ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000569

Priorities in Parkinson's disease research.

Identifieur interne : 000569 ( Hal/Checkpoint ); précédent : 000568; suivant : 000570

Priorities in Parkinson's disease research.

Auteurs : Wassilios G. Meissner [France] ; Mark Frasier [États-Unis] ; Thomas Gasser [France] ; Christopher G. Goetz [États-Unis] ; Andres Lozano ; Paola Piccini [Royaume-Uni] ; José A. Obeso [Espagne] ; Olivier Rascol [France] ; Anthony Schapira [Royaume-Uni] ; Valerie Voon [Canada] ; David M. Weiner [États-Unis] ; François Tison [France] ; Erwan Bezard [France]

Source :

Nature Reviews Drug Discovery [ 1474-1784 ] ; 2011-04-30.

RBID : Hal:hal-01222559

Abstract

The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.

Url:

https://hal.archives-ouvertes.fr/hal-01222559

DOI: 10.1038

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Le document en format XML

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<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
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<country>France</country>
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<region type="region" nuts="2">Nouvelle-Aquitaine</region>
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<idno type="DOI">10.1038</idno>
<series><title level="j">Nature Reviews Drug Discovery</title>
<idno type="ISSN">1474-1784</idno>
<imprint><date type="datePub">2011-04-30</date>
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<front><div type="abstract" xml:lang="en">The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Priorities in Parkinson's disease research.</title>
            <author role="aut">              <persName>                <forename type="first">Wassilios G</forename>
                <surname>Meissner</surname>
              </persName>
              <idno type="halauthorid">1212312</idno>
              <affiliation ref="#struct-244085"></affiliation>
              <affiliation ref="#struct-75075"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Mark</forename>
                <surname>Frasier</surname>
              </persName>
              <idno type="halauthorid">1063811</idno>
              <affiliation ref="#struct-263807"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Thomas</forename>
                <surname>Gasser</surname>
              </persName>
              <idno type="halauthorid">410307</idno>
              <affiliation ref="#struct-518"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Christopher G</forename>
                <surname>Goetz</surname>
              </persName>
              <idno type="halauthorid">1063812</idno>
              <affiliation ref="#struct-263808"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Andres</forename>
                <surname>Lozano</surname>
              </persName>
              <idno type="halauthorid">1063813</idno>
            </author>
            <author role="aut">              <persName>                <forename type="first">Paola</forename>
                <surname>Piccini</surname>
              </persName>
              <idno type="halauthorid">617433</idno>
              <affiliation ref="#struct-158764"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">José A</forename>
                <surname>Obeso</surname>
              </persName>
              <idno type="halauthorid">1063814</idno>
              <affiliation ref="#struct-171923"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Olivier</forename>
                <surname>Rascol</surname>
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              <idno type="halauthorid">762386</idno>
              <affiliation ref="#struct-2618"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Anthony</forename>
                <surname>Schapira</surname>
              </persName>
              <idno type="halauthorid">1063815</idno>
              <affiliation ref="#struct-95915"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Valerie</forename>
                <surname>Voon</surname>
              </persName>
              <idno type="halauthorid">405089</idno>
              <affiliation ref="#struct-93969"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">David M</forename>
                <surname>Weiner</surname>
              </persName>
              <idno type="halauthorid">1063816</idno>
              <affiliation ref="#struct-263809"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">François</forename>
                <surname>Tison</surname>
              </persName>
              <idno type="halauthorid">224383</idno>
              <affiliation ref="#struct-75075"></affiliation>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Erwan</forename>
                <surname>Bezard</surname>
              </persName>
              <idno type="halauthorid">537314</idno>
              <affiliation ref="#struct-244085"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Chantal</forename>
                <surname>GUERIN</surname>
              </persName>
              <email type="md5">eb4bde61f74652335183b0bd05630b2c</email>
              <email type="domain">u-bordeaux.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2015-10-30 11:08:20</date>
              <date type="whenModified">2017-02-09 15:02:19</date>
              <date type="whenReleased">2015-10-30 11:08:20</date>
              <date type="whenProduced">2011-04-30</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="321070">                <persName>                  <forename>Chantal</forename>
                  <surname>GUERIN</surname>
                </persName>
                <email type="md5">eb4bde61f74652335183b0bd05630b2c</email>
                <email type="domain">u-bordeaux.fr</email>
              </name>
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            <idno type="halId">hal-01222559</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01222559</idno>
            <idno type="halBibtex">meissner:hal-01222559</idno>
            <idno type="halRefHtml">Nature Reviews Drug Discovery, Nature Publishing Group, 2011, 10 (5), pp.377-93. <10.1038></idno>
            <idno type="halRef">Nature Reviews Drug Discovery, Nature Publishing Group, 2011, 10 (5), pp.377-93. <10.1038></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="DSM-LSCE" p="CEA">LSCE</idno>
            <idno type="stamp" n="CEA-UPSAY" p="CEA">CEA - Université Paris-Saclay</idno>
            <idno type="stamp" n="LSCE">Laboratoire des Sciences du Climat et de l’Environnement</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Priorities in Parkinson's disease research.</title>
                <author role="aut">                  <persName>                    <forename type="first">Wassilios G</forename>
                    <surname>Meissner</surname>
                  </persName>
                  <idno type="halauthorid">1212312</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                  <affiliation ref="#struct-75075"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Mark</forename>
                    <surname>Frasier</surname>
                  </persName>
                  <idno type="halauthorid">1063811</idno>
                  <affiliation ref="#struct-263807"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Thomas</forename>
                    <surname>Gasser</surname>
                  </persName>
                  <idno type="halauthorid">410307</idno>
                  <affiliation ref="#struct-518"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Christopher G</forename>
                    <surname>Goetz</surname>
                  </persName>
                  <idno type="halauthorid">1063812</idno>
                  <affiliation ref="#struct-263808"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Andres</forename>
                    <surname>Lozano</surname>
                  </persName>
                  <idno type="halauthorid">1063813</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Paola</forename>
                    <surname>Piccini</surname>
                  </persName>
                  <idno type="halauthorid">617433</idno>
                  <affiliation ref="#struct-158764"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">José A</forename>
                    <surname>Obeso</surname>
                  </persName>
                  <idno type="halauthorid">1063814</idno>
                  <affiliation ref="#struct-171923"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Olivier</forename>
                    <surname>Rascol</surname>
                  </persName>
                  <idno type="halauthorid">762386</idno>
                  <affiliation ref="#struct-2618"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Anthony</forename>
                    <surname>Schapira</surname>
                  </persName>
                  <idno type="halauthorid">1063815</idno>
                  <affiliation ref="#struct-95915"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Valerie</forename>
                    <surname>Voon</surname>
                  </persName>
                  <idno type="halauthorid">405089</idno>
                  <affiliation ref="#struct-93969"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">David M</forename>
                    <surname>Weiner</surname>
                  </persName>
                  <idno type="halauthorid">1063816</idno>
                  <affiliation ref="#struct-263809"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">François</forename>
                    <surname>Tison</surname>
                  </persName>
                  <idno type="halauthorid">224383</idno>
                  <affiliation ref="#struct-75075"></affiliation>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Erwan</forename>
                    <surname>Bezard</surname>
                  </persName>
                  <idno type="halauthorid">537314</idno>
                  <affiliation ref="#struct-244085"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">17327</idno>
                <idno type="issn">1474-1784</idno>
                <idno type="eissn">1474-1784</idno>
                <title level="j">Nature Reviews Drug Discovery</title>
                <imprint>                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">10</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">377-93</biblScope>
                  <date type="datePub">2011-04-30</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038</idno>
              <idno type="pubmed">21532567</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.</abstract>
          </profileDesc>
        </hal>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Priorities in Parkinson's disease research.

Priorities in Parkinson's disease research.

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