ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000464

ER stress inhibits neuronal death by promoting autophagy

Identifieur interne : 000464 ( Hal/Checkpoint ); précédent : 000463; suivant : 000465

ER stress inhibits neuronal death by promoting autophagy

Auteurs : Antoine Fouillet [France] ; Clémence Levet [France] ; Angélique Virgone [France] ; Marion Robin [France] ; Pierre Dourlen [France] ; Jennifer Rieusset [France] ; Elise Belaidi [France] ; Michel Ovize [France] ; Monique Touret [France] ; Serge Nataf [France] ; Bertrand Mollereau [France]

Source :

Autophagy [ 1554-8627 ] ; 2012-06-01.

RBID : Hal:ensl-00807628

Descripteurs français

mix :
- ER stress, apoptosis, autophagy, drosophila, mouse, parkinson.

Abstract

Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases but its relationship and role in disease progression remain unclear. Using genetic and pharmacological approaches, we showed that mild ER stress ("preconditioning") is neuroprotective in Drosophila and mouse models of Parkinson disease. In addition, we found that the combination of mild ER stress and apoptotic signals triggers an autophagic response both in vivo and in vitro. We showed that when autophagy is impaired, ER-mediated protection is lost. We further demonstrated that autophagy inhibits caspase activation and apoptosis. Based on our findings, we conclude that autophagy is required for the neuroprotection mediated by mild ER stress, and therefore ER preconditioning has potential therapeutic value for the treatment of neurodegenerative diseases.

Url:

https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807628

DOI: 10.4161

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000345
to stream Hal, to step Curation: 000345

Links to Exploration step

Hal:ensl-00807628

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ER stress inhibits neuronal death by promoting autophagy</title>
<author><name sortKey="Fouillet, Antoine" sort="Fouillet, Antoine" uniqKey="Fouillet A" first="Antoine" last="Fouillet">Antoine Fouillet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Levet, Clemence" sort="Levet, Clemence" uniqKey="Levet C" first="Clémence" last="Levet">Clémence Levet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Virgone, Angelique" sort="Virgone, Angelique" uniqKey="Virgone A" first="Angélique" last="Virgone">Angélique Virgone</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Robin, Marion" sort="Robin, Marion" uniqKey="Robin M" first="Marion" last="Robin">Marion Robin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Dourlen, Pierre" sort="Dourlen, Pierre" uniqKey="Dourlen P" first="Pierre" last="Dourlen">Pierre Dourlen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Rieusset, Jennifer" sort="Rieusset, Jennifer" uniqKey="Rieusset J" first="Jennifer" last="Rieusset">Jennifer Rieusset</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218708" status="INCOMING">  <orgName>INSERM</orgName>
  <desc>    <address>      <addrLine>Lyon</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-322939" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-322939" type="direct"><org type="institution" xml:id="struct-322939" status="INCOMING">  <orgName>Faculté de Médecine Lyon-Sud</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Belaidi, Elise" sort="Belaidi, Elise" uniqKey="Belaidi E" first="Elise" last="Belaidi">Elise Belaidi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218709" status="INCOMING">  <orgName>Service d'Explorations Fonctionnelles Cardiovasculaires</orgName>
  <orgName type="acronym">SEFC</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300074" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID">  <orgName>Hospices Civils de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ovize, Michel" sort="Ovize, Michel" uniqKey="Ovize M" first="Michel" last="Ovize">Michel Ovize</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218709" status="INCOMING">  <orgName>Service d'Explorations Fonctionnelles Cardiovasculaires</orgName>
  <orgName type="acronym">SEFC</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300074" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID">  <orgName>Hospices Civils de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Touret, Monique" sort="Touret, Monique" uniqKey="Touret M" first="Monique" last="Touret">Monique Touret</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Nataf, Serge" sort="Nataf, Serge" uniqKey="Nataf S" first="Serge" last="Nataf">Serge Nataf</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mollereau, Bertrand" sort="Mollereau, Bertrand" uniqKey="Mollereau B" first="Bertrand" last="Mollereau">Bertrand Mollereau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:ensl-00807628</idno>
<idno type="halId">ensl-00807628</idno>
<idno type="halUri">https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807628</idno>
<idno type="url">https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807628</idno>
<idno type="doi">10.4161</idno>
<date when="2012-06-01">2012-06-01</date>
<idno type="wicri:Area/Hal/Corpus">000345</idno>
<idno type="wicri:Area/Hal/Curation">000345</idno>
<idno type="wicri:Area/Hal/Checkpoint">000464</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000464</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">ER stress inhibits neuronal death by promoting autophagy</title>
<author><name sortKey="Fouillet, Antoine" sort="Fouillet, Antoine" uniqKey="Fouillet A" first="Antoine" last="Fouillet">Antoine Fouillet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Levet, Clemence" sort="Levet, Clemence" uniqKey="Levet C" first="Clémence" last="Levet">Clémence Levet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Virgone, Angelique" sort="Virgone, Angelique" uniqKey="Virgone A" first="Angélique" last="Virgone">Angélique Virgone</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Robin, Marion" sort="Robin, Marion" uniqKey="Robin M" first="Marion" last="Robin">Marion Robin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Dourlen, Pierre" sort="Dourlen, Pierre" uniqKey="Dourlen P" first="Pierre" last="Dourlen">Pierre Dourlen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Rieusset, Jennifer" sort="Rieusset, Jennifer" uniqKey="Rieusset J" first="Jennifer" last="Rieusset">Jennifer Rieusset</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218708" status="INCOMING">  <orgName>INSERM</orgName>
  <desc>    <address>      <addrLine>Lyon</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-322939" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-322939" type="direct"><org type="institution" xml:id="struct-322939" status="INCOMING">  <orgName>Faculté de Médecine Lyon-Sud</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Belaidi, Elise" sort="Belaidi, Elise" uniqKey="Belaidi E" first="Elise" last="Belaidi">Elise Belaidi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218709" status="INCOMING">  <orgName>Service d'Explorations Fonctionnelles Cardiovasculaires</orgName>
  <orgName type="acronym">SEFC</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300074" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID">  <orgName>Hospices Civils de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ovize, Michel" sort="Ovize, Michel" uniqKey="Ovize M" first="Michel" last="Ovize">Michel Ovize</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218709" status="INCOMING">  <orgName>Service d'Explorations Fonctionnelles Cardiovasculaires</orgName>
  <orgName type="acronym">SEFC</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-300074" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID">  <orgName>Hospices Civils de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Touret, Monique" sort="Touret, Monique" uniqKey="Touret M" first="Monique" last="Touret">Monique Touret</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Nataf, Serge" sort="Nataf, Serge" uniqKey="Nataf S" first="Serge" last="Nataf">Serge Nataf</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-301088" status="VALID">  <orgName>Université de Lyon</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mollereau, Bertrand" sort="Mollereau, Bertrand" uniqKey="Mollereau B" first="Bertrand" last="Mollereau">Bertrand Mollereau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-39378" status="VALID">  <orgName>Laboratoire de Biologie Moléculaire de la Cellule</orgName>
  <orgName type="acronym">LBMC</orgName>
  <desc>    <address>      <addrLine>46 allée d'Italie 69364 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
  </desc>
  <listRelation>    <relation active="#struct-6818" type="direct"></relation>
    <relation active="#struct-194495" type="direct"></relation>
    <relation name="UMR 5239" active="#struct-441569" type="direct"></relation>
    <relation name="U1210" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-6818" type="direct"><org type="institution" xml:id="struct-6818" status="VALID">  <idno type="IdRef">149154992</idno>
  <orgName>École normale supérieure - Lyon</orgName>
  <orgName type="acronym">ENS Lyon</orgName>
  <desc>    <address>      <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ens-lyon.eu/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">  <orgName>Université Claude Bernard Lyon 1</orgName>
  <orgName type="acronym">UCBL</orgName>
  <desc>    <address>      <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-lyon1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR 5239" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1210" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.4161</idno>
<series><title level="j">Autophagy</title>
<idno type="ISSN">1554-8627</idno>
<imprint><date type="datePub">2012-06-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="fr"><term>ER stress</term>
<term>apoptosis</term>
<term>autophagy</term>
<term>drosophila</term>
<term>mouse</term>
<term>parkinson</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases but its relationship and role in disease progression remain unclear. Using genetic and pharmacological approaches, we showed that mild ER stress ("preconditioning") is neuroprotective in Drosophila and mouse models of Parkinson disease. In addition, we found that the combination of mild ER stress and apoptotic signals triggers an autophagic response both in vivo and in vitro. We showed that when autophagy is impaired, ER-mediated protection is lost. We further demonstrated that autophagy inhibits caspase activation and apoptosis. Based on our findings, we conclude that autophagy is required for the neuroprotection mediated by mild ER stress, and therefore ER preconditioning has potential therapeutic value for the treatment of neurodegenerative diseases.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">ER stress inhibits neuronal death by promoting autophagy</title>
            <author role="aut">              <persName>                <forename type="first">Antoine</forename>
                <surname>Fouillet</surname>
              </persName>
              <idno type="halauthorid">834110</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Clémence</forename>
                <surname>Levet</surname>
              </persName>
              <idno type="halauthorid">834111</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Angélique</forename>
                <surname>Virgone</surname>
              </persName>
              <idno type="halauthorid">834112</idno>
              <affiliation ref="#struct-301088"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Marion</forename>
                <surname>Robin</surname>
              </persName>
              <idno type="halauthorid">833840</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Pierre</forename>
                <surname>Dourlen</surname>
              </persName>
              <idno type="halauthorid">112698</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Jennifer</forename>
                <surname>Rieusset</surname>
              </persName>
              <idno type="halauthorid">834113</idno>
              <affiliation ref="#struct-218708"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Elise</forename>
                <surname>Belaidi</surname>
              </persName>
              <idno type="halauthorid">160156</idno>
              <affiliation ref="#struct-218709"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Michel</forename>
                <surname>Ovize</surname>
              </persName>
              <idno type="halauthorid">411188</idno>
              <affiliation ref="#struct-218709"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Monique</forename>
                <surname>Touret</surname>
              </persName>
              <idno type="halauthorid">834114</idno>
              <affiliation ref="#struct-301088"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Serge</forename>
                <surname>Nataf</surname>
              </persName>
              <idno type="halauthorid">156039</idno>
              <affiliation ref="#struct-301088"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Bertrand</forename>
                <surname>Mollereau</surname>
              </persName>
              <idno type="halauthorid">766018</idno>
              <affiliation ref="#struct-39378"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Agnès</forename>
                <surname>Ganivet</surname>
              </persName>
              <email type="md5">ceea73c32b6cb9b059e3d4a4d617354f</email>
              <email type="domain">ens-lyon.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2013-04-04 09:32:07</date>
              <date type="whenWritten">2012-06</date>
              <date type="whenModified">2013-04-04 09:32:07</date>
              <date type="whenReleased">2013-04-04 09:32:07</date>
              <date type="whenProduced">2012-06-01</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="165107">                <persName>                  <forename>Agnès</forename>
                  <surname>Ganivet</surname>
                </persName>
                <email type="md5">ceea73c32b6cb9b059e3d4a4d617354f</email>
                <email type="domain">ens-lyon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">ensl-00807628</idno>
            <idno type="halUri">https://hal-ens-lyon.archives-ouvertes.fr/ensl-00807628</idno>
            <idno type="halBibtex">fouillet:ensl-00807628</idno>
            <idno type="halRefHtml">Autophagy, Taylor & Francis, 2012, 8 (6), pp.915 - 926. <10.4161></idno>
            <idno type="halRef">Autophagy, Taylor & Francis, 2012, 8 (6), pp.915 - 926. <10.4161></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="ENS-LYON">École Normale Supérieure de Lyon</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">ER stress inhibits neuronal death by promoting autophagy</title>
                <author role="aut">                  <persName>                    <forename type="first">Antoine</forename>
                    <surname>Fouillet</surname>
                  </persName>
                  <idno type="halauthorid">834110</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Clémence</forename>
                    <surname>Levet</surname>
                  </persName>
                  <idno type="halauthorid">834111</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Angélique</forename>
                    <surname>Virgone</surname>
                  </persName>
                  <idno type="halauthorid">834112</idno>
                  <affiliation ref="#struct-301088"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marion</forename>
                    <surname>Robin</surname>
                  </persName>
                  <idno type="halauthorid">833840</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pierre</forename>
                    <surname>Dourlen</surname>
                  </persName>
                  <idno type="halauthorid">112698</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jennifer</forename>
                    <surname>Rieusset</surname>
                  </persName>
                  <idno type="halauthorid">834113</idno>
                  <affiliation ref="#struct-218708"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Elise</forename>
                    <surname>Belaidi</surname>
                  </persName>
                  <idno type="halauthorid">160156</idno>
                  <affiliation ref="#struct-218709"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Michel</forename>
                    <surname>Ovize</surname>
                  </persName>
                  <idno type="halauthorid">411188</idno>
                  <affiliation ref="#struct-218709"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Monique</forename>
                    <surname>Touret</surname>
                  </persName>
                  <idno type="halauthorid">834114</idno>
                  <affiliation ref="#struct-301088"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Serge</forename>
                    <surname>Nataf</surname>
                  </persName>
                  <idno type="halauthorid">156039</idno>
                  <affiliation ref="#struct-301088"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Bertrand</forename>
                    <surname>Mollereau</surname>
                  </persName>
                  <idno type="halauthorid">766018</idno>
                  <affiliation ref="#struct-39378"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">28676</idno>
                <idno type="issn">1554-8627</idno>
                <idno type="eissn">1554-8635</idno>
                <title level="j">Autophagy</title>
                <imprint>                  <publisher>Taylor & Francis</publisher>
                  <biblScope unit="volume">8</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">915 - 926</biblScope>
                  <date type="datePub">2012-06-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.4161</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="fr">ER stress</term>
                <term xml:lang="fr">autophagy</term>
                <term xml:lang="fr">parkinson</term>
                <term xml:lang="fr">apoptosis</term>
                <term xml:lang="fr">drosophila</term>
                <term xml:lang="fr">mouse</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases but its relationship and role in disease progression remain unclear. Using genetic and pharmacological approaches, we showed that mild ER stress ("preconditioning") is neuroprotective in Drosophila and mouse models of Parkinson disease. In addition, we found that the combination of mild ER stress and apoptotic signals triggers an autophagic response both in vivo and in vitro. We showed that when autophagy is impaired, ER-mediated protection is lost. We further demonstrated that autophagy inhibits caspase activation and apoptosis. Based on our findings, we conclude that autophagy is required for the neuroprotection mediated by mild ER stress, and therefore ER preconditioning has potential therapeutic value for the treatment of neurodegenerative diseases.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000464 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000464 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:ensl-00807628
   |texte=   ER stress inhibits neuronal death by promoting autophagy
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

ER stress inhibits neuronal death by promoting autophagy

ER stress inhibits neuronal death by promoting autophagy

Source :

Descripteurs français

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri