Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia
Identifieur interne : 000225 ( Hal/Checkpoint ); précédent : 000224; suivant : 000226Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia
Auteurs : Alice Poisson [France]Source :
Descripteurs français
English descriptors
- mix :
Abstract
Mirror movements and akinesia can be both found during Parkinson’s disease. Although very different, they may both reflect an abnormal cerebral plasticity during the disease and the perturbation of the motor inhibitory control. This work reveals that mirror movements are linked to a1/ disruption of the reactive inhibitory control and 2/ to the overactivation of numerous cortical areas. The latter could be the result of a compensatory recruitment aiming at improving the movement. But they could as well reflect a deleterious loss of cerebral activation specificity during Parkinson’s disease. The second experience shows that in healthy subject, the proactive inhibitory control is underpinned by the noradrenergic system. Last but not least the third part of this work reveals an abnormal implementation of the proactive inhibitory control in Parkinson’s disease and suggests its involvement in akinesia. Brought together these results suggest that an abnormal plasticity phenomenon underlies the mirror movements and the akinesia in Parkinson’s disease. More precisely, we observed a default of the reactive inhibitory control associated to mirror movements in Parkinson’s disease and an excess of proactive inhibitory control that seems to be linked to akinesia. The finding of an adrenergic modulation of the proactive inhibitory control opens the fields for the development of noradrenergic therapeutics in akinesia
Url:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Hal:tel-01138139Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia</title><title xml:lang="fr">Plasticité anormale et maladie de Parkinson : de l'akinésie à l'hyperkinésie</title><author><name sortKey="Poisson, Alice" sort="Poisson, Alice" uniqKey="Poisson A" first="Alice" last="Poisson">Alice Poisson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-5460" status="VALID"> <orgName>Centre d'Exploration et de Recherche Médicales par Émission de Positons</orgName> <orgName type="acronym">CERMEP</orgName> <desc> <address> <addrLine>59 bd Pinel, 69003 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cermep.fr/</ref> </desc> <listRelation> <relation active="#struct-51016" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-300071" type="direct"></relation> <relation active="#struct-300074" type="direct"></relation> <relation active="#struct-300201" type="direct"></relation> <relation active="#struct-300284" type="direct"></relation> <relation active="#struct-303623" type="direct"></relation> <relation active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"> <idno type="IdRef">026404796</idno> <orgName>Université Joseph Fourier - Grenoble 1</orgName> <orgName type="acronym">UJF</orgName> <date type="end">2015-12-31</date> <desc> <address> <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ujf-grenoble.fr/</ref> </desc></org></tutelle><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName><orgName type="acronym">UCBL</orgName><desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lyon1.fr/</ref></desc></org></tutelle><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID"> <orgName>CHU Grenoble</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID"> <orgName>Hospices Civils de Lyon</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300201" type="direct"><org type="institution" xml:id="struct-300201" status="VALID"> <orgName>CHU Saint-Etienne</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300284" type="direct"><org type="institution" xml:id="struct-300284" status="VALID"> <orgName>Université Jean Monnet [Saint-Etienne]</orgName> <desc> <address> <addrLine>10 Rue Tréfilerie, 42100 Saint-Étienne</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref> </desc></org></tutelle><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:tel-01138139</idno><idno type="halId">tel-01138139</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01138139</idno><idno type="url">https://tel.archives-ouvertes.fr/tel-01138139</idno><date when="2014-11-27">2014-11-27</date><idno type="wicri:Area/Hal/Corpus">000274</idno><idno type="wicri:Area/Hal/Curation">000274</idno><idno type="wicri:Area/Hal/Checkpoint">000225</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000225</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia</title><title xml:lang="fr">Plasticité anormale et maladie de Parkinson : de l'akinésie à l'hyperkinésie</title><author><name sortKey="Poisson, Alice" sort="Poisson, Alice" uniqKey="Poisson A" first="Alice" last="Poisson">Alice Poisson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-5460" status="VALID"> <orgName>Centre d'Exploration et de Recherche Médicales par Émission de Positons</orgName> <orgName type="acronym">CERMEP</orgName> <desc> <address> <addrLine>59 bd Pinel, 69003 Lyon</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cermep.fr/</ref> </desc> <listRelation> <relation active="#struct-51016" type="direct"></relation> <relation active="#struct-194495" type="direct"></relation> <relation active="#struct-300071" type="direct"></relation> <relation active="#struct-300074" type="direct"></relation> <relation active="#struct-300201" type="direct"></relation> <relation active="#struct-300284" type="direct"></relation> <relation active="#struct-303623" type="direct"></relation> <relation active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"> <idno type="IdRef">026404796</idno> <orgName>Université Joseph Fourier - Grenoble 1</orgName> <orgName type="acronym">UJF</orgName> <date type="end">2015-12-31</date> <desc> <address> <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ujf-grenoble.fr/</ref> </desc></org></tutelle><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName><orgName type="acronym">UCBL</orgName><desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-lyon1.fr/</ref></desc></org></tutelle><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID"> <orgName>CHU Grenoble</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300074" type="direct"><org type="institution" xml:id="struct-300074" status="VALID"> <orgName>Hospices Civils de Lyon</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300201" type="direct"><org type="institution" xml:id="struct-300201" status="VALID"> <orgName>CHU Saint-Etienne</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-300284" type="direct"><org type="institution" xml:id="struct-300284" status="VALID"> <orgName>Université Jean Monnet [Saint-Etienne]</orgName> <desc> <address> <addrLine>10 Rue Tréfilerie, 42100 Saint-Étienne</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref> </desc></org></tutelle><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName><orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Akinesia</term><term>FMRI</term><term>Mirror movements</term><term>Parkinson’s disease</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Akinésie</term><term>IRMf</term><term>Locus coeruleus</term><term>Maladie de Parkinson</term><term>Mouvements en miroir</term><term>Noradrénaline</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mirror movements and akinesia can be both found during Parkinson’s disease. Although very different, they may both reflect an abnormal cerebral plasticity during the disease and the perturbation of the motor inhibitory control. This work reveals that mirror movements are linked to a1/ disruption of the reactive inhibitory control and 2/ to the overactivation of numerous cortical areas. The latter could be the result of a compensatory recruitment aiming at improving the movement. But they could as well reflect a deleterious loss of cerebral activation specificity during Parkinson’s disease. The second experience shows that in healthy subject, the proactive inhibitory control is underpinned by the noradrenergic system. Last but not least the third part of this work reveals an abnormal implementation of the proactive inhibitory control in Parkinson’s disease and suggests its involvement in akinesia. Brought together these results suggest that an abnormal plasticity phenomenon underlies the mirror movements and the akinesia in Parkinson’s disease. More precisely, we observed a default of the reactive inhibitory control associated to mirror movements in Parkinson’s disease and an excess of proactive inhibitory control that seems to be linked to akinesia. The finding of an adrenergic modulation of the proactive inhibitory control opens the fields for the development of noradrenergic therapeutics in akinesia</div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia</title> <title xml:lang="fr">Plasticité anormale et maladie de Parkinson : de l'akinésie à l'hyperkinésie</title> <author role="aut"> <persName> <forename type="first">Alice</forename> <surname>POISSON</surname> </persName> <idno type="halauthorid">1011440</idno> <idno type="IdRef">http://www.idref.fr/144565544</idno> <affiliation ref="#struct-5460"></affiliation> </author> <editor role="depositor"> <persName> <forename>ABES</forename> <surname>STAR</surname> </persName> <email type="md5">f5aa7f563b02bb6adbba7496989af39a</email> <email type="domain">abes.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2015-04-01 11:22:27</date> <date type="whenModified">2015-04-23 13:45:49</date> <date type="whenReleased">2015-04-02 11:08:11</date> <date type="whenProduced">2014-11-27</date> <date type="whenEndEmbargoed">2015-04-01</date> <ref type="file" target="https://tel.archives-ouvertes.fr/tel-01138139/document"> <date notBefore="2015-04-01"></date> </ref> <ref type="file" subtype="author" n="1" target="https://tel.archives-ouvertes.fr/tel-01138139/file/TH2014PoissonAlice.pdf"> <date notBefore="2015-04-01"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="131274"> <persName> <forename>ABES</forename> <surname>STAR</surname> </persName> <email type="md5">f5aa7f563b02bb6adbba7496989af39a</email> <email type="domain">abes.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">tel-01138139</idno> <idno type="halUri">https://tel.archives-ouvertes.fr/tel-01138139</idno> <idno type="halBibtex">poisson:tel-01138139</idno> <idno type="halRefHtml">Neurosciences [q-bio.NC]. Université Claude Bernard - Lyon I, 2014. Français. <NNT : 2014LYO10261></idno> <idno type="halRef">Neurosciences [q-bio.NC]. Université Claude Bernard - Lyon I, 2014. Français. <NNT : 2014LYO10261></idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="STAR">STAR - Dépôt national des thèses électroniques</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno> <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno> <idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno> <idno type="stamp" n="THESES-EN-LIGNE-DAGROCAMPUS-OUEST">Thèses d'AGROCAMPUS OUEST</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno> </seriesStmt> <notesStmt></notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia</title> <title xml:lang="fr">Plasticité anormale et maladie de Parkinson : de l'akinésie à l'hyperkinésie</title> <author role="aut"> <persName> <forename type="first">Alice</forename> <surname>POISSON</surname> </persName> <idno type="halauthorid">1011440</idno> <idno type="IdRef">http://www.idref.fr/144565544</idno> <affiliation ref="#struct-5460"></affiliation> </author> </analytic> <monogr> <idno type="nnt">2014LYO10261</idno> <imprint> <date type="dateDefended">2014-11-27</date> </imprint> <authority type="institution">Université Claude Bernard - Lyon I</authority> <authority type="school">École Doctorale Neurosciences et Cognition (NSCo)</authority> <authority type="supervisor">Stéphane Christophe Thobois</authority> <authority type="supervisor">Bénédicte Ballanger</authority> <authority type="jury">Emmanuel Broussolle [Président]</authority> <authority type="jury">Luc Defebvre [Rapporteur]</authority> <authority type="jury">Emmanuelle Apartis [Rapporteur]</authority> <authority type="jury">Emmanuel Roze</authority> </monogr> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="fr">French</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">FMRI</term> <term xml:lang="en">Akinesia</term> <term xml:lang="en">Mirror movements</term> <term xml:lang="en">Parkinson’s disease</term> <term xml:lang="fr">IRMf</term> <term xml:lang="fr">Noradrénaline</term> <term xml:lang="fr">Maladie de Parkinson</term> <term xml:lang="fr">Mouvements en miroir</term> <term xml:lang="fr">Akinésie</term> <term xml:lang="fr">Locus coeruleus</term> </keywords> <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode> <classCode scheme="halTypology" n="THESE">Theses</classCode> </textClass> <abstract xml:lang="en">Mirror movements and akinesia can be both found during Parkinson’s disease. Although very different, they may both reflect an abnormal cerebral plasticity during the disease and the perturbation of the motor inhibitory control. This work reveals that mirror movements are linked to a1/ disruption of the reactive inhibitory control and 2/ to the overactivation of numerous cortical areas. The latter could be the result of a compensatory recruitment aiming at improving the movement. But they could as well reflect a deleterious loss of cerebral activation specificity during Parkinson’s disease. The second experience shows that in healthy subject, the proactive inhibitory control is underpinned by the noradrenergic system. Last but not least the third part of this work reveals an abnormal implementation of the proactive inhibitory control in Parkinson’s disease and suggests its involvement in akinesia. Brought together these results suggest that an abnormal plasticity phenomenon underlies the mirror movements and the akinesia in Parkinson’s disease. More precisely, we observed a default of the reactive inhibitory control associated to mirror movements in Parkinson’s disease and an excess of proactive inhibitory control that seems to be linked to akinesia. The finding of an adrenergic modulation of the proactive inhibitory control opens the fields for the development of noradrenergic therapeutics in akinesia</abstract> <abstract xml:lang="fr">Nous avons pris le parti pour cette thèse d'étudier en Imagerie par Résonance Magnétique fonctionnelle deux éléments sémiologiques de la maladie de Parkinson : les mouvements en miroir et l'akinésie. Ces deux phénomènes reflètent une plasticité cérébrale anormale dans cette maladie. Notre première expérience révèle que les mouvements en miroir chez les patients parkinsoniens sont contemporains 1/ d'un défaut d'inhibition, notamment réactive. 2/ de nombreuses hyperactivations, pouvant refléter soit un recrutement compensateur soit une perte délétère de la sélectivité de l'activation corticale. La deuxième expérience s'intéresse à une autre forme d'inhibition, l'inhibition proactive. Nos résultats révèlent que les structures participant au contrôle moteur proactif et notamment le précuneus et les cortex cingulaires postérieur et antérieur sont modulés par le système noradrénergiques chez le sujet sain. Dans une troisième expérience nous avons appliqué ce protocole expérimental à des sujets parkinsoniens. La comparaison avec les données issues de la première expérience révèlent 1/ que les sujets parkinsoniens ont une implémentation anormale du réseau d'inhibition proactive avec une difficulté à se placer en condition de déverrouillage moteur. Ce phénomène pourrait allonger le temps de réaction et participer à l'akinésie. 2/ que l'administration de clonidine renforce encore ce phénomène, en agissant sur les structures antérieures du réseau d'inhibition proactive (cortex cingulaire antérieur et cortex préfrontal dorsomédial). Tous ensembles ces résultats suggèrent une plasticité anormale dans la maladie de Parkinson sousjacente aux mouvements en miroir et à l'akinésie. Celle-ci se traduit 1/ par des défauts d'inhibition, notamment réactive, favorisant l'apparition de mouvements parasites, les mouvements en miroir, 2/ par un renforcement pathologique de l'inhibition proactive qui pourrait participer à l'allongement du temps de réaction et à l'akinésie. La découverte d'une modulation noradrénergique de ce réseau ouvre des portes thérapeutiques nouvelles dans l akinésie parkinsonienne mais également dans l'impulsivité dont certains composants, notamment moteur, semblent être liés à l'inhibition proactive</abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000225 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000225 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Hal
|étape= Checkpoint
|type= RBID
|clé= Hal:tel-01138139
|texte= Deleterious plasticity in Parkinson’s disease from akinesia to hyperkinesia
}}
| This area was generated with Dilib version V0.6.29. |  |