ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000629

Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study

Identifieur interne : 000629 ( Hal/Checkpoint ); précédent : 000628; suivant : 000630

Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study

Auteurs : Ulla Miguel [France] ; Stephane C. Thobois [France] ; Pierre-Michel Llorca [France] ; Philippe P. Derost [France] ; Jean-Jacques Lemaire [France] ; Isabelle Chereau-Boudet [France] ; Ingrid De Chazeron [France] ; Audrey Schmitt [France] ; Benedicte Ballanger [France] ; Emmanuel Broussolle [France] ; Franck Durif [France]

Source :

Journal of Neurology, Neurosurgery and Psychiatry [ 0022-3050 ] ; 2010-11-03.

RBID : Hal:hal-00591165

English descriptors

mix :
- PARKINSON'S DISEASE, PSYCHIATRY.

Abstract

Hypomanic symptoms depending on anatomical location of contacts are reported in Parkinson's disease (PD) patients treated by deep-brain-stimulation (DBS) of subthalamic nucleus (STN) area. However, the underlying cortical and subcortical dysfunction remains debated. In this study, we investigated five PD patients implanted with DBS-STN who presented reversible and reproducible hypomanic symptoms after stimulation of specific "manic" contacts. Hypomanic symptoms were assessed using the Bech and Rafaelsen Mania Scale (MAS). A 3-D anatomical location of "euthymic" and "manic" contacts, after matching post operative CT scan with pre-operative stereotactic MRI, and a H215O PET study in conditions testing "euthymic" and "manic" contacts, were performed. In the "euthymic" condition, MAS score (mean ± SD) was 0.6 ± 0.5 compared to 7.8 ± 3.1 in the "manic" condition. Nine of ten "manic" contacts were located in the substantia nigra mainly in its ventral part. PET showed that hypomania was associated with a strong asymmetrical cerebral activation involving preferentially the right hemisphere, and was mediated by an activation of the anterior cingulate and medial prefrontal cortex. The present study demonstrates the role of subcortical structures in the genesis of hypomania in PD patients treated with DBS and stresses the implication of substantia nigra.

Url:

https://hal.archives-ouvertes.fr/hal-00591165

DOI: 10.1136/jnnp.2009.199323

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000220
to stream Hal, to step Curation: 000220

Links to Exploration step

Hal:hal-00591165

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study</title>
<author><name sortKey="Miguel, Ulla" sort="Miguel, Ulla" uniqKey="Miguel U" first="Ulla" last="Miguel">Ulla Miguel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane C" sort="Thobois, Stephane C" uniqKey="Thobois S" first="Stephane C" last="Thobois">Stephane C. Thobois</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Llorca, Pierre Michel" sort="Llorca, Pierre Michel" uniqKey="Llorca P" first="Pierre-Michel" last="Llorca">Pierre-Michel Llorca</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Derost, Philippe P" sort="Derost, Philippe P" uniqKey="Derost P" first="Philippe P" last="Derost">Philippe P. Derost</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lemaire, Jean Jacques" sort="Lemaire, Jean Jacques" uniqKey="Lemaire J" first="Jean-Jacques" last="Lemaire">Jean-Jacques Lemaire</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chereau Boudet, Isabelle" sort="Chereau Boudet, Isabelle" uniqKey="Chereau Boudet I" first="Isabelle" last="Chereau-Boudet">Isabelle Chereau-Boudet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Chazeron, Ingrid" sort="De Chazeron, Ingrid" uniqKey="De Chazeron I" first="Ingrid" last="De Chazeron">Ingrid De Chazeron</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Schmitt, Audrey" sort="Schmitt, Audrey" uniqKey="Schmitt A" first="Audrey" last="Schmitt">Audrey Schmitt</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00591165</idno>
<idno type="halId">hal-00591165</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00591165</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00591165</idno>
<idno type="doi">10.1136/jnnp.2009.199323</idno>
<date when="2010-11-03">2010-11-03</date>
<idno type="wicri:Area/Hal/Corpus">000220</idno>
<idno type="wicri:Area/Hal/Curation">000220</idno>
<idno type="wicri:Area/Hal/Checkpoint">000629</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000629</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study</title>
<author><name sortKey="Miguel, Ulla" sort="Miguel, Ulla" uniqKey="Miguel U" first="Ulla" last="Miguel">Ulla Miguel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane C" sort="Thobois, Stephane C" uniqKey="Thobois S" first="Stephane C" last="Thobois">Stephane C. Thobois</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Llorca, Pierre Michel" sort="Llorca, Pierre Michel" uniqKey="Llorca P" first="Pierre-Michel" last="Llorca">Pierre-Michel Llorca</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Derost, Philippe P" sort="Derost, Philippe P" uniqKey="Derost P" first="Philippe P" last="Derost">Philippe P. Derost</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lemaire, Jean Jacques" sort="Lemaire, Jean Jacques" uniqKey="Lemaire J" first="Jean-Jacques" last="Lemaire">Jean-Jacques Lemaire</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chereau Boudet, Isabelle" sort="Chereau Boudet, Isabelle" uniqKey="Chereau Boudet I" first="Isabelle" last="Chereau-Boudet">Isabelle Chereau-Boudet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Chazeron, Ingrid" sort="De Chazeron, Ingrid" uniqKey="De Chazeron I" first="Ingrid" last="De Chazeron">Ingrid De Chazeron</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Schmitt, Audrey" sort="Schmitt, Audrey" uniqKey="Schmitt A" first="Audrey" last="Schmitt">Audrey Schmitt</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-154807" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-339022" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-339022" type="direct"><org type="institution" xml:id="struct-339022" status="INCOMING">  <orgName>Hopital Neurologique Pierre Wertheimer</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-122738" status="INCOMING">  <orgName>Centres d'addictologies - Région Centre</orgName>
  <desc>    <address>      <addrLine>Centre Médico-Psychologique B - 58 rue Montalembert - 63000 Clermont-Ferrand</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300144" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID">  <orgName>CHU Clermont-Ferrand</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1136/jnnp.2009.199323</idno>
<series><title level="j">Journal of Neurology, Neurosurgery and Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<imprint><date type="datePub">2010-11-03</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>PARKINSON'S DISEASE</term>
<term>PSYCHIATRY</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Hypomanic symptoms depending on anatomical location of contacts are reported in Parkinson's disease (PD) patients treated by deep-brain-stimulation (DBS) of subthalamic nucleus (STN) area. However, the underlying cortical and subcortical dysfunction remains debated. In this study, we investigated five PD patients implanted with DBS-STN who presented reversible and reproducible hypomanic symptoms after stimulation of specific "manic" contacts. Hypomanic symptoms were assessed using the Bech and Rafaelsen Mania Scale (MAS). A 3-D anatomical location of "euthymic" and "manic" contacts, after matching post operative CT scan with pre-operative stereotactic MRI, and a H215O PET study in conditions testing "euthymic" and "manic" contacts, were performed. In the "euthymic" condition, MAS score (mean ± SD) was 0.6 ± 0.5 compared to 7.8 ± 3.1 in the "manic" condition. Nine of ten "manic" contacts were located in the substantia nigra mainly in its ventral part. PET showed that hypomania was associated with a strong asymmetrical cerebral activation involving preferentially the right hemisphere, and was mediated by an activation of the anterior cingulate and medial prefrontal cortex. The present study demonstrates the role of subcortical structures in the genesis of hypomania in PD patients treated with DBS and stresses the implication of substantia nigra.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study</title>
            <author role="crp">              <persName>                <forename type="first">Ulla</forename>
                <surname>Miguel</surname>
              </persName>
              <email type="md5">b582e7c3d49ca6a221b71e76f5f35b6f</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605640</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Stephane C</forename>
                <surname>Thobois</surname>
              </persName>
              <email type="md5">6d9ad19fb3c37520f0a1f444a86495cd</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="halauthorid">605641</idno>
              <affiliation ref="#struct-154807"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Pierre-Michel</forename>
                <surname>Llorca</surname>
              </persName>
              <email type="md5">f55ae82cd568403b5c82fb6c464352a9</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605642</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Philippe P</forename>
                <surname>Derost</surname>
              </persName>
              <email type="md5">2a0f24f25dd4721757ba0971f7e6a0a2</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605643</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Jean-Jacques</forename>
                <surname>Lemaire</surname>
              </persName>
              <email type="md5">e5c90a9b86a1e26725a1a40d6098b7e9</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605644</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Isabelle</forename>
                <surname>Chereau-Boudet</surname>
              </persName>
              <email type="md5">df9df987cbd7352341288bb1fdaf2512</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605645</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Ingrid</forename>
                <surname>De Chazeron</surname>
              </persName>
              <email type="md5">419f278f7ed93fd6dda023c423e6653e</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605646</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Audrey</forename>
                <surname>Schmitt</surname>
              </persName>
              <email type="md5">e8e1fa49053ba4f1d52d9322844b3b7b</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605647</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Benedicte</forename>
                <surname>Ballanger</surname>
              </persName>
              <email type="md5">651a2b5f6f49e4eecf95609be7487a77</email>
              <email type="domain">isc.cnrs.fr</email>
              <idno type="halauthorid">605648</idno>
              <affiliation ref="#struct-154807"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Emmanuel</forename>
                <surname>Broussolle</surname>
              </persName>
              <email type="md5">ee8d526cb1a3980bfae5996803311b31</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="halauthorid">584684</idno>
              <affiliation ref="#struct-154807"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Franck</forename>
                <surname>Durif</surname>
              </persName>
              <email type="md5">4a9e78852fb8d887d32d423bddafe681</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="halauthorid">605649</idno>
              <affiliation ref="#struct-122738"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Hal</forename>
                <surname>Peer</surname>
              </persName>
              <email type="md5">5622baf37011fbdddae7d4c59b5831b9</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2011-05-07 02:54:59</date>
              <date type="whenWritten">2009-11-05</date>
              <date type="whenModified">2011-05-07 02:54:59</date>
              <date type="whenReleased">2011-05-07 02:54:59</date>
              <date type="whenProduced">2010-11-03</date>
              <date type="whenEndEmbargoed">2011-05-07</date>
              <ref type="file" target="https://hal.archives-ouvertes.fr/hal-00591165/document">                <date notBefore="2011-05-07"></date>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.archives-ouvertes.fr/hal-00591165/file/PEER_stage2_10.1136%252Fjnnp.2009.199323.pdf">                <date notBefore="2011-05-07"></date>
              </ref>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="148147">                <persName>                  <forename>Hal</forename>
                  <surname>Peer</surname>
                </persName>
                <email type="md5">5622baf37011fbdddae7d4c59b5831b9</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00591165</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00591165</idno>
            <idno type="halBibtex">miguel:hal-00591165</idno>
            <idno type="halRefHtml">Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2010, 82 (6), pp.607. <10.1136/jnnp.2009.199323></idno>
            <idno type="halRef">Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2010, 82 (6), pp.607. <10.1136/jnnp.2009.199323></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="PEER">PEER Publishing and the Ecology of European Research</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study</title>
                <author role="crp">                  <persName>                    <forename type="first">Ulla</forename>
                    <surname>Miguel</surname>
                  </persName>
                  <email type="md5">b582e7c3d49ca6a221b71e76f5f35b6f</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605640</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Stephane C</forename>
                    <surname>Thobois</surname>
                  </persName>
                  <email type="md5">6d9ad19fb3c37520f0a1f444a86495cd</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="halauthorid">605641</idno>
                  <affiliation ref="#struct-154807"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pierre-Michel</forename>
                    <surname>Llorca</surname>
                  </persName>
                  <email type="md5">f55ae82cd568403b5c82fb6c464352a9</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605642</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Philippe P</forename>
                    <surname>Derost</surname>
                  </persName>
                  <email type="md5">2a0f24f25dd4721757ba0971f7e6a0a2</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605643</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jean-Jacques</forename>
                    <surname>Lemaire</surname>
                  </persName>
                  <email type="md5">e5c90a9b86a1e26725a1a40d6098b7e9</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605644</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Isabelle</forename>
                    <surname>Chereau-Boudet</surname>
                  </persName>
                  <email type="md5">df9df987cbd7352341288bb1fdaf2512</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605645</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Ingrid</forename>
                    <surname>De Chazeron</surname>
                  </persName>
                  <email type="md5">419f278f7ed93fd6dda023c423e6653e</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605646</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Audrey</forename>
                    <surname>Schmitt</surname>
                  </persName>
                  <email type="md5">e8e1fa49053ba4f1d52d9322844b3b7b</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605647</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Benedicte</forename>
                    <surname>Ballanger</surname>
                  </persName>
                  <email type="md5">651a2b5f6f49e4eecf95609be7487a77</email>
                  <email type="domain">isc.cnrs.fr</email>
                  <idno type="halauthorid">605648</idno>
                  <affiliation ref="#struct-154807"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Emmanuel</forename>
                    <surname>Broussolle</surname>
                  </persName>
                  <email type="md5">ee8d526cb1a3980bfae5996803311b31</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="halauthorid">584684</idno>
                  <affiliation ref="#struct-154807"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Franck</forename>
                    <surname>Durif</surname>
                  </persName>
                  <email type="md5">4a9e78852fb8d887d32d423bddafe681</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="halauthorid">605649</idno>
                  <affiliation ref="#struct-122738"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">15872</idno>
                <idno type="issn">0022-3050</idno>
                <idno type="eissn">1468-330X</idno>
                <title level="j">Journal of Neurology, Neurosurgery and Psychiatry</title>
                <imprint>                  <publisher>BMJ Publishing Group</publisher>
                  <biblScope unit="volume">82</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">607</biblScope>
                  <date type="datePub">2010-11-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1136/jnnp.2009.199323</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">PARKINSON'S DISEASE</term>
                <term xml:lang="en">PSYCHIATRY</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Hypomanic symptoms depending on anatomical location of contacts are reported in Parkinson's disease (PD) patients treated by deep-brain-stimulation (DBS) of subthalamic nucleus (STN) area. However, the underlying cortical and subcortical dysfunction remains debated. In this study, we investigated five PD patients implanted with DBS-STN who presented reversible and reproducible hypomanic symptoms after stimulation of specific "manic" contacts. Hypomanic symptoms were assessed using the Bech and Rafaelsen Mania Scale (MAS). A 3-D anatomical location of "euthymic" and "manic" contacts, after matching post operative CT scan with pre-operative stereotactic MRI, and a H215O PET study in conditions testing "euthymic" and "manic" contacts, were performed. In the "euthymic" condition, MAS score (mean ± SD) was 0.6 ± 0.5 compared to 7.8 ± 3.1 in the "manic" condition. Nine of ten "manic" contacts were located in the substantia nigra mainly in its ventral part. PET showed that hypomania was associated with a strong asymmetrical cerebral activation involving preferentially the right hemisphere, and was mediated by an activation of the anterior cingulate and medial prefrontal cortex. The present study demonstrates the role of subcortical structures in the genesis of hypomania in PD patients treated with DBS and stresses the implication of substantia nigra.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000629 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000629 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-00591165
   |texte=   Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study

Contact-dependent reproducible hypomania induced by Deep Brain Stimulation in Parkinson's disease: Clinical, anatomical and functional imaging study

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri