes, uncoupling cellular respiration. This in turn leads to oxidative stress and energy deficit that trigger critical downstream mechanisms, ultimately resulting in neuronal vulnerability and loss. Here we review the molecular and cellular downstream effects triggered by mitochondrial dysfunction, and the different experimental models that are obtained by the administration of selective mitochondrial toxins or by the expression of mutant genes.</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000734 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000734 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Hal |étape= Checkpoint |type= RBID |clé= Hal:hal-00848870 |texte= Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |