ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000056

Weight Gain following Pallidal Deep Brain Stimulation: A PET Study

Identifieur interne : 000056 ( Hal/Checkpoint ); précédent : 000055; suivant : 000057

Weight Gain following Pallidal Deep Brain Stimulation: A PET Study

Auteurs : Paul Sauleau [France] ; Sophie Drapier [France] ; Joan Duprez [France] ; Jean-François Houvenaghel [France] ; Thibaut Dondaine [France] ; Claire Haegelen [France] ; Dominique Drapier [France] ; Pierre Jannin [France] ; Gabriel Robert [France] ; Florence Le Jeune [France] ; Marc Vérin [France]

Source :

PLoS ONE [ 1932-6203 ] ; 2016-04.

RBID : Hal:hal-01304356

English descriptors

mix :
- Deep-brain stimulation, Dopaminergics, Drug metabolism, Parkinson Disease, Positron emission tomography, Surgical and invasive medical procedures, Weight gain, Bioenergetics.

Abstract

The mechanisms behind weight gain following deep brain stimulation (DBS) surgery seem to be multifactorial and suspected depending on the target, either the subthalamic nucleus (STN) or the globus pallidus internus (GPi). Decreased energy expenditure following motor improvement and behavioral and/or metabolic changes are possible explanations. Focusing on GPi target, our objective was to analyze correlations between changes in brain metabolism (measured with PET) and weight gain following GPi-DBS in patients with Parkinson’s disease (PD). Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose PET four months before and four months after the start of GPi-DBS in 19 PD patients. Dopaminergic medication was included in the analysis to control for its possible influence on brain metabolism. Body mass index increased significantly by 0.66 ± 1.3 kg/m2 ( p = 0.040). There were correlations between weight gain and changes in brain metabolism in premotor areas, including the left and right superior gyri (Brodmann area, BA 6), left superior gyrus (BA 8), the dorsolateral prefrontal cortex (right middle gyrus, BAs 9 and 46), and the left and right somatosensory association cortices (BA 7). However, we found no correlation between weight gain and metabolic changes in limbic and associative areas. Additionally, there was a trend toward a correlation between reduced dyskinesia and weight gain ( r = 0.428, p = 0.067). These findings suggest that, unlike STN-DBS, motor improvement is the major contributing factor for weight gain following GPi-DBS PD, confirming the motor selectivity of this target

Url:

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01304356

DOI: 10.1371/journal.pone.0153438

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Le document en format XML

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<author><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name>
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<idno type="DOI">10.1371/journal.pone.0153438</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2016-04</date>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Deep-brain stimulation</term>
<term> Dopaminergics</term>
<term> Drug metabolism</term>
<term> Parkinson Disease</term>
<term> Positron emission tomography</term>
<term> Surgical and invasive medical procedures</term>
<term> Weight gain</term>
<term>Bioenergetics</term>
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<front><div type="abstract" xml:lang="en">The mechanisms behind weight gain following deep brain stimulation (DBS) surgery seem to be multifactorial and suspected depending on the target, either the subthalamic nucleus (STN) or the globus pallidus internus (GPi). Decreased energy expenditure following motor improvement and behavioral and/or metabolic changes are possible explanations. Focusing on GPi target, our objective was to analyze correlations between changes in brain metabolism (measured with PET) and weight gain following GPi-DBS in patients with Parkinson’s disease (PD). Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose PET four months before and four months after the start of GPi-DBS in 19 PD patients. Dopaminergic medication was included in the analysis to control for its possible influence on brain metabolism. Body mass index increased significantly by 0.66 ± 1.3 kg/m2 ( p = 0.040). There were correlations between weight gain and changes in brain metabolism in premotor areas, including the left and right superior gyri (Brodmann area, BA 6), left superior gyrus (BA 8), the dorsolateral prefrontal cortex (right middle gyrus, BAs 9 and 46), and the left and right somatosensory association cortices (BA 7). However, we found no correlation between weight gain and metabolic changes in limbic and associative areas. Additionally, there was a trend toward a correlation between reduced dyskinesia and weight gain ( r = 0.428, p = 0.067). These findings suggest that, unlike STN-DBS, motor improvement is the major contributing factor for weight gain following GPi-DBS PD, confirming the motor selectivity of this target</div>
</front>
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<hal api="V3">          <titleStmt>            <title xml:lang="en">Weight Gain following Pallidal Deep Brain Stimulation: A PET Study</title>
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                <surname>Sauleau</surname>
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            <author role="aut">              <persName>                <forename type="first">Sophie</forename>
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            <author role="aut">              <persName>                <forename type="first">Marc</forename>
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              <date type="whenModified">2016-10-20 14:12:10</date>
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            <idno type="stamp" n="LTSI" p="INSERM">Laboratoire Traitement du Signal et de l'Image</idno>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Weight Gain following Pallidal Deep Brain Stimulation: A PET Study</title>
                <author role="aut">                  <persName>                    <forename type="first">Paul</forename>
                    <surname>Sauleau</surname>
                  </persName>
                  <idno type="halauthorid">296413</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Sophie</forename>
                    <surname>Drapier</surname>
                  </persName>
                  <idno type="halauthorid">773331</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                  <affiliation ref="#struct-155115"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Joan</forename>
                    <surname>Duprez</surname>
                  </persName>
                  <idno type="halauthorid">1232336</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jean-François</forename>
                    <surname>Houvenaghel</surname>
                  </persName>
                  <idno type="halauthorid">1147005</idno>
                  <affiliation ref="#struct-155115"></affiliation>
                  <affiliation ref="#struct-238036"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Thibaut</forename>
                    <surname>Dondaine</surname>
                  </persName>
                  <idno type="halauthorid">740415</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Claire</forename>
                    <surname>Haegelen</surname>
                  </persName>
                  <idno type="halauthorid">169922</idno>
                  <affiliation ref="#struct-33417"></affiliation>
                  <affiliation ref="#struct-182223"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Dominique</forename>
                    <surname>Drapier</surname>
                  </persName>
                  <idno type="halauthorid">547173</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                  <affiliation ref="#struct-238034"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pierre</forename>
                    <surname>Jannin</surname>
                  </persName>
                  <idno type="halauthorid">140493</idno>
                  <affiliation ref="#struct-182223"></affiliation>
                  <affiliation ref="#struct-33417"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Gabriel</forename>
                    <surname>Robert</surname>
                  </persName>
                  <idno type="halauthorid">76122</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                  <affiliation ref="#struct-238034"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Florence</forename>
                    <surname>Le Jeune</surname>
                  </persName>
                  <idno type="halauthorid">1210829</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marc</forename>
                    <surname>Vérin</surname>
                  </persName>
                  <idno type="halauthorid">362876</idno>
                  <affiliation ref="#struct-238036"></affiliation>
                  <affiliation ref="#struct-155115"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">e0153438</biblScope>
                  <date type="datePub">2016-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0153438</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">Bioenergetics</term>
                <term xml:lang="en"> Deep-brain stimulation</term>
                <term xml:lang="en"> Dopaminergics</term>
                <term xml:lang="en"> Drug metabolism</term>
                <term xml:lang="en"> Parkinson Disease</term>
                <term xml:lang="en"> Positron emission tomography</term>
                <term xml:lang="en"> Surgical and invasive medical procedures</term>
                <term xml:lang="en"> Weight gain</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">The mechanisms behind weight gain following deep brain stimulation (DBS) surgery seem to be multifactorial and suspected depending on the target, either the subthalamic nucleus (STN) or the globus pallidus internus (GPi). Decreased energy expenditure following motor improvement and behavioral and/or metabolic changes are possible explanations. Focusing on GPi target, our objective was to analyze correlations between changes in brain metabolism (measured with PET) and weight gain following GPi-DBS in patients with Parkinson’s disease (PD). Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose PET four months before and four months after the start of GPi-DBS in 19 PD patients. Dopaminergic medication was included in the analysis to control for its possible influence on brain metabolism. Body mass index increased significantly by 0.66 ± 1.3 kg/m2 ( p = 0.040). There were correlations between weight gain and changes in brain metabolism in premotor areas, including the left and right superior gyri (Brodmann area, BA 6), left superior gyrus (BA 8), the dorsolateral prefrontal cortex (right middle gyrus, BAs 9 and 46), and the left and right somatosensory association cortices (BA 7). However, we found no correlation between weight gain and metabolic changes in limbic and associative areas. Additionally, there was a trend toward a correlation between reduced dyskinesia and weight gain ( r = 0.428, p = 0.067). These findings suggest that, unlike STN-DBS, motor improvement is the major contributing factor for weight gain following GPi-DBS PD, confirming the motor selectivity of this target</abstract>
          </profileDesc>
        </hal>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Weight Gain following Pallidal Deep Brain Stimulation: A PET Study

Weight Gain following Pallidal Deep Brain Stimulation: A PET Study

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