Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning
Identifieur interne : 000157 ( Hal/Checkpoint ); précédent : 000156; suivant : 000158Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning
Auteurs : Ana B. Graciano Fouquier [France] ; Eric Bardinet [France] ; Marie-Laure Welter [France] ; Carine Karachi [France] ; Jérôme Yelnik [France] ; Sara Fernandez Vidal [France] ; Stanley Durrleman [France]Source :
English descriptors
- mix :
Abstract
Introduction:In deep brain stimulation (DBS), precise electrode implantation is key to a successful surgical outcome. Aiming at a satisfying implantation, the location of a stimulation target in a patient's brain is usually estimated during surgical planning using pre-operative magnetic resonance images (MRI). Since targeted basal ganglia (BG) (e.g. subthalamic nucleus/STN) are hardly or partially visible on T1/T2-weighted (T1/T2w) MRI, indirect methods are used to complement MRI-based targeting, such as atlas-based registration. In our radiological department, MRI are acquired at 1.5T, and a 3D histological basal ganglia atlas (Yelnik, 2007), comprising a T1w MRI from a post-mortem specimen and its associated BG meshes, is aligned to each patient T1w MRI through piecewise-linear (PL) transforms (Bardinet, 2009). Although results are robust, nonlinear deformations could improve targeting accuracy, especially when the atlas and the patient anatomies present large morphological differences. However, nonlinear deformations (e.g. ANTS - Avants, 2008) may correctly warp high-contrast brain structures, but deform low-contrast ones (e.g. STN) in an anatomically spurious way. Thus, this study assesses an iconic-geometric nonlinear registration method to warp the 3D histological atlas into patient data, aiming at a more anatomically-robust and precise localization of the STN in DBS for Parkinson's disease.Methods:The adopted algorithm finds a simultaneous registration from the source atlas MRI and a subset of its BG meshes (e.g. thalamus, putamen, caudate nucleus) to the target patient MRI and its respective meshes, obtained from the recon-all tool of Freesurfer. This compound iconic and geometric registration is based on a unified diffeomorphic framework built upon Durrleman (2013,2014). The sought deformation is found by minimizing an objective function consisting of a sum of similarity measures between source and target data, and a regularization factor. Iconic and geometric data are interpolated by a gaussian kernel applied to points distributed across the data domain, controlling how deformations propagate in high/low contrast regions. The geometric constraints (atlas and patient meshes) ensure precise mappings of the respective brain structures and influence the deformations of surrounding structures. Thus, accurate registration of visible structures around the STN should improve its location.Results:The algorithm was tested on a cohort of 30 parkinsonian patients, whose available data included 1.5T T1/T2w MRI, and neurologist annotations based on per-operative electrophysiological recordings of STN activity, that included levels of neuronal activity and anatomical labels (e.g. STN). Atlas meshes were warped into patient space using ANTS, the PL method, and the iconic-geometric nonlinear registration. Warped STN meshes from each method were quantitatively evaluated and compared. Shape indices (size, shape fractional anisotropy, elongation) showed that the proposed approach preserves the STN anatomical properties across the population, unlike ANTS. Besides, its STN meshes present lower average intensities computed from their overlap with the T2w MRI, where the STN partially appears as a hypointensity, indicating a possibly better STN localization. Finally, the PL and iconic-geometric methods were tested against the coherence between their warped STN meshes and per-operative STN electrophysiological labels using confusion matrices. The new method proved to be more specific, presenting less false positives (points with absence of STN activity inside warped STN meshes), whereas its sensibility (related to true positives, points within the STN meshes recognized as the STN by the electrophysiology) remained competitive with the currently adopted method.Conclusions:The proposed nonlinear deformation model is suitable for the given atlas-to-patient registration task, since it improved STN location estimation precision and preserved its anatomical features.
Url:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Hal:hal-01187468Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning</title>
<author><name sortKey="Graciano Fouquier, Ana B" sort="Graciano Fouquier, Ana B" uniqKey="Graciano Fouquier A" first="Ana B." last="Graciano Fouquier">Ana B. Graciano Fouquier</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-215031" status="OLD"> <idno type="RNSR">201221057R</idno>
<orgName>Algorithms, models and methods for images and signals of the human brain</orgName>
<orgName type="acronym">ARAMIS</orgName>
<date type="end">2015-12-31</date>
<desc> <address> <addrLine>Hôpital de la Pitié-Salpêtrière Batiment ICM 47 boulevard de l'hopital 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/equipes/aramis</ref>
</desc>
<listRelation> <relation active="#struct-86790" type="direct"></relation>
<relation active="#struct-300009" type="indirect"></relation>
<relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-246044" type="direct"></relation>
<relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="indirect"></relation>
<relation active="#struct-353778" type="indirect"></relation>
<relation name="UMR7225" active="#struct-441569" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-86790" type="direct"><org type="laboratory" xml:id="struct-86790" status="VALID"> <idno type="RNSR">196718247G</idno>
<orgName>Inria Paris-Rocquencourt</orgName>
<desc> <address> <addrLine>INRIA Rocquencourt : Domaine de Voluceau, Rocquencourt B.P. 105 78153 le Chesnay Cedex / INRIA Paris - 23 avenue d'Italie 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/centre/paris-rocquencourt</ref>
</desc>
<listRelation> <relation active="#struct-300009" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"> <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc> <address> <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-246044" type="direct"><org type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="indirect"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106232" status="VALID"> <orgName>Centre de Neuro-Imagerie de Recherche</orgName>
<orgName type="acronym">CENIR</orgName>
<desc> <address> <addrLine>CENIR - Centre de Neuroimagerie de Recherche Bâtiment de Médecine Physique et Réadaptation niveau -1 47-83 boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cenir.org/</ref>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fernandez Vidal, Sara" sort="Fernandez Vidal, Sara" uniqKey="Fernandez Vidal S" first="Sara" last="Fernandez Vidal">Sara Fernandez Vidal</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106232" status="VALID"> <orgName>Centre de Neuro-Imagerie de Recherche</orgName>
<orgName type="acronym">CENIR</orgName>
<desc> <address> <addrLine>CENIR - Centre de Neuroimagerie de Recherche Bâtiment de Médecine Physique et Réadaptation niveau -1 47-83 boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cenir.org/</ref>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Durrleman, Stanley" sort="Durrleman, Stanley" uniqKey="Durrleman S" first="Stanley" last="Durrleman">Stanley Durrleman</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-215031" status="OLD"> <idno type="RNSR">201221057R</idno>
<orgName>Algorithms, models and methods for images and signals of the human brain</orgName>
<orgName type="acronym">ARAMIS</orgName>
<date type="end">2015-12-31</date>
<desc> <address> <addrLine>Hôpital de la Pitié-Salpêtrière Batiment ICM 47 boulevard de l'hopital 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/equipes/aramis</ref>
</desc>
<listRelation> <relation active="#struct-86790" type="direct"></relation>
<relation active="#struct-300009" type="indirect"></relation>
<relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-246044" type="direct"></relation>
<relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="indirect"></relation>
<relation active="#struct-353778" type="indirect"></relation>
<relation name="UMR7225" active="#struct-441569" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-86790" type="direct"><org type="laboratory" xml:id="struct-86790" status="VALID"> <idno type="RNSR">196718247G</idno>
<orgName>Inria Paris-Rocquencourt</orgName>
<desc> <address> <addrLine>INRIA Rocquencourt : Domaine de Voluceau, Rocquencourt B.P. 105 78153 le Chesnay Cedex / INRIA Paris - 23 avenue d'Italie 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/centre/paris-rocquencourt</ref>
</desc>
<listRelation> <relation active="#struct-300009" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"> <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc> <address> <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-246044" type="direct"><org type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="indirect"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01187468</idno>
<idno type="halId">hal-01187468</idno>
<idno type="halUri">https://hal.inria.fr/hal-01187468</idno>
<idno type="url">https://hal.inria.fr/hal-01187468</idno>
<date when="2015-06-14">2015-06-14</date>
<idno type="wicri:Area/Hal/Corpus">000105</idno>
<idno type="wicri:Area/Hal/Curation">000105</idno>
<idno type="wicri:Area/Hal/Checkpoint">000157</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000157</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning</title>
<author><name sortKey="Graciano Fouquier, Ana B" sort="Graciano Fouquier, Ana B" uniqKey="Graciano Fouquier A" first="Ana B." last="Graciano Fouquier">Ana B. Graciano Fouquier</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-215031" status="OLD"> <idno type="RNSR">201221057R</idno>
<orgName>Algorithms, models and methods for images and signals of the human brain</orgName>
<orgName type="acronym">ARAMIS</orgName>
<date type="end">2015-12-31</date>
<desc> <address> <addrLine>Hôpital de la Pitié-Salpêtrière Batiment ICM 47 boulevard de l'hopital 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/equipes/aramis</ref>
</desc>
<listRelation> <relation active="#struct-86790" type="direct"></relation>
<relation active="#struct-300009" type="indirect"></relation>
<relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-246044" type="direct"></relation>
<relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="indirect"></relation>
<relation active="#struct-353778" type="indirect"></relation>
<relation name="UMR7225" active="#struct-441569" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-86790" type="direct"><org type="laboratory" xml:id="struct-86790" status="VALID"> <idno type="RNSR">196718247G</idno>
<orgName>Inria Paris-Rocquencourt</orgName>
<desc> <address> <addrLine>INRIA Rocquencourt : Domaine de Voluceau, Rocquencourt B.P. 105 78153 le Chesnay Cedex / INRIA Paris - 23 avenue d'Italie 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/centre/paris-rocquencourt</ref>
</desc>
<listRelation> <relation active="#struct-300009" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"> <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc> <address> <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-246044" type="direct"><org type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="indirect"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106232" status="VALID"> <orgName>Centre de Neuro-Imagerie de Recherche</orgName>
<orgName type="acronym">CENIR</orgName>
<desc> <address> <addrLine>CENIR - Centre de Neuroimagerie de Recherche Bâtiment de Médecine Physique et Réadaptation niveau -1 47-83 boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cenir.org/</ref>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fernandez Vidal, Sara" sort="Fernandez Vidal, Sara" uniqKey="Fernandez Vidal S" first="Sara" last="Fernandez Vidal">Sara Fernandez Vidal</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106232" status="VALID"> <orgName>Centre de Neuro-Imagerie de Recherche</orgName>
<orgName type="acronym">CENIR</orgName>
<desc> <address> <addrLine>CENIR - Centre de Neuroimagerie de Recherche Bâtiment de Médecine Physique et Réadaptation niveau -1 47-83 boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cenir.org/</ref>
</desc>
<listRelation> <relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Durrleman, Stanley" sort="Durrleman, Stanley" uniqKey="Durrleman S" first="Stanley" last="Durrleman">Stanley Durrleman</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-215031" status="OLD"> <idno type="RNSR">201221057R</idno>
<orgName>Algorithms, models and methods for images and signals of the human brain</orgName>
<orgName type="acronym">ARAMIS</orgName>
<date type="end">2015-12-31</date>
<desc> <address> <addrLine>Hôpital de la Pitié-Salpêtrière Batiment ICM 47 boulevard de l'hopital 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/equipes/aramis</ref>
</desc>
<listRelation> <relation active="#struct-86790" type="direct"></relation>
<relation active="#struct-300009" type="indirect"></relation>
<relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-246044" type="direct"></relation>
<relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="indirect"></relation>
<relation active="#struct-353778" type="indirect"></relation>
<relation name="UMR7225" active="#struct-441569" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-86790" type="direct"><org type="laboratory" xml:id="struct-86790" status="VALID"> <idno type="RNSR">196718247G</idno>
<orgName>Inria Paris-Rocquencourt</orgName>
<desc> <address> <addrLine>INRIA Rocquencourt : Domaine de Voluceau, Rocquencourt B.P. 105 78153 le Chesnay Cedex / INRIA Paris - 23 avenue d'Italie 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/centre/paris-rocquencourt</ref>
</desc>
<listRelation> <relation active="#struct-300009" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"> <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc> <address> <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-246044" type="direct"><org type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno>
<orgName>Institut du Cerveau et de la Moëlle Epinière</orgName>
<orgName type="acronym">ICM</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation>
<relation name="U1127" active="#struct-303623" type="direct"></relation>
<relation active="#struct-353778" type="direct"></relation>
<relation name="UMR7225" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1127" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-353778" type="indirect"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName>
<desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7225" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Basal Ganglia</term>
<term>Data Registration</term>
<term>Degenerative Disease</term>
<term>Electrophysiology</term>
<term>Informatics</term>
<term>Movement Disorder</term>
<term>Spatial Warping</term>
<term>Structural MRI</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Introduction:In deep brain stimulation (DBS), precise electrode implantation is key to a successful surgical outcome. Aiming at a satisfying implantation, the location of a stimulation target in a patient's brain is usually estimated during surgical planning using pre-operative magnetic resonance images (MRI). Since targeted basal ganglia (BG) (e.g. subthalamic nucleus/STN) are hardly or partially visible on T1/T2-weighted (T1/T2w) MRI, indirect methods are used to complement MRI-based targeting, such as atlas-based registration. In our radiological department, MRI are acquired at 1.5T, and a 3D histological basal ganglia atlas (Yelnik, 2007), comprising a T1w MRI from a post-mortem specimen and its associated BG meshes, is aligned to each patient T1w MRI through piecewise-linear (PL) transforms (Bardinet, 2009). Although results are robust, nonlinear deformations could improve targeting accuracy, especially when the atlas and the patient anatomies present large morphological differences. However, nonlinear deformations (e.g. ANTS - Avants, 2008) may correctly warp high-contrast brain structures, but deform low-contrast ones (e.g. STN) in an anatomically spurious way. Thus, this study assesses an iconic-geometric nonlinear registration method to warp the 3D histological atlas into patient data, aiming at a more anatomically-robust and precise localization of the STN in DBS for Parkinson's disease.Methods:The adopted algorithm finds a simultaneous registration from the source atlas MRI and a subset of its BG meshes (e.g. thalamus, putamen, caudate nucleus) to the target patient MRI and its respective meshes, obtained from the recon-all tool of Freesurfer. This compound iconic and geometric registration is based on a unified diffeomorphic framework built upon Durrleman (2013,2014). The sought deformation is found by minimizing an objective function consisting of a sum of similarity measures between source and target data, and a regularization factor. Iconic and geometric data are interpolated by a gaussian kernel applied to points distributed across the data domain, controlling how deformations propagate in high/low contrast regions. The geometric constraints (atlas and patient meshes) ensure precise mappings of the respective brain structures and influence the deformations of surrounding structures. Thus, accurate registration of visible structures around the STN should improve its location.Results:The algorithm was tested on a cohort of 30 parkinsonian patients, whose available data included 1.5T T1/T2w MRI, and neurologist annotations based on per-operative electrophysiological recordings of STN activity, that included levels of neuronal activity and anatomical labels (e.g. STN). Atlas meshes were warped into patient space using ANTS, the PL method, and the iconic-geometric nonlinear registration. Warped STN meshes from each method were quantitatively evaluated and compared. Shape indices (size, shape fractional anisotropy, elongation) showed that the proposed approach preserves the STN anatomical properties across the population, unlike ANTS. Besides, its STN meshes present lower average intensities computed from their overlap with the T2w MRI, where the STN partially appears as a hypointensity, indicating a possibly better STN localization. Finally, the PL and iconic-geometric methods were tested against the coherence between their warped STN meshes and per-operative STN electrophysiological labels using confusion matrices. The new method proved to be more specific, presenting less false positives (points with absence of STN activity inside warped STN meshes), whereas its sensibility (related to true positives, points within the STN meshes recognized as the STN by the electrophysiology) remained competitive with the currently adopted method.Conclusions:The proposed nonlinear deformation model is suitable for the given atlas-to-patient registration task, since it improved STN location estimation precision and preserved its anatomical features.</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning</title>
<author role="crp"><persName><forename type="first">Ana B.</forename>
<surname>Graciano Fouquier</surname>
</persName>
<email type="md5">321a13c6f0d308041cce1f29dc0200f9</email>
<email type="domain">inria.fr</email>
<idno type="idhal" notation="string">graciano-fouquier-ana-beatriz</idno>
<idno type="idhal" notation="numeric">4893</idno>
<idno type="halauthorid">1200573</idno>
<affiliation ref="#struct-215031"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Eric</forename>
<surname>Bardinet</surname>
</persName>
<idno type="halauthorid">98501</idno>
<affiliation ref="#struct-106232"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<idno type="halauthorid">214475</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Carine</forename>
<surname>Karachi</surname>
</persName>
<idno type="halauthorid">527644</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jérôme</forename>
<surname>Yelnik</surname>
</persName>
<idno type="halauthorid">404202</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sara</forename>
<surname>Fernandez Vidal</surname>
</persName>
<idno type="halauthorid">1200266</idno>
<affiliation ref="#struct-106232"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Stanley</forename>
<surname>Durrleman</surname>
</persName>
<idno type="halauthorid">311527</idno>
<affiliation ref="#struct-215031"></affiliation>
</author>
<editor role="depositor"><persName><forename>Graciano Fouquier</forename>
<surname>Ana Beatriz</surname>
</persName>
<email type="md5">0c63e4ef1fa4bbeba59f85f26597447f</email>
<email type="domain">gmail.com</email>
</editor>
<funder ref="#projanr-41615"></funder>
<funder ref="#projanr-26971"></funder>
</titleStmt>
<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2015-08-27 15:56:37</date>
<date type="whenModified">2016-06-09 15:26:36</date>
<date type="whenReleased">2015-08-28 14:47:20</date>
<date type="whenProduced">2015-06-14</date>
<date type="whenEndEmbargoed">2015-08-27</date>
<ref type="file" target="https://hal.inria.fr/hal-01187468/document"><date notBefore="2015-08-27"></date>
</ref>
<ref type="file" subtype="author" n="1" target="https://hal.inria.fr/hal-01187468/file/3005_GracianoFouquier_0611_043746.pdf"><date notBefore="2015-08-27"></date>
</ref>
</edition>
<respStmt><resp>contributor</resp>
<name key="320374"><persName><forename>Graciano Fouquier</forename>
<surname>Ana Beatriz</surname>
</persName>
<email type="md5">0c63e4ef1fa4bbeba59f85f26597447f</email>
<email type="domain">gmail.com</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt><distributor>CCSD</distributor>
<idno type="halId">hal-01187468</idno>
<idno type="halUri">https://hal.inria.fr/hal-01187468</idno>
<idno type="halBibtex">gracianofouquier:hal-01187468</idno>
<idno type="halRefHtml">Organization for Human Brain Mapping (OHBM) 2015, Jun 2015, Honolulu, Hawaii, United States. 2015</idno>
<idno type="halRef">Organization for Human Brain Mapping (OHBM) 2015, Jun 2015, Honolulu, Hawaii, United States. 2015</idno>
<availability status="restricted"><licence target="http://hal.archives-ouvertes.fr/licences/copyright/">Copyright</licence>
</availability>
</publicationStmt>
<seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
<idno type="stamp" n="ICM" p="UPMC">Institut du Cerveau et de la Moëlle Epinière</idno>
<idno type="stamp" n="APHP" p="INSERM">AP-HP</idno>
<idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
<idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
<idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
<idno type="stamp" n="INRIA2">INRIA 2</idno>
<idno type="stamp" n="ARAMISLAB">ARAMISLAB - Algorithms, models and methods for images and signals of the human brain </idno>
<idno type="stamp" n="">ARAMILAB</idno>
</seriesStmt>
<notesStmt><note type="audience" n="2">International</note>
<note type="invited" n="0">No</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
<note type="proceedings" n="0">No</note>
</notesStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning</title>
<author role="crp"><persName><forename type="first">Ana B.</forename>
<surname>Graciano Fouquier</surname>
</persName>
<email type="md5">321a13c6f0d308041cce1f29dc0200f9</email>
<email type="domain">inria.fr</email>
<idno type="idhal" notation="string">graciano-fouquier-ana-beatriz</idno>
<idno type="idhal" notation="numeric">4893</idno>
<idno type="halauthorid">1200573</idno>
<affiliation ref="#struct-215031"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Eric</forename>
<surname>Bardinet</surname>
</persName>
<idno type="halauthorid">98501</idno>
<affiliation ref="#struct-106232"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<idno type="halauthorid">214475</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Carine</forename>
<surname>Karachi</surname>
</persName>
<idno type="halauthorid">527644</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jérôme</forename>
<surname>Yelnik</surname>
</persName>
<idno type="halauthorid">404202</idno>
<affiliation ref="#struct-246044"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sara</forename>
<surname>Fernandez Vidal</surname>
</persName>
<idno type="halauthorid">1200266</idno>
<affiliation ref="#struct-106232"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Stanley</forename>
<surname>Durrleman</surname>
</persName>
<idno type="halauthorid">311527</idno>
<affiliation ref="#struct-215031"></affiliation>
</author>
</analytic>
<monogr><meeting><title>Organization for Human Brain Mapping (OHBM) 2015</title>
<date type="start">2015-06-14</date>
<date type="end">2015-06-18</date>
<settlement>Honolulu, Hawaii</settlement>
<country key="US">United States</country>
</meeting>
<imprint><date type="datePub">2015-06-18</date>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><keywords scheme="author"><term xml:lang="en">Spatial Warping</term>
<term xml:lang="en">Structural MRI</term>
<term xml:lang="en">Basal Ganglia</term>
<term xml:lang="en">Data Registration</term>
<term xml:lang="en">Degenerative Disease</term>
<term xml:lang="en">Electrophysiology</term>
<term xml:lang="en">Informatics</term>
<term xml:lang="en">Movement Disorder</term>
</keywords>
<classCode scheme="halDomain" n="info.info-im">Computer Science [cs]/Medical Imaging</classCode>
<classCode scheme="halDomain" n="info.info-ts">Computer Science [cs]/Signal and Image Processing</classCode>
<classCode scheme="halTypology" n="COMM">Conference papers</classCode>
</textClass>
<abstract xml:lang="en">Introduction:In deep brain stimulation (DBS), precise electrode implantation is key to a successful surgical outcome. Aiming at a satisfying implantation, the location of a stimulation target in a patient's brain is usually estimated during surgical planning using pre-operative magnetic resonance images (MRI). Since targeted basal ganglia (BG) (e.g. subthalamic nucleus/STN) are hardly or partially visible on T1/T2-weighted (T1/T2w) MRI, indirect methods are used to complement MRI-based targeting, such as atlas-based registration. In our radiological department, MRI are acquired at 1.5T, and a 3D histological basal ganglia atlas (Yelnik, 2007), comprising a T1w MRI from a post-mortem specimen and its associated BG meshes, is aligned to each patient T1w MRI through piecewise-linear (PL) transforms (Bardinet, 2009). Although results are robust, nonlinear deformations could improve targeting accuracy, especially when the atlas and the patient anatomies present large morphological differences. However, nonlinear deformations (e.g. ANTS - Avants, 2008) may correctly warp high-contrast brain structures, but deform low-contrast ones (e.g. STN) in an anatomically spurious way. Thus, this study assesses an iconic-geometric nonlinear registration method to warp the 3D histological atlas into patient data, aiming at a more anatomically-robust and precise localization of the STN in DBS for Parkinson's disease.Methods:The adopted algorithm finds a simultaneous registration from the source atlas MRI and a subset of its BG meshes (e.g. thalamus, putamen, caudate nucleus) to the target patient MRI and its respective meshes, obtained from the recon-all tool of Freesurfer. This compound iconic and geometric registration is based on a unified diffeomorphic framework built upon Durrleman (2013,2014). The sought deformation is found by minimizing an objective function consisting of a sum of similarity measures between source and target data, and a regularization factor. Iconic and geometric data are interpolated by a gaussian kernel applied to points distributed across the data domain, controlling how deformations propagate in high/low contrast regions. The geometric constraints (atlas and patient meshes) ensure precise mappings of the respective brain structures and influence the deformations of surrounding structures. Thus, accurate registration of visible structures around the STN should improve its location.Results:The algorithm was tested on a cohort of 30 parkinsonian patients, whose available data included 1.5T T1/T2w MRI, and neurologist annotations based on per-operative electrophysiological recordings of STN activity, that included levels of neuronal activity and anatomical labels (e.g. STN). Atlas meshes were warped into patient space using ANTS, the PL method, and the iconic-geometric nonlinear registration. Warped STN meshes from each method were quantitatively evaluated and compared. Shape indices (size, shape fractional anisotropy, elongation) showed that the proposed approach preserves the STN anatomical properties across the population, unlike ANTS. Besides, its STN meshes present lower average intensities computed from their overlap with the T2w MRI, where the STN partially appears as a hypointensity, indicating a possibly better STN localization. Finally, the PL and iconic-geometric methods were tested against the coherence between their warped STN meshes and per-operative STN electrophysiological labels using confusion matrices. The new method proved to be more specific, presenting less false positives (points with absence of STN activity inside warped STN meshes), whereas its sensibility (related to true positives, points within the STN meshes recognized as the STN by the electrophysiology) remained competitive with the currently adopted method.Conclusions:The proposed nonlinear deformation model is suitable for the given atlas-to-patient registration task, since it improved STN location estimation precision and preserved its anatomical features.</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000157 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000157 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Hal |étape= Checkpoint |type= RBID |clé= Hal:hal-01187468 |texte= Assessment of an iconic-geometric nonlinear registration method for deep brain stimulation (DBS) planning }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |