La maladie de Parkinson en France (serveur d'exploration)

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A critique of available scales and presentation of the non-human primate dyskinesia rating scale

Identifieur interne : 000451 ( Hal/Checkpoint ); précédent : 000450; suivant : 000452

A critique of available scales and presentation of the non-human primate dyskinesia rating scale

Auteurs : Susan H. Fox [Canada] ; Tom H. Johnston [Canada] ; Qin Li [Royaume-Uni] ; Jonathan Brotchie [Canada] ; Erwan Bezard [France]

Source :

RBID : Hal:hal-01290089

Abstract

Levodopa-induced dyskinesia (LID) is a major limitation of long-term management of Parkinson's disease. The roadblocks that have hindered the development of new treatments for levodopa-induced dyskinesia were discussed at a meeting organized by the Michael J. Fox Foundation for Parkinson's research (New York, NY, March 2011). Among these, the lack of consensus methodology and clinical applicability for eliciting and rating LID in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys was highlighted as a particular concern. Here we present an update on the practical use of rating scales for evaluating LID in MPTP-lesioned primate models of PD, with a focus on macaques, and present specifics on the Non-Human Primate Dyskinesia Rating Scale.

Url:
DOI: 10.1002/mds.25133

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Hal:hal-01290089

Le document en format XML

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<div type="abstract" xml:lang="en">Levodopa-induced dyskinesia (LID) is a major limitation of long-term management of Parkinson's disease. The roadblocks that have hindered the development of new treatments for levodopa-induced dyskinesia were discussed at a meeting organized by the Michael J. Fox Foundation for Parkinson's research (New York, NY, March 2011). Among these, the lack of consensus methodology and clinical applicability for eliciting and rating LID in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys was highlighted as a particular concern. Here we present an update on the practical use of rating scales for evaluating LID in MPTP-lesioned primate models of PD, with a focus on macaques, and present specifics on the Non-Human Primate Dyskinesia Rating Scale.</div>
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