Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.
Identifieur interne : 000C13 ( PubMed/Curation ); précédent : 000C12; suivant : 000C14Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.
Auteurs : Kim L. Roberts [Royaume-Uni] ; Holly Shelton ; Peter Stilwell ; Wendy S. BarclaySource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Sous-type H1N1 du virus de la grippe A.
- virologie : Appareil respiratoire, Furets.
- transmission : Animaux, Cinétique, Facteurs temps, Fièvre, Flambées de maladies, Grippe humaine, Humains, Modèles animaux de maladie humaine, Température du corps.
English descriptors
- KwdEn :
- MESH :
- metabolism : Influenza A Virus, H1N1 Subtype.
- transmission : Influenza, Human.
- virology : Ferrets, Respiratory System.
- Animals, Body Temperature, Disease Models, Animal, Disease Outbreaks, Fever, Humans, Kinetics, Time Factors.
Abstract
During the early phase of the 2009 influenza pandemic, attempts were made to contain the spread of the virus. Success of reactive control measures may be compromised if the proportion of transmission that occurs before overt clinical symptoms develop is high. In this study we investigated the timing of transmission of an early prototypic strain of pandemic H1N1 2009 influenza virus in the ferret model. Ferrets are the only animal model in which this can be assessed because they display typical influenza-like clinical signs including fever and sneezing after infection. We assessed transmission from infected animals to sentinels that were placed either in direct contact or in adjacent cages, the latter reflecting the respiratory droplet (RD) transmission route. We found that pre-symptomatic influenza transmission occurred via both contact and respiratory droplet exposure before the earliest clinical sign, fever, developed. Three of 3 animals exposed in direct contact between day 1 and 2 after infection of the donor animals became infected, and 2/3 of the animals exposed at this time period by the RD route acquired the infection, with the third animal becoming seropositive indicating either a low level infection or significant exposure. Moreover, this efficient transmission did not temporally correlate with respiratory symptoms, such as coughs and sneezes, but rather with the peak viral titre in the nose. Indeed respiratory droplet transmission did not occur late in infection, even though this was when sneezing and coughing were most apparent. None of the 3 animals exposed at this time by the RD route became infected and these animals remained seronegative at the end of the experiment. These data have important implications for pandemic planning strategies and suggest that successful containment is highly unlikely for a human-adapted influenza virus that transmits efficiently within a population.
DOI: 10.1371/journal.pone.0043303
PubMed: 22952661
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Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Shelton, Holly" sort="Shelton, Holly" uniqKey="Shelton H" first="Holly" last="Shelton">Holly Shelton</name></author><author><name sortKey="Stilwell, Peter" sort="Stilwell, Peter" uniqKey="Stilwell P" first="Peter" last="Stilwell">Peter Stilwell</name></author><author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S" last="Barclay">Wendy S. 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Barclay</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Temperature</term><term>Disease Models, Animal</term><term>Disease Outbreaks</term><term>Ferrets (virology)</term><term>Fever</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (metabolism)</term><term>Influenza, Human (transmission)</term><term>Kinetics</term><term>Respiratory System (virology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Appareil respiratoire (virologie)</term><term>Cinétique</term><term>Facteurs temps</term><term>Fièvre</term><term>Flambées de maladies</term><term>Furets (virologie)</term><term>Grippe humaine (transmission)</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Sous-type H1N1 du virus de la grippe A (métabolisme)</term><term>Température du corps</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Furets</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Temperature</term><term>Disease Models, Animal</term><term>Disease Outbreaks</term><term>Fever</term><term>Humans</term><term>Kinetics</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term><term>Cinétique</term><term>Facteurs temps</term><term>Fièvre</term><term>Flambées de maladies</term><term>Grippe humaine</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Température du corps</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the early phase of the 2009 influenza pandemic, attempts were made to contain the spread of the virus. Success of reactive control measures may be compromised if the proportion of transmission that occurs before overt clinical symptoms develop is high. In this study we investigated the timing of transmission of an early prototypic strain of pandemic H1N1 2009 influenza virus in the ferret model. Ferrets are the only animal model in which this can be assessed because they display typical influenza-like clinical signs including fever and sneezing after infection. We assessed transmission from infected animals to sentinels that were placed either in direct contact or in adjacent cages, the latter reflecting the respiratory droplet (RD) transmission route. We found that pre-symptomatic influenza transmission occurred via both contact and respiratory droplet exposure before the earliest clinical sign, fever, developed. Three of 3 animals exposed in direct contact between day 1 and 2 after infection of the donor animals became infected, and 2/3 of the animals exposed at this time period by the RD route acquired the infection, with the third animal becoming seropositive indicating either a low level infection or significant exposure. Moreover, this efficient transmission did not temporally correlate with respiratory symptoms, such as coughs and sneezes, but rather with the peak viral titre in the nose. Indeed respiratory droplet transmission did not occur late in infection, even though this was when sneezing and coughing were most apparent. None of the 3 animals exposed at this time by the RD route became infected and these animals remained seronegative at the end of the experiment. These data have important implications for pandemic planning strategies and suggest that successful containment is highly unlikely for a human-adapted influenza virus that transmits efficiently within a population.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22952661</PMID><DateCompleted><Year>2013</Year><Month>02</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>8</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.</ArticleTitle><Pagination><MedlinePgn>e43303</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0043303</ELocationID><Abstract><AbstractText>During the early phase of the 2009 influenza pandemic, attempts were made to contain the spread of the virus. Success of reactive control measures may be compromised if the proportion of transmission that occurs before overt clinical symptoms develop is high. In this study we investigated the timing of transmission of an early prototypic strain of pandemic H1N1 2009 influenza virus in the ferret model. Ferrets are the only animal model in which this can be assessed because they display typical influenza-like clinical signs including fever and sneezing after infection. We assessed transmission from infected animals to sentinels that were placed either in direct contact or in adjacent cages, the latter reflecting the respiratory droplet (RD) transmission route. We found that pre-symptomatic influenza transmission occurred via both contact and respiratory droplet exposure before the earliest clinical sign, fever, developed. Three of 3 animals exposed in direct contact between day 1 and 2 after infection of the donor animals became infected, and 2/3 of the animals exposed at this time period by the RD route acquired the infection, with the third animal becoming seropositive indicating either a low level infection or significant exposure. Moreover, this efficient transmission did not temporally correlate with respiratory symptoms, such as coughs and sneezes, but rather with the peak viral titre in the nose. Indeed respiratory droplet transmission did not occur late in infection, even though this was when sneezing and coughing were most apparent. None of the 3 animals exposed at this time by the RD route became infected and these animals remained seronegative at the end of the experiment. These data have important implications for pandemic planning strategies and suggest that successful containment is highly unlikely for a human-adapted influenza virus that transmits efficiently within a population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Kim L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shelton</LastName><ForeName>Holly</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Stilwell</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Barclay</LastName><ForeName>Wendy S</ForeName><Initials>WS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0600504</GrantID><Agency>Medical Research 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