ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000322

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Identifieur interne : 000322 ( Hal/Checkpoint ); précédent : 000321; suivant : 000323

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Auteurs : Daniel Rial [Brésil] ; Adalberto A. Castro [Brésil] ; Nuno Machado [Portugal] ; Pedro Garção [Portugal] ; Francisco Q. Gonçalves [Portugal] ; Henrique B. Silva [Portugal] ; Angelo R. Tomé [Portugal] ; Attila Köfalvi [Portugal] ; Olga Corti [France] ; Rita Raisman-Vozari [France] ; Rodrigo A. Cunha [Portugal] ; Rui D. Prediger [Brésil]

Source :

PLoS ONE [ 1932-6203 ] ; 2014.

RBID : Hal:hal-01369276

Abstract

There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the parkin gene cause early-onset familial PD, Parkin-deficient mice do not display spontaneous degeneration of the nigrostriatal pathway or enhanced vulnerability to dopaminergic neurotoxins such as 6-OHDA and MPTP. Here, we employed adult homozygous C57BL/6 mice with parkin gene deletion on exon 3 (parkin−/−) to further investigate the relevance of Parkin in the regulation of non-motor features, namely olfactory, emotional, cognitive and hippocampal synaptic plasticity. Parkin−/− mice displayed normal performance on behavioral tests evaluating olfaction (olfactory discrimination), anxiety (elevated plus-maze), depressive-like behavior (forced swimming and tail suspension) and motor function (rotarod, grasping strength and pole). However, parkin−/− mice displayed a poor performance in the open field habituation, object location and modified Y-maze tasks suggestive of procedural and short-term spatial memory deficits. These behavioral impairments were accompanied by impaired hippocampal long-term potentiation (LTP). These findings indicate that the genetic deletion of parkin causes deficiencies in hippocampal synaptic plasticity, resulting in memory deficits with no major olfactory, emotional or motor impairments. Therefore, parkin−/− mice may represent a promising animal model to study the early stages of PD and for testing new therapeutic strategies to restore learning and memory and synaptic plasticity impairments in PD.

Url:

http://hal.upmc.fr/hal-01369276

DOI: 10.1371/journal.pone.0114216

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000129
to stream Hal, to step Curation: 000129

Links to Exploration step

Hal:hal-01369276

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease</title>
<author><name sortKey="Rial, Daniel" sort="Rial, Daniel" uniqKey="Rial D" first="Daniel" last="Rial">Daniel Rial</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
<author><name sortKey="Castro, Adalberto A" sort="Castro, Adalberto A" uniqKey="Castro A" first="Adalberto A." last="Castro">Adalberto A. Castro</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
<author><name sortKey="Machado, Nuno" sort="Machado, Nuno" uniqKey="Machado N" first="Nuno" last="Machado">Nuno Machado</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Garcao, Pedro" sort="Garcao, Pedro" uniqKey="Garcao P" first="Pedro" last="Garção">Pedro Garção</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Goncalves, Francisco Q" sort="Goncalves, Francisco Q" uniqKey="Goncalves F" first="Francisco Q." last="Gonçalves">Francisco Q. Gonçalves</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Silva, Henrique B" sort="Silva, Henrique B" uniqKey="Silva H" first="Henrique B." last="Silva">Henrique B. Silva</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Tome, Angelo R" sort="Tome, Angelo R" uniqKey="Tome A" first="Angelo R." last="Tomé">Angelo R. Tomé</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Kofalvi, Attila" sort="Kofalvi, Attila" uniqKey="Kofalvi A" first="Attila" last="Köfalvi">Attila Köfalvi</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Corti, Olga" sort="Corti, Olga" uniqKey="Corti O" first="Olga" last="Corti">Olga Corti</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID">  <idno type="RNSR">200918525B</idno>
  <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
  <orgName type="acronym">ICM</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="UM75" active="#struct-93591" type="direct"></relation>
    <relation name="U1127" active="#struct-303623" type="direct"></relation>
    <relation active="#struct-353778" type="direct"></relation>
    <relation name="UMR7225" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">  <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID">  <idno type="RNSR">200918525B</idno>
  <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
  <orgName type="acronym">ICM</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="UM75" active="#struct-93591" type="direct"></relation>
    <relation name="U1127" active="#struct-303623" type="direct"></relation>
    <relation active="#struct-353778" type="direct"></relation>
    <relation name="UMR7225" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">  <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Cunha, Rodrigo A" sort="Cunha, Rodrigo A" uniqKey="Cunha R" first="Rodrigo A." last="Cunha">Rodrigo A. Cunha</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Prediger, Rui D" sort="Prediger, Rui D" uniqKey="Prediger R" first="Rui D." last="Prediger">Rui D. Prediger</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01369276</idno>
<idno type="halId">hal-01369276</idno>
<idno type="halUri">http://hal.upmc.fr/hal-01369276</idno>
<idno type="url">http://hal.upmc.fr/hal-01369276</idno>
<idno type="doi">10.1371/journal.pone.0114216</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Hal/Corpus">000129</idno>
<idno type="wicri:Area/Hal/Curation">000129</idno>
<idno type="wicri:Area/Hal/Checkpoint">000322</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000322</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease</title>
<author><name sortKey="Rial, Daniel" sort="Rial, Daniel" uniqKey="Rial D" first="Daniel" last="Rial">Daniel Rial</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
<author><name sortKey="Castro, Adalberto A" sort="Castro, Adalberto A" uniqKey="Castro A" first="Adalberto A." last="Castro">Adalberto A. Castro</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
<author><name sortKey="Machado, Nuno" sort="Machado, Nuno" uniqKey="Machado N" first="Nuno" last="Machado">Nuno Machado</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Garcao, Pedro" sort="Garcao, Pedro" uniqKey="Garcao P" first="Pedro" last="Garção">Pedro Garção</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Goncalves, Francisco Q" sort="Goncalves, Francisco Q" uniqKey="Goncalves F" first="Francisco Q." last="Gonçalves">Francisco Q. Gonçalves</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Silva, Henrique B" sort="Silva, Henrique B" uniqKey="Silva H" first="Henrique B." last="Silva">Henrique B. Silva</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Tome, Angelo R" sort="Tome, Angelo R" uniqKey="Tome A" first="Angelo R." last="Tomé">Angelo R. Tomé</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Kofalvi, Attila" sort="Kofalvi, Attila" uniqKey="Kofalvi A" first="Attila" last="Köfalvi">Attila Köfalvi</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Corti, Olga" sort="Corti, Olga" uniqKey="Corti O" first="Olga" last="Corti">Olga Corti</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID">  <idno type="RNSR">200918525B</idno>
  <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
  <orgName type="acronym">ICM</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="UM75" active="#struct-93591" type="direct"></relation>
    <relation name="U1127" active="#struct-303623" type="direct"></relation>
    <relation active="#struct-353778" type="direct"></relation>
    <relation name="UMR7225" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">  <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID">  <idno type="RNSR">200918525B</idno>
  <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
  <orgName type="acronym">ICM</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation name="UM75" active="#struct-93591" type="direct"></relation>
    <relation name="U1127" active="#struct-303623" type="direct"></relation>
    <relation active="#struct-353778" type="direct"></relation>
    <relation name="UMR7225" active="#struct-441569" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID">  <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
  <orgName type="acronym">UPMC</orgName>
  <desc>    <address>      <addrLine>4 place Jussieu - 75005 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.upmc.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID">  <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
  <desc>    <address>      <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Cunha, Rodrigo A" sort="Cunha, Rodrigo A" uniqKey="Cunha R" first="Rodrigo A." last="Cunha">Rodrigo A. Cunha</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300707" status="VALID">  <orgName>Universidade de Coimbra [Coimbra]</orgName>
  <desc>    <address>      <addrLine>Palácio dos GrilosRua da Ilha3000-214 Coimbra</addrLine>
      <country key="PT"></country>
    </address>
    <ref type="url">http://www.uc.pt/</ref>
  </desc>
</hal:affiliation>
<country>Portugal</country>
</affiliation>
</author>
<author><name sortKey="Prediger, Rui D" sort="Prediger, Rui D" uniqKey="Prediger R" first="Rui D." last="Prediger">Rui D. Prediger</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-119004" status="VALID">  <orgName>Universidade Federal de Santa Catarina [Florianópolis]</orgName>
  <orgName type="acronym">UFSC</orgName>
  <desc>    <address>      <addrLine>R. Eng. Agronômico Andrei Cristian Ferreira, s/n - Trindade, Florianópolis - SC, 88040-900</addrLine>
      <country key="BR"></country>
    </address>
    <ref type="url">http://www.ufsc.br/</ref>
  </desc>
</hal:affiliation>
<country>Brésil</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pone.0114216</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the parkin gene cause early-onset familial PD, Parkin-deficient mice do not display spontaneous degeneration of the nigrostriatal pathway or enhanced vulnerability to dopaminergic neurotoxins such as 6-OHDA and MPTP. Here, we employed adult homozygous C57BL/6 mice with parkin gene deletion on exon 3 (parkin−/−) to further investigate the relevance of Parkin in the regulation of non-motor features, namely olfactory, emotional, cognitive and hippocampal synaptic plasticity. Parkin−/− mice displayed normal performance on behavioral tests evaluating olfaction (olfactory discrimination), anxiety (elevated plus-maze), depressive-like behavior (forced swimming and tail suspension) and motor function (rotarod, grasping strength and pole). However, parkin−/− mice displayed a poor performance in the open field habituation, object location and modified Y-maze tasks suggestive of procedural and short-term spatial memory deficits. These behavioral impairments were accompanied by impaired hippocampal long-term potentiation (LTP). These findings indicate that the genetic deletion of parkin causes deficiencies in hippocampal synaptic plasticity, resulting in memory deficits with no major olfactory, emotional or motor impairments. Therefore, parkin−/− mice may represent a promising animal model to study the early stages of PD and for testing new therapeutic strategies to restore learning and memory and synaptic plasticity impairments in PD.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease</title>
            <author role="aut">              <persName>                <forename type="first">Daniel</forename>
                <surname>Rial</surname>
              </persName>
              <idno type="halauthorid">1385690</idno>
              <affiliation ref="#struct-119004"></affiliation>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Adalberto A.</forename>
                <surname>Castro</surname>
              </persName>
              <idno type="halauthorid">1385691</idno>
              <affiliation ref="#struct-119004"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Nuno</forename>
                <surname>Machado</surname>
              </persName>
              <idno type="halauthorid">627808</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Pedro</forename>
                <surname>Garção</surname>
              </persName>
              <idno type="halauthorid">1385692</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Francisco Q.</forename>
                <surname>Gonçalves</surname>
              </persName>
              <idno type="halauthorid">1385693</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Henrique B.</forename>
                <surname>Silva</surname>
              </persName>
              <idno type="halauthorid">1385694</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Angelo R.</forename>
                <surname>Tomé</surname>
              </persName>
              <idno type="halauthorid">1385695</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Attila</forename>
                <surname>Köfalvi</surname>
              </persName>
              <idno type="halauthorid">1385696</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Olga</forename>
                <surname>Corti</surname>
              </persName>
              <idno type="halauthorid">200494</idno>
              <affiliation ref="#struct-246044"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Rita</forename>
                <surname>Raisman-Vozari</surname>
              </persName>
              <idno type="halauthorid">974635</idno>
              <affiliation ref="#struct-246044"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Rodrigo A.</forename>
                <surname>Cunha</surname>
              </persName>
              <idno type="halauthorid">1385697</idno>
              <affiliation ref="#struct-300707"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Rui D.</forename>
                <surname>Prediger</surname>
              </persName>
              <idno type="halauthorid">1385698</idno>
              <affiliation ref="#struct-119004"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Gestionnaire</forename>
                <surname>HAL-UPMC</surname>
              </persName>
              <email type="md5">6d9ad2d5331d206e4ad27346e79eb6c9</email>
              <email type="domain">upmc.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2016-09-20 16:53:17</date>
              <date type="whenModified">2016-09-21 09:41:06</date>
              <date type="whenReleased">2016-09-20 17:15:47</date>
              <date type="whenProduced">2014</date>
              <date type="whenEndEmbargoed">2016-09-20</date>
              <ref type="file" target="http://hal.upmc.fr/hal-01369276/document">                <date notBefore="2016-09-20"></date>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="http://hal.upmc.fr/hal-01369276/file/journal.pone.0114216.PDF">                <date notBefore="2016-09-20"></date>
              </ref>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="320715">                <persName>                  <forename>Gestionnaire</forename>
                  <surname>HAL-UPMC</surname>
                </persName>
                <email type="md5">6d9ad2d5331d206e4ad27346e79eb6c9</email>
                <email type="domain">upmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-01369276</idno>
            <idno type="halUri">http://hal.upmc.fr/hal-01369276</idno>
            <idno type="halBibtex">rial:hal-01369276</idno>
            <idno type="halRefHtml">PLoS ONE, Public Library of Science, 2014, 9 (12), pp.0114216. <10.1371/journal.pone.0114216></idno>
            <idno type="halRef">PLoS ONE, Public Library of Science, 2014, 9 (12), pp.0114216. <10.1371/journal.pone.0114216></idno>
            <availability status="restricted">              <licence target="http://creativecommons.org/licenses/by/">Attribution</licence>
            </availability>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ICM" p="UPMC">Institut du Cerveau et de la Moëlle Epinière</idno>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease</title>
                <author role="aut">                  <persName>                    <forename type="first">Daniel</forename>
                    <surname>Rial</surname>
                  </persName>
                  <idno type="halauthorid">1385690</idno>
                  <affiliation ref="#struct-119004"></affiliation>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Adalberto A.</forename>
                    <surname>Castro</surname>
                  </persName>
                  <idno type="halauthorid">1385691</idno>
                  <affiliation ref="#struct-119004"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Nuno</forename>
                    <surname>Machado</surname>
                  </persName>
                  <idno type="halauthorid">627808</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pedro</forename>
                    <surname>Garção</surname>
                  </persName>
                  <idno type="halauthorid">1385692</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Francisco Q.</forename>
                    <surname>Gonçalves</surname>
                  </persName>
                  <idno type="halauthorid">1385693</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Henrique B.</forename>
                    <surname>Silva</surname>
                  </persName>
                  <idno type="halauthorid">1385694</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Angelo R.</forename>
                    <surname>Tomé</surname>
                  </persName>
                  <idno type="halauthorid">1385695</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Attila</forename>
                    <surname>Köfalvi</surname>
                  </persName>
                  <idno type="halauthorid">1385696</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Olga</forename>
                    <surname>Corti</surname>
                  </persName>
                  <idno type="halauthorid">200494</idno>
                  <affiliation ref="#struct-246044"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Rita</forename>
                    <surname>Raisman-Vozari</surname>
                  </persName>
                  <idno type="halauthorid">974635</idno>
                  <affiliation ref="#struct-246044"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Rodrigo A.</forename>
                    <surname>Cunha</surname>
                  </persName>
                  <idno type="halauthorid">1385697</idno>
                  <affiliation ref="#struct-300707"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Rui D.</forename>
                    <surname>Prediger</surname>
                  </persName>
                  <idno type="halauthorid">1385698</idno>
                  <affiliation ref="#struct-119004"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">9</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">0114216</biblScope>
                  <date type="datePub">2014</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0114216</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.gen">Life Sciences [q-bio]/Genetics</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the parkin gene cause early-onset familial PD, Parkin-deficient mice do not display spontaneous degeneration of the nigrostriatal pathway or enhanced vulnerability to dopaminergic neurotoxins such as 6-OHDA and MPTP. Here, we employed adult homozygous C57BL/6 mice with parkin gene deletion on exon 3 (parkin−/−) to further investigate the relevance of Parkin in the regulation of non-motor features, namely olfactory, emotional, cognitive and hippocampal synaptic plasticity. Parkin−/− mice displayed normal performance on behavioral tests evaluating olfaction (olfactory discrimination), anxiety (elevated plus-maze), depressive-like behavior (forced swimming and tail suspension) and motor function (rotarod, grasping strength and pole). However, parkin−/− mice displayed a poor performance in the open field habituation, object location and modified Y-maze tasks suggestive of procedural and short-term spatial memory deficits. These behavioral impairments were accompanied by impaired hippocampal long-term potentiation (LTP). These findings indicate that the genetic deletion of parkin causes deficiencies in hippocampal synaptic plasticity, resulting in memory deficits with no major olfactory, emotional or motor impairments. Therefore, parkin−/− mice may represent a promising animal model to study the early stages of PD and for testing new therapeutic strategies to restore learning and memory and synaptic plasticity impairments in PD.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000322 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000322 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-01369276
   |texte=   Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri